Mutagenetix > Incidental Mutation

Incidental Mutation 'R1728:Pik3c2b'

198373

Institutional Source

Beutler Lab

Gene Symbol

Pik3c2b

Ensembl Gene

ENSMUSG00000026447

Gene Name

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta

Synonyms

C330011J12Rik, PI3K-C2beta

MMRRC Submission

039760-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.206) question?

Stock #

R1728 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

133045667-133108687 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 133066627 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 110 (P110S)

Ref Sequence

ENSEMBL: ENSMUSP00000115469 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077730] [ENSMUST00000153707]

AlphaFold

E9QAN8

Predicted Effect

probably benign
Transcript: ENSMUST00000077730
AA Change: P110S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000076911
Gene: ENSMUSG00000026447
AA Change: P110S

Domain	Start	End	E-Value	Type
low complexity region	155	160	N/A	INTRINSIC
low complexity region	168	183	N/A	INTRINSIC
PI3K_rbd	363	465	2.15e-19	SMART
PI3K_C2	618	726	6.17e-29	SMART
PI3Ka	804	990	1.66e-84	SMART
PI3Kc	1078	1340	3.45e-132	SMART
PX	1364	1476	9.44e-27	SMART
low complexity region	1481	1492	N/A	INTRINSIC
C2	1517	1622	1.82e-18	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124934

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145153

Predicted Effect

probably benign
Transcript: ENSMUST00000153707
AA Change: P110S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000115469
Gene: ENSMUSG00000026447
AA Change: P110S

Domain	Start	End	E-Value	Type
low complexity region	155	160	N/A	INTRINSIC
low complexity region	168	183	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186515

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.0%
20x: 91.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal epidermal growth, differentiation and function. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 223 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447A16Rik	G	A	15: 37,439,600 (GRCm38)		probably benign	Het
Aadat	A	G	8: 60,526,712 (GRCm38)	T203A	probably damaging	Het
Abca13	T	A	11: 9,249,680 (GRCm38)	F104L	probably benign	Het
Acox1	T	A	11: 116,198,283 (GRCm38)		probably null	Het
Adamts17	C	T	7: 67,149,956 (GRCm38)	R1060*	probably null	Het
Adgrg6	T	C	10: 14,439,782 (GRCm38)	T593A	probably damaging	Het
Ankrd12	G	T	17: 65,984,076 (GRCm38)	P1454Q	probably benign	Het
Ap2m1	T	A	16: 20,539,338 (GRCm38)	N35K	probably damaging	Het
Aspm	A	G	1: 139,473,574 (GRCm38)	I1111V	probably benign	Het
Atr	G	A	9: 95,897,581 (GRCm38)	V1331I	probably benign	Het
Bola1	C	T	3: 96,197,110 (GRCm38)	G56D	probably benign	Het
Brsk1	A	G	7: 4,704,219 (GRCm38)	D257G	probably damaging	Het
C4bp	C	G	1: 130,642,988 (GRCm38)	V284L	probably benign	Het
Cacna1s	T	C	1: 136,118,716 (GRCm38)	F1761S	probably benign	Het
Camsap2	C	T	1: 136,281,315 (GRCm38)	R802Q	probably benign	Het
Cbs	G	T	17: 31,620,949 (GRCm38)	A337E	probably benign	Het
Ccdc129	T	C	6: 55,968,541 (GRCm38)	F749S	probably benign	Het
Ccdc186	A	C	19: 56,809,220 (GRCm38)	H306Q	probably benign	Het
Ccdc93	C	T	1: 121,456,126 (GRCm38)	P192L	probably benign	Het
Ccdc93	T	C	1: 121,461,939 (GRCm38)	V237A	probably benign	Het
Cd55	C	A	1: 130,459,633 (GRCm38)	A143S	probably benign	Het
Cd55	C	T	1: 130,449,423 (GRCm38)	V333I	probably benign	Het
Cdh19	C	A	1: 110,893,384 (GRCm38)	E541D	probably damaging	Het
Cdh7	C	G	1: 110,065,735 (GRCm38)	L307V	possibly damaging	Het
Cfh	C	T	1: 140,147,697 (GRCm38)	V268I	possibly damaging	Het
Cfhr2	A	C	1: 139,813,459 (GRCm38)	N259K	probably benign	Het
Cfhr2	A	G	1: 139,813,442 (GRCm38)	M265T	probably benign	Het
Chil1	C	T	1: 134,188,529 (GRCm38)	A250V	probably damaging	Het
Chrnb1	C	A	11: 69,785,762 (GRCm38)	D388Y	probably damaging	Het
Clcn1	T	A	6: 42,299,514 (GRCm38)	F360Y	possibly damaging	Het
Clgn	A	G	8: 83,423,030 (GRCm38)	S387G	probably damaging	Het
Cntnap5a	T	C	1: 116,455,101 (GRCm38)	L1033S	probably benign	Het
Cntnap5a	C	T	1: 116,455,143 (GRCm38)	T1047I	probably benign	Het
Cntnap5a	C	A	1: 116,455,004 (GRCm38)	L1001I	probably benign	Het
Coil	G	A	11: 88,973,976 (GRCm38)	V10I	probably damaging	Het
Col4a1	G	A	8: 11,212,712 (GRCm38)	P1256S	possibly damaging	Het
Copa	T	A	1: 172,111,987 (GRCm38)	F597Y	probably benign	Het
Crb1	A	T	1: 139,237,622 (GRCm38)	H921Q	probably benign	Het
Crb1	G	A	1: 139,241,138 (GRCm38)	P881S	probably damaging	Het
Crb1	C	T	1: 139,242,995 (GRCm38)	G825R	probably damaging	Het
Crb1	C	T	1: 139,243,417 (GRCm38)	R684H	probably benign	Het
Crb1	T	C	1: 139,234,779 (GRCm38)	M1214V	probably benign	Het
Crybg1	T	A	10: 44,004,019 (GRCm38)	Q391L	probably damaging	Het
Cspg4	G	T	9: 56,898,537 (GRCm38)	V2211L	probably benign	Het
Cxcr4	C	T	1: 128,589,277 (GRCm38)	V216I	probably benign	Het
Cyb5r1	C	T	1: 134,407,667 (GRCm38)	R147W	probably damaging	Het
Ddx59	T	C	1: 136,417,053 (GRCm38)	V154A	probably benign	Het
Dhx30	T	C	9: 110,098,751 (GRCm38)	H101R	probably damaging	Het
Dnah11	T	A	12: 117,916,931 (GRCm38)	D3818V	probably damaging	Het
Dnah17	C	T	11: 118,069,519 (GRCm38)	C2572Y	possibly damaging	Het
Dsel	G	C	1: 111,859,994 (GRCm38)	T937S	probably benign	Het
Dsel	T	C	1: 111,859,457 (GRCm38)	N1116S	probably benign	Het
Dstyk	C	T	1: 132,456,984 (GRCm38)	L739F	probably damaging	Het
Ehf	T	G	2: 103,273,906 (GRCm38)	T186P	possibly damaging	Het
En1	A	G	1: 120,603,621 (GRCm38)	S197G	unknown	Het
Etnk2	C	A	1: 133,365,587 (GRCm38)	D89E	probably benign	Het
Etnk2	G	T	1: 133,365,765 (GRCm38)	G149W	probably damaging	Het
Etnk2	C	T	1: 133,365,816 (GRCm38)	R166*	probably null	Het
Etnk2	T	A	1: 133,376,915 (GRCm38)	V292E	probably benign	Het
Etnk2	G	A	1: 133,365,817 (GRCm38)	R166Q	probably benign	Het
Fam187b	C	T	7: 30,989,020 (GRCm38)	Q268*	probably null	Het
Fam72a	C	T	1: 131,538,895 (GRCm38)	T139M	probably benign	Het
Fam72a	T	C	1: 131,530,668 (GRCm38)	I56T	probably benign	Het
Fat3	A	C	9: 15,996,315 (GRCm38)	V2797G	possibly damaging	Het
Fcamr	G	A	1: 130,812,629 (GRCm38)	G262S	probably benign	Het
Fcamr	A	G	1: 130,814,597 (GRCm38)	N574D	probably benign	Het
Fcamr	A	C	1: 130,804,627 (GRCm38)	N117T	probably benign	Het
Fcamr	A	G	1: 130,812,809 (GRCm38)	M322V	probably benign	Het
Fcamr	T	C	1: 130,812,738 (GRCm38)	V298A	probably benign	Het
Fcamr	A	G	1: 130,804,569 (GRCm38)	R98G	probably benign	Het
Fcamr	A	G	1: 130,812,692 (GRCm38)	I283V	probably benign	Het
Fcamr	A	G	1: 130,811,580 (GRCm38)	I206V	probably benign	Het
Fcamr	C	T	1: 130,812,816 (GRCm38)	P324L	probably benign	Het
Fcmr	T	C	1: 130,878,269 (GRCm38)	S321P	probably benign	Het
Fcmr	A	G	1: 130,875,974 (GRCm38)	T172A	probably benign	Het
Fut10	T	A	8: 31,201,390 (GRCm38)	S88T	probably benign	Het
Gabarap	C	T	11: 69,991,689 (GRCm38)		probably benign	Het
Gli2	C	T	1: 118,868,087 (GRCm38)	A113T	possibly damaging	Het
Gli2	G	T	1: 119,002,044 (GRCm38)	H44Q	probably benign	Het
Glrx2	C	T	1: 143,739,740 (GRCm38)	A27V	possibly damaging	Het
Gm28040	AGTG	AGTGGCACCTTTGGTG	1: 133,327,321 (GRCm38)		probably benign	Het
Gm5346	T	C	8: 43,625,583 (GRCm38)	N535D	probably damaging	Het
Gpr25	G	A	1: 136,260,710 (GRCm38)	P55L	probably benign	Het
Gse1	G	A	8: 120,568,253 (GRCm38)		probably benign	Het
Heatr4	T	C	12: 83,967,572 (GRCm38)	I630M	probably benign	Het
Hectd4	A	T	5: 121,301,839 (GRCm38)	Y1134F	possibly damaging	Het
Igfn1	T	C	1: 135,970,411 (GRCm38)	S806G	probably benign	Het
Igfn1	T	C	1: 135,998,683 (GRCm38)	I10V	unknown	Het
Igfn1	G	A	1: 135,959,928 (GRCm38)	P2466L	probably damaging	Het
Igfn1	C	T	1: 135,979,915 (GRCm38)	A231T	probably benign	Het
Igfn1	C	T	1: 135,972,127 (GRCm38)	R482Q	probably benign	Het
Igfn1	G	A	1: 135,982,475 (GRCm38)	R124W	probably benign	Het
Igfn1	G	A	1: 135,968,199 (GRCm38)	A1543V	probably benign	Het
Igfn1	T	C	1: 135,998,625 (GRCm38)	E29G	probably benign	Het
Ikbke	T	C	1: 131,269,823 (GRCm38)	S447G	probably benign	Het
Ikbke	C	A	1: 131,265,937 (GRCm38)	A459S	probably benign	Het
Ildr1	A	T	16: 36,708,336 (GRCm38)	T48S	possibly damaging	Het
Ipo9	A	G	1: 135,402,250 (GRCm38)	V484A	probably benign	Het
Ipo9	CTC	CTCTTC	1: 135,386,271 (GRCm38)		probably benign	Het
Ipo9	ATCCTCCTCCTCCTCCTC	ATCCTCCTCCTCCTCCTCCTC	1: 135,386,268 (GRCm38)		probably benign	Het
Jarid2	T	A	13: 44,906,276 (GRCm38)	N661K	probably damaging	Het
Kcnh5	T	C	12: 75,137,691 (GRCm38)	D86G	probably benign	Het
Kcnt2	G	A	1: 140,354,547 (GRCm38)	S90N	probably benign	Het
Kif14	T	C	1: 136,525,783 (GRCm38)	V1433A	probably benign	Het
Kif14	G	A	1: 136,478,365 (GRCm38)	A556T	probably benign	Het
Kif14	A	G	1: 136,468,279 (GRCm38)	N108D	probably benign	Het
Kif14	A	G	1: 136,468,975 (GRCm38)	K340E	probably damaging	Het
Kif14	C	T	1: 136,503,431 (GRCm38)	L1189F	probably benign	Het
Kif14	A	G	1: 136,490,332 (GRCm38)	S868G	probably benign	Het
Kif14	T	C	1: 136,515,961 (GRCm38)	F1291L	probably benign	Het
Kif1b	T	C	4: 149,187,722 (GRCm38)	T1541A	probably damaging	Het
Kif21b	A	G	1: 136,160,121 (GRCm38)	I983V	possibly damaging	Het
Kif26a	T	C	12: 112,176,785 (GRCm38)	S1158P	possibly damaging	Het
Kmt2d	A	G	15: 98,865,132 (GRCm38)	C279R	probably damaging	Het
Kpna3	T	A	14: 61,367,701 (GRCm38)	E499V	probably benign	Het
Krt16	T	C	11: 100,247,707 (GRCm38)	E205G	probably damaging	Het
Lad1	C	T	1: 135,828,023 (GRCm38)	R346C	probably damaging	Het
Lad1	C	T	1: 135,827,381 (GRCm38)	P132S	possibly damaging	Het
Lax1	G	A	1: 133,683,634 (GRCm38)	P67S	probably damaging	Het
Lax1	T	C	1: 133,680,569 (GRCm38)	N145D	probably benign	Het
Lax1	T	C	1: 133,679,978 (GRCm38)	R342G	probably benign	Het
Lgr6	G	T	1: 134,990,635 (GRCm38)	H263N	probably benign	Het
Lgr6	C	T	1: 135,003,476 (GRCm38)	S3N	probably benign	Het
Lgr6	C	T	1: 134,987,088 (GRCm38)	V641I	probably benign	Het
Lmod1	C	T	1: 135,364,073 (GRCm38)	T222I	probably benign	Het
Mb21d2	A	G	16: 28,828,421 (GRCm38)	V267A	probably benign	Het
Mfrp	A	G	9: 44,104,587 (GRCm38)	T334A	possibly damaging	Het
Morc1	T	A	16: 48,612,297 (GRCm38)	D709E	probably benign	Het
Mrgpra2b	A	G	7: 47,464,879 (GRCm38)	I35T	probably benign	Het
Mroh3	G	C	1: 136,192,144 (GRCm38)	Q440E	possibly damaging	Het
Mybph	C	T	1: 134,197,480 (GRCm38)	R249C	probably benign	Het
Mycbp2	A	T	14: 103,155,178 (GRCm38)	C3206S	probably damaging	Het
Nav1	A	T	1: 135,584,727 (GRCm38)	D198E	possibly damaging	Het
Ndufaf7	A	T	17: 78,937,629 (GRCm38)	K59M	probably damaging	Het
Necab3	T	C	2: 154,546,875 (GRCm38)	S208G	probably benign	Het
Nr5a2	C	A	1: 136,952,125 (GRCm38)	R35L	probably benign	Het
Obsl1	G	A	1: 75,486,756 (GRCm38)	T1764M	probably benign	Het
Olfr1026	T	A	2: 85,924,122 (GRCm38)	L285I	possibly damaging	Het
Olfr1240	C	T	2: 89,439,583 (GRCm38)	R232H	probably benign	Het
Olfr402	A	G	11: 74,155,976 (GRCm38)	D274G	probably damaging	Het
Olfr453	C	A	6: 42,744,135 (GRCm38)	L33M	possibly damaging	Het
Olfr870	A	T	9: 20,170,913 (GRCm38)	Y219*	probably null	Het
Optc	A	T	1: 133,903,796 (GRCm38)		probably null	Het
Optc	C	G	1: 133,905,170 (GRCm38)	S64T	probably benign	Het
Otoa	T	C	7: 121,125,439 (GRCm38)	V447A	probably benign	Het
Papss1	A	G	3: 131,605,967 (GRCm38)	N319D	probably benign	Het
Patj	G	A	4: 98,431,780 (GRCm38)	G428D	possibly damaging	Het
Pcdhb3	G	A	18: 37,301,878 (GRCm38)	G299D	probably damaging	Het
Pcsk4	T	C	10: 80,323,570 (GRCm38)	D432G	probably damaging	Het
Pde5a	G	T	3: 122,748,240 (GRCm38)	L126F	probably damaging	Het
Pigr	C	T	1: 130,844,522 (GRCm38)	A159V	possibly damaging	Het
Pinx1	A	G	14: 63,878,110 (GRCm38)		probably null	Het
Plec	C	A	15: 76,177,692 (GRCm38)	E2547*	probably null	Het
Plekha6	C	G	1: 133,287,846 (GRCm38)	T792S	probably benign	Het
Ppfia4	G	A	1: 134,299,321 (GRCm38)	P1159S	probably benign	Het
Ppil2	C	G	16: 17,089,419 (GRCm38)		probably benign	Het
Prelp	C	T	1: 133,915,131 (GRCm38)	R92K	probably benign	Het
Prrx1	T	A	1: 163,261,967 (GRCm38)	N97I	probably damaging	Het
Ptpn7	A	G	1: 135,134,475 (GRCm38)	Q53R	probably benign	Het
Ptprc	T	C	1: 138,112,254 (GRCm38)	K212E	possibly damaging	Het
Ptprc	A	G	1: 138,107,823 (GRCm38)	S405P	probably benign	Het
Ptprc	A	G	1: 138,107,837 (GRCm38)	V400A	probably benign	Het
Ptprc	T	G	1: 138,099,676 (GRCm38)	N478T	probably benign	Het
Ptprc	C	A	1: 138,107,824 (GRCm38)	E402D	probably benign	Het
Rab29	A	G	1: 131,872,110 (GRCm38)	Q141R	probably benign	Het
Rbsn	A	T	6: 92,190,019 (GRCm38)	L548Q	possibly damaging	Het
Ren1	T	A	1: 133,354,206 (GRCm38)	W22R	probably damaging	Het
Ren1	C	T	1: 133,354,237 (GRCm38)	T32I	probably benign	Het
Ren1	A	C	1: 133,356,457 (GRCm38)	K187Q	probably benign	Het
Ren1	C	A	1: 133,358,982 (GRCm38)		probably null	Het
Ren1	A	T	1: 133,359,983 (GRCm38)	N352Y	probably benign	Het
Ren1	A	T	1: 133,359,079 (GRCm38)	E315D	probably benign	Het
Ren1	C	G	1: 133,360,007 (GRCm38)	L360V	probably benign	Het
Rnpep	G	C	1: 135,283,977 (GRCm38)	A11G	probably benign	Het
Rnpep	C	T	1: 135,263,096 (GRCm38)	A571T	possibly damaging	Het
Ryr2	C	T	13: 11,587,422 (GRCm38)	V4525M	possibly damaging	Het
Sctr	G	A	1: 120,063,257 (GRCm38)	S440N	possibly damaging	Het
Sctr	T	C	1: 120,031,656 (GRCm38)	F110L	probably benign	Het
Serpinb10	C	T	1: 107,538,473 (GRCm38)	S63F	probably damaging	Het
Serpinb2	C	T	1: 107,523,890 (GRCm38)	H258Y	probably benign	Het
Serpinb2	C	T	1: 107,523,894 (GRCm38)	T259I	probably benign	Het
Serpinb2	G	A	1: 107,515,635 (GRCm38)	A55T	probably damaging	Het
Serpinb2	A	C	1: 107,524,543 (GRCm38)	S284R	probably benign	Het
Serpinb2	C	A	1: 107,523,834 (GRCm38)	A239E	probably benign	Het
Serpinb8	A	G	1: 107,597,527 (GRCm38)	S20G	probably benign	Het
Serpinb8	A	C	1: 107,607,004 (GRCm38)	L268F	probably benign	Het
Serpinb8	G	A	1: 107,598,954 (GRCm38)	A75T	probably benign	Het
Sis	A	T	3: 72,965,645 (GRCm38)	C53*	probably null	Het
Slc13a5	C	T	11: 72,266,459 (GRCm38)		probably null	Het
Slc26a9	C	T	1: 131,763,870 (GRCm38)	A617V	probably benign	Het
Slc26a9	C	A	1: 131,766,012 (GRCm38)	R747S	probably benign	Het
Slc9a8	T	C	2: 167,424,145 (GRCm38)	F14S	probably benign	Het
Spock3	T	C	8: 63,348,977 (GRCm38)	L330P	probably damaging	Het
Stab2	T	G	10: 86,938,039 (GRCm38)	R809S	probably benign	Het
Steap3	T	C	1: 120,227,750 (GRCm38)	N493S	probably benign	Het
Steap3	G	A	1: 120,234,378 (GRCm38)	A350V	probably benign	Het
Tecta	G	A	9: 42,391,922 (GRCm38)	T138I	probably benign	Het
Thsd7b	G	C	1: 129,678,183 (GRCm38)	A554P	probably benign	Het
Thsd7b	C	T	1: 129,628,891 (GRCm38)	T328I	probably damaging	Het
Thsd7b	T	A	1: 129,667,937 (GRCm38)	F498Y	probably benign	Het
Thsd7b	A	C	1: 130,116,631 (GRCm38)	Q1116P	probably benign	Het
Tnnt2	C	T	1: 135,845,506 (GRCm38)		probably benign	Het
Traf7	A	G	17: 24,512,379 (GRCm38)	F228L	probably damaging	Het
Trhr	A	G	15: 44,197,153 (GRCm38)	E23G	probably damaging	Het
Trove2	T	C	1: 143,760,034 (GRCm38)	D458G	probably benign	Het
Trove2	C	T	1: 143,760,014 (GRCm38)	V465I	probably benign	Het
Ttn	C	T	2: 76,813,339 (GRCm38)	G11436R	probably damaging	Het
Tubgcp2	T	C	7: 139,998,055 (GRCm38)	T779A	probably benign	Het
Tusc2	A	T	9: 107,564,631 (GRCm38)	I68F	probably damaging	Het
Ube2t	C	T	1: 134,972,167 (GRCm38)	A149V	probably benign	Het
Upf2	A	T	2: 6,027,450 (GRCm38)	S191C	probably damaging	Het
Usp24	A	G	4: 106,360,421 (GRCm38)	N447S	possibly damaging	Het
Usp42	T	C	5: 143,714,626 (GRCm38)	D1214G	probably damaging	Het
Vcam1	T	A	3: 116,114,515 (GRCm38)	I633L	probably benign	Het
Vmn2r73	T	C	7: 85,857,878 (GRCm38)	Y742C	probably damaging	Het
Vmn2r81	C	A	10: 79,270,655 (GRCm38)	T489K	probably benign	Het
Zan	C	A	5: 137,415,018 (GRCm38)		probably benign	Het
Zc3h11a	G	A	1: 133,622,154 (GRCm38)	P695S	probably benign	Het
Zc3h11a	C	T	1: 133,624,621 (GRCm38)	V583I	probably benign	Het
Zfp616	A	C	11: 74,085,771 (GRCm38)	K955N	probably damaging	Het
Zfyve9	A	C	4: 108,718,501 (GRCm38)	V461G	possibly damaging	Het
Zp3r	A	G	1: 130,596,814 (GRCm38)	L164P	probably benign	Het
Zp3r	C	A	1: 130,619,414 (GRCm38)	E8D	possibly damaging	Het

Other mutations in Pik3c2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01086:Pik3c2b	APN	1	133,091,618 (GRCm38)	missense	probably damaging	0.98
IGL01288:Pik3c2b	APN	1	133,094,805 (GRCm38)	missense	probably damaging	0.96
IGL01313:Pik3c2b	APN	1	133,071,631 (GRCm38)	nonsense	probably null
IGL01367:Pik3c2b	APN	1	133,105,988 (GRCm38)	missense	probably benign	0.02
IGL02379:Pik3c2b	APN	1	133,094,791 (GRCm38)	missense	probably damaging	1.00
IGL02638:Pik3c2b	APN	1	133,077,318 (GRCm38)	splice site	probably benign
IGL02728:Pik3c2b	APN	1	133,092,327 (GRCm38)	missense	probably benign	0.09
IGL02992:Pik3c2b	APN	1	133,066,980 (GRCm38)	nonsense	probably null
IGL03121:Pik3c2b	APN	1	133,079,745 (GRCm38)	missense	probably benign	0.00
R0453:Pik3c2b	UTSW	1	133,077,396 (GRCm38)	missense	probably damaging	1.00
R0518:Pik3c2b	UTSW	1	133,105,992 (GRCm38)	missense	probably damaging	1.00
R0616:Pik3c2b	UTSW	1	133,100,831 (GRCm38)	missense	probably damaging	1.00
R0659:Pik3c2b	UTSW	1	133,071,200 (GRCm38)	missense	probably damaging	0.99
R1542:Pik3c2b	UTSW	1	133,090,034 (GRCm38)	missense	probably damaging	1.00
R1716:Pik3c2b	UTSW	1	133,094,826 (GRCm38)	missense	probably damaging	1.00
R1729:Pik3c2b	UTSW	1	133,066,627 (GRCm38)	missense	probably benign	0.00
R1730:Pik3c2b	UTSW	1	133,066,627 (GRCm38)	missense	probably benign	0.00
R1739:Pik3c2b	UTSW	1	133,066,627 (GRCm38)	missense	probably benign	0.00
R1762:Pik3c2b	UTSW	1	133,066,627 (GRCm38)	missense	probably benign	0.00
R1783:Pik3c2b	UTSW	1	133,066,627 (GRCm38)	missense	probably benign	0.00
R1784:Pik3c2b	UTSW	1	133,066,627 (GRCm38)	missense	probably benign	0.00
R1785:Pik3c2b	UTSW	1	133,066,627 (GRCm38)	missense	probably benign	0.00
R1816:Pik3c2b	UTSW	1	133,101,370 (GRCm38)	missense	probably benign	0.00
R1897:Pik3c2b	UTSW	1	133,066,916 (GRCm38)	missense	possibly damaging	0.57
R2006:Pik3c2b	UTSW	1	133,066,544 (GRCm38)	missense	probably damaging	1.00
R2067:Pik3c2b	UTSW	1	133,099,611 (GRCm38)	missense	probably damaging	1.00
R2271:Pik3c2b	UTSW	1	133,103,428 (GRCm38)	missense	probably benign
R2294:Pik3c2b	UTSW	1	133,066,775 (GRCm38)	missense	probably damaging	1.00
R2320:Pik3c2b	UTSW	1	133,103,413 (GRCm38)	missense	probably damaging	1.00
R4735:Pik3c2b	UTSW	1	133,067,049 (GRCm38)	missense	probably benign	0.25
R4926:Pik3c2b	UTSW	1	133,099,626 (GRCm38)	nonsense	probably null
R4948:Pik3c2b	UTSW	1	133,099,715 (GRCm38)	critical splice donor site	probably null
R4997:Pik3c2b	UTSW	1	133,105,081 (GRCm38)	missense	probably damaging	1.00
R5304:Pik3c2b	UTSW	1	133,070,408 (GRCm38)	missense	possibly damaging	0.50
R5461:Pik3c2b	UTSW	1	133,099,702 (GRCm38)	missense	possibly damaging	0.66
R5722:Pik3c2b	UTSW	1	133,103,836 (GRCm38)	missense	probably damaging	1.00
R5971:Pik3c2b	UTSW	1	133,074,627 (GRCm38)	splice site	probably null
R5980:Pik3c2b	UTSW	1	133,088,308 (GRCm38)	missense	probably benign	0.43
R6036:Pik3c2b	UTSW	1	133,090,713 (GRCm38)	missense	possibly damaging	0.95
R6138:Pik3c2b	UTSW	1	133,074,627 (GRCm38)	splice site	probably null
R6223:Pik3c2b	UTSW	1	133,070,357 (GRCm38)	missense	probably damaging	1.00
R6273:Pik3c2b	UTSW	1	133,066,711 (GRCm38)	missense	probably benign	0.02
R6742:Pik3c2b	UTSW	1	133,075,821 (GRCm38)	missense	probably benign
R6954:Pik3c2b	UTSW	1	133,066,303 (GRCm38)	missense	possibly damaging	0.50
R6998:Pik3c2b	UTSW	1	133,102,372 (GRCm38)	missense	probably benign	0.23
R7103:Pik3c2b	UTSW	1	133,105,974 (GRCm38)	missense	probably damaging	1.00
R7133:Pik3c2b	UTSW	1	133,090,234 (GRCm38)	missense	possibly damaging	0.73
R7161:Pik3c2b	UTSW	1	133,106,112 (GRCm38)	missense	probably damaging	0.98
R7183:Pik3c2b	UTSW	1	133,066,465 (GRCm38)	missense	probably benign	0.00
R7193:Pik3c2b	UTSW	1	133,079,774 (GRCm38)	missense	probably benign	0.00
R7252:Pik3c2b	UTSW	1	133,094,734 (GRCm38)	missense	probably benign	0.19
R7263:Pik3c2b	UTSW	1	133,090,202 (GRCm38)	missense	probably damaging	0.98
R7404:Pik3c2b	UTSW	1	133,090,706 (GRCm38)	missense	probably damaging	1.00
R7709:Pik3c2b	UTSW	1	133,079,841 (GRCm38)	critical splice donor site	probably null
R7712:Pik3c2b	UTSW	1	133,085,611 (GRCm38)	missense	probably damaging	1.00
R7823:Pik3c2b	UTSW	1	133,102,305 (GRCm38)	missense	probably damaging	1.00
R7831:Pik3c2b	UTSW	1	133,071,242 (GRCm38)	missense	possibly damaging	0.94
R7913:Pik3c2b	UTSW	1	133,090,061 (GRCm38)	critical splice donor site	probably null
R7916:Pik3c2b	UTSW	1	133,100,904 (GRCm38)	missense	probably benign	0.30
R7960:Pik3c2b	UTSW	1	133,103,849 (GRCm38)	missense	probably damaging	1.00
R7981:Pik3c2b	UTSW	1	133,075,809 (GRCm38)	critical splice acceptor site	probably null
R8346:Pik3c2b	UTSW	1	133,090,246 (GRCm38)	missense	probably damaging	0.97
R8938:Pik3c2b	UTSW	1	133,088,330 (GRCm38)	missense	probably benign	0.19
R8997:Pik3c2b	UTSW	1	133,090,779 (GRCm38)	missense	possibly damaging	0.83
R9416:Pik3c2b	UTSW	1	133,077,449 (GRCm38)	missense	probably damaging	1.00
R9598:Pik3c2b	UTSW	1	133,084,987 (GRCm38)	critical splice donor site	probably null
R9621:Pik3c2b	UTSW	1	133,071,607 (GRCm38)	missense	probably damaging	1.00
R9742:Pik3c2b	UTSW	1	133,094,749 (GRCm38)	missense	probably damaging	1.00
R9776:Pik3c2b	UTSW	1	133,090,850 (GRCm38)	missense	possibly damaging	0.64
R9786:Pik3c2b	UTSW	1	133,091,600 (GRCm38)	missense	possibly damaging	0.94
U15987:Pik3c2b	UTSW	1	133,074,627 (GRCm38)	splice site	probably null
X0060:Pik3c2b	UTSW	1	133,084,936 (GRCm38)	missense	probably benign	0.18
Z1176:Pik3c2b	UTSW	1	133,099,686 (GRCm38)	nonsense	probably null
Z1176:Pik3c2b	UTSW	1	133,066,553 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GATGAGCCAGCCTTGGACTTCTAC -3'
(R):5'- GGCTGTTCTGCCGAAGAGAAACTG -3'

Sequencing Primer
(F):5'- TTGGACTTCTACAGCAAGCC -3'
(R):5'- GCAAGGGAGGGGCATCC -3'

Posted On

2014-05-23