Incidental Mutation 'R9287:Rims2'
| ID |
704055 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rims2
|
| Ensembl Gene |
ENSMUSG00000037386 |
| Gene Name |
regulating synaptic membrane exocytosis 2 |
| Synonyms |
RIM2, 2810036I15Rik, Syt3-rs |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.661)
|
| Stock # |
R9287 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
39061681-39547768 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 39543086 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 1440
(A1440V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000048719
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042917]
[ENSMUST00000082054]
[ENSMUST00000226410]
[ENSMUST00000227243]
|
| AlphaFold |
Q9EQZ7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000042917
AA Change: A1440V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000048719
Gene: ENSMUSG00000037386
AA Change: A1440V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
30 |
154 |
9.5e-18 |
PFAM |
|
low complexity region
|
315 |
335 |
N/A |
INTRINSIC |
|
low complexity region
|
492 |
498 |
N/A |
INTRINSIC |
|
low complexity region
|
511 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
527 |
540 |
N/A |
INTRINSIC |
|
PDZ
|
646 |
725 |
8.27e-16 |
SMART |
|
low complexity region
|
740 |
748 |
N/A |
INTRINSIC |
|
C2
|
790 |
897 |
4.08e-21 |
SMART |
|
low complexity region
|
905 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1101 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1130 |
N/A |
INTRINSIC |
|
low complexity region
|
1208 |
1238 |
N/A |
INTRINSIC |
|
C2
|
1432 |
1535 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082054
AA Change: A1398V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000080711
Gene: ENSMUSG00000037386
AA Change: A1398V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
76 |
194 |
2.2e-11 |
PFAM |
|
low complexity region
|
355 |
375 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
538 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
561 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
580 |
N/A |
INTRINSIC |
|
PDZ
|
686 |
765 |
8.27e-16 |
SMART |
|
low complexity region
|
780 |
788 |
N/A |
INTRINSIC |
|
C2
|
830 |
937 |
4.08e-21 |
SMART |
|
low complexity region
|
945 |
959 |
N/A |
INTRINSIC |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1166 |
1196 |
N/A |
INTRINSIC |
|
C2
|
1390 |
1493 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000226410
AA Change: A153V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000227243
AA Change: A1418V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
|
| Meta Mutation Damage Score |
0.1754 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (109/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
PHENOTYPE: Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9430097D07Rik |
T |
A |
2: 32,465,178 (GRCm39) |
|
probably benign |
Het |
| Aadacl2 |
C |
A |
3: 59,932,573 (GRCm39) |
H363N |
probably damaging |
Het |
| Ace3 |
T |
G |
11: 105,888,246 (GRCm39) |
S319A |
probably damaging |
Het |
| Amer3 |
C |
T |
1: 34,627,900 (GRCm39) |
P713L |
possibly damaging |
Het |
| Aoah |
T |
C |
13: 21,186,879 (GRCm39) |
L453P |
probably damaging |
Het |
| Asz1 |
A |
T |
6: 18,051,290 (GRCm39) |
L463Q |
possibly damaging |
Het |
| Bpifb6 |
T |
A |
2: 153,746,535 (GRCm39) |
V143D |
probably damaging |
Het |
| Cad |
T |
A |
5: 31,230,000 (GRCm39) |
M1499K |
possibly damaging |
Het |
| Casp9 |
T |
A |
4: 141,534,471 (GRCm39) |
C294S |
probably benign |
Het |
| Ccdc7b |
T |
A |
8: 129,890,321 (GRCm39) |
S65T |
probably benign |
Het |
| Cdh23 |
G |
A |
10: 60,143,306 (GRCm39) |
A3005V |
possibly damaging |
Het |
| Cfap54 |
T |
C |
10: 92,805,565 (GRCm39) |
Y1515C |
possibly damaging |
Het |
| Chrm5 |
A |
C |
2: 112,309,610 (GRCm39) |
F502C |
probably damaging |
Het |
| Cnst |
A |
T |
1: 179,407,108 (GRCm39) |
T52S |
possibly damaging |
Het |
| Cntn6 |
T |
C |
6: 104,809,471 (GRCm39) |
I502T |
possibly damaging |
Het |
| Col7a1 |
G |
A |
9: 108,787,457 (GRCm39) |
V617M |
unknown |
Het |
| Ctsb |
A |
G |
14: 63,370,875 (GRCm39) |
D29G |
probably benign |
Het |
| Cyp3a44 |
T |
A |
5: 145,725,202 (GRCm39) |
Q333L |
possibly damaging |
Het |
| Dnajc27 |
T |
C |
12: 4,146,256 (GRCm39) |
V95A |
possibly damaging |
Het |
| Eea1 |
T |
A |
10: 95,831,445 (GRCm39) |
Y179N |
probably damaging |
Het |
| Erbb2 |
T |
C |
11: 98,326,107 (GRCm39) |
M961T |
probably damaging |
Het |
| Fat4 |
G |
A |
3: 38,945,781 (GRCm39) |
G1558D |
probably damaging |
Het |
| Foxh1 |
T |
C |
15: 76,553,126 (GRCm39) |
E196G |
probably damaging |
Het |
| Gcc2 |
T |
A |
10: 58,105,217 (GRCm39) |
L151* |
probably null |
Het |
| Gcdh |
C |
T |
8: 85,616,313 (GRCm39) |
G294D |
probably damaging |
Het |
| Gcnt3 |
A |
T |
9: 69,941,693 (GRCm39) |
F292I |
probably damaging |
Het |
| Glod4 |
T |
C |
11: 76,128,510 (GRCm39) |
S131G |
probably benign |
Het |
| Gpc2 |
G |
A |
5: 138,272,586 (GRCm39) |
L576F |
unknown |
Het |
| Gphn |
G |
A |
12: 78,609,646 (GRCm39) |
S330N |
possibly damaging |
Het |
| Heatr5a |
C |
T |
12: 51,967,260 (GRCm39) |
C872Y |
probably damaging |
Het |
| Hephl1 |
G |
A |
9: 14,995,775 (GRCm39) |
S449L |
probably benign |
Het |
| Hrh2 |
G |
T |
13: 54,368,358 (GRCm39) |
M111I |
probably benign |
Het |
| Igfn1 |
A |
G |
1: 135,925,544 (GRCm39) |
V70A |
probably benign |
Het |
| Il2 |
G |
A |
3: 37,179,988 (GRCm39) |
T23I |
probably damaging |
Het |
| Irak4 |
A |
G |
15: 94,460,917 (GRCm39) |
T382A |
possibly damaging |
Het |
| Itih2 |
A |
G |
2: 10,128,297 (GRCm39) |
S135P |
possibly damaging |
Het |
| Kansl3 |
C |
T |
1: 36,388,497 (GRCm39) |
D457N |
probably damaging |
Het |
| Kcns3 |
A |
G |
12: 11,141,601 (GRCm39) |
I366T |
probably damaging |
Het |
| Kif26a |
C |
A |
12: 112,145,719 (GRCm39) |
Y1743* |
probably null |
Het |
| Lama4 |
A |
T |
10: 38,981,960 (GRCm39) |
I1730F |
probably damaging |
Het |
| Lax1 |
T |
C |
1: 133,607,931 (GRCm39) |
N270S |
probably benign |
Het |
| Lrp1 |
G |
T |
10: 127,403,233 (GRCm39) |
D2113E |
probably damaging |
Het |
| Lrp6 |
A |
G |
6: 134,483,259 (GRCm39) |
V482A |
probably benign |
Het |
| Luzp2 |
A |
G |
7: 54,914,108 (GRCm39) |
|
probably benign |
Het |
| Mc5r |
C |
A |
18: 68,472,200 (GRCm39) |
D186E |
probably damaging |
Het |
| Mcph1 |
A |
T |
8: 18,657,293 (GRCm39) |
|
probably null |
Het |
| Mgam |
A |
G |
6: 40,705,905 (GRCm39) |
|
probably benign |
Het |
| Mmrn1 |
A |
C |
6: 60,952,939 (GRCm39) |
T407P |
probably damaging |
Het |
| Mrpl1 |
T |
C |
5: 96,386,806 (GRCm39) |
V265A |
probably benign |
Het |
| Mrpl15 |
C |
T |
1: 4,846,856 (GRCm39) |
G240D |
probably damaging |
Het |
| Msx1 |
A |
T |
5: 37,978,795 (GRCm39) |
M240K |
probably damaging |
Het |
| Mtf1 |
T |
C |
4: 124,724,934 (GRCm39) |
L337P |
probably damaging |
Het |
| Muc5ac |
T |
A |
7: 141,361,626 (GRCm39) |
C1646S |
probably damaging |
Het |
| Mvb12a |
C |
A |
8: 71,999,638 (GRCm39) |
T219N |
probably damaging |
Het |
| Myo16 |
G |
A |
8: 10,526,114 (GRCm39) |
V885M |
unknown |
Het |
| N4bp2 |
T |
A |
5: 65,960,855 (GRCm39) |
S509T |
probably benign |
Het |
| Nckap1 |
A |
G |
2: 80,383,750 (GRCm39) |
V144A |
possibly damaging |
Het |
| Nkx2-6 |
G |
T |
14: 69,412,404 (GRCm39) |
G191C |
possibly damaging |
Het |
| Nmnat2 |
T |
C |
1: 152,962,138 (GRCm39) |
I126T |
probably damaging |
Het |
| Nrp2 |
C |
T |
1: 62,835,014 (GRCm39) |
R863W |
probably damaging |
Het |
| Nup188 |
C |
T |
2: 30,226,726 (GRCm39) |
R1168C |
probably damaging |
Het |
| Oas3 |
T |
A |
5: 120,892,754 (GRCm39) |
D1091V |
probably damaging |
Het |
| Optn |
T |
A |
2: 5,036,126 (GRCm39) |
Q452L |
probably damaging |
Het |
| Or8b47 |
C |
T |
9: 38,435,082 (GRCm39) |
T18I |
probably damaging |
Het |
| Pcca |
G |
A |
14: 122,854,178 (GRCm39) |
V157I |
probably benign |
Het |
| Pcdha9 |
A |
G |
18: 37,132,281 (GRCm39) |
D450G |
probably benign |
Het |
| Pcnx1 |
T |
A |
12: 82,042,323 (GRCm39) |
S38T |
probably benign |
Het |
| Phrf1 |
C |
G |
7: 140,840,055 (GRCm39) |
D1083E |
probably benign |
Het |
| Plaat5 |
T |
A |
19: 7,596,691 (GRCm39) |
Y159* |
probably null |
Het |
| Plcb4 |
G |
A |
2: 135,829,817 (GRCm39) |
A947T |
probably benign |
Het |
| Ppp1r3g |
G |
A |
13: 36,152,834 (GRCm39) |
D85N |
possibly damaging |
Het |
| Pramel34 |
G |
A |
5: 93,785,969 (GRCm39) |
H104Y |
possibly damaging |
Het |
| Prom2 |
A |
C |
2: 127,380,185 (GRCm39) |
V349G |
probably damaging |
Het |
| Prrc2c |
C |
T |
1: 162,541,843 (GRCm39) |
S382N |
probably benign |
Het |
| Rai14 |
A |
T |
15: 10,592,204 (GRCm39) |
N230K |
probably benign |
Het |
| Rexo5 |
A |
T |
7: 119,402,025 (GRCm39) |
K142I |
probably damaging |
Het |
| Rgs22 |
T |
C |
15: 36,098,409 (GRCm39) |
H484R |
probably damaging |
Het |
| Serpinb1a |
T |
C |
13: 33,026,946 (GRCm39) |
E332G |
probably damaging |
Het |
| Sh2b1 |
TGGGGACCAGCTCAGCCACGGGGACCAGCTC |
TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC |
7: 126,066,742 (GRCm39) |
|
probably benign |
Het |
| Slc26a7 |
C |
T |
4: 14,516,165 (GRCm39) |
G555S |
possibly damaging |
Het |
| Slc4a2 |
A |
T |
5: 24,639,123 (GRCm39) |
D386V |
probably damaging |
Het |
| Slc6a17 |
C |
T |
3: 107,384,551 (GRCm39) |
V350M |
probably damaging |
Het |
| Smc2 |
A |
G |
4: 52,449,361 (GRCm39) |
Y174C |
probably damaging |
Het |
| Smoc2 |
A |
G |
17: 14,619,686 (GRCm39) |
Y355C |
probably damaging |
Het |
| Smpd1 |
T |
A |
7: 105,204,442 (GRCm39) |
V107E |
probably benign |
Het |
| Snapc1 |
T |
C |
12: 74,018,773 (GRCm39) |
|
probably benign |
Het |
| Spata31e2 |
T |
C |
1: 26,722,426 (GRCm39) |
D918G |
possibly damaging |
Het |
| Steap4 |
T |
G |
5: 8,026,683 (GRCm39) |
F215L |
probably benign |
Het |
| Tbc1d1 |
T |
A |
5: 64,435,364 (GRCm39) |
S501T |
probably damaging |
Het |
| Tec |
A |
G |
5: 72,926,117 (GRCm39) |
Y312H |
probably damaging |
Het |
| Ticrr |
C |
A |
7: 79,343,516 (GRCm39) |
T1127K |
possibly damaging |
Het |
| Tlk2 |
A |
G |
11: 105,147,722 (GRCm39) |
D438G |
probably benign |
Het |
| Tln2 |
C |
A |
9: 67,277,980 (GRCm39) |
V343L |
probably benign |
Het |
| Tmem156 |
T |
A |
5: 65,231,148 (GRCm39) |
I241F |
probably damaging |
Het |
| Tmtc1 |
G |
T |
6: 148,186,390 (GRCm39) |
N559K |
probably benign |
Het |
| Trbv4 |
A |
T |
6: 41,036,696 (GRCm39) |
I74F |
probably benign |
Het |
| Trmt1l |
C |
T |
1: 151,328,899 (GRCm39) |
P524S |
probably damaging |
Het |
| Trpa1 |
A |
T |
1: 14,956,040 (GRCm39) |
C776* |
probably null |
Het |
| Ttc41 |
T |
A |
10: 86,599,830 (GRCm39) |
S1043R |
probably benign |
Het |
| Ttn |
A |
G |
2: 76,576,646 (GRCm39) |
L24749S |
probably damaging |
Het |
| Ube2o |
C |
T |
11: 116,471,942 (GRCm39) |
G100R |
probably damaging |
Het |
| Unc5b |
T |
C |
10: 60,609,532 (GRCm39) |
E588G |
possibly damaging |
Het |
| Usp43 |
G |
T |
11: 67,770,922 (GRCm39) |
Q571K |
probably damaging |
Het |
| Vmn1r127 |
G |
A |
7: 21,052,927 (GRCm39) |
P287L |
possibly damaging |
Het |
| Wasf3 |
T |
A |
5: 146,397,857 (GRCm39) |
M208K |
possibly damaging |
Het |
| Xab2 |
A |
G |
8: 3,663,000 (GRCm39) |
F527S |
possibly damaging |
Het |
| Zfp644 |
T |
G |
5: 106,785,774 (GRCm39) |
N258H |
possibly damaging |
Het |
| Zfp947 |
A |
C |
17: 22,364,594 (GRCm39) |
F360C |
probably damaging |
Het |
|
| Other mutations in Rims2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:Rims2
|
APN |
15 |
39,323,011 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL00502:Rims2
|
APN |
15 |
39,370,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00556:Rims2
|
APN |
15 |
39,320,070 (GRCm39) |
splice site |
probably null |
|
|
IGL00811:Rims2
|
APN |
15 |
39,155,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00827:Rims2
|
APN |
15 |
39,335,755 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Rims2
|
APN |
15 |
39,321,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02951:Rims2
|
APN |
15 |
39,398,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03009:Rims2
|
APN |
15 |
39,430,393 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03080:Rims2
|
APN |
15 |
39,399,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Rims2
|
APN |
15 |
39,322,989 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03252:Rims2
|
APN |
15 |
39,315,748 (GRCm39) |
missense |
probably benign |
|
|
IGL03365:Rims2
|
APN |
15 |
39,339,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03393:Rims2
|
APN |
15 |
39,326,009 (GRCm39) |
splice site |
probably null |
|
|
IGL03409:Rims2
|
APN |
15 |
39,320,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
rhyme
|
UTSW |
15 |
39,315,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4486001:Rims2
|
UTSW |
15 |
39,339,916 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0009:Rims2
|
UTSW |
15 |
39,398,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0009:Rims2
|
UTSW |
15 |
39,398,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0078:Rims2
|
UTSW |
15 |
39,398,251 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0367:Rims2
|
UTSW |
15 |
39,326,011 (GRCm39) |
splice site |
probably null |
|
|
R0401:Rims2
|
UTSW |
15 |
39,373,028 (GRCm39) |
splice site |
probably benign |
|
|
R0531:Rims2
|
UTSW |
15 |
39,430,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0791:Rims2
|
UTSW |
15 |
39,543,021 (GRCm39) |
splice site |
probably benign |
|
|
R0838:Rims2
|
UTSW |
15 |
39,544,421 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1201:Rims2
|
UTSW |
15 |
39,479,720 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1318:Rims2
|
UTSW |
15 |
39,381,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1457:Rims2
|
UTSW |
15 |
39,374,710 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1619:Rims2
|
UTSW |
15 |
39,370,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1672:Rims2
|
UTSW |
15 |
39,155,584 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1743:Rims2
|
UTSW |
15 |
39,543,046 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1766:Rims2
|
UTSW |
15 |
39,325,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1779:Rims2
|
UTSW |
15 |
39,545,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Rims2
|
UTSW |
15 |
39,300,439 (GRCm39) |
nonsense |
probably null |
|
|
R1985:Rims2
|
UTSW |
15 |
39,208,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1986:Rims2
|
UTSW |
15 |
39,208,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2113:Rims2
|
UTSW |
15 |
39,374,722 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2260:Rims2
|
UTSW |
15 |
39,341,962 (GRCm39) |
nonsense |
probably null |
|
|
R2510:Rims2
|
UTSW |
15 |
39,449,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3693:Rims2
|
UTSW |
15 |
39,341,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3937:Rims2
|
UTSW |
15 |
39,301,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4425:Rims2
|
UTSW |
15 |
39,301,320 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4453:Rims2
|
UTSW |
15 |
39,155,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4474:Rims2
|
UTSW |
15 |
39,325,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4518:Rims2
|
UTSW |
15 |
39,300,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4526:Rims2
|
UTSW |
15 |
39,301,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4833:Rims2
|
UTSW |
15 |
39,399,310 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4936:Rims2
|
UTSW |
15 |
39,301,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Rims2
|
UTSW |
15 |
39,317,841 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5001:Rims2
|
UTSW |
15 |
39,315,824 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5054:Rims2
|
UTSW |
15 |
39,381,265 (GRCm39) |
splice site |
probably null |
|
|
R5072:Rims2
|
UTSW |
15 |
39,325,986 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5171:Rims2
|
UTSW |
15 |
39,300,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5429:Rims2
|
UTSW |
15 |
39,208,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5623:Rims2
|
UTSW |
15 |
39,342,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Rims2
|
UTSW |
15 |
39,208,809 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5685:Rims2
|
UTSW |
15 |
39,300,602 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5784:Rims2
|
UTSW |
15 |
39,399,383 (GRCm39) |
splice site |
probably null |
|
|
R5790:Rims2
|
UTSW |
15 |
39,544,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5822:Rims2
|
UTSW |
15 |
39,339,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5963:Rims2
|
UTSW |
15 |
39,300,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5988:Rims2
|
UTSW |
15 |
39,155,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Rims2
|
UTSW |
15 |
39,538,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6239:Rims2
|
UTSW |
15 |
39,061,758 (GRCm39) |
start codon destroyed |
unknown |
|
|
R6407:Rims2
|
UTSW |
15 |
39,315,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6418:Rims2
|
UTSW |
15 |
39,373,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6495:Rims2
|
UTSW |
15 |
39,381,208 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6502:Rims2
|
UTSW |
15 |
39,398,251 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6753:Rims2
|
UTSW |
15 |
39,430,369 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6855:Rims2
|
UTSW |
15 |
39,208,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6948:Rims2
|
UTSW |
15 |
39,374,737 (GRCm39) |
missense |
probably benign |
|
|
R7058:Rims2
|
UTSW |
15 |
39,449,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Rims2
|
UTSW |
15 |
39,300,473 (GRCm39) |
missense |
probably benign |
|
|
R7217:Rims2
|
UTSW |
15 |
39,339,885 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7223:Rims2
|
UTSW |
15 |
39,300,428 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7289:Rims2
|
UTSW |
15 |
39,301,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7459:Rims2
|
UTSW |
15 |
39,381,235 (GRCm39) |
missense |
probably benign |
|
|
R7663:Rims2
|
UTSW |
15 |
39,370,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7792:Rims2
|
UTSW |
15 |
39,061,923 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7836:Rims2
|
UTSW |
15 |
39,544,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8082:Rims2
|
UTSW |
15 |
39,339,919 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8489:Rims2
|
UTSW |
15 |
39,479,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8730:Rims2
|
UTSW |
15 |
39,381,239 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8830:Rims2
|
UTSW |
15 |
39,300,758 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8857:Rims2
|
UTSW |
15 |
39,543,044 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8893:Rims2
|
UTSW |
15 |
39,398,350 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9010:Rims2
|
UTSW |
15 |
39,315,786 (GRCm39) |
nonsense |
probably null |
|
|
R9030:Rims2
|
UTSW |
15 |
39,339,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9395:Rims2
|
UTSW |
15 |
39,155,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9451:Rims2
|
UTSW |
15 |
39,300,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9506:Rims2
|
UTSW |
15 |
39,335,832 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0034:Rims2
|
UTSW |
15 |
39,300,930 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,544,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Rims2
|
UTSW |
15 |
39,342,086 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,301,165 (GRCm39) |
missense |
probably benign |
0.24 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGTCACATTCCCTCAATTTCATGC -3'
(R):5'- ACAGCTCCCTCAGAATGCTG -3'
Sequencing Primer
(F):5'- TGCTACTTTTAACAAGATTACCAGC -3'
(R):5'- TCCCTCAGAATGCTGGCAGAC -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation