Incidental Mutation 'RF021:Trdc'
ID 603899
Institutional Source Beutler Lab
Gene Symbol Trdc
Ensembl Gene ENSMUSG00000104876
Gene Name T cell receptor delta, constant region
Synonyms Tcrd-C
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # RF021 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 54142851-54146108 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 54144203 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 115 (V115A)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103685]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000103685
SMART Domains Protein: ENSMUSP00000100458
Gene: ENSMUSG00000076873

IGv 35 113 2.06e-14 SMART
Predicted Effect
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.3%
Validation Efficiency 91% (50/55)
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter allele are viable, healthy, and exhibit normal T cell development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik TTATTATTATTAT TTATTATTATTATTAATATTATTATTAT 3: 37,050,748 (GRCm38) probably benign Het
A030005L19Rik GTGGTGGCTG GTGGTGGCTGTGGTGGCTG 1: 82,913,569 (GRCm38) probably benign Het
AI837181 CGG CGGTGG 19: 5,425,234 (GRCm38) probably benign Het
Ankrd44 T C 1: 54,778,312 (GRCm38) H79R probably damaging Het
Atg9a T A 1: 75,182,629 (GRCm38) E826V probably damaging Het
Atrnl1 T C 19: 57,642,473 (GRCm38) V224A probably benign Het
Cpn2 G A 16: 30,259,338 (GRCm38) A515V probably benign Het
Cyp2a12 T C 7: 27,035,360 (GRCm38) F402S possibly damaging Het
Defb22 TGCGGCA TGCGGCAGAGCTGGGCGTTGCGGCA 2: 152,485,832 (GRCm38) probably benign Het
Diexf A G 1: 193,120,666 (GRCm38) F248L probably benign Het
Dnah10 G T 5: 124,777,907 (GRCm38) V2016F probably damaging Het
Dock10 T C 1: 80,564,573 (GRCm38) probably null Het
Efhd2 GCC GCCGCCCCC 4: 141,874,773 (GRCm38) probably benign Het
Fam131a A C 16: 20,694,940 (GRCm38) probably benign Het
Gm6614 A T 6: 142,008,714 (GRCm38) V31E probably damaging Het
Gm7247 AGACCAGACC A 14: 51,364,324 (GRCm38) probably benign Het
Gna13 T C 11: 109,392,392 (GRCm38) V186A probably benign Het
Grk3 T A 5: 112,941,688 (GRCm38) I333L probably benign Het
Gstp1 A T 19: 4,035,507 (GRCm38) V200E probably benign Het
Gtf2h1 T G 7: 46,803,865 (GRCm38) V74G possibly damaging Het
Kcnh8 G A 17: 52,978,239 (GRCm38) R1079H probably benign Het
Kiz A G 2: 146,870,830 (GRCm38) D138G possibly damaging Het
Kmt2b TTCTCCT TTCTCCTTCTCCT 7: 30,586,357 (GRCm38) probably benign Het
Lats1 A G 10: 7,710,608 (GRCm38) T912A probably damaging Het
Lce1m GCTGCCACC GCTGCCACCACTTCTGCCACC 3: 93,018,269 (GRCm38) probably benign Het
Lce1m TGCC TGCCGCCGCTGCCGCC 3: 93,018,295 (GRCm38) probably benign Het
Lrrc2 TTGATTCGGTTCACC T 9: 110,981,676 (GRCm38) probably null Het
Med12l T C 3: 59,073,290 (GRCm38) F359S probably benign Het
Mut A G 17: 40,951,758 (GRCm38) I444V probably benign Het
Ncoa2 CTTAAAA C 1: 13,149,109 (GRCm38) probably benign Het
Ngp A G 9: 110,421,756 (GRCm38) T114A possibly damaging Het
Nlrc5 A T 8: 94,476,888 (GRCm38) T539S probably benign Het
Nxf1 A G 19: 8,772,309 (GRCm38) D190G probably damaging Het
Olfr229 A T 9: 39,910,045 (GRCm38) M81L probably benign Het
Olfr769 A T 10: 129,112,342 (GRCm38) F28I probably damaging Het
Pramef25 C G 4: 143,948,908 (GRCm38) Q449H probably damaging Het
Prdm15 G A 16: 97,808,756 (GRCm38) H563Y probably damaging Het
Rbm12 CAGG CAGGGATTGCGGGACCTGGTATTGCGGGACCAGG 2: 156,096,106 (GRCm38) probably benign Het
Sema3g C T 14: 31,227,841 (GRCm38) H660Y probably damaging Het
Stpg2 A T 3: 139,212,250 (GRCm38) probably null Het
Taar7f C T 10: 24,050,423 (GRCm38) T305M possibly damaging Het
Tbcb C T 7: 30,224,346 (GRCm38) V208M probably damaging Het
Tenm2 T A 11: 36,024,203 (GRCm38) Q2169L possibly damaging Het
Tln1 A G 4: 43,555,890 (GRCm38) V108A probably damaging Het
Tmc8 T C 11: 117,783,234 (GRCm38) M42T probably benign Het
Ttbk2 A G 2: 120,748,634 (GRCm38) V669A probably benign Het
Tusc1 GCC GCCACCACC 4: 93,335,316 (GRCm38) probably benign Het
Vps16 A G 2: 130,438,209 (GRCm38) H118R probably benign Het
Wdpcp T A 11: 21,711,587 (GRCm38) C286* probably null Het
Zbed4 C A 15: 88,781,236 (GRCm38) Y502* probably null Het
Zdbf2 T A 1: 63,302,652 (GRCm38) N63K possibly damaging Het
Other mutations in Trdc
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5950:Trdc UTSW 14 54,144,311 (GRCm38) unclassified probably benign
R6683:Trdc UTSW 14 54,144,235 (GRCm38) unclassified probably benign
R7543:Trdc UTSW 14 54,144,235 (GRCm38) missense
R7815:Trdc UTSW 14 54,143,802 (GRCm38) unclassified probably benign
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-12-04