Incidental Mutation 'R1583:Adgrb3'
ID 177226
Institutional Source Beutler Lab
Gene Symbol Adgrb3
Ensembl Gene ENSMUSG00000033569
Gene Name adhesion G protein-coupled receptor B3
Synonyms Bai3, A830096D10Rik
MMRRC Submission 039620-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.468) question?
Stock # R1583 (G1)
Quality Score 108
Status Validated
Chromosome 1
Chromosomal Location 25067476-25829707 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 25226831 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000116231 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041838] [ENSMUST00000126626] [ENSMUST00000135518] [ENSMUST00000135518] [ENSMUST00000146592] [ENSMUST00000151309]
AlphaFold Q80ZF8
Predicted Effect probably null
Transcript: ENSMUST00000041838
SMART Domains Protein: ENSMUSP00000035612
Gene: ENSMUSG00000033569

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
low complexity region 212 223 N/A INTRINSIC
TSP1 294 343 2.1e-12 SMART
TSP1 348 398 7.97e-13 SMART
TSP1 403 453 6.28e-11 SMART
TSP1 458 508 1.48e-7 SMART
HormR 510 576 4.15e-20 SMART
Pfam:DUF3497 586 810 1.7e-52 PFAM
GPS 815 868 1.24e-21 SMART
Pfam:7tm_2 874 1143 2.1e-64 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119680
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126096
Predicted Effect probably null
Transcript: ENSMUST00000126626
SMART Domains Protein: ENSMUSP00000115442
Gene: ENSMUSG00000033569

DomainStartEndE-ValueType
Pfam:7tm_2 4 273 7.3e-65 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134022
Predicted Effect probably null
Transcript: ENSMUST00000135518
SMART Domains Protein: ENSMUSP00000119804
Gene: ENSMUSG00000033569

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
low complexity region 212 223 N/A INTRINSIC
TSP1 294 343 2.1e-12 SMART
TSP1 348 398 7.97e-13 SMART
TSP1 403 453 6.28e-11 SMART
TSP1 458 508 1.48e-7 SMART
HormR 510 576 4.15e-20 SMART
Pfam:DUF3497 586 810 1.7e-52 PFAM
GPS 815 868 1.24e-21 SMART
Pfam:7tm_2 874 1143 2.1e-64 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000135518
SMART Domains Protein: ENSMUSP00000119804
Gene: ENSMUSG00000033569

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
low complexity region 212 223 N/A INTRINSIC
TSP1 294 343 2.1e-12 SMART
TSP1 348 398 7.97e-13 SMART
TSP1 403 453 6.28e-11 SMART
TSP1 458 508 1.48e-7 SMART
HormR 510 576 4.15e-20 SMART
Pfam:DUF3497 586 810 1.7e-52 PFAM
GPS 815 868 1.24e-21 SMART
Pfam:7tm_2 874 1143 2.1e-64 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000146592
SMART Domains Protein: ENSMUSP00000116759
Gene: ENSMUSG00000033569

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
TSP1 87 136 2.1e-12 SMART
TSP1 141 191 7.97e-13 SMART
TSP1 196 246 6.28e-11 SMART
TSP1 251 301 1.48e-7 SMART
HormR 303 369 4.15e-20 SMART
Pfam:DUF3497 379 603 2.5e-52 PFAM
GPS 608 661 1.24e-21 SMART
Pfam:7tm_2 667 903 5.4e-66 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000151309
SMART Domains Protein: ENSMUSP00000116231
Gene: ENSMUSG00000033569

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
low complexity region 212 223 N/A INTRINSIC
TSP1 294 343 2.1e-12 SMART
TSP1 348 398 7.97e-13 SMART
TSP1 403 453 6.28e-11 SMART
TSP1 458 508 1.48e-7 SMART
HormR 510 576 4.15e-20 SMART
Pfam:GAIN 589 794 1.1e-44 PFAM
GPS 815 868 1.24e-21 SMART
Pfam:7tm_2 875 1143 2.7e-63 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153568
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.2%
  • 20x: 88.8%
Validation Efficiency 99% (79/80)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a conditional allele activated in Purkinje cells exhibit impaired motor learning with alterned climbing fiber electrophysiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A G 5: 76,882,681 (GRCm38) S691P probably benign Het
Ankar A G 1: 72,679,555 (GRCm38) probably benign Het
Aplf A T 6: 87,646,033 (GRCm38) Y355N probably damaging Het
Bms1 A G 6: 118,389,389 (GRCm38) probably benign Het
Catsperb T C 12: 101,463,114 (GRCm38) I182T probably damaging Het
Cd300ld2 T C 11: 115,013,777 (GRCm38) D88G probably benign Het
Cebpz T C 17: 78,934,752 (GRCm38) N491S probably damaging Het
Crybg2 T C 4: 134,081,459 (GRCm38) S1415P probably damaging Het
Ddc A G 11: 11,829,131 (GRCm38) V331A probably benign Het
Decr2 T C 17: 26,083,024 (GRCm38) E244G probably damaging Het
Dhrs11 A G 11: 84,823,117 (GRCm38) M136T probably damaging Het
Eapp G A 12: 54,685,948 (GRCm38) Q126* probably null Het
Fam111a T A 19: 12,587,778 (GRCm38) V297D probably damaging Het
Fam84a G A 12: 14,150,408 (GRCm38) A106V probably benign Het
Fbxo10 A C 4: 45,062,118 (GRCm38) L136R probably damaging Het
Fbxo30 T A 10: 11,291,374 (GRCm38) H613Q possibly damaging Het
Frk A T 10: 34,591,810 (GRCm38) probably null Het
Gm10392 T A 11: 77,517,481 (GRCm38) D104V probably benign Het
Gm960 T A 19: 4,652,171 (GRCm38) K282N probably damaging Het
Gpn1 A G 5: 31,497,338 (GRCm38) E78G possibly damaging Het
Hhip T C 8: 79,990,276 (GRCm38) Y506C probably damaging Het
Hid1 G A 11: 115,356,750 (GRCm38) S274L possibly damaging Het
Immp2l G T 12: 41,703,765 (GRCm38) probably benign Het
Klhl21 T C 4: 152,009,624 (GRCm38) F228L possibly damaging Het
Lamc1 T A 1: 153,243,478 (GRCm38) probably null Het
Lars G A 18: 42,210,050 (GRCm38) R1101C probably damaging Het
Magi2 T C 5: 19,227,332 (GRCm38) V15A probably benign Het
Map2k7 T C 8: 4,243,621 (GRCm38) probably null Het
Mga T A 2: 119,963,960 (GRCm38) H2590Q possibly damaging Het
Mlxip T C 5: 123,450,223 (GRCm38) I238T possibly damaging Het
Mylk T A 16: 34,875,586 (GRCm38) D230E probably benign Het
Nacad T A 11: 6,601,185 (GRCm38) T669S probably benign Het
Nin C T 12: 70,031,738 (GRCm38) M1691I probably benign Het
Nlrp4d C T 7: 10,382,237 (GRCm38) A203T probably damaging Het
Olfr1204 T G 2: 88,852,262 (GRCm38) F104C probably damaging Het
Olfr1301 A T 2: 111,754,425 (GRCm38) M59L probably damaging Het
Olfr1495 A T 19: 13,768,510 (GRCm38) H56L probably benign Het
Olfr201 A G 16: 59,269,031 (GRCm38) V212A probably benign Het
Olfr433 T C 1: 174,042,480 (GRCm38) F177L probably benign Het
Olfr729 C A 14: 50,148,774 (GRCm38) M33I probably benign Het
Osbp C A 19: 11,977,829 (GRCm38) Q282K probably benign Het
Osbpl2 A G 2: 180,148,463 (GRCm38) S177G probably damaging Het
Pax1 A G 2: 147,366,255 (GRCm38) H261R possibly damaging Het
Pcif1 A T 2: 164,886,727 (GRCm38) L274F probably damaging Het
Pkhd1 A G 1: 20,117,825 (GRCm38) S3420P probably benign Het
Prss3 A C 6: 41,377,627 (GRCm38) probably benign Het
Ptk2b T C 14: 66,163,114 (GRCm38) T751A possibly damaging Het
Pus10 T C 11: 23,673,239 (GRCm38) V126A probably damaging Het
Rai14 A C 15: 10,587,916 (GRCm38) D258E probably damaging Het
Rbp3 T C 14: 33,954,524 (GRCm38) V143A possibly damaging Het
Sarm1 G A 11: 78,483,327 (GRCm38) Q625* probably null Het
Scgb1b21 T G 7: 33,527,667 (GRCm38) noncoding transcript Het
Scrn1 A T 6: 54,520,769 (GRCm38) V279E probably damaging Het
Sipa1l2 T C 8: 125,421,895 (GRCm38) T1670A probably damaging Het
Slc9a4 A T 1: 40,600,962 (GRCm38) I305F probably benign Het
Smarcc1 A G 9: 110,213,617 (GRCm38) T918A probably damaging Het
Tas2r109 A T 6: 132,980,426 (GRCm38) H180Q probably benign Het
Tas2r121 G A 6: 132,700,230 (GRCm38) R260* probably null Het
Tenm3 T C 8: 48,279,074 (GRCm38) D1249G probably benign Het
Tgtp1 C G 11: 48,987,530 (GRCm38) G116A probably damaging Het
Tial1 A G 7: 128,443,910 (GRCm38) Y317H probably damaging Het
Trim66 A T 7: 109,455,080 (GRCm38) W1308R probably damaging Het
Ulk2 T G 11: 61,783,545 (GRCm38) K878N possibly damaging Het
Zfp41 T A 15: 75,618,291 (GRCm38) S31T possibly damaging Het
Other mutations in Adgrb3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Adgrb3 APN 1 25,228,500 (GRCm38) missense probably benign 0.09
IGL00507:Adgrb3 APN 1 25,074,715 (GRCm38) missense possibly damaging 0.93
IGL00828:Adgrb3 APN 1 25,488,119 (GRCm38) missense possibly damaging 0.73
IGL01285:Adgrb3 APN 1 25,093,787 (GRCm38) missense probably benign 0.32
IGL01309:Adgrb3 APN 1 25,112,271 (GRCm38) missense possibly damaging 0.69
IGL01540:Adgrb3 APN 1 25,112,171 (GRCm38) splice site probably null
IGL01608:Adgrb3 APN 1 25,553,774 (GRCm38) missense probably damaging 1.00
IGL01638:Adgrb3 APN 1 25,559,751 (GRCm38) splice site probably benign
IGL01657:Adgrb3 APN 1 25,826,493 (GRCm38) missense probably benign 0.03
IGL01666:Adgrb3 APN 1 25,460,751 (GRCm38) missense probably damaging 0.96
IGL01712:Adgrb3 APN 1 25,826,279 (GRCm38) missense probably benign
IGL01767:Adgrb3 APN 1 25,559,814 (GRCm38) missense probably benign 0.00
IGL01987:Adgrb3 APN 1 25,101,431 (GRCm38) critical splice donor site probably null
IGL02201:Adgrb3 APN 1 25,420,550 (GRCm38) splice site probably benign
IGL02584:Adgrb3 APN 1 25,504,984 (GRCm38) missense probably damaging 0.98
IGL02685:Adgrb3 APN 1 25,084,242 (GRCm38) critical splice donor site probably null
IGL02886:Adgrb3 APN 1 25,504,910 (GRCm38) splice site probably null
IGL02929:Adgrb3 APN 1 25,553,824 (GRCm38) missense probably benign 0.00
IGL03153:Adgrb3 APN 1 25,531,897 (GRCm38) nonsense probably null
IGL03165:Adgrb3 APN 1 25,094,394 (GRCm38) missense probably benign 0.05
IGL03227:Adgrb3 APN 1 25,547,475 (GRCm38) missense probably damaging 1.00
IGL03392:Adgrb3 APN 1 25,504,448 (GRCm38) missense probably damaging 0.99
schwach UTSW 1 25,111,691 (GRCm38) critical splice donor site probably null
R0007:Adgrb3 UTSW 1 25,111,691 (GRCm38) critical splice donor site probably null
R0048:Adgrb3 UTSW 1 25,101,482 (GRCm38) missense probably benign 0.02
R0048:Adgrb3 UTSW 1 25,101,482 (GRCm38) missense probably benign 0.02
R0322:Adgrb3 UTSW 1 25,221,748 (GRCm38) splice site probably benign
R0442:Adgrb3 UTSW 1 25,396,470 (GRCm38) missense probably damaging 0.96
R0563:Adgrb3 UTSW 1 25,547,554 (GRCm38) missense probably damaging 0.99
R1168:Adgrb3 UTSW 1 25,826,199 (GRCm38) missense probably benign
R1252:Adgrb3 UTSW 1 25,128,828 (GRCm38) missense probably damaging 1.00
R1264:Adgrb3 UTSW 1 25,559,850 (GRCm38) missense probably damaging 0.97
R1543:Adgrb3 UTSW 1 25,488,088 (GRCm38) missense probably benign 0.01
R1577:Adgrb3 UTSW 1 25,094,183 (GRCm38) missense possibly damaging 0.51
R1581:Adgrb3 UTSW 1 25,094,072 (GRCm38) missense possibly damaging 0.94
R1653:Adgrb3 UTSW 1 25,101,503 (GRCm38) missense probably benign 0.09
R1725:Adgrb3 UTSW 1 25,826,300 (GRCm38) missense probably damaging 1.00
R1792:Adgrb3 UTSW 1 25,228,471 (GRCm38) missense probably damaging 1.00
R1827:Adgrb3 UTSW 1 25,532,577 (GRCm38) missense probably damaging 0.99
R1838:Adgrb3 UTSW 1 25,084,270 (GRCm38) missense probably damaging 1.00
R1869:Adgrb3 UTSW 1 25,826,438 (GRCm38) missense possibly damaging 0.83
R1971:Adgrb3 UTSW 1 25,547,444 (GRCm38) missense probably benign 0.02
R2005:Adgrb3 UTSW 1 25,111,718 (GRCm38) missense probably benign 0.25
R2134:Adgrb3 UTSW 1 25,093,957 (GRCm38) missense probably damaging 0.99
R2142:Adgrb3 UTSW 1 25,068,209 (GRCm38) missense probably damaging 1.00
R2268:Adgrb3 UTSW 1 25,111,817 (GRCm38) missense possibly damaging 0.79
R3740:Adgrb3 UTSW 1 25,826,454 (GRCm38) missense probably benign 0.00
R3877:Adgrb3 UTSW 1 25,111,825 (GRCm38) missense probably damaging 1.00
R4120:Adgrb3 UTSW 1 25,094,307 (GRCm38) nonsense probably null
R4344:Adgrb3 UTSW 1 25,826,748 (GRCm38) missense possibly damaging 0.61
R4363:Adgrb3 UTSW 1 25,112,222 (GRCm38) missense probably damaging 1.00
R4438:Adgrb3 UTSW 1 25,831,027 (GRCm38) unclassified probably benign
R4465:Adgrb3 UTSW 1 25,094,366 (GRCm38) missense probably damaging 1.00
R4480:Adgrb3 UTSW 1 25,111,748 (GRCm38) missense probably damaging 1.00
R4554:Adgrb3 UTSW 1 25,084,279 (GRCm38) missense probably damaging 1.00
R4557:Adgrb3 UTSW 1 25,084,279 (GRCm38) missense probably damaging 1.00
R4622:Adgrb3 UTSW 1 25,826,488 (GRCm38) missense probably damaging 0.99
R4713:Adgrb3 UTSW 1 25,547,532 (GRCm38) missense probably damaging 1.00
R4772:Adgrb3 UTSW 1 25,531,875 (GRCm38) missense probably damaging 1.00
R4890:Adgrb3 UTSW 1 25,221,827 (GRCm38) missense probably damaging 1.00
R5045:Adgrb3 UTSW 1 25,074,779 (GRCm38) missense probably damaging 1.00
R5061:Adgrb3 UTSW 1 25,068,128 (GRCm38) utr 3 prime probably benign
R5097:Adgrb3 UTSW 1 25,826,084 (GRCm38) missense probably damaging 1.00
R5227:Adgrb3 UTSW 1 25,093,952 (GRCm38) missense possibly damaging 0.55
R5241:Adgrb3 UTSW 1 25,111,790 (GRCm38) missense possibly damaging 0.85
R5328:Adgrb3 UTSW 1 25,094,275 (GRCm38) missense possibly damaging 0.90
R5372:Adgrb3 UTSW 1 25,128,859 (GRCm38) missense probably benign 0.01
R5703:Adgrb3 UTSW 1 25,420,559 (GRCm38) missense probably damaging 1.00
R5747:Adgrb3 UTSW 1 25,826,562 (GRCm38) missense probably damaging 1.00
R5998:Adgrb3 UTSW 1 25,431,501 (GRCm38) splice site probably null
R6006:Adgrb3 UTSW 1 25,826,531 (GRCm38) missense possibly damaging 0.85
R6077:Adgrb3 UTSW 1 25,094,000 (GRCm38) nonsense probably null
R6183:Adgrb3 UTSW 1 25,094,370 (GRCm38) missense probably damaging 0.98
R6190:Adgrb3 UTSW 1 25,420,647 (GRCm38) missense probably benign 0.01
R6249:Adgrb3 UTSW 1 25,432,558 (GRCm38) missense probably damaging 1.00
R6310:Adgrb3 UTSW 1 25,111,718 (GRCm38) missense probably benign 0.13
R6450:Adgrb3 UTSW 1 25,420,602 (GRCm38) missense probably benign
R6678:Adgrb3 UTSW 1 25,460,810 (GRCm38) missense possibly damaging 0.84
R6679:Adgrb3 UTSW 1 25,131,296 (GRCm38) missense probably benign 0.01
R6685:Adgrb3 UTSW 1 25,111,736 (GRCm38) nonsense probably null
R6730:Adgrb3 UTSW 1 25,094,294 (GRCm38) missense probably damaging 1.00
R6805:Adgrb3 UTSW 1 25,826,172 (GRCm38) missense possibly damaging 0.83
R6847:Adgrb3 UTSW 1 25,093,922 (GRCm38) missense probably benign 0.03
R6929:Adgrb3 UTSW 1 25,111,771 (GRCm38) nonsense probably null
R6953:Adgrb3 UTSW 1 25,826,511 (GRCm38) missense probably damaging 1.00
R7062:Adgrb3 UTSW 1 25,826,085 (GRCm38) missense possibly damaging 0.90
R7244:Adgrb3 UTSW 1 25,131,269 (GRCm38) missense probably damaging 1.00
R7292:Adgrb3 UTSW 1 25,531,876 (GRCm38) missense probably damaging 1.00
R7325:Adgrb3 UTSW 1 25,532,630 (GRCm38) missense probably benign 0.01
R7378:Adgrb3 UTSW 1 25,531,919 (GRCm38) nonsense probably null
R7489:Adgrb3 UTSW 1 25,547,505 (GRCm38) missense probably damaging 1.00
R7615:Adgrb3 UTSW 1 25,098,897 (GRCm38) missense probably damaging 1.00
R7623:Adgrb3 UTSW 1 25,547,548 (GRCm38) missense probably damaging 1.00
R7787:Adgrb3 UTSW 1 25,432,544 (GRCm38) missense probably damaging 1.00
R7837:Adgrb3 UTSW 1 25,128,834 (GRCm38) missense probably damaging 1.00
R8064:Adgrb3 UTSW 1 25,420,556 (GRCm38) critical splice donor site probably null
R8152:Adgrb3 UTSW 1 25,221,757 (GRCm38) splice site probably null
R8161:Adgrb3 UTSW 1 25,093,922 (GRCm38) missense probably benign 0.03
R8225:Adgrb3 UTSW 1 25,826,516 (GRCm38) missense probably benign 0.00
R8417:Adgrb3 UTSW 1 25,488,053 (GRCm38) missense probably benign 0.21
R8694:Adgrb3 UTSW 1 25,826,391 (GRCm38) missense probably damaging 0.98
R8742:Adgrb3 UTSW 1 25,226,754 (GRCm38) missense probably benign 0.01
R8886:Adgrb3 UTSW 1 25,111,847 (GRCm38) missense probably damaging 1.00
R8941:Adgrb3 UTSW 1 25,094,154 (GRCm38) missense probably damaging 1.00
R8958:Adgrb3 UTSW 1 25,826,109 (GRCm38) missense possibly damaging 0.68
R8979:Adgrb3 UTSW 1 25,488,034 (GRCm38) missense probably benign 0.03
R9064:Adgrb3 UTSW 1 25,531,884 (GRCm38) missense possibly damaging 0.86
R9252:Adgrb3 UTSW 1 25,826,415 (GRCm38) missense probably benign 0.03
R9401:Adgrb3 UTSW 1 25,553,702 (GRCm38) missense probably damaging 1.00
R9739:Adgrb3 UTSW 1 25,553,768 (GRCm38) missense probably damaging 1.00
Z1088:Adgrb3 UTSW 1 25,131,271 (GRCm38) missense probably damaging 1.00
Z1176:Adgrb3 UTSW 1 25,093,914 (GRCm38) missense probably benign 0.37
Predicted Primers PCR Primer
(F):5'- TTACTCCTTGGACCAGGCTCACAC -3'
(R):5'- GTGATGGGCTGTAACCAAGCATTTG -3'

Sequencing Primer
(F):5'- TTCTGAGGTTCAACAGCAGC -3'
(R):5'- GCTGTAACCAAGCATTTGAAACTC -3'
Posted On 2014-04-24