Incidental Mutation 'R0600:Tet2'
| ID |
55280 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tet2
|
| Ensembl Gene |
ENSMUSG00000040943 |
| Gene Name |
tet methylcytosine dioxygenase 2 |
| Synonyms |
E130014J05Rik, Ayu17-449 |
| MMRRC Submission |
038789-MU
|
| Accession Numbers |
Ncbi RefSeq: NM_001040400.2; MGI:2443298
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0600 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
133463679-133545139 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 133467602 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 1633
(M1633T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143029
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098603]
[ENSMUST00000196398]
|
| AlphaFold |
Q4JK59 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098603
AA Change: M1625T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000096203
Gene: ENSMUSG00000040943
AA Change: M1625T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1203 |
1819 |
7e-301 |
SMART |
|
low complexity region
|
1832 |
1844 |
N/A |
INTRINSIC |
|
low complexity region
|
1885 |
1897 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196398
AA Change: M1633T
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000143029
Gene: ENSMUSG00000040943
AA Change: M1633T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
690 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
884 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
899 |
921 |
N/A |
INTRINSIC |
|
Tet_JBP
|
1211 |
1827 |
3.4e-305 |
SMART |
|
low complexity region
|
1840 |
1852 |
N/A |
INTRINSIC |
|
low complexity region
|
1893 |
1905 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197211
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000198974
AA Change: M132T
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000199381
|
| Meta Mutation Damage Score |
0.0777 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.1%
- 20x: 93.5%
|
| Validation Efficiency |
99% (95/96) |
| MGI Phenotype |
Strain: 5285413; 4345275; 3813933; 5301343
Lethality: D1-D2
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1246) : Targeted(6) Gene trapped(1240)
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310057M21Rik |
A |
G |
7: 131,357,660 (GRCm38) |
S150P |
probably damaging |
Het |
| 4932431P20Rik |
T |
A |
7: 29,533,265 (GRCm38) |
|
noncoding transcript |
Het |
| 5530400C23Rik |
T |
G |
6: 133,293,211 (GRCm38) |
|
probably benign |
Het |
| Ahctf1 |
A |
C |
1: 179,763,468 (GRCm38) |
|
probably null |
Het |
| Ang5 |
T |
C |
14: 43,962,749 (GRCm38) |
V90A |
probably benign |
Het |
| Ano9 |
C |
T |
7: 141,104,710 (GRCm38) |
G442R |
probably damaging |
Het |
| Apaf1 |
G |
A |
10: 91,060,052 (GRCm38) |
T386I |
probably damaging |
Het |
| Apob |
C |
A |
12: 8,006,440 (GRCm38) |
H1608N |
probably damaging |
Het |
| Arhgap12 |
C |
A |
18: 6,064,433 (GRCm38) |
|
probably benign |
Het |
| Asxl1 |
T |
A |
2: 153,399,904 (GRCm38) |
D791E |
probably benign |
Het |
| Avl9 |
T |
C |
6: 56,736,906 (GRCm38) |
V383A |
probably benign |
Het |
| Btbd1 |
A |
C |
7: 81,816,006 (GRCm38) |
D197E |
probably damaging |
Het |
| C87499 |
A |
T |
4: 88,629,299 (GRCm38) |
I45K |
probably damaging |
Het |
| Camta2 |
T |
C |
11: 70,673,959 (GRCm38) |
I938V |
possibly damaging |
Het |
| Cdca7 |
C |
A |
2: 72,483,467 (GRCm38) |
A200D |
possibly damaging |
Het |
| Cep104 |
A |
T |
4: 154,006,792 (GRCm38) |
Y923F |
possibly damaging |
Het |
| Cep135 |
G |
C |
5: 76,621,305 (GRCm38) |
V601L |
probably benign |
Het |
| Ces2b |
G |
A |
8: 104,835,910 (GRCm38) |
G291S |
probably benign |
Het |
| Col6a6 |
C |
T |
9: 105,761,440 (GRCm38) |
G1400D |
probably damaging |
Het |
| Cyth2 |
T |
C |
7: 45,813,117 (GRCm38) |
E1G |
probably damaging |
Het |
| Dand5 |
A |
T |
8: 84,816,292 (GRCm38) |
L185Q |
probably damaging |
Het |
| Dck |
T |
C |
5: 88,781,221 (GRCm38) |
V253A |
probably benign |
Het |
| Ddx20 |
A |
G |
3: 105,679,080 (GRCm38) |
S650P |
probably damaging |
Het |
| Dicer1 |
G |
A |
12: 104,706,864 (GRCm38) |
P799S |
probably damaging |
Het |
| Dst |
C |
T |
1: 34,189,119 (GRCm38) |
P1606L |
probably damaging |
Het |
| Eya2 |
G |
A |
2: 165,769,237 (GRCm38) |
C477Y |
probably damaging |
Het |
| Fam208b |
A |
T |
13: 3,576,054 (GRCm38) |
F1299I |
probably benign |
Het |
| Fip1l1 |
T |
A |
5: 74,595,842 (GRCm38) |
N498K |
probably damaging |
Het |
| Flt4 |
C |
T |
11: 49,636,339 (GRCm38) |
|
probably benign |
Het |
| Galntl6 |
T |
C |
8: 57,837,183 (GRCm38) |
|
probably null |
Het |
| Gda |
A |
T |
19: 21,434,303 (GRCm38) |
F44I |
possibly damaging |
Het |
| Gli2 |
G |
A |
1: 118,840,389 (GRCm38) |
R703C |
probably damaging |
Het |
| Gm14085 |
A |
T |
2: 122,514,398 (GRCm38) |
I162F |
probably damaging |
Het |
| Golgb1 |
T |
A |
16: 36,916,271 (GRCm38) |
L1960Q |
probably damaging |
Het |
| Gramd1b |
T |
C |
9: 40,308,355 (GRCm38) |
D341G |
probably damaging |
Het |
| Grid2 |
G |
T |
6: 63,503,435 (GRCm38) |
A78S |
probably benign |
Het |
| Hao2 |
A |
T |
3: 98,883,560 (GRCm38) |
|
probably benign |
Het |
| Hook3 |
A |
G |
8: 26,118,986 (GRCm38) |
V10A |
probably benign |
Het |
| Kif20a |
A |
G |
18: 34,629,209 (GRCm38) |
E425G |
probably damaging |
Het |
| Lrp1 |
T |
C |
10: 127,567,383 (GRCm38) |
D2107G |
probably benign |
Het |
| Lrriq3 |
T |
C |
3: 155,187,736 (GRCm38) |
I358T |
possibly damaging |
Het |
| Mad2l2 |
A |
G |
4: 148,140,924 (GRCm38) |
D17G |
possibly damaging |
Het |
| Mastl |
G |
T |
2: 23,133,346 (GRCm38) |
T455K |
probably benign |
Het |
| Mkln1 |
G |
T |
6: 31,432,927 (GRCm38) |
|
probably benign |
Het |
| Mmp1b |
A |
T |
9: 7,387,947 (GRCm38) |
Y16N |
possibly damaging |
Het |
| Mmp24 |
C |
T |
2: 155,792,597 (GRCm38) |
A79V |
probably benign |
Het |
| Mrps35 |
T |
A |
6: 147,070,734 (GRCm38) |
C292S |
possibly damaging |
Het |
| Myom1 |
T |
C |
17: 71,120,648 (GRCm38) |
F1435L |
possibly damaging |
Het |
| Nars2 |
C |
T |
7: 97,039,923 (GRCm38) |
H351Y |
probably damaging |
Het |
| Nat2 |
A |
T |
8: 67,501,267 (GRCm38) |
I10F |
probably damaging |
Het |
| Nfix |
G |
A |
8: 84,726,526 (GRCm38) |
R300C |
probably damaging |
Het |
| Olfm5 |
A |
T |
7: 104,153,869 (GRCm38) |
Y462* |
probably null |
Het |
| Olfr1228 |
C |
A |
2: 89,249,398 (GRCm38) |
E87* |
probably null |
Het |
| Olfr1339 |
C |
T |
4: 118,734,789 (GRCm38) |
H87Y |
probably damaging |
Het |
| Olfr1508 |
T |
C |
14: 52,463,509 (GRCm38) |
I167V |
probably benign |
Het |
| Olfr322 |
C |
A |
11: 58,666,160 (GRCm38) |
F200L |
probably damaging |
Het |
| Olfr340 |
C |
A |
2: 36,452,648 (GRCm38) |
A21E |
probably benign |
Het |
| Olfr44 |
A |
T |
9: 39,484,988 (GRCm38) |
F85L |
probably benign |
Het |
| Olfr495 |
T |
A |
7: 108,395,231 (GRCm38) |
I37N |
probably damaging |
Het |
| Olfr855 |
T |
C |
9: 19,585,304 (GRCm38) |
S256P |
possibly damaging |
Het |
| Olfr926 |
T |
A |
9: 38,877,815 (GRCm38) |
I213N |
probably damaging |
Het |
| Otog |
A |
T |
7: 46,251,395 (GRCm38) |
|
probably benign |
Het |
| Pdcd2l |
A |
T |
7: 34,192,807 (GRCm38) |
D212E |
possibly damaging |
Het |
| Pex5 |
T |
C |
6: 124,404,637 (GRCm38) |
N213S |
probably benign |
Het |
| Pkn3 |
C |
T |
2: 30,081,134 (GRCm38) |
P238S |
probably benign |
Het |
| Prl2b1 |
A |
T |
13: 27,390,740 (GRCm38) |
|
probably null |
Het |
| Ptprb |
A |
T |
10: 116,368,807 (GRCm38) |
I1849L |
possibly damaging |
Het |
| Rasal3 |
G |
T |
17: 32,393,526 (GRCm38) |
S787Y |
probably damaging |
Het |
| Scn2a |
T |
A |
2: 65,701,833 (GRCm38) |
D596E |
possibly damaging |
Het |
| Sdhd |
A |
T |
9: 50,603,764 (GRCm38) |
V9D |
possibly damaging |
Het |
| Serinc5 |
T |
C |
13: 92,708,057 (GRCm38) |
S436P |
probably damaging |
Het |
| Slc27a1 |
C |
T |
8: 71,584,164 (GRCm38) |
P348L |
probably damaging |
Het |
| Smg1 |
G |
A |
7: 118,160,383 (GRCm38) |
|
probably benign |
Het |
| Sorl1 |
A |
T |
9: 42,043,900 (GRCm38) |
|
probably benign |
Het |
| Sprtn |
T |
A |
8: 124,900,218 (GRCm38) |
H112Q |
probably damaging |
Het |
| Tmem68 |
A |
T |
4: 3,569,667 (GRCm38) |
C8S |
probably damaging |
Het |
| Tnrc6a |
T |
A |
7: 123,171,816 (GRCm38) |
I943N |
probably benign |
Het |
| Trib2 |
A |
T |
12: 15,794,068 (GRCm38) |
V191D |
probably damaging |
Het |
| Tsc22d4 |
T |
C |
5: 137,762,655 (GRCm38) |
S113P |
probably damaging |
Het |
| Ttc21b |
T |
C |
2: 66,239,570 (GRCm38) |
R250G |
probably damaging |
Het |
| Ubr2 |
T |
C |
17: 46,967,248 (GRCm38) |
Y721C |
probably damaging |
Het |
| Ubtfl1 |
A |
T |
9: 18,409,364 (GRCm38) |
I63F |
probably damaging |
Het |
| Ush1c |
G |
A |
7: 46,224,908 (GRCm38) |
P171S |
probably benign |
Het |
| Utp20 |
A |
T |
10: 88,767,461 (GRCm38) |
N1843K |
probably damaging |
Het |
| Vangl1 |
A |
G |
3: 102,166,937 (GRCm38) |
Y285H |
probably damaging |
Het |
| Virma |
A |
G |
4: 11,498,769 (GRCm38) |
D70G |
probably damaging |
Het |
| Vmn2r102 |
T |
C |
17: 19,678,015 (GRCm38) |
F431L |
probably benign |
Het |
| Wdr17 |
A |
G |
8: 54,661,495 (GRCm38) |
I662T |
probably damaging |
Het |
| Wisp2 |
G |
A |
2: 163,825,313 (GRCm38) |
C78Y |
probably damaging |
Het |
| Zfp160 |
G |
A |
17: 21,027,006 (GRCm38) |
R606H |
probably benign |
Het |
| Zfp369 |
C |
T |
13: 65,296,434 (GRCm38) |
R464C |
probably damaging |
Het |
|
| Other mutations in Tet2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00341:Tet2
|
APN |
3 |
133,488,085 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL00401:Tet2
|
APN |
3 |
133,466,882 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
IGL01528:Tet2
|
APN |
3 |
133,480,298 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02053:Tet2
|
APN |
3 |
133,488,523 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL02142:Tet2
|
APN |
3 |
133,480,139 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL02512:Tet2
|
APN |
3 |
133,469,308 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL03148:Tet2
|
APN |
3 |
133,481,363 (GRCm38) |
missense |
probably benign |
0.18 |
|
IGL03182:Tet2
|
APN |
3 |
133,471,398 (GRCm38) |
nonsense |
probably null |
|
|
IGL03371:Tet2
|
APN |
3 |
133,467,551 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
P0022:Tet2
|
UTSW |
3 |
133,486,893 (GRCm38) |
missense |
probably benign |
0.01 |
|
P0023:Tet2
|
UTSW |
3 |
133,486,893 (GRCm38) |
missense |
probably benign |
0.01 |
|
P0031:Tet2
|
UTSW |
3 |
133,480,202 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R0012:Tet2
|
UTSW |
3 |
133,476,558 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0012:Tet2
|
UTSW |
3 |
133,476,558 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0463:Tet2
|
UTSW |
3 |
133,486,666 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R0522:Tet2
|
UTSW |
3 |
133,466,804 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0593:Tet2
|
UTSW |
3 |
133,488,109 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0600:Tet2
|
UTSW |
3 |
133,467,725 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0698:Tet2
|
UTSW |
3 |
133,467,384 (GRCm38) |
missense |
probably benign |
0.32 |
|
R0723:Tet2
|
UTSW |
3 |
133,467,284 (GRCm38) |
missense |
probably benign |
|
|
R0726:Tet2
|
UTSW |
3 |
133,468,184 (GRCm38) |
missense |
probably benign |
|
|
R0747:Tet2
|
UTSW |
3 |
133,467,470 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1006:Tet2
|
UTSW |
3 |
133,476,601 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1382:Tet2
|
UTSW |
3 |
133,476,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1455:Tet2
|
UTSW |
3 |
133,473,645 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R1550:Tet2
|
UTSW |
3 |
133,469,519 (GRCm38) |
missense |
probably benign |
0.32 |
|
R1647:Tet2
|
UTSW |
3 |
133,485,880 (GRCm38) |
missense |
probably benign |
|
|
R1662:Tet2
|
UTSW |
3 |
133,466,852 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R1727:Tet2
|
UTSW |
3 |
133,487,290 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1738:Tet2
|
UTSW |
3 |
133,481,387 (GRCm38) |
missense |
probably benign |
0.08 |
|
R1749:Tet2
|
UTSW |
3 |
133,480,131 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1869:Tet2
|
UTSW |
3 |
133,481,441 (GRCm38) |
splice site |
probably null |
|
|
R1887:Tet2
|
UTSW |
3 |
133,487,333 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R1937:Tet2
|
UTSW |
3 |
133,488,638 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R1939:Tet2
|
UTSW |
3 |
133,488,638 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R1940:Tet2
|
UTSW |
3 |
133,488,638 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R1997:Tet2
|
UTSW |
3 |
133,486,589 (GRCm38) |
nonsense |
probably null |
|
|
R2082:Tet2
|
UTSW |
3 |
133,485,727 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R2084:Tet2
|
UTSW |
3 |
133,487,767 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R2215:Tet2
|
UTSW |
3 |
133,486,601 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2321:Tet2
|
UTSW |
3 |
133,486,339 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R2873:Tet2
|
UTSW |
3 |
133,486,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3439:Tet2
|
UTSW |
3 |
133,466,831 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R3783:Tet2
|
UTSW |
3 |
133,479,363 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R3894:Tet2
|
UTSW |
3 |
133,469,477 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R3916:Tet2
|
UTSW |
3 |
133,486,055 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R3966:Tet2
|
UTSW |
3 |
133,487,657 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R4457:Tet2
|
UTSW |
3 |
133,485,563 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R4633:Tet2
|
UTSW |
3 |
133,485,549 (GRCm38) |
missense |
probably benign |
0.33 |
|
R4646:Tet2
|
UTSW |
3 |
133,488,082 (GRCm38) |
missense |
probably benign |
0.02 |
|
R4647:Tet2
|
UTSW |
3 |
133,488,082 (GRCm38) |
missense |
probably benign |
0.02 |
|
R4648:Tet2
|
UTSW |
3 |
133,488,082 (GRCm38) |
missense |
probably benign |
0.02 |
|
R4691:Tet2
|
UTSW |
3 |
133,486,083 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R4805:Tet2
|
UTSW |
3 |
133,467,315 (GRCm38) |
missense |
probably benign |
0.32 |
|
R4829:Tet2
|
UTSW |
3 |
133,476,620 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4901:Tet2
|
UTSW |
3 |
133,467,044 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4975:Tet2
|
UTSW |
3 |
133,486,759 (GRCm38) |
unclassified |
probably benign |
|
|
R5004:Tet2
|
UTSW |
3 |
133,487,379 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R5075:Tet2
|
UTSW |
3 |
133,486,906 (GRCm38) |
missense |
probably benign |
|
|
R5137:Tet2
|
UTSW |
3 |
133,476,565 (GRCm38) |
missense |
probably benign |
0.32 |
|
R5324:Tet2
|
UTSW |
3 |
133,485,913 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5590:Tet2
|
UTSW |
3 |
133,476,480 (GRCm38) |
splice site |
probably null |
|
|
R5854:Tet2
|
UTSW |
3 |
133,487,885 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5856:Tet2
|
UTSW |
3 |
133,486,640 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5865:Tet2
|
UTSW |
3 |
133,487,099 (GRCm38) |
missense |
probably benign |
0.08 |
|
R5879:Tet2
|
UTSW |
3 |
133,487,960 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R5935:Tet2
|
UTSW |
3 |
133,488,535 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R6012:Tet2
|
UTSW |
3 |
133,466,781 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R6075:Tet2
|
UTSW |
3 |
133,471,435 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R6181:Tet2
|
UTSW |
3 |
133,487,759 (GRCm38) |
nonsense |
probably null |
|
|
R6188:Tet2
|
UTSW |
3 |
133,480,326 (GRCm38) |
missense |
probably benign |
0.18 |
|
R6339:Tet2
|
UTSW |
3 |
133,486,417 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R6612:Tet2
|
UTSW |
3 |
133,487,335 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R6923:Tet2
|
UTSW |
3 |
133,479,341 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6934:Tet2
|
UTSW |
3 |
133,483,237 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7076:Tet2
|
UTSW |
3 |
133,467,023 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R7155:Tet2
|
UTSW |
3 |
133,469,591 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R7184:Tet2
|
UTSW |
3 |
133,473,630 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7200:Tet2
|
UTSW |
3 |
133,487,192 (GRCm38) |
missense |
probably benign |
0.18 |
|
R7459:Tet2
|
UTSW |
3 |
133,480,289 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R7504:Tet2
|
UTSW |
3 |
133,487,339 (GRCm38) |
missense |
probably benign |
0.33 |
|
R7524:Tet2
|
UTSW |
3 |
133,480,229 (GRCm38) |
missense |
probably benign |
0.33 |
|
R7613:Tet2
|
UTSW |
3 |
133,466,748 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R7653:Tet2
|
UTSW |
3 |
133,486,385 (GRCm38) |
missense |
probably benign |
0.18 |
|
R7691:Tet2
|
UTSW |
3 |
133,486,849 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7770:Tet2
|
UTSW |
3 |
133,480,295 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R7807:Tet2
|
UTSW |
3 |
133,486,541 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R7813:Tet2
|
UTSW |
3 |
133,473,643 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7978:Tet2
|
UTSW |
3 |
133,487,665 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R8055:Tet2
|
UTSW |
3 |
133,467,992 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R8164:Tet2
|
UTSW |
3 |
133,467,134 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R8236:Tet2
|
UTSW |
3 |
133,487,786 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8755:Tet2
|
UTSW |
3 |
133,488,278 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8962:Tet2
|
UTSW |
3 |
133,488,043 (GRCm38) |
missense |
probably benign |
0.22 |
|
R9009:Tet2
|
UTSW |
3 |
133,487,599 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R9014:Tet2
|
UTSW |
3 |
133,467,188 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9128:Tet2
|
UTSW |
3 |
133,469,613 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9166:Tet2
|
UTSW |
3 |
133,468,172 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9190:Tet2
|
UTSW |
3 |
133,481,386 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R9344:Tet2
|
UTSW |
3 |
133,469,354 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R9360:Tet2
|
UTSW |
3 |
133,487,142 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R9471:Tet2
|
UTSW |
3 |
133,485,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9488:Tet2
|
UTSW |
3 |
133,487,342 (GRCm38) |
missense |
probably benign |
0.18 |
|
R9534:Tet2
|
UTSW |
3 |
133,467,928 (GRCm38) |
nonsense |
probably null |
|
|
R9557:Tet2
|
UTSW |
3 |
133,485,805 (GRCm38) |
missense |
probably benign |
|
|
R9621:Tet2
|
UTSW |
3 |
133,488,006 (GRCm38) |
nonsense |
probably null |
|
|
R9644:Tet2
|
UTSW |
3 |
133,487,303 (GRCm38) |
nonsense |
probably null |
|
|
R9719:Tet2
|
UTSW |
3 |
133,486,042 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
X0021:Tet2
|
UTSW |
3 |
133,486,295 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
X0066:Tet2
|
UTSW |
3 |
133,488,373 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCATGAACCTCACACTTTGCAC -3'
(R):5'- CCAGTGGACAATGGTTCCCCTTTC -3'
Sequencing Primer
(F):5'- GATCCTGAAAGTTGTGCTCAC -3'
(R):5'- ACAATGGTTCCCCTTTCTTAGGTTC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation