Incidental Mutation 'R6465:Or6b6'
ID 517775
Institutional Source Beutler Lab
Gene Symbol Or6b6
Ensembl Gene ENSMUSG00000045013
Gene Name olfactory receptor family 6 subfamily B member 6
Synonyms MOR103-4, Olfr711, GA_x6K02T2PBJ9-9352783-9351839
MMRRC Submission 044598-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R6465 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 106570575-106574658 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 106571419 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 44 (V44E)
Ref Sequence ENSEMBL: ENSMUSP00000149016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051715] [ENSMUST00000207200] [ENSMUST00000216335]
AlphaFold Q9EPG2
Predicted Effect possibly damaging
Transcript: ENSMUST00000051715
AA Change: V44E

PolyPhen 2 Score 0.630 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000055724
Gene: ENSMUSG00000045013
AA Change: V44E

Pfam:7tm_4 31 307 1.5e-58 PFAM
Pfam:7tm_1 41 290 1.2e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000207200
AA Change: V44E

PolyPhen 2 Score 0.630 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216335
AA Change: V44E

PolyPhen 2 Score 0.630 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.1%
Validation Efficiency 95% (40/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 G A 6: 128,518,041 (GRCm39) T1415I probably damaging Het
Acvr2b T A 9: 119,262,369 (GRCm39) W461R probably damaging Het
Adam23 G T 1: 63,605,827 (GRCm39) C637F probably damaging Het
Apol8 T G 15: 77,634,148 (GRCm39) T143P probably benign Het
Bfsp1 A C 2: 143,699,975 (GRCm39) probably null Het
Cytl1 T C 5: 37,895,014 (GRCm39) V99A probably benign Het
Dock2 A T 11: 34,453,413 (GRCm39) V793E probably damaging Het
Fxyd5 G T 7: 30,737,305 (GRCm39) T81K probably damaging Het
Gcm1 A G 9: 77,972,151 (GRCm39) Y364C probably damaging Het
Get3 A T 8: 85,745,194 (GRCm39) M291K probably benign Het
Haghl T C 17: 26,002,793 (GRCm39) N190S possibly damaging Het
Inpp5j C A 11: 3,452,293 (GRCm39) R319L possibly damaging Het
Ints10 A G 8: 69,260,188 (GRCm39) N304S probably benign Het
Isoc1 T A 18: 58,804,328 (GRCm39) C119S probably damaging Het
Klhl18 A G 9: 110,257,988 (GRCm39) M414T probably benign Het
Krtap2-4 A G 11: 99,505,585 (GRCm39) probably benign Het
Krtap3-1 G A 11: 99,457,277 (GRCm39) P45S possibly damaging Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Myo7a A G 7: 97,711,887 (GRCm39) V1754A possibly damaging Het
Nedd4l T A 18: 65,288,335 (GRCm39) D119E probably benign Het
Nsun7 T C 5: 66,452,929 (GRCm39) V548A probably benign Het
Or5m12 A T 2: 85,734,883 (GRCm39) S172T probably benign Het
Parvg A G 15: 84,213,141 (GRCm39) D127G probably damaging Het
Pate13 A T 9: 35,819,921 (GRCm39) N25Y possibly damaging Het
Piezo2 T A 18: 63,174,734 (GRCm39) M2007L possibly damaging Het
Pou2f3 A C 9: 43,051,162 (GRCm39) F175V probably damaging Het
Ptprn2 T C 12: 117,233,209 (GRCm39) I958T probably damaging Het
Pwwp2b T C 7: 138,835,951 (GRCm39) V464A probably benign Het
Pzp A G 6: 128,468,582 (GRCm39) Y982H probably damaging Het
Rad17 T A 13: 100,773,588 (GRCm39) N202I probably benign Het
Rtel1 T A 2: 180,977,733 (GRCm39) D271E possibly damaging Het
Sos2 T C 12: 69,643,549 (GRCm39) S943G probably benign Het
Tdpoz6 A G 3: 93,600,303 (GRCm39) I22T probably damaging Het
Tm9sf2 A G 14: 122,378,619 (GRCm39) H241R probably benign Het
Ttc8 A G 12: 98,930,829 (GRCm39) E291G probably damaging Het
Unc93a2 G T 17: 7,641,842 (GRCm39) T202K probably damaging Het
Wfikkn1 A G 17: 26,097,692 (GRCm39) C211R probably damaging Het
Ylpm1 T A 12: 85,096,576 (GRCm39) D1219E probably damaging Het
Zc3hav1 T C 6: 38,308,784 (GRCm39) Y586C possibly damaging Het
Zcchc4 T A 5: 52,976,618 (GRCm39) F471I probably benign Het
Zfp719 C A 7: 43,240,108 (GRCm39) Y565* probably null Het
Other mutations in Or6b6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02600:Or6b6 APN 7 106,570,756 (GRCm39) missense possibly damaging 0.51
R0087:Or6b6 UTSW 7 106,571,323 (GRCm39) missense probably benign 0.01
R0580:Or6b6 UTSW 7 106,571,447 (GRCm39) missense probably damaging 1.00
R1375:Or6b6 UTSW 7 106,571,305 (GRCm39) missense probably damaging 1.00
R1538:Or6b6 UTSW 7 106,571,190 (GRCm39) nonsense probably null
R1875:Or6b6 UTSW 7 106,571,389 (GRCm39) missense possibly damaging 0.86
R2156:Or6b6 UTSW 7 106,570,775 (GRCm39) missense probably damaging 1.00
R4290:Or6b6 UTSW 7 106,570,918 (GRCm39) missense probably damaging 0.97
R4332:Or6b6 UTSW 7 106,571,354 (GRCm39) missense probably benign 0.00
R4400:Or6b6 UTSW 7 106,571,209 (GRCm39) missense probably damaging 1.00
R4688:Or6b6 UTSW 7 106,571,068 (GRCm39) missense probably benign 0.02
R4868:Or6b6 UTSW 7 106,570,974 (GRCm39) missense probably benign
R4970:Or6b6 UTSW 7 106,570,778 (GRCm39) missense probably benign 0.35
R5006:Or6b6 UTSW 7 106,570,808 (GRCm39) missense probably damaging 1.00
R5082:Or6b6 UTSW 7 106,570,871 (GRCm39) missense probably benign 0.00
R5121:Or6b6 UTSW 7 106,571,438 (GRCm39) missense probably benign
R6541:Or6b6 UTSW 7 106,571,410 (GRCm39) missense probably benign 0.20
R7419:Or6b6 UTSW 7 106,571,353 (GRCm39) missense probably benign 0.01
R8048:Or6b6 UTSW 7 106,571,671 (GRCm39) start gained probably benign
R9310:Or6b6 UTSW 7 106,570,678 (GRCm39) missense probably damaging 1.00
R9470:Or6b6 UTSW 7 106,571,461 (GRCm39) missense probably benign 0.26
R9603:Or6b6 UTSW 7 106,571,103 (GRCm39) nonsense probably null
Z1177:Or6b6 UTSW 7 106,571,122 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2018-05-21