|Institutional Source||Beutler Lab|
|Gene Name||killer cell lectin-like receptor subfamily G, member 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4995 (G1)|
|Chromosomal Location||122270596-122282882 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 122278275 bp|
|Amino Acid Change||Aspartic acid to Valine at position 66 (D66V)|
|Ref Sequence||ENSEMBL: ENSMUSP00000032207 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000032207]|
|Predicted Effect||probably benign
AA Change: D66V
PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
AA Change: D66V
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||99% (86/87)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]
PHENOTYPE: Mice homozygous for a null allele have no abnormal phenoptype. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Klrg1||
(F):5'- AGGGAGGAACAGCTCTATATTTTC -3'
(R):5'- GCACTTCAGGGGTGACATTG -3'
(F):5'- CTACATGTTTTCATTTACCACTCCC -3'
(R):5'- GACATTGTGGACCATTCAGC -3'