Incidental Mutation 'R8936:Dock5'
ID 680673
Institutional Source Beutler Lab
Gene Symbol Dock5
Ensembl Gene ENSMUSG00000044447
Gene Name dedicator of cytokinesis 5
Synonyms 1110060D06Rik, rlc, lr2
MMRRC Submission 068779-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.346) question?
Stock # R8936 (G1)
Quality Score 211.009
Status Not validated
Chromosome 14
Chromosomal Location 67989584-68170891 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 68083439 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 157 (R157*)
Ref Sequence ENSEMBL: ENSMUSP00000036674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039135]
AlphaFold B2RY04
Predicted Effect probably null
Transcript: ENSMUST00000039135
AA Change: R157*
SMART Domains Protein: ENSMUSP00000036674
Gene: ENSMUSG00000044447
AA Change: R157*

DomainStartEndE-ValueType
SH3 11 68 1.45e-13 SMART
Pfam:DOCK_N 71 434 9e-110 PFAM
Pfam:DOCK-C2 439 636 1.1e-57 PFAM
low complexity region 752 764 N/A INTRINSIC
Pfam:DHR-2 1133 1635 6.4e-99 PFAM
low complexity region 1663 1692 N/A INTRINSIC
low complexity region 1815 1824 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
PHENOTYPE: Mutations at this locus result in lens abnormalities involving cataracts and rupturing of the lens nucleus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 A G 19: 43,797,101 (GRCm39) K491E probably benign Het
Abcd3 T C 3: 121,569,117 (GRCm39) I374V probably benign Het
Adam34 G A 8: 44,104,439 (GRCm39) T402I probably benign Het
Angptl7 G T 4: 148,581,790 (GRCm39) H199N probably benign Het
Ankrd11 A G 8: 123,621,840 (GRCm39) C671R possibly damaging Het
Anxa7 G A 14: 20,521,495 (GRCm39) P67L unknown Het
Ap3d1 T A 10: 80,547,952 (GRCm39) Q913H probably benign Het
Arhgef37 A G 18: 61,656,948 (GRCm39) I39T probably damaging Het
Armh4 G A 14: 50,008,024 (GRCm39) T483I probably damaging Het
C3ar1 T A 6: 122,828,044 (GRCm39) T58S probably damaging Het
Caap1 A T 4: 94,389,332 (GRCm39) L334Q probably damaging Het
Ccr1 A T 9: 123,763,882 (GRCm39) I216K probably damaging Het
Cdh9 T A 15: 16,831,162 (GRCm39) probably null Het
Cept1 A G 3: 106,411,921 (GRCm39) F351S possibly damaging Het
Cfap61 A G 2: 145,791,879 (GRCm39) D112G possibly damaging Het
Cul9 T A 17: 46,839,528 (GRCm39) S817C possibly damaging Het
Dido1 A G 2: 180,303,195 (GRCm39) S1570P probably benign Het
Disc1 A G 8: 125,814,754 (GRCm39) D206G probably damaging Het
Dpp6 A G 5: 27,926,140 (GRCm39) D738G probably damaging Het
Enpep A G 3: 129,125,884 (GRCm39) F83L possibly damaging Het
F10 G T 8: 13,095,086 (GRCm39) W81L probably damaging Het
Fam217a T C 13: 35,095,147 (GRCm39) D356G probably damaging Het
Fes T C 7: 80,031,473 (GRCm39) E467G probably damaging Het
Fignl2 A T 15: 100,951,339 (GRCm39) D314E unknown Het
Foxh1 T C 15: 76,552,719 (GRCm39) probably benign Het
Gdpd5 T C 7: 99,109,199 (GRCm39) L573P probably benign Het
Gigyf1 T A 5: 137,523,469 (GRCm39) S934T probably damaging Het
Gm7356 C T 17: 14,221,937 (GRCm39) V31I probably benign Het
Hoatz A G 9: 51,011,298 (GRCm39) probably null Het
Hoxa2 C A 6: 52,140,517 (GRCm39) K156N probably damaging Het
Ifi203 G A 1: 173,756,857 (GRCm39) probably benign Het
Il5ra A T 6: 106,692,604 (GRCm39) D380E possibly damaging Het
Ino80c C A 18: 24,254,865 (GRCm39) probably benign Het
Kif18a T A 2: 109,163,966 (GRCm39) W772R probably benign Het
Lipo3 G T 19: 33,557,880 (GRCm39) Q171K probably damaging Het
Mga A T 2: 119,794,709 (GRCm39) T2798S probably damaging Het
Msantd5l A G 11: 51,145,249 (GRCm39) S113P probably damaging Het
Mybpc1 T A 10: 88,394,437 (GRCm39) T297S probably benign Het
Myh7 T G 14: 55,228,440 (GRCm39) Q222P probably benign Het
N4bp2l2 T C 5: 150,585,362 (GRCm39) D206G probably benign Het
Nacc2 G C 2: 25,952,216 (GRCm39) T380S probably benign Het
Niban3 T A 8: 72,060,307 (GRCm39) probably benign Het
Nkpd1 T A 7: 19,255,875 (GRCm39) D186E probably damaging Het
Nol10 A T 12: 17,466,863 (GRCm39) E581V probably benign Het
Ntrk1 A T 3: 87,693,366 (GRCm39) N255K possibly damaging Het
Nudt5 T G 2: 5,869,228 (GRCm39) D151E probably benign Het
Obscn A T 11: 58,892,858 (GRCm39) L6796Q probably benign Het
Or10p21 C T 10: 128,847,802 (GRCm39) A216V probably benign Het
Or4k2 A G 14: 50,423,999 (GRCm39) I225T possibly damaging Het
Oxct2b A G 4: 123,010,838 (GRCm39) T253A probably benign Het
Patl1 G A 19: 11,891,725 (GRCm39) C10Y probably damaging Het
Pikfyve A G 1: 65,310,427 (GRCm39) R1905G possibly damaging Het
Pkhd1l1 A G 15: 44,402,312 (GRCm39) E2228G possibly damaging Het
Plcg1 A G 2: 160,589,986 (GRCm39) K135E probably benign Het
Proz A G 8: 13,115,319 (GRCm39) T112A probably benign Het
Prune2 A G 19: 17,099,199 (GRCm39) N1568D probably benign Het
Rbm4 A G 19: 4,837,539 (GRCm39) V431A probably benign Het
Rgs19 G T 2: 181,333,058 (GRCm39) C40* probably null Het
Rimbp3 T A 16: 17,030,884 (GRCm39) I1436K probably benign Het
Rnps1 T A 17: 24,641,176 (GRCm39) M192K probably damaging Het
Rrad C T 8: 105,355,222 (GRCm39) R262Q possibly damaging Het
Slc17a9 G A 2: 180,380,210 (GRCm39) V318I probably benign Het
Slc5a12 A G 2: 110,467,455 (GRCm39) I412V probably damaging Het
Smc4 T A 3: 68,925,491 (GRCm39) N329K probably benign Het
St3gal4 G A 9: 34,964,723 (GRCm39) R165W probably damaging Het
Strbp G A 2: 37,493,949 (GRCm39) R375* probably null Het
Tacc2 A G 7: 130,228,367 (GRCm39) N1684S possibly damaging Het
Tet1 A T 10: 62,676,063 (GRCm39) L671* probably null Het
Tex2 C A 11: 106,458,144 (GRCm39) E429* probably null Het
Tgm4 T C 9: 122,869,541 (GRCm39) I40T possibly damaging Het
Tmem132d C T 5: 127,869,676 (GRCm39) D553N probably damaging Het
Tnks A T 8: 35,320,501 (GRCm39) Y723* probably null Het
Tnks1bp1 A T 2: 84,894,320 (GRCm39) T1416S probably benign Het
Tnxb T A 17: 34,904,646 (GRCm39) L1137Q probably damaging Het
Tor4a A C 2: 25,085,202 (GRCm39) C68G probably damaging Het
Tubb2b A C 13: 34,312,445 (GRCm39) V116G probably damaging Het
Upb1 T A 10: 75,250,827 (GRCm39) S99T probably benign Het
Vmn1r31 T A 6: 58,449,083 (GRCm39) I261F unknown Het
Vmn1r53 T C 6: 90,200,571 (GRCm39) Y251C probably benign Het
Vmn2r58 T C 7: 41,513,981 (GRCm39) R221G Het
Vmn2r88 A T 14: 51,655,983 (GRCm39) I740F possibly damaging Het
Zfp644 C T 5: 106,783,503 (GRCm39) G1015R probably damaging Het
Zfy1 T C Y: 738,726 (GRCm39) D160G unknown Het
Zscan25 T A 5: 145,223,200 (GRCm39) V156E probably damaging Het
Zyg11b A T 4: 108,109,356 (GRCm39) F443I Het
Other mutations in Dock5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00504:Dock5 APN 14 68,024,338 (GRCm39) splice site probably benign
IGL00930:Dock5 APN 14 68,008,526 (GRCm39) missense probably damaging 1.00
IGL01525:Dock5 APN 14 68,043,169 (GRCm39) splice site probably benign
IGL01759:Dock5 APN 14 68,118,708 (GRCm39) nonsense probably null
IGL01941:Dock5 APN 14 68,049,681 (GRCm39) missense probably damaging 1.00
IGL02025:Dock5 APN 14 68,000,736 (GRCm39) missense probably damaging 1.00
IGL02093:Dock5 APN 14 68,076,992 (GRCm39) splice site probably benign
IGL02179:Dock5 APN 14 68,043,945 (GRCm39) splice site probably benign
IGL02208:Dock5 APN 14 68,065,899 (GRCm39) missense probably benign 0.06
IGL02605:Dock5 APN 14 68,065,887 (GRCm39) missense probably benign 0.18
IGL02608:Dock5 APN 14 68,065,888 (GRCm39) missense probably benign 0.01
IGL02938:Dock5 APN 14 67,994,667 (GRCm39) splice site probably benign
IGL02971:Dock5 APN 14 67,994,558 (GRCm39) missense probably null 1.00
IGL02983:Dock5 APN 14 68,002,119 (GRCm39) missense probably damaging 1.00
IGL03151:Dock5 APN 14 68,103,516 (GRCm39) missense probably damaging 1.00
IGL03410:Dock5 APN 14 68,083,535 (GRCm39) missense probably benign 0.04
PIT4366001:Dock5 UTSW 14 68,062,123 (GRCm39) missense possibly damaging 0.83
R0026:Dock5 UTSW 14 68,083,530 (GRCm39) missense probably benign 0.00
R0058:Dock5 UTSW 14 68,018,485 (GRCm39) missense probably benign 0.00
R0058:Dock5 UTSW 14 68,018,485 (GRCm39) missense probably benign 0.00
R0112:Dock5 UTSW 14 68,057,090 (GRCm39) missense probably benign
R0127:Dock5 UTSW 14 68,083,491 (GRCm39) missense probably benign 0.13
R0144:Dock5 UTSW 14 68,023,735 (GRCm39) missense probably benign 0.18
R0312:Dock5 UTSW 14 68,033,440 (GRCm39) missense possibly damaging 0.82
R0360:Dock5 UTSW 14 68,060,129 (GRCm39) splice site probably benign
R0364:Dock5 UTSW 14 68,060,129 (GRCm39) splice site probably benign
R0496:Dock5 UTSW 14 68,054,967 (GRCm39) missense probably damaging 1.00
R0506:Dock5 UTSW 14 68,022,241 (GRCm39) splice site probably benign
R0586:Dock5 UTSW 14 68,046,481 (GRCm39) missense probably damaging 1.00
R0597:Dock5 UTSW 14 68,022,383 (GRCm39) splice site probably null
R0625:Dock5 UTSW 14 68,078,612 (GRCm39) missense probably benign
R1109:Dock5 UTSW 14 68,043,927 (GRCm39) missense possibly damaging 0.80
R1221:Dock5 UTSW 14 67,996,610 (GRCm39) missense probably benign 0.00
R1278:Dock5 UTSW 14 68,077,015 (GRCm39) missense possibly damaging 0.80
R1927:Dock5 UTSW 14 68,083,511 (GRCm39) missense possibly damaging 0.60
R1944:Dock5 UTSW 14 67,994,584 (GRCm39) nonsense probably null
R1946:Dock5 UTSW 14 68,023,765 (GRCm39) missense probably damaging 1.00
R2046:Dock5 UTSW 14 68,049,591 (GRCm39) missense probably benign
R2101:Dock5 UTSW 14 68,031,459 (GRCm39) missense probably benign 0.02
R2252:Dock5 UTSW 14 68,022,261 (GRCm39) missense probably damaging 0.98
R2882:Dock5 UTSW 14 68,077,069 (GRCm39) missense probably damaging 0.99
R3110:Dock5 UTSW 14 68,095,371 (GRCm39) missense possibly damaging 0.72
R3112:Dock5 UTSW 14 68,095,371 (GRCm39) missense possibly damaging 0.72
R4236:Dock5 UTSW 14 67,993,941 (GRCm39) missense probably benign 0.02
R4242:Dock5 UTSW 14 68,065,939 (GRCm39) missense probably benign 0.19
R4244:Dock5 UTSW 14 68,012,031 (GRCm39) missense probably benign 0.41
R4646:Dock5 UTSW 14 68,080,228 (GRCm39) missense probably benign 0.01
R4793:Dock5 UTSW 14 68,037,803 (GRCm39) missense probably benign 0.26
R4841:Dock5 UTSW 14 68,055,012 (GRCm39) missense probably damaging 0.98
R4842:Dock5 UTSW 14 68,055,012 (GRCm39) missense probably damaging 0.98
R5159:Dock5 UTSW 14 68,029,738 (GRCm39) missense probably benign 0.04
R5164:Dock5 UTSW 14 68,055,110 (GRCm39) nonsense probably null
R5206:Dock5 UTSW 14 68,000,633 (GRCm39) missense probably benign 0.35
R5207:Dock5 UTSW 14 68,013,733 (GRCm39) missense probably benign 0.06
R5322:Dock5 UTSW 14 68,007,715 (GRCm39) missense probably benign 0.41
R5374:Dock5 UTSW 14 68,043,205 (GRCm39) missense possibly damaging 0.81
R5413:Dock5 UTSW 14 68,002,104 (GRCm39) missense probably damaging 1.00
R5476:Dock5 UTSW 14 68,051,456 (GRCm39) missense possibly damaging 0.92
R5504:Dock5 UTSW 14 68,040,535 (GRCm39) missense probably benign 0.01
R5677:Dock5 UTSW 14 68,015,052 (GRCm39) missense probably benign 0.00
R5773:Dock5 UTSW 14 68,033,507 (GRCm39) missense possibly damaging 0.95
R5845:Dock5 UTSW 14 68,078,550 (GRCm39) missense possibly damaging 0.82
R5957:Dock5 UTSW 14 68,095,443 (GRCm39) missense probably benign
R6154:Dock5 UTSW 14 68,097,361 (GRCm39) missense probably benign 0.03
R6268:Dock5 UTSW 14 68,027,724 (GRCm39) nonsense probably null
R6393:Dock5 UTSW 14 68,060,051 (GRCm39) missense probably benign 0.32
R6512:Dock5 UTSW 14 68,062,097 (GRCm39) missense possibly damaging 0.93
R6759:Dock5 UTSW 14 68,033,445 (GRCm39) missense probably benign 0.00
R7012:Dock5 UTSW 14 68,060,035 (GRCm39) missense probably damaging 1.00
R7061:Dock5 UTSW 14 68,007,703 (GRCm39) missense probably damaging 0.96
R7196:Dock5 UTSW 14 67,993,919 (GRCm39) missense probably damaging 1.00
R7200:Dock5 UTSW 14 68,009,151 (GRCm39) nonsense probably null
R7311:Dock5 UTSW 14 68,065,951 (GRCm39) missense probably benign 0.25
R7359:Dock5 UTSW 14 68,003,337 (GRCm39) missense probably benign 0.10
R7422:Dock5 UTSW 14 68,046,479 (GRCm39) missense probably benign 0.01
R7588:Dock5 UTSW 14 68,000,607 (GRCm39) critical splice donor site probably null
R7637:Dock5 UTSW 14 68,023,789 (GRCm39) missense possibly damaging 0.95
R7709:Dock5 UTSW 14 68,033,454 (GRCm39) missense probably benign 0.44
R7763:Dock5 UTSW 14 68,058,776 (GRCm39) missense probably damaging 0.97
R8044:Dock5 UTSW 14 68,062,141 (GRCm39) missense probably damaging 1.00
R8076:Dock5 UTSW 14 68,040,426 (GRCm39) splice site probably null
R8168:Dock5 UTSW 14 68,007,646 (GRCm39) splice site probably null
R8353:Dock5 UTSW 14 68,054,957 (GRCm39) splice site probably null
R8480:Dock5 UTSW 14 68,073,859 (GRCm39) missense probably benign 0.32
R8535:Dock5 UTSW 14 68,031,425 (GRCm39) missense probably benign 0.19
R8708:Dock5 UTSW 14 68,004,820 (GRCm39) missense probably benign 0.02
R8732:Dock5 UTSW 14 68,083,449 (GRCm39) missense possibly damaging 0.85
R8888:Dock5 UTSW 14 68,055,112 (GRCm39) missense possibly damaging 0.95
R8895:Dock5 UTSW 14 68,055,112 (GRCm39) missense possibly damaging 0.95
R8962:Dock5 UTSW 14 67,994,640 (GRCm39) missense probably benign
R8972:Dock5 UTSW 14 68,013,749 (GRCm39) missense probably damaging 1.00
R9244:Dock5 UTSW 14 67,996,563 (GRCm39) missense probably damaging 0.99
R9345:Dock5 UTSW 14 68,060,071 (GRCm39) missense possibly damaging 0.74
R9679:Dock5 UTSW 14 68,018,450 (GRCm39) missense probably damaging 1.00
X0023:Dock5 UTSW 14 68,008,537 (GRCm39) missense probably benign 0.15
Z1177:Dock5 UTSW 14 68,051,382 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- TCCCCAAGAGTCACTGATACA -3'
(R):5'- GTGAAGATAGATGCCTTCTCTTCA -3'

Sequencing Primer
(F):5'- CTGTAAAGTCCTGGGATCAGAGCTC -3'
(R):5'- GATAGATGCCTTCTCTTCATTGCATC -3'
Posted On 2021-08-31