Incidental Mutation 'R7164:Cfap206'
| ID |
557786 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cfap206
|
| Ensembl Gene |
ENSMUSG00000028294 |
| Gene Name |
cilia and flagella associated protein 206 |
| Synonyms |
1700003M02Rik |
| MMRRC Submission |
045331-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.307)
|
| Stock # |
R7164 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
34688559-34730206 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 34719656 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 253
(M253L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000103771
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029971]
[ENSMUST00000108136]
[ENSMUST00000137514]
[ENSMUST00000162495]
|
| AlphaFold |
Q6PE87 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000029971
AA Change: M253L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000029971
Gene: ENSMUSG00000028294
AA Change: M253L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3508
|
214 |
491 |
6.1e-108 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108136
AA Change: M253L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000103771
Gene: ENSMUSG00000028294
AA Change: M253L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3508
|
213 |
493 |
3.8e-127 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000137514
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162495
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
100% (59/59) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610037L13Rik |
C |
A |
4: 107,894,890 (GRCm38) |
D155E |
not run |
Het |
| 4932415D10Rik |
G |
A |
10: 82,286,229 (GRCm38) |
T3649I |
probably damaging |
Het |
| Actn2 |
G |
A |
13: 12,278,961 (GRCm38) |
H558Y |
probably damaging |
Het |
| Akap9 |
G |
C |
5: 4,060,364 (GRCm38) |
E3022D |
probably damaging |
Het |
| Anapc2 |
C |
T |
2: 25,284,999 (GRCm38) |
R710C |
probably damaging |
Het |
| Bcl6 |
G |
A |
16: 23,966,226 (GRCm38) |
R675* |
probably null |
Het |
| Carmil3 |
A |
G |
14: 55,501,282 (GRCm38) |
E844G |
probably damaging |
Het |
| Cdk17 |
T |
G |
10: 93,232,481 (GRCm38) |
S367A |
probably benign |
Het |
| Chd3 |
T |
G |
11: 69,362,306 (GRCm38) |
K228Q |
probably damaging |
Het |
| Cit |
T |
A |
5: 115,985,787 (GRCm38) |
I1503N |
possibly damaging |
Het |
| Csn1s1 |
A |
G |
5: 87,674,228 (GRCm38) |
N119S |
possibly damaging |
Het |
| Degs1 |
A |
G |
1: 182,279,125 (GRCm38) |
S226P |
probably damaging |
Het |
| Espl1 |
T |
C |
15: 102,313,203 (GRCm38) |
W976R |
probably damaging |
Het |
| Fbxl4 |
C |
T |
4: 22,386,218 (GRCm38) |
P275L |
probably benign |
Het |
| Flnb |
A |
G |
14: 7,915,944 (GRCm38) |
|
probably null |
Het |
| Gm996 |
T |
A |
2: 25,578,567 (GRCm38) |
H444L |
possibly damaging |
Het |
| Gnptab |
T |
A |
10: 88,434,070 (GRCm38) |
Y878* |
probably null |
Het |
| Gpr89 |
A |
T |
3: 96,871,398 (GRCm38) |
M453K |
probably benign |
Het |
| Igsf5 |
A |
T |
16: 96,372,848 (GRCm38) |
Q26L |
possibly damaging |
Het |
| Inpp5e |
T |
A |
2: 26,407,983 (GRCm38) |
D202V |
possibly damaging |
Het |
| Itga3 |
C |
T |
11: 95,052,479 (GRCm38) |
V931M |
possibly damaging |
Het |
| Kcnab3 |
T |
C |
11: 69,331,358 (GRCm38) |
|
probably null |
Het |
| Klk4 |
T |
C |
7: 43,881,698 (GRCm38) |
I17T |
possibly damaging |
Het |
| Lrrc73 |
T |
C |
17: 46,256,243 (GRCm38) |
L206P |
probably damaging |
Het |
| Manba |
A |
T |
3: 135,542,388 (GRCm38) |
N346I |
probably damaging |
Het |
| Map4k4 |
T |
C |
1: 39,973,972 (GRCm38) |
Y76H |
possibly damaging |
Het |
| Map4k5 |
T |
C |
12: 69,830,436 (GRCm38) |
T312A |
probably benign |
Het |
| Masp2 |
A |
G |
4: 148,610,115 (GRCm38) |
|
probably null |
Het |
| Mast1 |
T |
C |
8: 84,935,304 (GRCm38) |
D63G |
possibly damaging |
Het |
| Mtf2 |
T |
A |
5: 108,093,369 (GRCm38) |
S254T |
possibly damaging |
Het |
| Myo16 |
A |
T |
8: 10,569,585 (GRCm38) |
T1379S |
unknown |
Het |
| Myo5a |
A |
G |
9: 75,180,153 (GRCm38) |
E1097G |
probably benign |
Het |
| Nat1 |
T |
C |
8: 67,491,677 (GRCm38) |
V238A |
possibly damaging |
Het |
| Nhlrc2 |
A |
G |
19: 56,592,499 (GRCm38) |
D493G |
probably damaging |
Het |
| Olfr1165-ps |
T |
C |
2: 88,101,832 (GRCm38) |
K52E |
probably damaging |
Het |
| Olfr1331 |
C |
T |
4: 118,869,725 (GRCm38) |
P315S |
probably benign |
Het |
| Olfr1462 |
A |
T |
19: 13,190,906 (GRCm38) |
M80L |
probably benign |
Het |
| Olfr291 |
A |
G |
7: 84,857,043 (GRCm38) |
I227V |
possibly damaging |
Het |
| Olfr50 |
T |
C |
2: 36,793,697 (GRCm38) |
S154P |
probably benign |
Het |
| Olfr919 |
A |
G |
9: 38,698,219 (GRCm38) |
I49T |
possibly damaging |
Het |
| Pcsk5 |
C |
T |
19: 17,451,985 (GRCm38) |
C1543Y |
probably damaging |
Het |
| Pde4d |
A |
G |
13: 109,032,688 (GRCm38) |
D88G |
probably benign |
Het |
| Pld5 |
A |
T |
1: 176,213,621 (GRCm38) |
M1K |
probably null |
Het |
| Prmt6 |
A |
G |
3: 110,250,364 (GRCm38) |
M203T |
probably benign |
Het |
| Prr14l |
A |
T |
5: 32,829,166 (GRCm38) |
V995D |
probably damaging |
Het |
| Psg18 |
T |
C |
7: 18,350,937 (GRCm38) |
E199G |
possibly damaging |
Het |
| Pth1r |
A |
G |
9: 110,723,747 (GRCm38) |
I439T |
possibly damaging |
Het |
| Ptprc |
T |
A |
1: 138,117,862 (GRCm38) |
I87F |
probably benign |
Het |
| Slc44a1 |
T |
C |
4: 53,528,711 (GRCm38) |
S154P |
probably benign |
Het |
| Slco1c1 |
T |
A |
6: 141,542,129 (GRCm38) |
Y192* |
probably null |
Het |
| Spag16 |
A |
G |
1: 70,724,866 (GRCm38) |
H615R |
possibly damaging |
Het |
| Tas2r114 |
G |
A |
6: 131,689,765 (GRCm38) |
A100V |
possibly damaging |
Het |
| U2af1l4 |
T |
C |
7: 30,565,119 (GRCm38) |
S103P |
probably benign |
Het |
| Usp10 |
T |
C |
8: 119,942,108 (GRCm38) |
S383P |
probably damaging |
Het |
| Vmn2r113 |
A |
G |
17: 22,948,163 (GRCm38) |
R505G |
probably benign |
Het |
| Vmn2r75 |
A |
C |
7: 86,165,384 (GRCm38) |
D300E |
probably damaging |
Het |
| Zfp318 |
T |
A |
17: 46,397,306 (GRCm38) |
|
probably null |
Het |
| Zfp318 |
T |
C |
17: 46,405,939 (GRCm38) |
V999A |
probably damaging |
Het |
| Zfp324 |
A |
T |
7: 12,968,883 (GRCm38) |
H58L |
probably damaging |
Het |
| Zfp707 |
A |
G |
15: 75,975,118 (GRCm38) |
E339G |
possibly damaging |
Het |
|
| Other mutations in Cfap206 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00797:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00798:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00826:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00919:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01062:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01064:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01069:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01070:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01086:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01087:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01090:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01098:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01111:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01133:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01135:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01147:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01152:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01153:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01154:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01155:Cfap206
|
APN |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01289:Cfap206
|
APN |
4 |
34,716,469 (GRCm38) |
missense |
probably null |
0.98 |
|
IGL01845:Cfap206
|
APN |
4 |
34,719,610 (GRCm38) |
missense |
possibly damaging |
0.57 |
|
IGL02115:Cfap206
|
APN |
4 |
34,722,623 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
IGL03241:Cfap206
|
APN |
4 |
34,711,553 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03405:Cfap206
|
APN |
4 |
34,716,445 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
ANU05:Cfap206
|
UTSW |
4 |
34,721,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB001:Cfap206
|
UTSW |
4 |
34,728,833 (GRCm38) |
missense |
probably benign |
0.10 |
|
BB011:Cfap206
|
UTSW |
4 |
34,728,833 (GRCm38) |
missense |
probably benign |
0.10 |
|
R0012:Cfap206
|
UTSW |
4 |
34,714,519 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R0689:Cfap206
|
UTSW |
4 |
34,722,668 (GRCm38) |
missense |
probably benign |
0.23 |
|
R0730:Cfap206
|
UTSW |
4 |
34,711,391 (GRCm38) |
missense |
probably benign |
|
|
R1567:Cfap206
|
UTSW |
4 |
34,716,490 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1694:Cfap206
|
UTSW |
4 |
34,719,058 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1706:Cfap206
|
UTSW |
4 |
34,688,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1837:Cfap206
|
UTSW |
4 |
34,728,813 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1909:Cfap206
|
UTSW |
4 |
34,722,714 (GRCm38) |
missense |
probably benign |
|
|
R2098:Cfap206
|
UTSW |
4 |
34,719,053 (GRCm38) |
nonsense |
probably null |
|
|
R2568:Cfap206
|
UTSW |
4 |
34,711,566 (GRCm38) |
nonsense |
probably null |
|
|
R3125:Cfap206
|
UTSW |
4 |
34,716,310 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R3784:Cfap206
|
UTSW |
4 |
34,716,445 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5249:Cfap206
|
UTSW |
4 |
34,714,502 (GRCm38) |
missense |
probably benign |
|
|
R5483:Cfap206
|
UTSW |
4 |
34,711,404 (GRCm38) |
missense |
probably benign |
0.39 |
|
R5569:Cfap206
|
UTSW |
4 |
34,724,892 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6247:Cfap206
|
UTSW |
4 |
34,692,530 (GRCm38) |
missense |
probably benign |
|
|
R6555:Cfap206
|
UTSW |
4 |
34,719,049 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6791:Cfap206
|
UTSW |
4 |
34,711,414 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R6865:Cfap206
|
UTSW |
4 |
34,714,448 (GRCm38) |
missense |
possibly damaging |
0.57 |
|
R7814:Cfap206
|
UTSW |
4 |
34,716,347 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7924:Cfap206
|
UTSW |
4 |
34,728,833 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8092:Cfap206
|
UTSW |
4 |
34,728,897 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R8240:Cfap206
|
UTSW |
4 |
34,728,902 (GRCm38) |
start codon destroyed |
probably null |
1.00 |
|
R8323:Cfap206
|
UTSW |
4 |
34,719,647 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8969:Cfap206
|
UTSW |
4 |
34,692,522 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9144:Cfap206
|
UTSW |
4 |
34,722,667 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R9336:Cfap206
|
UTSW |
4 |
34,716,494 (GRCm38) |
missense |
probably benign |
|
|
Z1176:Cfap206
|
UTSW |
4 |
34,719,661 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAACTTCCTGAGGTTGCCAC -3'
(R):5'- TGGGGCTACAAAAGACATTCC -3'
Sequencing Primer
(F):5'- GTTGCCACCTTTGGGAGTCAC -3'
(R):5'- AGACTCCCAGCTTCAGAT -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation