Incidental Mutation 'R2516:Vmn2r97'
| ID |
253859 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r97
|
| Ensembl Gene |
ENSMUSG00000091491 |
| Gene Name |
vomeronasal 2, receptor 97 |
| Synonyms |
EG627367 |
| MMRRC Submission |
040420-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R2516 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19134584-19168333 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 19167814 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Isoleucine
at position 689
(M689I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129313
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168710]
[ENSMUST00000232219]
|
| AlphaFold |
K7N6Z2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168710
AA Change: M689I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: M689I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
442 |
2.9e-36 |
PFAM |
|
Pfam:NCD3G
|
513 |
566 |
4.9e-21 |
PFAM |
|
Pfam:7tm_3
|
599 |
834 |
1.7e-52 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232219
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
98% (65/66) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
A |
T |
2: 69,159,673 (GRCm39) |
I6N |
possibly damaging |
Het |
| Aen |
T |
C |
7: 78,555,616 (GRCm39) |
V188A |
probably damaging |
Het |
| Afg3l1 |
A |
G |
8: 124,228,693 (GRCm39) |
E753G |
probably damaging |
Het |
| Alas1 |
G |
A |
9: 106,115,859 (GRCm39) |
T385I |
probably damaging |
Het |
| Alms1 |
C |
A |
6: 85,644,945 (GRCm39) |
|
probably benign |
Het |
| Ankrd65 |
A |
G |
4: 155,875,868 (GRCm39) |
T30A |
possibly damaging |
Het |
| App |
T |
C |
16: 84,775,117 (GRCm39) |
S582G |
probably damaging |
Het |
| Arfgef1 |
A |
T |
1: 10,223,879 (GRCm39) |
V1473E |
possibly damaging |
Het |
| Arhgap21 |
G |
A |
2: 20,859,809 (GRCm39) |
P1196S |
probably damaging |
Het |
| Arhgap24 |
A |
G |
5: 103,039,776 (GRCm39) |
T238A |
probably benign |
Het |
| Atf7 |
T |
C |
15: 102,437,439 (GRCm39) |
|
probably benign |
Het |
| Best1 |
G |
T |
19: 9,970,675 (GRCm39) |
S55* |
probably null |
Het |
| Capn11 |
A |
G |
17: 45,944,725 (GRCm39) |
V514A |
probably damaging |
Het |
| Cep104 |
T |
A |
4: 154,073,603 (GRCm39) |
M52K |
probably damaging |
Het |
| Clca3a1 |
C |
T |
3: 144,443,619 (GRCm39) |
|
probably null |
Het |
| Cyp3a25 |
T |
C |
5: 145,939,837 (GRCm39) |
|
probably null |
Het |
| Dmxl2 |
G |
A |
9: 54,307,378 (GRCm39) |
P2197S |
probably damaging |
Het |
| Drosha |
T |
C |
15: 12,859,551 (GRCm39) |
|
probably null |
Het |
| Exosc9 |
A |
G |
3: 36,617,311 (GRCm39) |
K355R |
probably benign |
Het |
| Fut1 |
A |
C |
7: 45,268,622 (GRCm39) |
H192P |
probably benign |
Het |
| Gm572 |
T |
A |
4: 148,748,841 (GRCm39) |
V166D |
possibly damaging |
Het |
| Gm9966 |
C |
T |
7: 95,607,735 (GRCm39) |
P19S |
unknown |
Het |
| Gmds |
C |
T |
13: 32,284,456 (GRCm39) |
V219I |
probably damaging |
Het |
| Gsn |
G |
A |
2: 35,173,965 (GRCm39) |
E25K |
probably benign |
Het |
| Il4i1 |
T |
C |
7: 44,489,315 (GRCm39) |
F368S |
probably damaging |
Het |
| Irak1bp1 |
T |
C |
9: 82,712,373 (GRCm39) |
L98P |
probably damaging |
Het |
| Khdrbs3 |
T |
C |
15: 68,896,544 (GRCm39) |
|
probably benign |
Het |
| Kndc1 |
T |
C |
7: 139,501,738 (GRCm39) |
I925T |
probably damaging |
Het |
| Laptm4a |
T |
C |
12: 8,988,151 (GRCm39) |
I296T |
probably benign |
Het |
| Lpl |
A |
T |
8: 69,340,170 (GRCm39) |
H55L |
probably benign |
Het |
| Lrrk2 |
C |
A |
15: 91,640,130 (GRCm39) |
N1558K |
probably benign |
Het |
| Mfsd2a |
A |
G |
4: 122,844,280 (GRCm39) |
L289P |
probably damaging |
Het |
| Mmrn2 |
T |
A |
14: 34,120,759 (GRCm39) |
M543K |
probably benign |
Het |
| Mnat1 |
T |
C |
12: 73,228,550 (GRCm39) |
|
probably benign |
Het |
| Msto1 |
A |
T |
3: 88,819,200 (GRCm39) |
|
probably null |
Het |
| Mtus1 |
A |
G |
8: 41,535,776 (GRCm39) |
Y647H |
probably damaging |
Het |
| Nars1 |
A |
T |
18: 64,638,087 (GRCm39) |
V289E |
probably damaging |
Het |
| Oit3 |
T |
A |
10: 59,264,167 (GRCm39) |
K322N |
probably damaging |
Het |
| Oit3 |
G |
A |
10: 59,277,507 (GRCm39) |
|
probably benign |
Het |
| Or4k1 |
T |
C |
14: 50,377,440 (GRCm39) |
I219V |
probably benign |
Het |
| Or5b113 |
T |
A |
19: 13,342,557 (GRCm39) |
C188* |
probably null |
Het |
| Or5m12 |
A |
G |
2: 85,734,900 (GRCm39) |
I166T |
probably benign |
Het |
| Or6c211 |
G |
A |
10: 129,506,155 (GRCm39) |
R78W |
probably damaging |
Het |
| Pecr |
A |
T |
1: 72,316,469 (GRCm39) |
C79S |
probably damaging |
Het |
| Plekhn1 |
T |
C |
4: 156,307,116 (GRCm39) |
D478G |
probably damaging |
Het |
| Pls1 |
A |
T |
9: 95,658,616 (GRCm39) |
M264K |
probably benign |
Het |
| Ptprj |
C |
A |
2: 90,305,340 (GRCm39) |
|
probably benign |
Het |
| Pygm |
A |
G |
19: 6,447,631 (GRCm39) |
D646G |
probably benign |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
| Scn8a |
T |
C |
15: 100,867,043 (GRCm39) |
V283A |
probably benign |
Het |
| Shisa5 |
T |
C |
9: 108,885,575 (GRCm39) |
|
probably null |
Het |
| Slc10a4 |
A |
G |
5: 73,165,848 (GRCm39) |
I246V |
possibly damaging |
Het |
| Slc1a1 |
A |
T |
19: 28,870,312 (GRCm39) |
I104F |
probably benign |
Het |
| Slc22a8 |
A |
G |
19: 8,587,559 (GRCm39) |
Y511C |
probably benign |
Het |
| Slc6a5 |
A |
G |
7: 49,606,210 (GRCm39) |
N706S |
probably benign |
Het |
| Sos2 |
T |
C |
12: 69,697,433 (GRCm39) |
K96E |
probably damaging |
Het |
| Stom |
G |
A |
2: 35,205,977 (GRCm39) |
R251* |
probably null |
Het |
| Sycp1 |
T |
C |
3: 102,752,382 (GRCm39) |
E800G |
probably benign |
Het |
| Tab2 |
G |
A |
10: 7,783,245 (GRCm39) |
P679L |
probably damaging |
Het |
| Tiam2 |
G |
A |
17: 3,503,657 (GRCm39) |
V945I |
probably damaging |
Het |
| Trpm5 |
G |
T |
7: 142,628,254 (GRCm39) |
P1007Q |
probably damaging |
Het |
| Uchl1 |
T |
G |
5: 66,839,956 (GRCm39) |
I139S |
probably damaging |
Het |
| Vmn1r232 |
A |
G |
17: 21,134,288 (GRCm39) |
I104T |
possibly damaging |
Het |
| Zc3h18 |
A |
T |
8: 123,129,904 (GRCm39) |
|
probably benign |
Het |
| Zfhx4 |
C |
T |
3: 5,468,418 (GRCm39) |
P2859S |
probably benign |
Het |
| Zfp456 |
T |
C |
13: 67,510,491 (GRCm39) |
K99R |
probably benign |
Het |
|
| Other mutations in Vmn2r97 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r97
|
APN |
17 |
19,167,921 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00962:Vmn2r97
|
APN |
17 |
19,149,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01704:Vmn2r97
|
APN |
17 |
19,168,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01888:Vmn2r97
|
APN |
17 |
19,149,286 (GRCm39) |
nonsense |
probably null |
|
|
IGL02429:Vmn2r97
|
APN |
17 |
19,150,596 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02742:Vmn2r97
|
APN |
17 |
19,149,432 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02934:Vmn2r97
|
APN |
17 |
19,149,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02978:Vmn2r97
|
APN |
17 |
19,168,298 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03230:Vmn2r97
|
APN |
17 |
19,149,668 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03241:Vmn2r97
|
APN |
17 |
19,148,438 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03050:Vmn2r97
|
UTSW |
17 |
19,167,900 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
PIT4469001:Vmn2r97
|
UTSW |
17 |
19,149,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0482:Vmn2r97
|
UTSW |
17 |
19,167,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Vmn2r97
|
UTSW |
17 |
19,134,734 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0944:Vmn2r97
|
UTSW |
17 |
19,167,665 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1061:Vmn2r97
|
UTSW |
17 |
19,148,440 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Vmn2r97
|
UTSW |
17 |
19,168,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Vmn2r97
|
UTSW |
17 |
19,149,397 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1860:Vmn2r97
|
UTSW |
17 |
19,167,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1938:Vmn2r97
|
UTSW |
17 |
19,149,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1944:Vmn2r97
|
UTSW |
17 |
19,160,500 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2027:Vmn2r97
|
UTSW |
17 |
19,149,944 (GRCm39) |
missense |
unknown |
|
|
R2106:Vmn2r97
|
UTSW |
17 |
19,168,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2153:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2154:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R3739:Vmn2r97
|
UTSW |
17 |
19,148,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Vmn2r97
|
UTSW |
17 |
19,149,890 (GRCm39) |
missense |
probably benign |
|
|
R3885:Vmn2r97
|
UTSW |
17 |
19,148,596 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3899:Vmn2r97
|
UTSW |
17 |
19,167,873 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4115:Vmn2r97
|
UTSW |
17 |
19,148,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4247:Vmn2r97
|
UTSW |
17 |
19,167,542 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4287:Vmn2r97
|
UTSW |
17 |
19,168,337 (GRCm39) |
intron |
probably benign |
|
|
R4439:Vmn2r97
|
UTSW |
17 |
19,150,616 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4523:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4783:Vmn2r97
|
UTSW |
17 |
19,149,550 (GRCm39) |
missense |
probably benign |
|
|
R4948:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4981:Vmn2r97
|
UTSW |
17 |
19,160,436 (GRCm39) |
nonsense |
probably null |
|
|
R5029:Vmn2r97
|
UTSW |
17 |
19,168,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5200:Vmn2r97
|
UTSW |
17 |
19,148,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Vmn2r97
|
UTSW |
17 |
19,148,617 (GRCm39) |
nonsense |
probably null |
|
|
R5637:Vmn2r97
|
UTSW |
17 |
19,167,628 (GRCm39) |
nonsense |
probably null |
|
|
R5765:Vmn2r97
|
UTSW |
17 |
19,167,442 (GRCm39) |
nonsense |
probably null |
|
|
R5885:Vmn2r97
|
UTSW |
17 |
19,168,035 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6272:Vmn2r97
|
UTSW |
17 |
19,167,861 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6553:Vmn2r97
|
UTSW |
17 |
19,150,566 (GRCm39) |
nonsense |
probably null |
|
|
R6818:Vmn2r97
|
UTSW |
17 |
19,168,193 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6880:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7012:Vmn2r97
|
UTSW |
17 |
19,167,756 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7023:Vmn2r97
|
UTSW |
17 |
19,134,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7044:Vmn2r97
|
UTSW |
17 |
19,134,629 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7191:Vmn2r97
|
UTSW |
17 |
19,150,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7503:Vmn2r97
|
UTSW |
17 |
19,148,470 (GRCm39) |
missense |
probably benign |
|
|
R7862:Vmn2r97
|
UTSW |
17 |
19,167,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Vmn2r97
|
UTSW |
17 |
19,149,326 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7890:Vmn2r97
|
UTSW |
17 |
19,149,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7936:Vmn2r97
|
UTSW |
17 |
19,150,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7978:Vmn2r97
|
UTSW |
17 |
19,167,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8405:Vmn2r97
|
UTSW |
17 |
19,134,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8755:Vmn2r97
|
UTSW |
17 |
19,168,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8790:Vmn2r97
|
UTSW |
17 |
19,160,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8850:Vmn2r97
|
UTSW |
17 |
19,149,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9060:Vmn2r97
|
UTSW |
17 |
19,134,585 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R9079:Vmn2r97
|
UTSW |
17 |
19,149,640 (GRCm39) |
missense |
probably benign |
|
|
R9252:Vmn2r97
|
UTSW |
17 |
19,167,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9278:Vmn2r97
|
UTSW |
17 |
19,134,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r97
|
UTSW |
17 |
19,149,368 (GRCm39) |
missense |
probably benign |
|
|
R9422:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9496:Vmn2r97
|
UTSW |
17 |
19,149,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r97
|
UTSW |
17 |
19,149,919 (GRCm39) |
missense |
probably benign |
|
|
R9601:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
|
|
R9672:Vmn2r97
|
UTSW |
17 |
19,149,442 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9773:Vmn2r97
|
UTSW |
17 |
19,168,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9795:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGACACTCCTATTGTCAAGGC -3'
(R):5'- AACAGCTGAGCCCTTGTTG -3'
Sequencing Primer
(F):5'- TGTCAAGGCAAATAATCGAGCTCTG -3'
(R):5'- GCTGAGCCCTTGTTGCATAAAATG -3'
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| Posted On |
2014-12-04 |
Incidental Mutation