Mutagenetix > Incidental Mutation

Incidental Mutation 'RF021:Trdc'

603899

Institutional Source

Beutler Lab

Gene Symbol

Trdc

Ensembl Gene

ENSMUSG00000104876

Gene Name

T cell receptor delta, constant region

Synonyms

Tcrd-C

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

RF021 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

54142851-54146108 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 54144203 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 115 (V115A)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103685]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000103685

SMART Domains

Protein: ENSMUSP00000100458
Gene: ENSMUSG00000076873

Domain	Start	End	E-Value	Type
IGv	35	113	2.06e-14	SMART

Predicted Effect

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.3%
20x: 98.3%

Validation Efficiency

91% (50/55)

MGI Phenotype

PHENOTYPE: Mice homozygous for a reporter allele are viable, healthy, and exhibit normal T cell development. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	TTATTATTATTAT	TTATTATTATTATTAATATTATTATTAT	3: 37,050,748 (GRCm38)		probably benign	Het
A030005L19Rik	GTGGTGGCTG	GTGGTGGCTGTGGTGGCTG	1: 82,913,569 (GRCm38)		probably benign	Het
AI837181	CGG	CGGTGG	19: 5,425,234 (GRCm38)		probably benign	Het
Ankrd44	T	C	1: 54,778,312 (GRCm38)	H79R	probably damaging	Het
Atg9a	T	A	1: 75,182,629 (GRCm38)	E826V	probably damaging	Het
Atrnl1	T	C	19: 57,642,473 (GRCm38)	V224A	probably benign	Het
Cpn2	G	A	16: 30,259,338 (GRCm38)	A515V	probably benign	Het
Cyp2a12	T	C	7: 27,035,360 (GRCm38)	F402S	possibly damaging	Het
Defb22	TGCGGCA	TGCGGCAGAGCTGGGCGTTGCGGCA	2: 152,485,832 (GRCm38)		probably benign	Het
Diexf	A	G	1: 193,120,666 (GRCm38)	F248L	probably benign	Het
Dnah10	G	T	5: 124,777,907 (GRCm38)	V2016F	probably damaging	Het
Dock10	T	C	1: 80,564,573 (GRCm38)		probably null	Het
Efhd2	GCC	GCCGCCCCC	4: 141,874,773 (GRCm38)		probably benign	Het
Fam131a	A	C	16: 20,694,940 (GRCm38)		probably benign	Het
Gm6614	A	T	6: 142,008,714 (GRCm38)	V31E	probably damaging	Het
Gm7247	AGACCAGACC	A	14: 51,364,324 (GRCm38)		probably benign	Het
Gna13	T	C	11: 109,392,392 (GRCm38)	V186A	probably benign	Het
Grk3	T	A	5: 112,941,688 (GRCm38)	I333L	probably benign	Het
Gstp1	A	T	19: 4,035,507 (GRCm38)	V200E	probably benign	Het
Gtf2h1	T	G	7: 46,803,865 (GRCm38)	V74G	possibly damaging	Het
Kcnh8	G	A	17: 52,978,239 (GRCm38)	R1079H	probably benign	Het
Kiz	A	G	2: 146,870,830 (GRCm38)	D138G	possibly damaging	Het
Kmt2b	TTCTCCT	TTCTCCTTCTCCT	7: 30,586,357 (GRCm38)		probably benign	Het
Lats1	A	G	10: 7,710,608 (GRCm38)	T912A	probably damaging	Het
Lce1m	GCTGCCACC	GCTGCCACCACTTCTGCCACC	3: 93,018,269 (GRCm38)		probably benign	Het
Lce1m	TGCC	TGCCGCCGCTGCCGCC	3: 93,018,295 (GRCm38)		probably benign	Het
Lrrc2	TTGATTCGGTTCACC	T	9: 110,981,676 (GRCm38)		probably null	Het
Med12l	T	C	3: 59,073,290 (GRCm38)	F359S	probably benign	Het
Mut	A	G	17: 40,951,758 (GRCm38)	I444V	probably benign	Het
Ncoa2	CTTAAAA	C	1: 13,149,109 (GRCm38)		probably benign	Het
Ngp	A	G	9: 110,421,756 (GRCm38)	T114A	possibly damaging	Het
Nlrc5	A	T	8: 94,476,888 (GRCm38)	T539S	probably benign	Het
Nxf1	A	G	19: 8,772,309 (GRCm38)	D190G	probably damaging	Het
Olfr229	A	T	9: 39,910,045 (GRCm38)	M81L	probably benign	Het
Olfr769	A	T	10: 129,112,342 (GRCm38)	F28I	probably damaging	Het
Pramef25	C	G	4: 143,948,908 (GRCm38)	Q449H	probably damaging	Het
Prdm15	G	A	16: 97,808,756 (GRCm38)	H563Y	probably damaging	Het
Rbm12	CAGG	CAGGGATTGCGGGACCTGGTATTGCGGGACCAGG	2: 156,096,106 (GRCm38)		probably benign	Het
Sema3g	C	T	14: 31,227,841 (GRCm38)	H660Y	probably damaging	Het
Smarca2	AGCAGCAGCAGCAGCAGCAGCA	AGCAGCAGCAGCAGCAGCAGCAGCAGCA	19: 26,630,997 (GRCm38)		probably benign	Het
Stpg2	A	T	3: 139,212,250 (GRCm38)		probably null	Het
Taar7f	C	T	10: 24,050,423 (GRCm38)	T305M	possibly damaging	Het
Tbcb	C	T	7: 30,224,346 (GRCm38)	V208M	probably damaging	Het
Tenm2	T	A	11: 36,024,203 (GRCm38)	Q2169L	possibly damaging	Het
Tln1	A	G	4: 43,555,890 (GRCm38)	V108A	probably damaging	Het
Tmc8	T	C	11: 117,783,234 (GRCm38)	M42T	probably benign	Het
Ttbk2	A	G	2: 120,748,634 (GRCm38)	V669A	probably benign	Het
Tusc1	GCC	GCCACCACC	4: 93,335,316 (GRCm38)		probably benign	Het
Vps16	A	G	2: 130,438,209 (GRCm38)	H118R	probably benign	Het
Wdpcp	T	A	11: 21,711,587 (GRCm38)	C286*	probably null	Het
Zbed4	C	A	15: 88,781,236 (GRCm38)	Y502*	probably null	Het
Zdbf2	T	A	1: 63,302,652 (GRCm38)	N63K	possibly damaging	Het

Other mutations in Trdc

Allele	Source	Chr	Coord	Type	Predicted Effect
R5950:Trdc	UTSW	14	54,144,311 (GRCm38)	unclassified	probably benign
R6683:Trdc	UTSW	14	54,144,235 (GRCm38)	unclassified	probably benign
R7543:Trdc	UTSW	14	54,144,235 (GRCm38)	missense
R7815:Trdc	UTSW	14	54,143,802 (GRCm38)	unclassified	probably benign

Predicted Primers

PCR Primer
(F):5'- TTCCCAGACTGGCCTGCC -3'
(R):5'- TTGGCTGTACTGGGGAAGATAAG -3'

Sequencing Primer
(F):5'- ACTGGCCTGCCTGGGTG -3'
(R):5'- GAAGTCTAGGAGTGTTTCACCACAC -3'

Posted On

2019-12-04