|Institutional Source||Beutler Lab|
|Gene Name||tumor suppressor candidate 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||RF021 (G1)|
|Chromosomal Location||93334138-93335511 bp(-) (GRCm38)|
|Type of Mutation||small insertion (2 aa in frame mutation)|
|DNA Base Change (assembly)||GCC to GCCACCACC at 93335316 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000069652 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000066774]|
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||91% (50/55)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tusc1||
(F):5'- ACATGACCTCCAGCTTCTCTAG -3'
(R):5'- AGCAGAGGACAAGGCTTTC -3'
(F):5'- AAGAGGCTGCGGTTCTCG -3'
(R):5'- ACAAGGCTTTCCGGGCAC -3'