Mutagenetix > Incidental Mutation

Incidental Mutation 'R7807:Alms1'

600857

Institutional Source

Beutler Lab

Gene Symbol

Alms1

Ensembl Gene

ENSMUSG00000063810

Gene Name

ALMS1, centrosome and basal body associated

Synonyms

MMRRC Submission

045862-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7807 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

85587531-85702753 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85622976 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 1595 (S1595T)

Ref Sequence

ENSEMBL: ENSMUSP00000071904 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072018] [ENSMUST00000213058]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000072018
AA Change: S1595T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000071904
Gene: ENSMUSG00000063810
AA Change: S1595T

Domain	Start	End	E-Value	Type
coiled coil region	10	39	N/A	INTRINSIC
low complexity region	67	80	N/A	INTRINSIC
low complexity region	98	119	N/A	INTRINSIC
Blast:MYSc	127	233	1e-21	BLAST
internal_repeat_3	408	511	2.48e-7	PROSPERO
internal_repeat_2	414	804	2.09e-12	PROSPERO
internal_repeat_1	438	834	4.54e-18	PROSPERO
internal_repeat_3	652	757	2.48e-7	PROSPERO
low complexity region	903	908	N/A	INTRINSIC
internal_repeat_1	916	1385	4.54e-18	PROSPERO
internal_repeat_2	1024	1390	2.09e-12	PROSPERO
low complexity region	1572	1586	N/A	INTRINSIC
low complexity region	2004	2017	N/A	INTRINSIC
low complexity region	2760	2773	N/A	INTRINSIC
low complexity region	2950	2968	N/A	INTRINSIC
low complexity region	3013	3030	N/A	INTRINSIC
Pfam:ALMS_motif	3125	3247	1.8e-42	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213058
AA Change: S2064T

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (68/68)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a large tandem-repeat domain as well as additional low complexity regions. The encoded protein functions in microtubule organization, particularly in the formation and maintanance of cilia. Mutations in this gene cause Alstrom syndrome. There is a pseudogene for this gene located adjacent in the same region of chromosome 2. Alternative splice variants have been described but their full length nature has not been determined. [provided by RefSeq, Apr 2014]
PHENOTYPE: Homozygous null mice display obesity starting after puberty, hypogonadism, hyperinsulinemia, male-specific hyperglycemia, retinal dysfunction, and late-onset hearing loss. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402H24Rik	T	C	2: 130,710,865	K1092E	probably damaging	Het
AB124611	C	A	9: 21,535,980	T146K	probably benign	Het
Ankrd44	A	T	1: 54,792,476	I56N	probably damaging	Het
Anln	C	A	9: 22,360,880	V648F	probably damaging	Het
Arhgap29	A	G	3: 122,014,332	D1053G	probably benign	Het
Baalc	T	C	15: 38,934,017	S68P	probably benign	Het
Begain	T	C	12: 109,038,930	D52G	probably damaging	Het
Blmh	A	G	11: 76,946,214	I41V	probably benign	Het
Bpifc	T	A	10: 85,976,250	I365F	possibly damaging	Het
C2	G	T	17: 34,876,371	S199R	possibly damaging	Het
Ccbe1	T	A	18: 66,066,757	H298L	probably damaging	Het
Ccdc112	T	A	18: 46,290,759	K304I	probably damaging	Het
Ccdc15	T	C	9: 37,315,382	E432G	probably benign	Het
Cdh13	T	A	8: 118,283,855	M1K	probably null	Het
Cipc	T	C	12: 86,962,125	S253P	possibly damaging	Het
Clcn1	A	G	6: 42,310,348		probably null	Het
Clock	A	T	5: 76,243,135	N273K	probably benign	Het
Cyp19a1	T	C	9: 54,166,842	D476G	probably benign	Het
Dnah7b	A	G	1: 46,214,367	I1811V	probably benign	Het
Fat1	C	A	8: 45,041,973	T4091K	probably damaging	Het
Gm10340	T	A	14: 3,134,925	N64K	probably damaging	Het
Gm12394	A	C	4: 42,793,885	H82Q	probably benign	Het
Hectd1	G	A	12: 51,745,388	R2523C	probably damaging	Het
Hgf	A	G	5: 16,577,011	H244R	probably damaging	Het
Hgs	G	T	11: 120,479,934	A567S	probably damaging	Het
Igdcc4	T	C	9: 65,133,795	V1036A	probably benign	Het
Keg1	G	A	19: 12,714,634		probably null	Het
Klhl8	A	T	5: 103,876,066	L156Q	probably damaging	Het
Lmln	T	C	16: 33,107,131	Y521H	probably benign	Het
Lrrc7	A	G	3: 158,160,487	S1206P	probably damaging	Het
Mad1l1	T	A	5: 140,088,786	I550F	probably benign	Het
Marf1	C	T	16: 14,153,889	W28*	probably null	Het
Mfsd11	T	G	11: 116,863,907	S215A	probably benign	Het
Mpped2	C	A	2: 106,744,740	H57N	possibly damaging	Het
Mslnl	A	G	17: 25,746,777	M542V	probably benign	Het
Myh6	G	T	14: 54,942,440	H1903Q	probably damaging	Het
Neo1	T	C	9: 58,990,494	T60A	probably benign	Het
Npm2	T	A	14: 70,652,507		probably null	Het
Olfr1165-ps	T	C	2: 88,101,565	S141G	probably benign	Het
Olfr1355	T	A	10: 78,879,209	S12R	probably benign	Het
Olfr1487	C	A	19: 13,619,921	T210K	probably damaging	Het
Pax9	A	T	12: 56,697,065	I166F	possibly damaging	Het
Pcsk9	A	G	4: 106,463,895	S6P	possibly damaging	Het
Pikfyve	A	G	1: 65,269,942	Y1893C	probably damaging	Het
Pirb	T	C	7: 3,719,865	T43A	possibly damaging	Het
Pou3f1	A	G	4: 124,658,281	D192G	possibly damaging	Het
Pus3	C	G	9: 35,566,725	R418G	probably damaging	Het
Rexo1	C	T	10: 80,550,136	V363I	probably benign	Het
Sdcbp	A	G	4: 6,393,688	T269A	probably damaging	Het
Sele	T	C	1: 164,053,893	V523A	probably benign	Het
Serpinb8	T	A	1: 107,604,727	M183K	probably damaging	Het
Sh2d4a	T	G	8: 68,282,381	S51A	probably benign	Het
Siglec15	A	G	18: 78,047,481	S201P	probably damaging	Het
Slc10a5	C	T	3: 10,335,469	V44I	probably benign	Het
Slc16a13	A	G	11: 70,220,562	V39A	probably damaging	Het
Slc25a13	G	A	6: 6,117,164	R184W	probably damaging	Het
Slc35f5	T	A	1: 125,584,541	D359E	probably damaging	Het
Slc3a1	A	G	17: 85,063,943	E641G	probably benign	Het
Slf1	T	C	13: 77,046,704	D834G	probably damaging	Het
Stim1	T	C	7: 102,427,141	I433T	probably damaging	Het
Stra6	T	A	9: 58,150,161	I418K	probably damaging	Het
Tanc2	A	G	11: 105,867,654	N747S	probably benign	Het
Tet2	T	C	3: 133,486,541	T711A	possibly damaging	Het
Trpm6	T	C	19: 18,829,856	I988T	probably benign	Het
Ttc41	T	A	10: 86,776,631	I1256N	probably benign	Het
Uba2	T	C	7: 34,163,213	D100G	possibly damaging	Het
Vmn1r43	A	G	6: 89,870,237	I89T	probably benign	Het
Vmn2r58	T	A	7: 41,872,486	Y62F	probably benign	Het
Ylpm1	C	T	12: 85,014,081	Q428*	probably null	Het
Zcrb1	T	C	15: 93,391,121	D88G	probably damaging	Het
Zmym1	A	C	4: 127,047,874	I907S	probably damaging	Het

Other mutations in Alms1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00227:Alms1	APN	6	85,677,964 (GRCm38)	missense	probably damaging	1.00
IGL00331:Alms1	APN	6	85,641,371 (GRCm38)	missense	possibly damaging	0.94
IGL00658:Alms1	APN	6	85,628,961 (GRCm38)	missense	probably damaging	1.00
IGL00835:Alms1	APN	6	85,622,134 (GRCm38)	missense	probably damaging	1.00
IGL00930:Alms1	APN	6	85,601,310 (GRCm38)	missense	probably damaging	0.98
IGL01446:Alms1	APN	6	85,696,701 (GRCm38)	missense	probably damaging	1.00
IGL01448:Alms1	APN	6	85,677,899 (GRCm38)	missense	possibly damaging	0.93
IGL01563:Alms1	APN	6	85,627,983 (GRCm38)	missense	probably damaging	1.00
IGL01632:Alms1	APN	6	85,627,946 (GRCm38)	missense	probably benign	0.07
IGL01651:Alms1	APN	6	85,656,476 (GRCm38)	missense	probably benign	0.05
IGL01670:Alms1	APN	6	85,678,150 (GRCm38)	missense	probably benign	0.00
IGL01716:Alms1	APN	6	85,628,094 (GRCm38)	missense	probably benign	0.01
IGL01719:Alms1	APN	6	85,628,094 (GRCm38)	missense	probably benign	0.01
IGL01720:Alms1	APN	6	85,628,094 (GRCm38)	missense	probably benign	0.01
IGL01723:Alms1	APN	6	85,628,094 (GRCm38)	missense	probably benign	0.01
IGL01877:Alms1	APN	6	85,622,411 (GRCm38)	missense	possibly damaging	0.55
IGL01919:Alms1	APN	6	85,628,004 (GRCm38)	missense	possibly damaging	0.77
IGL01976:Alms1	APN	6	85,622,665 (GRCm38)	missense	possibly damaging	0.73
IGL02003:Alms1	APN	6	85,622,223 (GRCm38)	missense	possibly damaging	0.54
IGL02069:Alms1	APN	6	85,628,823 (GRCm38)	missense	probably benign	0.12
IGL02070:Alms1	APN	6	85,651,403 (GRCm38)	missense	possibly damaging	0.74
IGL02079:Alms1	APN	6	85,628,634 (GRCm38)	missense	probably damaging	0.98
IGL02081:Alms1	APN	6	85,620,303 (GRCm38)	missense	possibly damaging	0.55
IGL02379:Alms1	APN	6	85,629,633 (GRCm38)	missense	probably damaging	0.98
IGL02412:Alms1	APN	6	85,628,872 (GRCm38)	missense	possibly damaging	0.91
IGL02606:Alms1	APN	6	85,599,967 (GRCm38)	missense	probably benign
IGL02636:Alms1	APN	6	85,628,654 (GRCm38)	missense	probably benign	0.28
IGL02702:Alms1	APN	6	85,599,849 (GRCm38)	missense	probably benign	0.12
IGL02815:Alms1	APN	6	85,667,957 (GRCm38)	critical splice donor site	probably null
IGL02926:Alms1	APN	6	85,641,450 (GRCm38)	missense	probably damaging	1.00
IGL02945:Alms1	APN	6	85,620,933 (GRCm38)	missense	probably damaging	0.96
IGL02959:Alms1	APN	6	85,629,052 (GRCm38)	nonsense	probably null
IGL03124:Alms1	APN	6	85,678,419 (GRCm38)	missense	probably benign	0.03
IGL03199:Alms1	APN	6	85,622,497 (GRCm38)	missense	possibly damaging	0.68
IGL03209:Alms1	APN	6	85,599,973 (GRCm38)	splice site	probably benign
IGL03247:Alms1	APN	6	85,678,597 (GRCm38)	missense	possibly damaging	0.85
ares	UTSW	6	85,621,275 (GRCm38)	nonsense	probably null
ares2	UTSW	6	85,677,990 (GRCm38)	nonsense	probably null
butterball	UTSW	6	85,696,771 (GRCm38)	missense	probably damaging	0.99
earthquake	UTSW	6	85,628,735 (GRCm38)	nonsense	probably null
fatty	UTSW	6	85,627,934 (GRCm38)	nonsense	probably null
gut_check	UTSW	6	85,620,369 (GRCm38)	nonsense	probably null
portly	UTSW	6	85,619,712 (GRCm38)	missense	probably benign	0.00
replete	UTSW	6	85,629,208 (GRCm38)	missense	possibly damaging	0.87
PIT4468001:Alms1	UTSW	6	85,624,719 (GRCm38)	critical splice donor site	probably null
R0003:Alms1	UTSW	6	85,629,210 (GRCm38)	missense	possibly damaging	0.90
R0095:Alms1	UTSW	6	85,620,253 (GRCm38)	missense	possibly damaging	0.90
R0110:Alms1	UTSW	6	85,620,369 (GRCm38)	nonsense	probably null
R0114:Alms1	UTSW	6	85,619,803 (GRCm38)	missense	probably benign	0.00
R0153:Alms1	UTSW	6	85,641,381 (GRCm38)	missense	possibly damaging	0.94
R0217:Alms1	UTSW	6	85,622,930 (GRCm38)	missense	probably damaging	0.99
R0328:Alms1	UTSW	6	85,610,814 (GRCm38)	splice site	probably null
R0410:Alms1	UTSW	6	85,587,803 (GRCm38)	missense	unknown
R0469:Alms1	UTSW	6	85,620,369 (GRCm38)	nonsense	probably null
R0491:Alms1	UTSW	6	85,702,600 (GRCm38)	missense	probably damaging	0.98
R0510:Alms1	UTSW	6	85,620,369 (GRCm38)	nonsense	probably null
R0522:Alms1	UTSW	6	85,621,615 (GRCm38)	missense	probably benign
R0525:Alms1	UTSW	6	85,587,760 (GRCm38)	missense	unknown
R0611:Alms1	UTSW	6	85,678,671 (GRCm38)	missense	possibly damaging	0.61
R0637:Alms1	UTSW	6	85,623,033 (GRCm38)	missense	possibly damaging	0.85
R0718:Alms1	UTSW	6	85,621,821 (GRCm38)	missense	probably benign	0.00
R0831:Alms1	UTSW	6	85,628,520 (GRCm38)	missense	probably benign	0.00
R1318:Alms1	UTSW	6	85,628,549 (GRCm38)	missense	possibly damaging	0.62
R1340:Alms1	UTSW	6	85,667,957 (GRCm38)	critical splice donor site	probably null
R1561:Alms1	UTSW	6	85,629,052 (GRCm38)	nonsense	probably null
R1648:Alms1	UTSW	6	85,678,402 (GRCm38)	missense	probably damaging	0.99
R1697:Alms1	UTSW	6	85,622,454 (GRCm38)	missense	possibly damaging	0.94
R1699:Alms1	UTSW	6	85,622,880 (GRCm38)	missense	possibly damaging	0.46
R1715:Alms1	UTSW	6	85,629,052 (GRCm38)	nonsense	probably null
R1723:Alms1	UTSW	6	85,628,753 (GRCm38)	missense	probably damaging	1.00
R1734:Alms1	UTSW	6	85,641,550 (GRCm38)	critical splice donor site	probably null
R1758:Alms1	UTSW	6	85,628,505 (GRCm38)	missense	probably damaging	0.99
R1804:Alms1	UTSW	6	85,621,275 (GRCm38)	nonsense	probably null
R1835:Alms1	UTSW	6	85,678,503 (GRCm38)	missense	possibly damaging	0.94
R1836:Alms1	UTSW	6	85,678,503 (GRCm38)	missense	possibly damaging	0.94
R2077:Alms1	UTSW	6	85,622,309 (GRCm38)	missense	possibly damaging	0.93
R2246:Alms1	UTSW	6	85,622,967 (GRCm38)	missense	possibly damaging	0.91
R2254:Alms1	UTSW	6	85,619,848 (GRCm38)	missense	probably damaging	1.00
R2280:Alms1	UTSW	6	85,677,973 (GRCm38)	missense	probably damaging	0.99
R2516:Alms1	UTSW	6	85,667,963 (GRCm38)	splice site	probably benign
R2519:Alms1	UTSW	6	85,667,963 (GRCm38)	splice site	probably benign
R2566:Alms1	UTSW	6	85,622,482 (GRCm38)	missense	possibly damaging	0.84
R2850:Alms1	UTSW	6	85,667,963 (GRCm38)	splice site	probably benign
R2850:Alms1	UTSW	6	85,621,299 (GRCm38)	missense	probably benign	0.00
R2932:Alms1	UTSW	6	85,620,562 (GRCm38)	missense	possibly damaging	0.89
R2944:Alms1	UTSW	6	85,628,391 (GRCm38)	missense	probably damaging	1.00
R2980:Alms1	UTSW	6	85,628,835 (GRCm38)	missense	probably damaging	1.00
R3084:Alms1	UTSW	6	85,678,140 (GRCm38)	missense	probably benign
R3086:Alms1	UTSW	6	85,678,140 (GRCm38)	missense	probably benign
R3122:Alms1	UTSW	6	85,667,963 (GRCm38)	splice site	probably benign
R3404:Alms1	UTSW	6	85,667,963 (GRCm38)	splice site	probably benign
R3405:Alms1	UTSW	6	85,667,963 (GRCm38)	splice site	probably benign
R3804:Alms1	UTSW	6	85,619,647 (GRCm38)	missense	probably damaging	1.00
R3904:Alms1	UTSW	6	85,621,678 (GRCm38)	missense	probably benign	0.00
R4014:Alms1	UTSW	6	85,678,352 (GRCm38)	missense	probably benign	0.41
R4056:Alms1	UTSW	6	85,587,803 (GRCm38)	missense	unknown
R4067:Alms1	UTSW	6	85,621,289 (GRCm38)	missense	probably damaging	1.00
R4110:Alms1	UTSW	6	85,620,888 (GRCm38)	missense	probably benign	0.00
R4111:Alms1	UTSW	6	85,620,888 (GRCm38)	missense	probably benign	0.00
R4112:Alms1	UTSW	6	85,620,888 (GRCm38)	missense	probably benign	0.00
R4194:Alms1	UTSW	6	85,677,990 (GRCm38)	nonsense	probably null
R4464:Alms1	UTSW	6	85,620,021 (GRCm38)	missense	possibly damaging	0.66
R4539:Alms1	UTSW	6	85,620,478 (GRCm38)	missense	possibly damaging	0.78
R4554:Alms1	UTSW	6	85,624,617 (GRCm38)	missense	probably benign
R4696:Alms1	UTSW	6	85,620,522 (GRCm38)	missense	probably damaging	1.00
R4825:Alms1	UTSW	6	85,678,245 (GRCm38)	missense	probably damaging	0.99
R4921:Alms1	UTSW	6	85,628,546 (GRCm38)	missense	probably benign	0.13
R5030:Alms1	UTSW	6	85,627,964 (GRCm38)	missense	probably damaging	0.98
R5051:Alms1	UTSW	6	85,627,934 (GRCm38)	nonsense	probably null
R5085:Alms1	UTSW	6	85,620,732 (GRCm38)	missense	possibly damaging	0.55
R5141:Alms1	UTSW	6	85,621,432 (GRCm38)	missense	probably benign	0.01
R5233:Alms1	UTSW	6	85,656,371 (GRCm38)	splice site	probably null
R5310:Alms1	UTSW	6	85,615,368 (GRCm38)	missense	possibly damaging	0.79
R5344:Alms1	UTSW	6	85,696,789 (GRCm38)	missense	probably benign	0.04
R5394:Alms1	UTSW	6	85,623,088 (GRCm38)	missense	probably benign	0.01
R5460:Alms1	UTSW	6	85,696,731 (GRCm38)	missense	probably benign	0.08
R5558:Alms1	UTSW	6	85,641,329 (GRCm38)	nonsense	probably null
R5650:Alms1	UTSW	6	85,620,271 (GRCm38)	missense	probably damaging	1.00
R5667:Alms1	UTSW	6	85,696,771 (GRCm38)	missense	probably damaging	0.99
R5671:Alms1	UTSW	6	85,629,208 (GRCm38)	missense	possibly damaging	0.87
R5688:Alms1	UTSW	6	85,599,895 (GRCm38)	missense	possibly damaging	0.92
R5815:Alms1	UTSW	6	85,622,838 (GRCm38)	missense	probably damaging	0.99
R5892:Alms1	UTSW	6	85,620,903 (GRCm38)	missense	probably damaging	0.99
R5947:Alms1	UTSW	6	85,619,712 (GRCm38)	missense	probably benign	0.00
R6031:Alms1	UTSW	6	85,622,955 (GRCm38)	missense	probably damaging	1.00
R6031:Alms1	UTSW	6	85,622,955 (GRCm38)	missense	probably damaging	1.00
R6144:Alms1	UTSW	6	85,623,074 (GRCm38)	missense	probably damaging	0.98
R6258:Alms1	UTSW	6	85,628,735 (GRCm38)	nonsense	probably null
R6260:Alms1	UTSW	6	85,628,735 (GRCm38)	nonsense	probably null
R6455:Alms1	UTSW	6	85,696,657 (GRCm38)	missense	probably damaging	0.99
R6569:Alms1	UTSW	6	85,641,339 (GRCm38)	missense	probably benign	0.07
R6637:Alms1	UTSW	6	85,619,734 (GRCm38)	missense	possibly damaging	0.78
R6866:Alms1	UTSW	6	85,621,098 (GRCm38)	missense	possibly damaging	0.85
R6918:Alms1	UTSW	6	85,622,661 (GRCm38)	missense	possibly damaging	0.87
R7121:Alms1	UTSW	6	85,624,622 (GRCm38)	missense	probably damaging	1.00
R7179:Alms1	UTSW	6	85,621,369 (GRCm38)	missense	probably benign	0.09
R7334:Alms1	UTSW	6	85,641,450 (GRCm38)	missense	probably damaging	0.99
R7376:Alms1	UTSW	6	85,622,106 (GRCm38)	missense	probably benign	0.10
R7394:Alms1	UTSW	6	85,622,223 (GRCm38)	missense	possibly damaging	0.54
R7413:Alms1	UTSW	6	85,628,306 (GRCm38)	missense	probably benign	0.03
R7511:Alms1	UTSW	6	85,609,425 (GRCm38)	missense	unknown
R7542:Alms1	UTSW	6	85,629,362 (GRCm38)	missense	possibly damaging	0.62
R7562:Alms1	UTSW	6	85,620,412 (GRCm38)	missense	probably damaging	1.00
R7575:Alms1	UTSW	6	85,622,159 (GRCm38)	missense	possibly damaging	0.49
R7577:Alms1	UTSW	6	85,615,320 (GRCm38)	missense	probably benign	0.09
R7618:Alms1	UTSW	6	85,678,417 (GRCm38)	missense	probably benign	0.07
R7653:Alms1	UTSW	6	85,620,595 (GRCm38)	missense	possibly damaging	0.47
R7672:Alms1	UTSW	6	85,615,351 (GRCm38)	missense	probably damaging	1.00
R7815:Alms1	UTSW	6	85,615,358 (GRCm38)	missense	probably benign	0.42
R7849:Alms1	UTSW	6	85,621,497 (GRCm38)	missense	possibly damaging	0.48
R7944:Alms1	UTSW	6	85,641,380 (GRCm38)	missense	probably benign	0.03
R7954:Alms1	UTSW	6	85,621,162 (GRCm38)	missense	probably damaging	0.98
R7971:Alms1	UTSW	6	85,628,679 (GRCm38)	missense	probably benign
R8048:Alms1	UTSW	6	85,641,334 (GRCm38)	missense	probably benign	0.13
R8223:Alms1	UTSW	6	85,643,240 (GRCm38)	nonsense	probably null
R8332:Alms1	UTSW	6	85,620,579 (GRCm38)	missense	probably benign	0.05
R8374:Alms1	UTSW	6	85,608,991 (GRCm38)	missense	probably benign	0.41
R8470:Alms1	UTSW	6	85,641,375 (GRCm38)	missense	probably damaging	0.99
R8755:Alms1	UTSW	6	85,621,574 (GRCm38)	missense	probably benign	0.01
R8979:Alms1	UTSW	6	85,621,027 (GRCm38)	missense	probably damaging	0.98
R9044:Alms1	UTSW	6	85,696,753 (GRCm38)	missense	probably damaging	0.98
R9057:Alms1	UTSW	6	85,609,832 (GRCm38)	missense	unknown
R9224:Alms1	UTSW	6	85,621,788 (GRCm38)	missense	possibly damaging	0.69
R9259:Alms1	UTSW	6	85,667,891 (GRCm38)	missense	possibly damaging	0.94
R9401:Alms1	UTSW	6	85,678,019 (GRCm38)	nonsense	probably null
R9459:Alms1	UTSW	6	85,627,964 (GRCm38)	missense	probably damaging	0.98
R9633:Alms1	UTSW	6	85,623,143 (GRCm38)	missense	probably damaging	0.99
R9716:Alms1	UTSW	6	85,601,252 (GRCm38)	missense	possibly damaging	0.84
R9730:Alms1	UTSW	6	85,629,438 (GRCm38)	missense	probably benign	0.00
R9790:Alms1	UTSW	6	85,619,443 (GRCm38)	missense	probably benign	0.04
R9791:Alms1	UTSW	6	85,619,443 (GRCm38)	missense	probably benign	0.04
R9802:Alms1	UTSW	6	85,629,238 (GRCm38)	missense	possibly damaging	0.61
X0013:Alms1	UTSW	6	85,656,455 (GRCm38)	missense	probably damaging	1.00
X0025:Alms1	UTSW	6	85,620,210 (GRCm38)	missense	probably damaging	0.96
Z1176:Alms1	UTSW	6	85,678,418 (GRCm38)	missense	probably benign	0.41

Predicted Primers

PCR Primer
(F):5'- CAATATAAAGCTGCCAGGTCTG -3'
(R):5'- AGTCCTTACCTTGGGTTCGG -3'

Sequencing Primer
(F):5'- CCAGGTCTGTAATGAGGTCTGAACC -3'
(R):5'- AAGTATCTGTTTGGCTTGATTCAG -3'

Posted On

2019-11-26