Incidental Mutation 'R7062:Adgrb3'
| ID |
548299 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb3
|
| Ensembl Gene |
ENSMUSG00000033569 |
| Gene Name |
adhesion G protein-coupled receptor B3 |
| Synonyms |
Bai3, A830096D10Rik |
| MMRRC Submission |
045158-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.409)
|
| Stock # |
R7062 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
25106557-25868788 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 25865166 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 226
(T226A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116231
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041838]
[ENSMUST00000135518]
[ENSMUST00000146592]
[ENSMUST00000151309]
|
| AlphaFold |
Q80ZF8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000041838
AA Change: T226A
PolyPhen 2
Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000035612
Gene: ENSMUSG00000033569
AA Change: T226A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
223 |
N/A |
INTRINSIC |
|
TSP1
|
294 |
343 |
2.1e-12 |
SMART |
|
TSP1
|
348 |
398 |
7.97e-13 |
SMART |
|
TSP1
|
403 |
453 |
6.28e-11 |
SMART |
|
TSP1
|
458 |
508 |
1.48e-7 |
SMART |
|
HormR
|
510 |
576 |
4.15e-20 |
SMART |
|
Pfam:DUF3497
|
586 |
810 |
1.7e-52 |
PFAM |
|
GPS
|
815 |
868 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
874 |
1143 |
2.1e-64 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000135518
AA Change: T226A
PolyPhen 2
Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000119804
Gene: ENSMUSG00000033569
AA Change: T226A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
223 |
N/A |
INTRINSIC |
|
TSP1
|
294 |
343 |
2.1e-12 |
SMART |
|
TSP1
|
348 |
398 |
7.97e-13 |
SMART |
|
TSP1
|
403 |
453 |
6.28e-11 |
SMART |
|
TSP1
|
458 |
508 |
1.48e-7 |
SMART |
|
HormR
|
510 |
576 |
4.15e-20 |
SMART |
|
Pfam:DUF3497
|
586 |
810 |
1.7e-52 |
PFAM |
|
GPS
|
815 |
868 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
874 |
1143 |
2.1e-64 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000146592
AA Change: T19A
PolyPhen 2
Score 0.697 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000116759
Gene: ENSMUSG00000033569
AA Change: T19A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
16 |
N/A |
INTRINSIC |
|
TSP1
|
87 |
136 |
2.1e-12 |
SMART |
|
TSP1
|
141 |
191 |
7.97e-13 |
SMART |
|
TSP1
|
196 |
246 |
6.28e-11 |
SMART |
|
TSP1
|
251 |
301 |
1.48e-7 |
SMART |
|
HormR
|
303 |
369 |
4.15e-20 |
SMART |
|
Pfam:DUF3497
|
379 |
603 |
2.5e-52 |
PFAM |
|
GPS
|
608 |
661 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
667 |
903 |
5.4e-66 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000151309
AA Change: T226A
PolyPhen 2
Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000116231
Gene: ENSMUSG00000033569
AA Change: T226A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
223 |
N/A |
INTRINSIC |
|
TSP1
|
294 |
343 |
2.1e-12 |
SMART |
|
TSP1
|
348 |
398 |
7.97e-13 |
SMART |
|
TSP1
|
403 |
453 |
6.28e-11 |
SMART |
|
TSP1
|
458 |
508 |
1.48e-7 |
SMART |
|
HormR
|
510 |
576 |
4.15e-20 |
SMART |
|
Pfam:GAIN
|
589 |
794 |
1.1e-44 |
PFAM |
|
GPS
|
815 |
868 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
875 |
1143 |
2.7e-63 |
PFAM |
|
| Meta Mutation Damage Score |
0.0814 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
99% (86/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a conditional allele activated in Purkinje cells exhibit impaired motor learning with alterned climbing fiber electrophysiology. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc9 |
T |
A |
6: 142,544,872 (GRCm39) |
D1370V |
probably damaging |
Het |
| Ackr1 |
A |
T |
1: 173,159,682 (GRCm39) |
I279N |
possibly damaging |
Het |
| Adcy10 |
A |
G |
1: 165,366,091 (GRCm39) |
H536R |
probably benign |
Het |
| Apol10b |
T |
A |
15: 77,469,473 (GRCm39) |
M235L |
probably benign |
Het |
| Arhgap44 |
T |
C |
11: 64,902,758 (GRCm39) |
T570A |
probably benign |
Het |
| Astn1 |
A |
G |
1: 158,516,081 (GRCm39) |
|
probably null |
Het |
| Camsap3 |
A |
G |
8: 3,657,834 (GRCm39) |
|
probably benign |
Het |
| Ccdc73 |
C |
T |
2: 104,782,223 (GRCm39) |
A193V |
probably damaging |
Het |
| Ccl20 |
G |
A |
1: 83,095,535 (GRCm39) |
C32Y |
probably damaging |
Het |
| Cdk11b |
A |
G |
4: 155,711,268 (GRCm39) |
E16G |
probably damaging |
Het |
| Celsr2 |
T |
A |
3: 108,309,826 (GRCm39) |
N1591I |
possibly damaging |
Het |
| Col5a2 |
T |
C |
1: 45,456,785 (GRCm39) |
E306G |
probably benign |
Het |
| Cpa1 |
C |
T |
6: 30,640,676 (GRCm39) |
A106V |
probably benign |
Het |
| Ctdspl |
G |
A |
9: 118,866,538 (GRCm39) |
R199H |
probably damaging |
Het |
| Cyfip2 |
G |
A |
11: 46,151,659 (GRCm39) |
P547S |
probably damaging |
Het |
| Cyp2c37 |
A |
T |
19: 39,983,990 (GRCm39) |
|
probably null |
Het |
| Dnajc16 |
A |
G |
4: 141,494,001 (GRCm39) |
F549L |
probably damaging |
Het |
| Dnm3 |
T |
A |
1: 161,962,060 (GRCm39) |
K50* |
probably null |
Het |
| Eci1 |
C |
T |
17: 24,645,714 (GRCm39) |
|
probably benign |
Het |
| Eif2b4 |
C |
T |
5: 31,350,175 (GRCm39) |
C49Y |
probably benign |
Het |
| Emc3 |
A |
T |
6: 113,499,757 (GRCm39) |
I56N |
probably damaging |
Het |
| Enthd1 |
A |
G |
15: 80,336,745 (GRCm39) |
L563P |
probably damaging |
Het |
| Ercc4 |
T |
A |
16: 12,950,811 (GRCm39) |
I635K |
probably damaging |
Het |
| Espl1 |
A |
C |
15: 102,207,331 (GRCm39) |
N265T |
probably benign |
Het |
| Fads2 |
T |
C |
19: 10,042,962 (GRCm39) |
|
probably null |
Het |
| Fam186a |
G |
A |
15: 99,831,521 (GRCm39) |
|
probably benign |
Het |
| Fastkd1 |
A |
T |
2: 69,534,666 (GRCm39) |
I368K |
possibly damaging |
Het |
| Fat1 |
G |
A |
8: 45,403,253 (GRCm39) |
M1I |
probably null |
Het |
| Foxj1 |
T |
C |
11: 116,222,819 (GRCm39) |
E328G |
probably benign |
Het |
| Gfod2 |
T |
C |
8: 106,449,508 (GRCm39) |
|
probably benign |
Het |
| Gm6525 |
C |
T |
3: 84,082,198 (GRCm39) |
R40C |
probably benign |
Het |
| Gna12 |
G |
A |
5: 140,771,240 (GRCm39) |
T144I |
probably benign |
Het |
| Ighv9-3 |
T |
C |
12: 114,104,712 (GRCm39) |
M11V |
probably benign |
Het |
| Kcnj14 |
T |
C |
7: 45,467,314 (GRCm39) |
Y344C |
probably damaging |
Het |
| Lrrc63 |
A |
T |
14: 75,323,737 (GRCm39) |
S496T |
probably benign |
Het |
| Ltn1 |
T |
C |
16: 87,224,491 (GRCm39) |
T78A |
probably damaging |
Het |
| Matr3 |
T |
A |
18: 35,712,072 (GRCm39) |
|
probably null |
Het |
| Mcpt4 |
A |
G |
14: 56,298,125 (GRCm39) |
M142T |
probably benign |
Het |
| Mroh7 |
A |
G |
4: 106,541,177 (GRCm39) |
F1154S |
probably damaging |
Het |
| Mrpl1 |
G |
T |
5: 96,361,650 (GRCm39) |
L12F |
probably benign |
Het |
| Myo3b |
G |
A |
2: 70,047,501 (GRCm39) |
V308I |
probably benign |
Het |
| Nfasc |
A |
G |
1: 132,529,707 (GRCm39) |
|
probably null |
Het |
| Npc1l1 |
T |
A |
11: 6,167,807 (GRCm39) |
M995L |
probably benign |
Het |
| Nvl |
A |
G |
1: 180,939,899 (GRCm39) |
I617T |
probably benign |
Het |
| Oas1h |
C |
A |
5: 120,999,528 (GRCm39) |
|
probably benign |
Het |
| Oasl2 |
T |
A |
5: 115,049,152 (GRCm39) |
Y197* |
probably null |
Het |
| Or4k1 |
A |
G |
14: 50,377,907 (GRCm39) |
L63P |
probably damaging |
Het |
| Or52ab7 |
T |
C |
7: 102,978,293 (GRCm39) |
V200A |
probably benign |
Het |
| Or5an1c |
T |
C |
19: 12,218,089 (GRCm39) |
N312S |
probably benign |
Het |
| Or5l13 |
T |
C |
2: 87,780,568 (GRCm39) |
E3G |
probably benign |
Het |
| Or5p70 |
C |
T |
7: 107,995,037 (GRCm39) |
R237* |
probably null |
Het |
| Or8g35 |
A |
T |
9: 39,381,353 (GRCm39) |
I223N |
probably benign |
Het |
| Orc6 |
T |
C |
8: 86,029,537 (GRCm39) |
V27A |
probably damaging |
Het |
| Parp4 |
A |
T |
14: 56,852,216 (GRCm39) |
R799S |
possibly damaging |
Het |
| Pcdhga1 |
C |
A |
18: 37,958,130 (GRCm39) |
S826R |
probably damaging |
Het |
| Phldb1 |
T |
C |
9: 44,607,432 (GRCm39) |
R1258G |
probably damaging |
Het |
| Ppfia1 |
T |
C |
7: 144,106,210 (GRCm39) |
S21G |
probably benign |
Het |
| Ppp1r18 |
C |
A |
17: 36,179,103 (GRCm39) |
T326K |
probably damaging |
Het |
| Psg26 |
A |
G |
7: 18,216,521 (GRCm39) |
L106P |
probably damaging |
Het |
| Rabgap1l |
A |
T |
1: 160,054,220 (GRCm39) |
D265E |
probably benign |
Het |
| Rasgrp4 |
T |
C |
7: 28,849,619 (GRCm39) |
L554P |
possibly damaging |
Het |
| Rnf17 |
G |
T |
14: 56,703,111 (GRCm39) |
V621L |
probably benign |
Het |
| Sart3 |
T |
C |
5: 113,883,663 (GRCm39) |
K783R |
possibly damaging |
Het |
| Slc23a2 |
T |
A |
2: 131,933,189 (GRCm39) |
I90F |
probably damaging |
Het |
| Slc5a2 |
A |
T |
7: 127,869,212 (GRCm39) |
M331L |
probably damaging |
Het |
| Slc5a7 |
C |
G |
17: 54,600,029 (GRCm39) |
G128A |
probably damaging |
Het |
| Smcr8 |
A |
T |
11: 60,671,180 (GRCm39) |
Q776L |
probably damaging |
Het |
| Smpd4 |
T |
A |
16: 17,458,835 (GRCm39) |
D519E |
probably damaging |
Het |
| Smurf1 |
A |
T |
5: 144,830,356 (GRCm39) |
|
probably null |
Het |
| Spata18 |
T |
A |
5: 73,816,636 (GRCm39) |
N125K |
probably benign |
Het |
| Spice1 |
T |
A |
16: 44,178,259 (GRCm39) |
M94K |
probably damaging |
Het |
| Stard4 |
T |
C |
18: 33,338,587 (GRCm39) |
|
probably null |
Het |
| Stx17 |
A |
G |
4: 48,140,442 (GRCm39) |
D49G |
probably benign |
Het |
| Tbce |
T |
C |
13: 14,194,380 (GRCm39) |
D93G |
possibly damaging |
Het |
| Tbx21 |
T |
A |
11: 96,989,719 (GRCm39) |
D491V |
probably damaging |
Het |
| Tmbim4 |
G |
T |
10: 120,044,731 (GRCm39) |
|
probably benign |
Het |
| Tmem209 |
C |
T |
6: 30,502,016 (GRCm39) |
R62H |
probably damaging |
Het |
| Tmem237 |
A |
T |
1: 59,158,771 (GRCm39) |
|
probably null |
Het |
| Tmprss9 |
T |
C |
10: 80,730,883 (GRCm39) |
I803T |
probably benign |
Het |
| Trip4 |
C |
T |
9: 65,792,292 (GRCm39) |
A7T |
probably benign |
Het |
| Unc13a |
T |
C |
8: 72,115,881 (GRCm39) |
D107G |
probably benign |
Het |
| Uso1 |
C |
A |
5: 92,340,599 (GRCm39) |
Q672K |
possibly damaging |
Het |
| Washc2 |
T |
A |
6: 116,196,949 (GRCm39) |
N239K |
possibly damaging |
Het |
| Zfp661 |
A |
G |
2: 127,419,040 (GRCm39) |
C367R |
probably damaging |
Het |
| Znrf3 |
T |
A |
11: 5,231,550 (GRCm39) |
E558D |
probably damaging |
Het |
|
| Other mutations in Adgrb3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00164:Adgrb3
|
APN |
1 |
25,267,581 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00507:Adgrb3
|
APN |
1 |
25,113,796 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00828:Adgrb3
|
APN |
1 |
25,527,200 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01285:Adgrb3
|
APN |
1 |
25,132,868 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL01309:Adgrb3
|
APN |
1 |
25,151,352 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01540:Adgrb3
|
APN |
1 |
25,151,252 (GRCm39) |
splice site |
probably null |
|
|
IGL01608:Adgrb3
|
APN |
1 |
25,592,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01638:Adgrb3
|
APN |
1 |
25,598,832 (GRCm39) |
splice site |
probably benign |
|
|
IGL01657:Adgrb3
|
APN |
1 |
25,865,574 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01666:Adgrb3
|
APN |
1 |
25,499,832 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01712:Adgrb3
|
APN |
1 |
25,865,360 (GRCm39) |
missense |
probably benign |
|
|
IGL01767:Adgrb3
|
APN |
1 |
25,598,895 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01987:Adgrb3
|
APN |
1 |
25,140,512 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02201:Adgrb3
|
APN |
1 |
25,459,631 (GRCm39) |
splice site |
probably benign |
|
|
IGL02584:Adgrb3
|
APN |
1 |
25,544,065 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02685:Adgrb3
|
APN |
1 |
25,123,323 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02886:Adgrb3
|
APN |
1 |
25,543,991 (GRCm39) |
splice site |
probably null |
|
|
IGL02929:Adgrb3
|
APN |
1 |
25,592,905 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03153:Adgrb3
|
APN |
1 |
25,570,978 (GRCm39) |
nonsense |
probably null |
|
|
IGL03165:Adgrb3
|
APN |
1 |
25,133,475 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03227:Adgrb3
|
APN |
1 |
25,586,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03392:Adgrb3
|
APN |
1 |
25,543,529 (GRCm39) |
missense |
probably damaging |
0.99 |
|
schwach
|
UTSW |
1 |
25,150,772 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0007:Adgrb3
|
UTSW |
1 |
25,150,772 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0048:Adgrb3
|
UTSW |
1 |
25,140,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0048:Adgrb3
|
UTSW |
1 |
25,140,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0322:Adgrb3
|
UTSW |
1 |
25,260,829 (GRCm39) |
splice site |
probably benign |
|
|
R0442:Adgrb3
|
UTSW |
1 |
25,435,551 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0563:Adgrb3
|
UTSW |
1 |
25,586,635 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1168:Adgrb3
|
UTSW |
1 |
25,865,280 (GRCm39) |
missense |
probably benign |
|
|
R1252:Adgrb3
|
UTSW |
1 |
25,167,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1264:Adgrb3
|
UTSW |
1 |
25,598,931 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1543:Adgrb3
|
UTSW |
1 |
25,527,169 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1577:Adgrb3
|
UTSW |
1 |
25,133,264 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1581:Adgrb3
|
UTSW |
1 |
25,133,153 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1583:Adgrb3
|
UTSW |
1 |
25,265,912 (GRCm39) |
splice site |
probably null |
|
|
R1653:Adgrb3
|
UTSW |
1 |
25,140,584 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1725:Adgrb3
|
UTSW |
1 |
25,865,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1792:Adgrb3
|
UTSW |
1 |
25,267,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Adgrb3
|
UTSW |
1 |
25,571,658 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1838:Adgrb3
|
UTSW |
1 |
25,123,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1869:Adgrb3
|
UTSW |
1 |
25,865,519 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1971:Adgrb3
|
UTSW |
1 |
25,586,525 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2005:Adgrb3
|
UTSW |
1 |
25,150,799 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2134:Adgrb3
|
UTSW |
1 |
25,133,038 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2142:Adgrb3
|
UTSW |
1 |
25,107,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2268:Adgrb3
|
UTSW |
1 |
25,150,898 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3740:Adgrb3
|
UTSW |
1 |
25,865,535 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3877:Adgrb3
|
UTSW |
1 |
25,150,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4120:Adgrb3
|
UTSW |
1 |
25,133,388 (GRCm39) |
nonsense |
probably null |
|
|
R4344:Adgrb3
|
UTSW |
1 |
25,865,829 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4363:Adgrb3
|
UTSW |
1 |
25,151,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4438:Adgrb3
|
UTSW |
1 |
25,870,108 (GRCm39) |
unclassified |
probably benign |
|
|
R4465:Adgrb3
|
UTSW |
1 |
25,133,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4480:Adgrb3
|
UTSW |
1 |
25,150,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4554:Adgrb3
|
UTSW |
1 |
25,123,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4557:Adgrb3
|
UTSW |
1 |
25,123,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Adgrb3
|
UTSW |
1 |
25,865,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4713:Adgrb3
|
UTSW |
1 |
25,586,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4772:Adgrb3
|
UTSW |
1 |
25,570,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4890:Adgrb3
|
UTSW |
1 |
25,260,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5045:Adgrb3
|
UTSW |
1 |
25,113,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5061:Adgrb3
|
UTSW |
1 |
25,107,209 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5097:Adgrb3
|
UTSW |
1 |
25,865,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Adgrb3
|
UTSW |
1 |
25,133,033 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R5241:Adgrb3
|
UTSW |
1 |
25,150,871 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5328:Adgrb3
|
UTSW |
1 |
25,133,356 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5372:Adgrb3
|
UTSW |
1 |
25,167,940 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5703:Adgrb3
|
UTSW |
1 |
25,459,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5747:Adgrb3
|
UTSW |
1 |
25,865,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5998:Adgrb3
|
UTSW |
1 |
25,470,582 (GRCm39) |
splice site |
probably null |
|
|
R6006:Adgrb3
|
UTSW |
1 |
25,865,612 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6077:Adgrb3
|
UTSW |
1 |
25,133,081 (GRCm39) |
nonsense |
probably null |
|
|
R6183:Adgrb3
|
UTSW |
1 |
25,133,451 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6190:Adgrb3
|
UTSW |
1 |
25,459,728 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6249:Adgrb3
|
UTSW |
1 |
25,471,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6310:Adgrb3
|
UTSW |
1 |
25,150,799 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6450:Adgrb3
|
UTSW |
1 |
25,459,683 (GRCm39) |
missense |
probably benign |
|
|
R6678:Adgrb3
|
UTSW |
1 |
25,499,891 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6679:Adgrb3
|
UTSW |
1 |
25,170,377 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6685:Adgrb3
|
UTSW |
1 |
25,150,817 (GRCm39) |
nonsense |
probably null |
|
|
R6730:Adgrb3
|
UTSW |
1 |
25,133,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6805:Adgrb3
|
UTSW |
1 |
25,865,253 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6847:Adgrb3
|
UTSW |
1 |
25,133,003 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6929:Adgrb3
|
UTSW |
1 |
25,150,852 (GRCm39) |
nonsense |
probably null |
|
|
R6953:Adgrb3
|
UTSW |
1 |
25,865,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7244:Adgrb3
|
UTSW |
1 |
25,170,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7292:Adgrb3
|
UTSW |
1 |
25,570,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7325:Adgrb3
|
UTSW |
1 |
25,571,711 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7378:Adgrb3
|
UTSW |
1 |
25,571,000 (GRCm39) |
nonsense |
probably null |
|
|
R7489:Adgrb3
|
UTSW |
1 |
25,586,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7615:Adgrb3
|
UTSW |
1 |
25,137,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7623:Adgrb3
|
UTSW |
1 |
25,586,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Adgrb3
|
UTSW |
1 |
25,471,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7837:Adgrb3
|
UTSW |
1 |
25,167,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8064:Adgrb3
|
UTSW |
1 |
25,459,637 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8152:Adgrb3
|
UTSW |
1 |
25,260,838 (GRCm39) |
splice site |
probably null |
|
|
R8161:Adgrb3
|
UTSW |
1 |
25,133,003 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8225:Adgrb3
|
UTSW |
1 |
25,865,597 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8417:Adgrb3
|
UTSW |
1 |
25,527,134 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8694:Adgrb3
|
UTSW |
1 |
25,865,472 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8742:Adgrb3
|
UTSW |
1 |
25,265,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8886:Adgrb3
|
UTSW |
1 |
25,150,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8941:Adgrb3
|
UTSW |
1 |
25,133,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8958:Adgrb3
|
UTSW |
1 |
25,865,190 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8979:Adgrb3
|
UTSW |
1 |
25,527,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9064:Adgrb3
|
UTSW |
1 |
25,570,965 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9252:Adgrb3
|
UTSW |
1 |
25,865,496 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9401:Adgrb3
|
UTSW |
1 |
25,592,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9739:Adgrb3
|
UTSW |
1 |
25,592,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Adgrb3
|
UTSW |
1 |
25,170,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgrb3
|
UTSW |
1 |
25,132,995 (GRCm39) |
missense |
probably benign |
0.37 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACTTTAGAGCCATGCAACAGAG -3'
(R):5'- GCCATGTCTTATGCACTTGG -3'
Sequencing Primer
(F):5'- CAAGTCACTTCAAAGTTGACAGG -3'
(R):5'- TGGTTGGAAAGCTGCTTAAAATCCG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation