|Institutional Source||Beutler Lab|
|Gene Name||cadherin 13|
|Synonyms||T-cadherin, 4932416G01Rik, Tcad|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7807 (G1)|
|Chromosomal Location||118283733-119324921 bp(+) (GRCm38)|
|Type of Mutation||start codon destroyed|
|DNA Base Change (assembly)||T to A at 118283855 bp|
|Amino Acid Change||Methionine to Lysine at position 1 (M1K)|
|Ref Sequence||ENSEMBL: ENSMUSP00000113527 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000117160]|
Crystal Structure of mouse T-cadherin EC1 EC2 [X-RAY DIFFRACTION]
Crystal structure of mouse T-cadherin EC1 [X-RAY DIFFRACTION]
|Predicted Effect||probably null
AA Change: M1K
PolyPhen 2 Score 0.771 (Sensitivity: 0.85; Specificity: 0.92)
AA Change: M1K
|Coding Region Coverage||
|Validation Efficiency||100% (68/68)|
FUNCTION: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased retinal neovascularization and increased adiponectin levels. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cdh13||
(F):5'- TGAAGGAATCCGTCTTGTAAAGCC -3'
(R):5'- TGACCTCGCATCTGAGCTAG -3'
(F):5'- TAAAGCCATTGGTCCTGGTCATCAG -3'
(R):5'- CATCTGAGCTAGCCGGGTATATC -3'