Mutagenetix > Incidental Mutation

Incidental Mutation 'R6700:Nbea'

528198

Institutional Source

Beutler Lab

Gene Symbol

Nbea

Ensembl Gene

ENSMUSG00000027799

Gene Name

neurobeachin

Synonyms

MMRRC Submission

044818-MU

Accession Numbers

Genbank: NM_030595

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6700 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

55625195-56183701 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 56082448 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 329 (N329S)

Ref Sequence

ENSEMBL: ENSMUSP00000029374 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029374]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000029374
AA Change: N329S

PolyPhen 2 Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000029374
Gene: ENSMUSG00000027799
AA Change: N329S

Domain	Start	End	E-Value	Type
low complexity region	19	40	N/A	INTRINSIC
Pfam:Laminin_G_3	228	393	2.8e-13	PFAM
Pfam:DUF4704	462	733	4e-113	PFAM
low complexity region	792	802	N/A	INTRINSIC
low complexity region	964	969	N/A	INTRINSIC
low complexity region	1781	1790	N/A	INTRINSIC
low complexity region	1791	1807	N/A	INTRINSIC
low complexity region	1835	1845	N/A	INTRINSIC
Pfam:DUF1088	1956	2122	3.5e-91	PFAM
Pfam:PH_BEACH	2148	2245	2.6e-32	PFAM
Beach	2276	2553	1.3e-205	SMART
WD40	2659	2696	2.12e2	SMART
WD40	2699	2742	2.22e0	SMART
WD40	2759	2798	9.21e0	SMART
WD40	2842	2880	2.88e-1	SMART
WD40	2883	2922	8.91e-1	SMART

Meta Mutation Damage Score

0.0657

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.0%

Validation Efficiency

100% (62/62)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele or transgene insertion die shortly after birth, are cyanotic, and exhibit no response to tactile stimuli, no spontaneous movement, and impaired CNS synaptic transmission. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Gene trapped(3) Transgenic(1)

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930563M21Rik	T	C	9: 55,973,856 (GRCm38)	E504G	unknown	Het
Aak1	G	A	6: 86,964,203 (GRCm38)	E660K	unknown	Het
Abcc9	A	G	6: 142,687,287 (GRCm38)	I243T	possibly damaging	Het
Baiap3	A	G	17: 25,244,026 (GRCm38)	S1013P	probably damaging	Het
Bdp1	A	T	13: 100,025,528 (GRCm38)	D2295E	probably benign	Het
Blm	A	G	7: 80,463,850 (GRCm38)	V1233A	possibly damaging	Het
Brsk1	G	T	7: 4,692,701 (GRCm38)	V62F	probably damaging	Het
Cacna2d1	A	G	5: 16,365,460 (GRCm38)	E1011G	probably damaging	Het
Cdh18	A	G	15: 23,474,105 (GRCm38)	Y687C	probably benign	Het
Cfap221	T	C	1: 119,955,691 (GRCm38)	E250G	possibly damaging	Het
Col5a3	C	T	9: 20,779,033 (GRCm38)	G1162R	probably damaging	Het
Cps1	G	T	1: 67,229,523 (GRCm38)		probably null	Het
Cyp4v3	A	G	8: 45,307,093 (GRCm38)	V34A	probably damaging	Het
Dnah9	C	T	11: 65,955,366 (GRCm38)	V2949M	probably damaging	Het
Dst	A	C	1: 34,256,323 (GRCm38)	Q3454P	probably damaging	Het
Filip1l	T	C	16: 57,571,248 (GRCm38)	L495P	possibly damaging	Het
Flnb	C	A	14: 7,892,189 (GRCm38)	H619Q	probably damaging	Het
Fst	G	C	13: 114,458,507 (GRCm38)	A27G	probably benign	Het
Ggnbp2	C	A	11: 84,840,105 (GRCm38)	R364L	probably damaging	Het
Gins1	C	T	2: 150,916,228 (GRCm38)	A78V	probably damaging	Het
Gm19410	T	A	8: 35,807,510 (GRCm38)	L1495H	possibly damaging	Het
Golgb1	C	T	16: 36,875,584 (GRCm38)		probably benign	Het
Lin7a	A	G	10: 107,380,306 (GRCm38)		probably null	Het
Lrp6	A	T	6: 134,479,560 (GRCm38)	C914S	probably damaging	Het
Lrrc8e	G	A	8: 4,236,034 (GRCm38)	G753D	probably damaging	Het
Mapk4	A	G	18: 73,930,811 (GRCm38)	Y447H	probably damaging	Het
Mbl1	A	G	14: 41,158,554 (GRCm38)	N133S	probably damaging	Het
Mrps30	A	T	13: 118,380,598 (GRCm38)	S362T	probably damaging	Het
Myo1c	C	T	11: 75,671,635 (GRCm38)	P918S	probably benign	Het
Olfr1477	A	T	19: 13,502,813 (GRCm38)	I157F	probably damaging	Het
Olfr427	G	A	1: 174,099,839 (GRCm38)	C127Y	probably damaging	Het
Olfr62	A	T	4: 118,666,412 (GRCm38)	K298N	probably benign	Het
Olfr633	G	A	7: 103,947,324 (GRCm38)	V253M	probably damaging	Het
Pik3c3	A	G	18: 30,316,901 (GRCm38)	E589G	probably benign	Het
Plb1	A	T	5: 32,333,464 (GRCm38)	D1035V	probably damaging	Het
Plekhg1	G	T	10: 3,957,373 (GRCm38)	M763I	probably benign	Het
Poc5	A	G	13: 96,394,495 (GRCm38)	N67S	probably benign	Het
Psmd13	T	A	7: 140,890,609 (GRCm38)	W255R	probably damaging	Het
Rbm27	A	G	18: 42,325,939 (GRCm38)	Y735C	probably damaging	Het
Rhpn2	A	T	7: 35,376,169 (GRCm38)	N257I	possibly damaging	Het
Rilpl2	C	T	5: 124,469,780 (GRCm38)	E126K	probably damaging	Het
Rp1	G	A	1: 4,349,896 (GRCm38)	T331M	probably damaging	Het
Sh3pxd2a	A	G	19: 47,364,707 (GRCm38)	V105A	possibly damaging	Het
Slc9a9	T	C	9: 94,936,311 (GRCm38)	S253P	possibly damaging	Het
St8sia3	C	T	18: 64,265,381 (GRCm38)		probably benign	Het
Strbp	T	C	2: 37,603,963 (GRCm38)	D366G	probably null	Het
Tbx5	A	G	5: 119,871,397 (GRCm38)	T324A	probably benign	Het
Tex15	T	A	8: 33,574,889 (GRCm38)	I1449N	possibly damaging	Het
Tmtc3	C	T	10: 100,471,477 (GRCm38)	V222I	probably benign	Het
Top3b	T	C	16: 16,892,669 (GRCm38)	S788P	possibly damaging	Het
Tsc22d4	A	G	5: 137,758,523 (GRCm38)	D71G	probably benign	Het
Tubgcp4	T	A	2: 121,189,848 (GRCm38)	V434E	probably benign	Het
Ufsp1	A	G	5: 137,294,896 (GRCm38)	Y36C	possibly damaging	Het
Unc79	T	A	12: 103,125,703 (GRCm38)	H1956Q	possibly damaging	Het
Usp34	A	T	11: 23,439,011 (GRCm38)	N2217I	probably damaging	Het
Vmn2r112	A	T	17: 22,603,481 (GRCm38)	D380V	possibly damaging	Het
Vmn2r13	A	G	5: 109,175,072 (GRCm38)	I117T	probably benign	Het
Vmn2r53	A	G	7: 12,581,706 (GRCm38)	Y729H	probably damaging	Het
Wnt3a	A	T	11: 59,249,761 (GRCm38)	L310M	probably damaging	Het
Zc3h7a	T	C	16: 11,158,967 (GRCm38)	Q155R	possibly damaging	Het

Other mutations in Nbea

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00540:Nbea	APN	3	55,628,493 (GRCm38)	missense	probably damaging	1.00
IGL00541:Nbea	APN	3	55,968,089 (GRCm38)	missense	probably benign	0.02
IGL00584:Nbea	APN	3	56,082,448 (GRCm38)	missense	probably damaging	0.98
IGL00648:Nbea	APN	3	56,009,260 (GRCm38)	missense	probably damaging	0.98
IGL00785:Nbea	APN	3	55,955,393 (GRCm38)	missense	probably benign
IGL00899:Nbea	APN	3	55,642,845 (GRCm38)	missense	probably benign	0.32
IGL00955:Nbea	APN	3	56,005,472 (GRCm38)	missense	possibly damaging	0.45
IGL01296:Nbea	APN	3	56,031,536 (GRCm38)	missense	probably benign	0.04
IGL01299:Nbea	APN	3	55,690,894 (GRCm38)	missense	probably damaging	1.00
IGL01393:Nbea	APN	3	56,005,308 (GRCm38)	missense	probably benign	0.02
IGL01550:Nbea	APN	3	55,805,248 (GRCm38)	missense	possibly damaging	0.93
IGL02023:Nbea	APN	3	55,681,016 (GRCm38)	missense	probably damaging	1.00
IGL02034:Nbea	APN	3	55,968,156 (GRCm38)	missense	probably damaging	1.00
IGL02061:Nbea	APN	3	55,717,887 (GRCm38)	missense	possibly damaging	0.54
IGL02082:Nbea	APN	3	55,968,167 (GRCm38)	missense	possibly damaging	0.88
IGL02113:Nbea	APN	3	55,992,492 (GRCm38)	missense	probably benign
IGL02188:Nbea	APN	3	55,983,837 (GRCm38)	missense	probably benign	0.00
IGL02319:Nbea	APN	3	55,985,738 (GRCm38)	missense	probably damaging	1.00
IGL02406:Nbea	APN	3	56,086,266 (GRCm38)	missense	probably benign	0.02
IGL02494:Nbea	APN	3	55,805,351 (GRCm38)	missense	probably benign	0.02
IGL02550:Nbea	APN	3	56,019,414 (GRCm38)	missense	probably damaging	0.98
IGL02706:Nbea	APN	3	56,037,278 (GRCm38)	missense	probably damaging	1.00
IGL02718:Nbea	APN	3	55,632,062 (GRCm38)	nonsense	probably null
IGL02822:Nbea	APN	3	56,019,447 (GRCm38)	missense	possibly damaging	0.93
IGL02885:Nbea	APN	3	55,631,986 (GRCm38)	missense	probably benign	0.01
IGL03000:Nbea	APN	3	56,004,627 (GRCm38)	missense	possibly damaging	0.94
IGL03081:Nbea	APN	3	56,079,918 (GRCm38)	missense	probably damaging	1.00
IGL03091:Nbea	APN	3	56,085,304 (GRCm38)	missense	probably damaging	1.00
IGL03368:Nbea	APN	3	56,079,930 (GRCm38)	missense	probably damaging	0.98
Neches	UTSW	3	55,953,034 (GRCm38)	critical splice donor site	probably null
scotland	UTSW	3	55,626,908 (GRCm38)	missense	probably damaging	1.00
Wales	UTSW	3	56,091,119 (GRCm38)	missense	probably damaging	1.00
FR4340:Nbea	UTSW	3	56,009,212 (GRCm38)	critical splice donor site	probably benign
G4846:Nbea	UTSW	3	56,087,497 (GRCm38)	missense	probably damaging	0.98
IGL02835:Nbea	UTSW	3	55,717,869 (GRCm38)	missense	possibly damaging	0.88
LCD18:Nbea	UTSW	3	55,701,527 (GRCm38)	intron	probably benign
R0087:Nbea	UTSW	3	56,091,023 (GRCm38)	missense	possibly damaging	0.92
R0220:Nbea	UTSW	3	56,005,303 (GRCm38)	missense	probably benign	0.30
R0324:Nbea	UTSW	3	56,057,948 (GRCm38)	critical splice donor site	probably null
R0330:Nbea	UTSW	3	55,642,817 (GRCm38)	missense	probably benign	0.27
R0391:Nbea	UTSW	3	56,037,277 (GRCm38)	missense	probably damaging	1.00
R0394:Nbea	UTSW	3	56,029,907 (GRCm38)	missense	probably damaging	1.00
R0419:Nbea	UTSW	3	55,819,294 (GRCm38)	missense	probably benign	0.05
R0503:Nbea	UTSW	3	55,642,836 (GRCm38)	missense	possibly damaging	0.79
R0521:Nbea	UTSW	3	56,008,268 (GRCm38)	missense	probably damaging	1.00
R0595:Nbea	UTSW	3	55,628,496 (GRCm38)	missense	probably benign	0.18
R0894:Nbea	UTSW	3	56,009,340 (GRCm38)	missense	possibly damaging	0.89
R1072:Nbea	UTSW	3	56,086,196 (GRCm38)	missense	possibly damaging	0.94
R1125:Nbea	UTSW	3	55,857,006 (GRCm38)	nonsense	probably null
R1169:Nbea	UTSW	3	55,968,323 (GRCm38)	missense	probably benign	0.00
R1241:Nbea	UTSW	3	56,058,040 (GRCm38)	missense	probably damaging	1.00
R1269:Nbea	UTSW	3	56,004,781 (GRCm38)	missense	probably benign	0.05
R1406:Nbea	UTSW	3	56,037,281 (GRCm38)	missense	probably benign	0.00
R1406:Nbea	UTSW	3	56,037,281 (GRCm38)	missense	probably benign	0.00
R1457:Nbea	UTSW	3	56,085,327 (GRCm38)	missense	probably damaging	1.00
R1482:Nbea	UTSW	3	56,079,993 (GRCm38)	missense	probably damaging	1.00
R1483:Nbea	UTSW	3	56,002,790 (GRCm38)	missense	probably benign	0.25
R1502:Nbea	UTSW	3	56,004,889 (GRCm38)	missense	probably benign	0.03
R1544:Nbea	UTSW	3	56,058,827 (GRCm38)	missense	probably damaging	0.99
R1629:Nbea	UTSW	3	56,002,891 (GRCm38)	missense	possibly damaging	0.52
R1647:Nbea	UTSW	3	55,630,229 (GRCm38)	missense	probably damaging	0.97
R1663:Nbea	UTSW	3	55,645,986 (GRCm38)	missense	possibly damaging	0.95
R1722:Nbea	UTSW	3	55,665,695 (GRCm38)	missense	probably damaging	1.00
R1757:Nbea	UTSW	3	55,630,189 (GRCm38)	missense	possibly damaging	0.83
R1771:Nbea	UTSW	3	55,934,519 (GRCm38)	missense	probably benign	0.00
R1796:Nbea	UTSW	3	55,643,708 (GRCm38)	missense	possibly damaging	0.48
R1844:Nbea	UTSW	3	56,082,436 (GRCm38)	missense	probably damaging	0.97
R1872:Nbea	UTSW	3	55,642,889 (GRCm38)	missense	probably benign	0.12
R1938:Nbea	UTSW	3	56,085,322 (GRCm38)	missense	probably damaging	1.00
R1940:Nbea	UTSW	3	55,953,100 (GRCm38)	missense	possibly damaging	0.78
R2062:Nbea	UTSW	3	56,086,157 (GRCm38)	splice site	probably benign
R2066:Nbea	UTSW	3	55,968,146 (GRCm38)	missense	probably damaging	1.00
R2097:Nbea	UTSW	3	55,723,217 (GRCm38)	missense	probably damaging	0.96
R2181:Nbea	UTSW	3	56,029,939 (GRCm38)	missense	possibly damaging	0.92
R2274:Nbea	UTSW	3	55,988,085 (GRCm38)	splice site	probably null
R2345:Nbea	UTSW	3	56,085,279 (GRCm38)	missense	probably damaging	1.00
R2423:Nbea	UTSW	3	56,085,306 (GRCm38)	missense	probably damaging	1.00
R2434:Nbea	UTSW	3	55,647,460 (GRCm38)	missense	possibly damaging	0.91
R2880:Nbea	UTSW	3	55,647,358 (GRCm38)	missense	probably benign	0.04
R2881:Nbea	UTSW	3	55,647,358 (GRCm38)	missense	probably benign	0.04
R2940:Nbea	UTSW	3	55,934,624 (GRCm38)	missense	probably benign	0.24
R3500:Nbea	UTSW	3	55,681,010 (GRCm38)	missense	possibly damaging	0.88
R3765:Nbea	UTSW	3	56,005,549 (GRCm38)	missense	probably damaging	1.00
R3790:Nbea	UTSW	3	56,005,029 (GRCm38)	missense	probably benign
R3808:Nbea	UTSW	3	55,717,848 (GRCm38)	missense	probably benign	0.02
R3845:Nbea	UTSW	3	56,086,292 (GRCm38)	splice site	probably benign
R4182:Nbea	UTSW	3	56,008,427 (GRCm38)	missense	probably damaging	0.99
R4385:Nbea	UTSW	3	56,000,638 (GRCm38)	missense	possibly damaging	0.77
R4419:Nbea	UTSW	3	56,009,600 (GRCm38)	missense	probably damaging	1.00
R4426:Nbea	UTSW	3	56,082,379 (GRCm38)	missense	probably damaging	0.98
R4451:Nbea	UTSW	3	55,992,332 (GRCm38)	critical splice donor site	probably null
R4456:Nbea	UTSW	3	55,643,784 (GRCm38)	missense	probably benign	0.00
R4604:Nbea	UTSW	3	55,723,648 (GRCm38)	missense	probably benign	0.18
R4687:Nbea	UTSW	3	56,058,065 (GRCm38)	missense	probably damaging	1.00
R4758:Nbea	UTSW	3	56,005,403 (GRCm38)	missense	probably benign
R4840:Nbea	UTSW	3	55,710,670 (GRCm38)	missense	probably benign	0.37
R4888:Nbea	UTSW	3	56,005,355 (GRCm38)	missense	possibly damaging	0.61
R4954:Nbea	UTSW	3	56,035,958 (GRCm38)	missense	probably damaging	1.00
R4972:Nbea	UTSW	3	56,085,246 (GRCm38)	missense	probably damaging	0.99
R4980:Nbea	UTSW	3	55,953,045 (GRCm38)	missense	probably benign	0.00
R4980:Nbea	UTSW	3	55,647,351 (GRCm38)	splice site	probably null
R5104:Nbea	UTSW	3	56,079,927 (GRCm38)	missense	probably damaging	1.00
R5139:Nbea	UTSW	3	55,626,963 (GRCm38)	missense	possibly damaging	0.90
R5166:Nbea	UTSW	3	56,019,453 (GRCm38)	missense	probably damaging	1.00
R5347:Nbea	UTSW	3	56,040,876 (GRCm38)	missense	probably damaging	1.00
R5350:Nbea	UTSW	3	56,019,424 (GRCm38)	missense	probably damaging	1.00
R5418:Nbea	UTSW	3	55,645,989 (GRCm38)	missense	possibly damaging	0.86
R5586:Nbea	UTSW	3	55,631,971 (GRCm38)	missense	probably benign	0.08
R5627:Nbea	UTSW	3	55,992,345 (GRCm38)	missense	probably damaging	1.00
R5683:Nbea	UTSW	3	55,628,586 (GRCm38)	missense	possibly damaging	0.53
R5765:Nbea	UTSW	3	56,005,298 (GRCm38)	missense	probably benign	0.15
R5853:Nbea	UTSW	3	55,992,401 (GRCm38)	missense	probably damaging	1.00
R5858:Nbea	UTSW	3	55,953,034 (GRCm38)	critical splice donor site	probably null
R5955:Nbea	UTSW	3	55,680,983 (GRCm38)	missense	probably benign	0.00
R5976:Nbea	UTSW	3	55,853,847 (GRCm38)	missense	probably benign	0.30
R6039:Nbea	UTSW	3	56,005,117 (GRCm38)	missense	probably benign	0.00
R6039:Nbea	UTSW	3	56,005,117 (GRCm38)	missense	probably benign	0.00
R6043:Nbea	UTSW	3	55,786,475 (GRCm38)	missense	probably benign	0.32
R6122:Nbea	UTSW	3	56,029,896 (GRCm38)	missense	probably damaging	1.00
R6218:Nbea	UTSW	3	55,628,484 (GRCm38)	missense	probably damaging	0.97
R6331:Nbea	UTSW	3	56,000,616 (GRCm38)	missense	possibly damaging	0.94
R6334:Nbea	UTSW	3	56,037,149 (GRCm38)	missense	probably damaging	1.00
R6393:Nbea	UTSW	3	56,091,119 (GRCm38)	missense	probably damaging	1.00
R6411:Nbea	UTSW	3	55,805,357 (GRCm38)	missense	probably benign	0.01
R6457:Nbea	UTSW	3	56,000,569 (GRCm38)	missense	probably damaging	1.00
R6476:Nbea	UTSW	3	56,004,806 (GRCm38)	missense	probably benign	0.00
R6488:Nbea	UTSW	3	55,717,843 (GRCm38)	missense	probably damaging	0.99
R6702:Nbea	UTSW	3	56,005,502 (GRCm38)	missense	probably benign	0.06
R6752:Nbea	UTSW	3	56,037,219 (GRCm38)	missense	probably benign
R6752:Nbea	UTSW	3	55,968,309 (GRCm38)	missense	probably benign	0.02
R6804:Nbea	UTSW	3	56,087,453 (GRCm38)	missense	probably benign	0.37
R6901:Nbea	UTSW	3	56,019,415 (GRCm38)	missense	probably damaging	1.00
R6933:Nbea	UTSW	3	55,723,610 (GRCm38)	missense	possibly damaging	0.63
R7124:Nbea	UTSW	3	55,992,444 (GRCm38)	missense	probably damaging	1.00
R7211:Nbea	UTSW	3	56,004,901 (GRCm38)	missense	probably benign	0.05
R7308:Nbea	UTSW	3	56,091,031 (GRCm38)	missense	probably damaging	1.00
R7405:Nbea	UTSW	3	55,805,266 (GRCm38)	missense	possibly damaging	0.94
R7669:Nbea	UTSW	3	55,717,779 (GRCm38)	missense	probably damaging	1.00
R7762:Nbea	UTSW	3	55,649,705 (GRCm38)	missense	probably damaging	1.00
R7833:Nbea	UTSW	3	56,002,797 (GRCm38)	missense	probably damaging	1.00
R7885:Nbea	UTSW	3	55,665,689 (GRCm38)	missense	probably damaging	0.97
R7935:Nbea	UTSW	3	56,058,665 (GRCm38)	missense	probably damaging	1.00
R8050:Nbea	UTSW	3	55,987,981 (GRCm38)	missense	probably damaging	0.99
R8108:Nbea	UTSW	3	55,819,315 (GRCm38)	missense	probably benign	0.11
R8290:Nbea	UTSW	3	56,058,635 (GRCm38)	nonsense	probably null
R8314:Nbea	UTSW	3	56,009,251 (GRCm38)	missense	probably damaging	0.99
R8321:Nbea	UTSW	3	56,183,097 (GRCm38)	missense	possibly damaging	0.86
R8376:Nbea	UTSW	3	55,643,655 (GRCm38)	missense	possibly damaging	0.79
R8410:Nbea	UTSW	3	56,037,263 (GRCm38)	missense	probably damaging	1.00
R8556:Nbea	UTSW	3	55,647,386 (GRCm38)	missense	probably benign	0.25
R8753:Nbea	UTSW	3	55,626,908 (GRCm38)	missense	probably damaging	1.00
R8844:Nbea	UTSW	3	56,090,994 (GRCm38)	missense	probably damaging	0.97
R8884:Nbea	UTSW	3	55,805,299 (GRCm38)	missense	probably benign	0.00
R8886:Nbea	UTSW	3	56,058,727 (GRCm38)	missense	probably damaging	1.00
R8890:Nbea	UTSW	3	56,019,363 (GRCm38)	splice site	probably benign
R9004:Nbea	UTSW	3	56,002,938 (GRCm38)	missense	probably benign	0.01
R9022:Nbea	UTSW	3	55,643,689 (GRCm38)	missense	possibly damaging	0.79
R9080:Nbea	UTSW	3	56,005,095 (GRCm38)	nonsense	probably null
R9087:Nbea	UTSW	3	55,642,736 (GRCm38)	critical splice donor site	probably null
R9104:Nbea	UTSW	3	55,955,388 (GRCm38)	missense	probably benign
R9165:Nbea	UTSW	3	56,004,868 (GRCm38)	missense	probably benign	0.15
R9219:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9221:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9222:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9260:Nbea	UTSW	3	55,983,812 (GRCm38)	missense	possibly damaging	0.50
R9263:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9265:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9294:Nbea	UTSW	3	56,091,092 (GRCm38)	missense	probably benign	0.00
R9360:Nbea	UTSW	3	56,035,898 (GRCm38)	missense	possibly damaging	0.96
R9387:Nbea	UTSW	3	55,991,039 (GRCm38)	missense	probably benign	0.12
R9428:Nbea	UTSW	3	56,090,972 (GRCm38)	frame shift	probably null
R9435:Nbea	UTSW	3	56,035,888 (GRCm38)	missense	possibly damaging	0.63
R9507:Nbea	UTSW	3	55,665,590 (GRCm38)	missense	probably damaging	1.00
R9514:Nbea	UTSW	3	56,029,945 (GRCm38)	missense	probably damaging	1.00
R9516:Nbea	UTSW	3	56,029,945 (GRCm38)	missense	probably damaging	1.00
R9674:Nbea	UTSW	3	56,058,762 (GRCm38)	missense	probably damaging	1.00
R9688:Nbea	UTSW	3	55,649,744 (GRCm38)	missense	probably benign	0.42
R9709:Nbea	UTSW	3	55,786,458 (GRCm38)	nonsense	probably null
RF051:Nbea	UTSW	3	56,009,212 (GRCm38)	critical splice donor site	probably benign
X0018:Nbea	UTSW	3	56,036,048 (GRCm38)	missense	probably benign	0.39
Z1088:Nbea	UTSW	3	55,723,163 (GRCm38)	missense	probably benign	0.34
Z1177:Nbea	UTSW	3	56,031,550 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGTGTCTGAAACAGTCTACACAC -3'
(R):5'- ACCCGGGCCATAAGAAATG -3'

Sequencing Primer
(F):5'- GGATGTTTCTACCAAATGGTC -3'
(R):5'- TGGGAGGAAGGGACATGAGGTATAC -3'

Posted On

2018-07-24