Incidental Mutation 'R7807:Cdh13'
ID 600865
Institutional Source Beutler Lab
Gene Symbol Cdh13
Ensembl Gene ENSMUSG00000031841
Gene Name cadherin 13
Synonyms T-cadherin, 4932416G01Rik, Tcad
MMRRC Submission 045862-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7807 (G1)
Quality Score 201.009
Status Validated
Chromosome 8
Chromosomal Location 119010472-120051660 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to A at 119010594 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000113527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117160]
AlphaFold Q9WTR5
PDB Structure Crystal Structure of mouse T-cadherin EC1 EC2 [X-RAY DIFFRACTION]
Crystal structure of mouse T-cadherin EC1 [X-RAY DIFFRACTION]
Predicted Effect probably null
Transcript: ENSMUST00000117160
AA Change: M1K

PolyPhen 2 Score 0.771 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000113527
Gene: ENSMUSG00000031841
AA Change: M1K

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Cadherin_pro 26 112 1.04e-17 SMART
CA 160 243 1.49e-18 SMART
CA 267 361 1.84e-23 SMART
CA 383 476 8.75e-16 SMART
CA 499 583 2.36e-21 SMART
CA 604 687 5.93e-2 SMART
low complexity region 695 714 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (68/68)
MGI Phenotype FUNCTION: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased retinal neovascularization and increased adiponectin levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AB124611 C A 9: 21,447,276 (GRCm39) T146K probably benign Het
Alms1 T A 6: 85,599,958 (GRCm39) S1595T possibly damaging Het
Ankrd44 A T 1: 54,831,635 (GRCm39) I56N probably damaging Het
Anln C A 9: 22,272,176 (GRCm39) V648F probably damaging Het
Arhgap29 A G 3: 121,807,981 (GRCm39) D1053G probably benign Het
Baalc T C 15: 38,797,412 (GRCm39) S68P probably benign Het
Begain T C 12: 109,004,856 (GRCm39) D52G probably damaging Het
Blmh A G 11: 76,837,040 (GRCm39) I41V probably benign Het
Bpifc T A 10: 85,812,114 (GRCm39) I365F possibly damaging Het
C2 G T 17: 35,095,347 (GRCm39) S199R possibly damaging Het
Ccbe1 T A 18: 66,199,828 (GRCm39) H298L probably damaging Het
Ccdc112 T A 18: 46,423,826 (GRCm39) K304I probably damaging Het
Ccdc15 T C 9: 37,226,678 (GRCm39) E432G probably benign Het
Cipc T C 12: 87,008,899 (GRCm39) S253P possibly damaging Het
Clcn1 A G 6: 42,287,282 (GRCm39) probably null Het
Clock A T 5: 76,390,982 (GRCm39) N273K probably benign Het
Cyp19a1 T C 9: 54,074,126 (GRCm39) D476G probably benign Het
Dnaaf9 T C 2: 130,552,785 (GRCm39) K1092E probably damaging Het
Dnah7b A G 1: 46,253,527 (GRCm39) I1811V probably benign Het
Fat1 C A 8: 45,495,010 (GRCm39) T4091K probably damaging Het
Gm10340 T A 14: 14,826,724 (GRCm39) N64K probably damaging Het
Hectd1 G A 12: 51,792,171 (GRCm39) R2523C probably damaging Het
Hgf A G 5: 16,782,009 (GRCm39) H244R probably damaging Het
Hgs G T 11: 120,370,760 (GRCm39) A567S probably damaging Het
Igdcc4 T C 9: 65,041,077 (GRCm39) V1036A probably benign Het
Keg1 G A 19: 12,691,998 (GRCm39) probably null Het
Klhl8 A T 5: 104,023,932 (GRCm39) L156Q probably damaging Het
Lmln T C 16: 32,927,501 (GRCm39) Y521H probably benign Het
Lrrc7 A G 3: 157,866,124 (GRCm39) S1206P probably damaging Het
Mad1l1 T A 5: 140,074,541 (GRCm39) I550F probably benign Het
Marf1 C T 16: 13,971,753 (GRCm39) W28* probably null Het
Mfsd11 T G 11: 116,754,733 (GRCm39) S215A probably benign Het
Mpped2 C A 2: 106,575,085 (GRCm39) H57N possibly damaging Het
Mslnl A G 17: 25,965,751 (GRCm39) M542V probably benign Het
Myh6 G T 14: 55,179,897 (GRCm39) H1903Q probably damaging Het
Neo1 T C 9: 58,897,777 (GRCm39) T60A probably benign Het
Npm2 T A 14: 70,889,947 (GRCm39) probably null Het
Or5b123 C A 19: 13,597,285 (GRCm39) T210K probably damaging Het
Or5d20-ps1 T C 2: 87,931,909 (GRCm39) S141G probably benign Het
Or7a39 T A 10: 78,715,043 (GRCm39) S12R probably benign Het
Pax9 A T 12: 56,743,850 (GRCm39) I166F possibly damaging Het
Pcsk9 A G 4: 106,321,092 (GRCm39) S6P possibly damaging Het
Pikfyve A G 1: 65,309,101 (GRCm39) Y1893C probably damaging Het
Pirb T C 7: 3,722,864 (GRCm39) T43A possibly damaging Het
Pou3f1 A G 4: 124,552,074 (GRCm39) D192G possibly damaging Het
Pus3 C G 9: 35,478,021 (GRCm39) R418G probably damaging Het
Rexo1 C T 10: 80,385,970 (GRCm39) V363I probably benign Het
Sdcbp A G 4: 6,393,688 (GRCm39) T269A probably damaging Het
Sele T C 1: 163,881,462 (GRCm39) V523A probably benign Het
Serpinb8 T A 1: 107,532,457 (GRCm39) M183K probably damaging Het
Sh2d4a T G 8: 68,735,033 (GRCm39) S51A probably benign Het
Siglec15 A G 18: 78,090,696 (GRCm39) S201P probably damaging Het
Slc10a5 C T 3: 10,400,529 (GRCm39) V44I probably benign Het
Slc16a13 A G 11: 70,111,388 (GRCm39) V39A probably damaging Het
Slc25a13 G A 6: 6,117,164 (GRCm39) R184W probably damaging Het
Slc35f5 T A 1: 125,512,278 (GRCm39) D359E probably damaging Het
Slc3a1 A G 17: 85,371,371 (GRCm39) E641G probably benign Het
Slf1 T C 13: 77,194,823 (GRCm39) D834G probably damaging Het
Spata31f1e A C 4: 42,793,885 (GRCm39) H82Q probably benign Het
Stim1 T C 7: 102,076,348 (GRCm39) I433T probably damaging Het
Stra6 T A 9: 58,057,444 (GRCm39) I418K probably damaging Het
Tanc2 A G 11: 105,758,480 (GRCm39) N747S probably benign Het
Tet2 T C 3: 133,192,302 (GRCm39) T711A possibly damaging Het
Trpm6 T C 19: 18,807,220 (GRCm39) I988T probably benign Het
Ttc41 T A 10: 86,612,495 (GRCm39) I1256N probably benign Het
Uba2 T C 7: 33,862,638 (GRCm39) D100G possibly damaging Het
Vmn1r43 A G 6: 89,847,219 (GRCm39) I89T probably benign Het
Vmn2r58 T A 7: 41,521,910 (GRCm39) Y62F probably benign Het
Ylpm1 C T 12: 85,060,855 (GRCm39) Q428* probably null Het
Zcrb1 T C 15: 93,289,002 (GRCm39) D88G probably damaging Het
Zmym1 A C 4: 126,941,667 (GRCm39) I907S probably damaging Het
Other mutations in Cdh13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00539:Cdh13 APN 8 120,039,245 (GRCm39) missense possibly damaging 0.87
IGL00659:Cdh13 APN 8 120,039,406 (GRCm39) missense probably damaging 1.00
IGL01662:Cdh13 APN 8 119,401,916 (GRCm39) missense probably damaging 0.99
IGL01719:Cdh13 APN 8 119,401,927 (GRCm39) missense probably benign 0.01
IGL02148:Cdh13 APN 8 119,925,697 (GRCm39) missense probably damaging 1.00
IGL02157:Cdh13 APN 8 119,232,410 (GRCm39) missense possibly damaging 0.68
IGL02188:Cdh13 APN 8 119,578,500 (GRCm39) missense probably benign 0.08
IGL02490:Cdh13 APN 8 119,822,062 (GRCm39) missense probably damaging 1.00
IGL02851:Cdh13 APN 8 119,401,897 (GRCm39) missense probably benign 0.32
IGL02958:Cdh13 APN 8 120,039,460 (GRCm39) missense possibly damaging 0.90
IGL03085:Cdh13 APN 8 120,015,463 (GRCm39) missense probably damaging 1.00
IGL03230:Cdh13 APN 8 119,969,056 (GRCm39) missense probably damaging 1.00
IGL03280:Cdh13 APN 8 120,040,873 (GRCm39) missense probably damaging 1.00
K3955:Cdh13 UTSW 8 119,401,843 (GRCm39) missense probably damaging 0.99
P0038:Cdh13 UTSW 8 119,401,843 (GRCm39) missense probably damaging 0.99
R0398:Cdh13 UTSW 8 120,040,786 (GRCm39) missense probably damaging 1.00
R2156:Cdh13 UTSW 8 119,963,703 (GRCm39) missense probably damaging 1.00
R3415:Cdh13 UTSW 8 119,401,946 (GRCm39) missense probably benign 0.35
R4243:Cdh13 UTSW 8 119,968,996 (GRCm39) missense probably damaging 1.00
R4839:Cdh13 UTSW 8 119,578,587 (GRCm39) nonsense probably null
R4851:Cdh13 UTSW 8 119,484,129 (GRCm39) missense possibly damaging 0.75
R5129:Cdh13 UTSW 8 119,821,954 (GRCm39) missense probably damaging 1.00
R5453:Cdh13 UTSW 8 119,925,706 (GRCm39) missense probably damaging 1.00
R5607:Cdh13 UTSW 8 119,484,213 (GRCm39) missense probably benign
R5608:Cdh13 UTSW 8 119,484,213 (GRCm39) missense probably benign
R5610:Cdh13 UTSW 8 119,578,462 (GRCm39) missense possibly damaging 0.95
R6035:Cdh13 UTSW 8 119,232,437 (GRCm39) missense probably benign 0.03
R6035:Cdh13 UTSW 8 119,232,437 (GRCm39) missense probably benign 0.03
R6556:Cdh13 UTSW 8 119,694,926 (GRCm39) missense probably damaging 0.99
R7124:Cdh13 UTSW 8 119,694,912 (GRCm39) missense probably damaging 1.00
R7349:Cdh13 UTSW 8 119,969,097 (GRCm39) missense probably damaging 0.97
R7418:Cdh13 UTSW 8 120,039,264 (GRCm39) missense probably damaging 1.00
R7679:Cdh13 UTSW 8 119,963,658 (GRCm39) missense probably benign 0.29
R8777:Cdh13 UTSW 8 119,963,706 (GRCm39) critical splice donor site probably null
R8777-TAIL:Cdh13 UTSW 8 119,963,706 (GRCm39) critical splice donor site probably null
R9175:Cdh13 UTSW 8 119,968,968 (GRCm39) missense probably damaging 1.00
R9481:Cdh13 UTSW 8 119,963,676 (GRCm39) missense
X0025:Cdh13 UTSW 8 119,232,418 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- TGAAGGAATCCGTCTTGTAAAGCC -3'
(R):5'- TGACCTCGCATCTGAGCTAG -3'

Sequencing Primer
(F):5'- TAAAGCCATTGGTCCTGGTCATCAG -3'
(R):5'- CATCTGAGCTAGCCGGGTATATC -3'
Posted On 2019-11-26