Incidental Mutation 'R1908:Dennd2b'
| ID |
210056 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd2b
|
| Ensembl Gene |
ENSMUSG00000031024 |
| Gene Name |
DENN domain containing 2B |
| Synonyms |
Denn2b, 2610305K15Rik, St5, 2010004M01Rik |
| MMRRC Submission |
039927-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.390)
|
| Stock # |
R1908 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
109123118-109302812 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 109124533 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 686
(Q686*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130119
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077909]
[ENSMUST00000079282]
[ENSMUST00000084738]
[ENSMUST00000143107]
[ENSMUST00000168005]
[ENSMUST00000156921]
|
| AlphaFold |
Q924W7 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000053298
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000077909
AA Change: Q1103*
|
| SMART Domains |
Protein: ENSMUSP00000077067
Gene: ENSMUSG00000031024
AA Change: Q1103*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
46 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
213 |
N/A |
INTRINSIC |
|
low complexity region
|
314 |
326 |
N/A |
INTRINSIC |
|
low complexity region
|
327 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
379 |
N/A |
INTRINSIC |
|
low complexity region
|
407 |
426 |
N/A |
INTRINSIC |
|
low complexity region
|
577 |
609 |
N/A |
INTRINSIC |
|
low complexity region
|
624 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
645 |
656 |
N/A |
INTRINSIC |
|
uDENN
|
690 |
781 |
1.16e-30 |
SMART |
|
DENN
|
788 |
972 |
7.84e-78 |
SMART |
|
low complexity region
|
1007 |
1014 |
N/A |
INTRINSIC |
|
dDENN
|
1019 |
1086 |
3.12e-22 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000079282
AA Change: Q1103*
|
| SMART Domains |
Protein: ENSMUSP00000078264
Gene: ENSMUSG00000031024
AA Change: Q1103*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
46 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
213 |
N/A |
INTRINSIC |
|
low complexity region
|
314 |
326 |
N/A |
INTRINSIC |
|
low complexity region
|
327 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
379 |
N/A |
INTRINSIC |
|
low complexity region
|
407 |
426 |
N/A |
INTRINSIC |
|
low complexity region
|
577 |
609 |
N/A |
INTRINSIC |
|
low complexity region
|
624 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
645 |
656 |
N/A |
INTRINSIC |
|
uDENN
|
690 |
781 |
1.16e-30 |
SMART |
|
DENN
|
788 |
972 |
7.84e-78 |
SMART |
|
low complexity region
|
1007 |
1014 |
N/A |
INTRINSIC |
|
dDENN
|
1019 |
1086 |
3.12e-22 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000084738
AA Change: Q686*
|
| SMART Domains |
Protein: ENSMUSP00000081789
Gene: ENSMUSG00000031024
AA Change: Q686*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
160 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
207 |
221 |
N/A |
INTRINSIC |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
uDENN
|
273 |
364 |
1.16e-30 |
SMART |
|
DENN
|
371 |
555 |
7.84e-78 |
SMART |
|
low complexity region
|
590 |
597 |
N/A |
INTRINSIC |
|
dDENN
|
602 |
669 |
3.12e-22 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000104387
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132877
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143107
|
| SMART Domains |
Protein: ENSMUSP00000123410
Gene: ENSMUSG00000046364
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Ribosomal_L18e
|
26 |
146 |
7.2e-27 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000168005
AA Change: Q686*
|
| SMART Domains |
Protein: ENSMUSP00000130119
Gene: ENSMUSG00000031024
AA Change: Q686*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
160 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
207 |
221 |
N/A |
INTRINSIC |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
uDENN
|
273 |
364 |
1.16e-30 |
SMART |
|
DENN
|
371 |
555 |
7.84e-78 |
SMART |
|
low complexity region
|
590 |
597 |
N/A |
INTRINSIC |
|
dDENN
|
602 |
669 |
3.12e-22 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198845
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207664
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156921
|
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 93.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
C |
A |
11: 109,847,924 (GRCm39) |
L852F |
possibly damaging |
Het |
| Abcc6 |
T |
C |
7: 45,669,558 (GRCm39) |
|
probably null |
Het |
| Alg11 |
T |
G |
8: 22,555,584 (GRCm39) |
C240G |
probably damaging |
Het |
| Aox1 |
A |
G |
1: 58,141,783 (GRCm39) |
I1190V |
probably damaging |
Het |
| Apc2 |
T |
G |
10: 80,150,678 (GRCm39) |
S1911A |
probably benign |
Het |
| Arfgef3 |
T |
C |
10: 18,528,511 (GRCm39) |
D292G |
possibly damaging |
Het |
| Arhgef4 |
C |
A |
1: 34,763,340 (GRCm39) |
S865R |
probably benign |
Het |
| Ass1 |
T |
A |
2: 31,383,160 (GRCm39) |
Y190* |
probably null |
Het |
| B4galnt3 |
A |
T |
6: 120,187,051 (GRCm39) |
|
probably null |
Het |
| Btnl10 |
C |
A |
11: 58,811,367 (GRCm39) |
P230Q |
possibly damaging |
Het |
| C3 |
A |
G |
17: 57,516,489 (GRCm39) |
Y1348H |
probably damaging |
Het |
| Ccdc198 |
G |
T |
14: 49,464,032 (GRCm39) |
D292E |
probably damaging |
Het |
| Cebpz |
A |
T |
17: 79,242,336 (GRCm39) |
Y439* |
probably null |
Het |
| Cic |
C |
A |
7: 24,986,265 (GRCm39) |
T1229K |
probably damaging |
Het |
| Clip4 |
T |
C |
17: 72,144,744 (GRCm39) |
S524P |
probably damaging |
Het |
| Col6a3 |
A |
C |
1: 90,739,421 (GRCm39) |
I269R |
probably damaging |
Het |
| Dbh |
C |
T |
2: 27,071,506 (GRCm39) |
T533I |
possibly damaging |
Het |
| Dcaf17 |
A |
T |
2: 70,890,713 (GRCm39) |
R83* |
probably null |
Het |
| Dnah1 |
A |
G |
14: 30,984,515 (GRCm39) |
L3923P |
probably damaging |
Het |
| Dnah7a |
A |
T |
1: 53,670,721 (GRCm39) |
D510E |
probably benign |
Het |
| Dock6 |
A |
G |
9: 21,752,925 (GRCm39) |
F296S |
probably damaging |
Het |
| Eif4enif1 |
T |
C |
11: 3,177,455 (GRCm39) |
S341P |
probably damaging |
Het |
| Epb41l1 |
G |
T |
2: 156,352,737 (GRCm39) |
G461V |
possibly damaging |
Het |
| Epg5 |
T |
A |
18: 78,002,247 (GRCm39) |
D555E |
probably benign |
Het |
| Fes |
T |
C |
7: 80,036,609 (GRCm39) |
R113G |
probably damaging |
Het |
| Garre1 |
T |
A |
7: 33,957,461 (GRCm39) |
I59L |
probably benign |
Het |
| Gm10684 |
A |
G |
9: 45,021,511 (GRCm39) |
|
probably benign |
Het |
| Gm12185 |
T |
C |
11: 48,806,231 (GRCm39) |
E320G |
probably benign |
Het |
| Gm14412 |
G |
T |
2: 177,007,269 (GRCm39) |
H209N |
probably damaging |
Het |
| Gm14412 |
A |
C |
2: 177,007,630 (GRCm39) |
S88R |
probably benign |
Het |
| Grhl1 |
T |
A |
12: 24,658,555 (GRCm39) |
L400Q |
probably damaging |
Het |
| Havcr1 |
T |
A |
11: 46,664,511 (GRCm39) |
Y216* |
probably null |
Het |
| Hephl1 |
A |
C |
9: 14,985,420 (GRCm39) |
Y745* |
probably null |
Het |
| Hmcn2 |
T |
G |
2: 31,301,922 (GRCm39) |
|
probably null |
Het |
| Hs3st6 |
A |
G |
17: 24,977,110 (GRCm39) |
K197E |
possibly damaging |
Het |
| Ifi214 |
C |
T |
1: 173,357,077 (GRCm39) |
V9I |
probably benign |
Het |
| Jakmip2 |
T |
C |
18: 43,700,209 (GRCm39) |
T450A |
probably benign |
Het |
| Lrp4 |
T |
A |
2: 91,328,753 (GRCm39) |
V1551D |
possibly damaging |
Het |
| Macf1 |
A |
T |
4: 123,351,634 (GRCm39) |
H1634Q |
possibly damaging |
Het |
| Mcpt8 |
T |
A |
14: 56,321,291 (GRCm39) |
I58F |
probably benign |
Het |
| Mga |
T |
A |
2: 119,757,075 (GRCm39) |
H1018Q |
possibly damaging |
Het |
| Myo10 |
T |
A |
15: 25,801,308 (GRCm39) |
V1499E |
probably damaging |
Het |
| Myom2 |
G |
T |
8: 15,131,023 (GRCm39) |
D320Y |
probably damaging |
Het |
| Or11g7 |
T |
A |
14: 50,691,295 (GRCm39) |
M262K |
probably damaging |
Het |
| Or13a27 |
T |
C |
7: 139,925,378 (GRCm39) |
I175V |
probably benign |
Het |
| Or2r11 |
C |
T |
6: 42,437,360 (GRCm39) |
V198M |
probably benign |
Het |
| Or2t26 |
A |
C |
11: 49,039,101 (GRCm39) |
N6H |
possibly damaging |
Het |
| Or4c115 |
G |
A |
2: 88,927,888 (GRCm39) |
P128S |
probably damaging |
Het |
| Or5d47 |
A |
T |
2: 87,804,403 (GRCm39) |
V202D |
possibly damaging |
Het |
| Pabpc4 |
G |
T |
4: 123,182,861 (GRCm39) |
R166L |
possibly damaging |
Het |
| Pcdhb8 |
A |
G |
18: 37,489,015 (GRCm39) |
E231G |
possibly damaging |
Het |
| Pomgnt2 |
A |
T |
9: 121,811,257 (GRCm39) |
I508N |
possibly damaging |
Het |
| Ppp2r5e |
C |
G |
12: 75,516,341 (GRCm39) |
A239P |
probably damaging |
Het |
| Prdm15 |
G |
T |
16: 97,638,885 (GRCm39) |
D58E |
probably benign |
Het |
| Rgl2 |
A |
G |
17: 34,151,122 (GRCm39) |
T117A |
probably benign |
Het |
| Rp1 |
A |
G |
1: 4,418,943 (GRCm39) |
I723T |
probably damaging |
Het |
| Serpina3g |
A |
G |
12: 104,207,536 (GRCm39) |
E233G |
probably damaging |
Het |
| Skint6 |
T |
A |
4: 112,749,187 (GRCm39) |
S798C |
probably benign |
Het |
| Slc35f1 |
T |
C |
10: 52,898,000 (GRCm39) |
L137P |
possibly damaging |
Het |
| Slc6a20a |
T |
C |
9: 123,485,373 (GRCm39) |
N246S |
probably damaging |
Het |
| Slc7a2 |
T |
C |
8: 41,369,534 (GRCm39) |
L663S |
probably benign |
Het |
| Slco1a4 |
A |
G |
6: 141,761,173 (GRCm39) |
|
probably null |
Het |
| Slit2 |
A |
G |
5: 48,439,330 (GRCm39) |
T41A |
probably damaging |
Het |
| Smc2 |
T |
C |
4: 52,450,863 (GRCm39) |
I227T |
probably damaging |
Het |
| Smg1 |
A |
G |
7: 117,753,422 (GRCm39) |
|
probably benign |
Het |
| Ssu2 |
A |
T |
6: 112,361,388 (GRCm39) |
L23M |
probably benign |
Het |
| Syne2 |
A |
G |
12: 76,141,053 (GRCm39) |
|
probably null |
Het |
| Tekt1 |
T |
C |
11: 72,242,761 (GRCm39) |
T249A |
probably benign |
Het |
| Tfr2 |
T |
C |
5: 137,569,954 (GRCm39) |
V120A |
probably benign |
Het |
| Thsd7b |
C |
T |
1: 129,605,846 (GRCm39) |
P529L |
probably damaging |
Het |
| Tll1 |
C |
T |
8: 64,478,141 (GRCm39) |
D871N |
probably damaging |
Het |
| Tlr11 |
A |
C |
14: 50,598,664 (GRCm39) |
I217L |
probably benign |
Het |
| Tmem87b |
T |
A |
2: 128,673,479 (GRCm39) |
V241D |
probably damaging |
Het |
| Tshz2 |
T |
A |
2: 169,727,465 (GRCm39) |
I218N |
possibly damaging |
Het |
| Vmn1r18 |
A |
T |
6: 57,367,026 (GRCm39) |
I176N |
possibly damaging |
Het |
| Vmn2r68 |
T |
A |
7: 84,883,260 (GRCm39) |
H164L |
probably benign |
Het |
| Vmn2r74 |
T |
C |
7: 85,601,650 (GRCm39) |
T663A |
probably benign |
Het |
| Vmn2r8 |
T |
C |
5: 108,945,436 (GRCm39) |
T724A |
probably benign |
Het |
| Wdr11 |
T |
C |
7: 129,206,954 (GRCm39) |
V289A |
possibly damaging |
Het |
| Zfp62 |
T |
A |
11: 49,107,047 (GRCm39) |
D379E |
probably damaging |
Het |
| Zfp78 |
C |
T |
7: 6,381,897 (GRCm39) |
P316S |
probably damaging |
Het |
| Zfyve27 |
T |
G |
19: 42,159,987 (GRCm39) |
M1R |
probably null |
Het |
| Zkscan8 |
G |
A |
13: 21,709,325 (GRCm39) |
P191L |
probably damaging |
Het |
|
| Other mutations in Dennd2b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00493:Dennd2b
|
APN |
7 |
109,126,915 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL01132:Dennd2b
|
APN |
7 |
109,169,212 (GRCm39) |
splice site |
probably null |
|
|
IGL01288:Dennd2b
|
APN |
7 |
109,139,029 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01645:Dennd2b
|
APN |
7 |
109,126,841 (GRCm39) |
nonsense |
probably null |
|
|
IGL01714:Dennd2b
|
APN |
7 |
109,169,269 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02021:Dennd2b
|
APN |
7 |
109,156,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02302:Dennd2b
|
APN |
7 |
109,124,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02496:Dennd2b
|
APN |
7 |
109,155,442 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02795:Dennd2b
|
APN |
7 |
109,155,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Bucolic
|
UTSW |
7 |
109,124,755 (GRCm39) |
nonsense |
probably null |
|
|
Halcyon
|
UTSW |
7 |
109,156,000 (GRCm39) |
nonsense |
probably null |
|
|
FR4340:Dennd2b
|
UTSW |
7 |
109,156,128 (GRCm39) |
unclassified |
probably benign |
|
|
FR4737:Dennd2b
|
UTSW |
7 |
109,156,128 (GRCm39) |
unclassified |
probably benign |
|
|
PIT4466001:Dennd2b
|
UTSW |
7 |
109,130,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4469001:Dennd2b
|
UTSW |
7 |
109,130,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4472001:Dennd2b
|
UTSW |
7 |
109,130,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0024:Dennd2b
|
UTSW |
7 |
109,123,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0124:Dennd2b
|
UTSW |
7 |
109,141,718 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0125:Dennd2b
|
UTSW |
7 |
109,155,545 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0365:Dennd2b
|
UTSW |
7 |
109,138,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0491:Dennd2b
|
UTSW |
7 |
109,156,411 (GRCm39) |
missense |
probably benign |
0.45 |
|
R0534:Dennd2b
|
UTSW |
7 |
109,140,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0662:Dennd2b
|
UTSW |
7 |
109,156,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0743:Dennd2b
|
UTSW |
7 |
109,156,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0772:Dennd2b
|
UTSW |
7 |
109,141,527 (GRCm39) |
splice site |
probably null |
|
|
R0774:Dennd2b
|
UTSW |
7 |
109,141,527 (GRCm39) |
splice site |
probably null |
|
|
R0787:Dennd2b
|
UTSW |
7 |
109,124,827 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0884:Dennd2b
|
UTSW |
7 |
109,156,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1518:Dennd2b
|
UTSW |
7 |
109,156,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1909:Dennd2b
|
UTSW |
7 |
109,124,533 (GRCm39) |
nonsense |
probably null |
|
|
R2232:Dennd2b
|
UTSW |
7 |
109,156,414 (GRCm39) |
missense |
probably benign |
|
|
R2358:Dennd2b
|
UTSW |
7 |
109,155,653 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2847:Dennd2b
|
UTSW |
7 |
109,124,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2869:Dennd2b
|
UTSW |
7 |
109,156,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2869:Dennd2b
|
UTSW |
7 |
109,156,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2870:Dennd2b
|
UTSW |
7 |
109,156,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2870:Dennd2b
|
UTSW |
7 |
109,156,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2871:Dennd2b
|
UTSW |
7 |
109,156,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2871:Dennd2b
|
UTSW |
7 |
109,156,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2873:Dennd2b
|
UTSW |
7 |
109,156,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2874:Dennd2b
|
UTSW |
7 |
109,156,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4534:Dennd2b
|
UTSW |
7 |
109,130,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4536:Dennd2b
|
UTSW |
7 |
109,130,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4559:Dennd2b
|
UTSW |
7 |
109,124,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4798:Dennd2b
|
UTSW |
7 |
109,156,240 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4846:Dennd2b
|
UTSW |
7 |
109,156,043 (GRCm39) |
nonsense |
probably null |
|
|
R5110:Dennd2b
|
UTSW |
7 |
109,141,697 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5181:Dennd2b
|
UTSW |
7 |
109,155,997 (GRCm39) |
missense |
probably benign |
|
|
R5268:Dennd2b
|
UTSW |
7 |
109,156,519 (GRCm39) |
missense |
probably benign |
|
|
R5403:Dennd2b
|
UTSW |
7 |
109,156,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5836:Dennd2b
|
UTSW |
7 |
109,140,552 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5932:Dennd2b
|
UTSW |
7 |
109,169,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5937:Dennd2b
|
UTSW |
7 |
109,156,478 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6180:Dennd2b
|
UTSW |
7 |
109,156,095 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6741:Dennd2b
|
UTSW |
7 |
109,144,304 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6781:Dennd2b
|
UTSW |
7 |
109,124,511 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7086:Dennd2b
|
UTSW |
7 |
109,124,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Dennd2b
|
UTSW |
7 |
109,124,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7644:Dennd2b
|
UTSW |
7 |
109,156,000 (GRCm39) |
nonsense |
probably null |
|
|
R8354:Dennd2b
|
UTSW |
7 |
109,124,755 (GRCm39) |
nonsense |
probably null |
|
|
R8745:Dennd2b
|
UTSW |
7 |
109,156,279 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8859:Dennd2b
|
UTSW |
7 |
109,123,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Dennd2b
|
UTSW |
7 |
109,139,642 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9178:Dennd2b
|
UTSW |
7 |
109,156,291 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9361:Dennd2b
|
UTSW |
7 |
109,126,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9564:Dennd2b
|
UTSW |
7 |
109,125,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9595:Dennd2b
|
UTSW |
7 |
109,155,973 (GRCm39) |
missense |
probably damaging |
0.96 |
|
RF062:Dennd2b
|
UTSW |
7 |
109,156,153 (GRCm39) |
unclassified |
probably benign |
|
|
X0067:Dennd2b
|
UTSW |
7 |
109,155,447 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGAATCTTCTGCCAAATGCTC -3'
(R):5'- AGCTAAGGAAGTGTCGAGCC -3'
Sequencing Primer
(F):5'- TCTTCTGCCAAATGCTCTTAAAG -3'
(R):5'- GGGGCTTCTCTAGACTCAGTATAAC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation