Incidental Mutation 'R6753:Rims2'
| ID |
530922 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rims2
|
| Ensembl Gene |
ENSMUSG00000037386 |
| Gene Name |
regulating synaptic membrane exocytosis 2 |
| Synonyms |
2810036I15Rik, Syt3-rs, RIM2 |
| MMRRC Submission |
044870-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.518)
|
| Stock # |
R6753 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
39198261-39684372 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 39566973 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Arginine
at position 871
(Q871R)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042917]
[ENSMUST00000082054]
[ENSMUST00000227243]
|
| AlphaFold |
Q9EQZ7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000042917
AA Change: Q1173R
PolyPhen 2
Score 0.237 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000048719
Gene: ENSMUSG00000037386
AA Change: Q1173R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
30 |
154 |
9.5e-18 |
PFAM |
|
low complexity region
|
315 |
335 |
N/A |
INTRINSIC |
|
low complexity region
|
492 |
498 |
N/A |
INTRINSIC |
|
low complexity region
|
511 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
527 |
540 |
N/A |
INTRINSIC |
|
PDZ
|
646 |
725 |
8.27e-16 |
SMART |
|
low complexity region
|
740 |
748 |
N/A |
INTRINSIC |
|
C2
|
790 |
897 |
4.08e-21 |
SMART |
|
low complexity region
|
905 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1101 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1130 |
N/A |
INTRINSIC |
|
low complexity region
|
1208 |
1238 |
N/A |
INTRINSIC |
|
C2
|
1432 |
1535 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000082054
AA Change: Q1131R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000080711
Gene: ENSMUSG00000037386
AA Change: Q1131R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
76 |
194 |
2.2e-11 |
PFAM |
|
low complexity region
|
355 |
375 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
538 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
561 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
580 |
N/A |
INTRINSIC |
|
PDZ
|
686 |
765 |
8.27e-16 |
SMART |
|
low complexity region
|
780 |
788 |
N/A |
INTRINSIC |
|
C2
|
830 |
937 |
4.08e-21 |
SMART |
|
low complexity region
|
945 |
959 |
N/A |
INTRINSIC |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1166 |
1196 |
N/A |
INTRINSIC |
|
C2
|
1390 |
1493 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227243
AA Change: Q1151R
PolyPhen 2
Score 0.232 (Sensitivity: 0.91; Specificity: 0.88)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227381
AA Change: Q871R
PolyPhen 2
Score 0.736 (Sensitivity: 0.85; Specificity: 0.92)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.3%
- 20x: 95.1%
|
| Validation Efficiency |
99% (68/69) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
PHENOTYPE: Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatk |
G |
A |
11: 120,010,151 (GRCm38) |
P1083S |
probably benign |
Het |
| Abcb5 |
T |
A |
12: 118,944,906 (GRCm38) |
N101I |
possibly damaging |
Het |
| Adrb2 |
A |
G |
18: 62,179,553 (GRCm38) |
V67A |
possibly damaging |
Het |
| Agk |
T |
A |
6: 40,368,570 (GRCm38) |
|
probably null |
Het |
| Akap10 |
A |
T |
11: 61,886,777 (GRCm38) |
M586K |
probably damaging |
Het |
| Akt3 |
A |
T |
1: 177,050,190 (GRCm38) |
Y337* |
probably null |
Het |
| Armc1 |
A |
G |
3: 19,144,398 (GRCm38) |
F133L |
possibly damaging |
Het |
| Bank1 |
T |
C |
3: 136,093,308 (GRCm38) |
E424G |
probably damaging |
Het |
| Cacna1a |
A |
G |
8: 84,580,205 (GRCm38) |
E1363G |
probably damaging |
Het |
| Cacna1d |
C |
A |
14: 30,042,786 (GRCm38) |
A2076S |
probably damaging |
Het |
| Ccdc73 |
T |
A |
2: 104,991,524 (GRCm38) |
L606* |
probably null |
Het |
| Ccdc8 |
C |
T |
7: 16,996,637 (GRCm38) |
Q684* |
probably null |
Het |
| Ces1b |
T |
A |
8: 93,067,020 (GRCm38) |
K314* |
probably null |
Het |
| Ces1e |
T |
A |
8: 93,215,128 (GRCm38) |
N238I |
probably damaging |
Het |
| Chd4 |
A |
G |
6: 125,114,300 (GRCm38) |
N1238S |
probably benign |
Het |
| Cmtr2 |
T |
A |
8: 110,222,979 (GRCm38) |
D640E |
probably damaging |
Het |
| Col7a1 |
C |
T |
9: 108,958,128 (GRCm38) |
T559I |
unknown |
Het |
| Comt |
T |
C |
16: 18,408,021 (GRCm38) |
K205R |
probably benign |
Het |
| Dbp |
A |
T |
7: 45,708,404 (GRCm38) |
E232V |
probably damaging |
Het |
| Dcbld2 |
A |
G |
16: 58,456,130 (GRCm38) |
T470A |
possibly damaging |
Het |
| Eml6 |
T |
A |
11: 29,754,987 (GRCm38) |
D1519V |
probably damaging |
Het |
| Evpl |
T |
A |
11: 116,237,906 (GRCm38) |
H31L |
possibly damaging |
Het |
| Exoc1 |
T |
A |
5: 76,563,339 (GRCm38) |
I86N |
probably damaging |
Het |
| Fat3 |
C |
T |
9: 15,915,061 (GRCm38) |
E4532K |
possibly damaging |
Het |
| Fgfr3 |
T |
C |
5: 33,732,159 (GRCm38) |
S301P |
probably benign |
Het |
| Gas2l1 |
C |
T |
11: 5,064,254 (GRCm38) |
V69I |
probably damaging |
Het |
| Gm2042 |
T |
A |
12: 87,958,084 (GRCm38) |
I107K |
probably damaging |
Het |
| Gucy1b1 |
T |
C |
3: 82,039,747 (GRCm38) |
D385G |
probably null |
Het |
| Ints1 |
T |
A |
5: 139,765,175 (GRCm38) |
E824D |
probably damaging |
Het |
| Itfg1 |
T |
C |
8: 85,835,078 (GRCm38) |
D142G |
probably benign |
Het |
| Jaml |
A |
G |
9: 45,107,379 (GRCm38) |
N359D |
probably benign |
Het |
| Kcnh7 |
T |
A |
2: 62,850,377 (GRCm38) |
I289L |
probably benign |
Het |
| Klf12 |
G |
A |
14: 100,109,776 (GRCm38) |
Q40* |
probably null |
Het |
| Mcm4 |
A |
C |
16: 15,629,362 (GRCm38) |
N579K |
possibly damaging |
Het |
| Mfsd2b |
A |
T |
12: 4,867,358 (GRCm38) |
F179I |
possibly damaging |
Het |
| Mmp11 |
C |
T |
10: 75,928,374 (GRCm38) |
V86M |
probably damaging |
Het |
| Mogs |
T |
C |
6: 83,115,882 (GRCm38) |
V101A |
probably damaging |
Het |
| Narf |
T |
A |
11: 121,242,626 (GRCm38) |
H84Q |
probably benign |
Het |
| Olfr987 |
C |
A |
2: 85,331,798 (GRCm38) |
M33I |
probably benign |
Het |
| Otog |
A |
C |
7: 46,249,071 (GRCm38) |
E204D |
probably benign |
Het |
| Parp8 |
G |
A |
13: 116,895,115 (GRCm38) |
H354Y |
possibly damaging |
Het |
| Pcnx |
C |
A |
12: 81,964,480 (GRCm38) |
D1238E |
probably damaging |
Het |
| Pi4ka |
A |
G |
16: 17,376,982 (GRCm38) |
L184P |
possibly damaging |
Het |
| Pkd1l3 |
C |
T |
8: 109,624,449 (GRCm38) |
T642I |
probably damaging |
Het |
| Pkhd1l1 |
G |
A |
15: 44,589,663 (GRCm38) |
E3995K |
probably benign |
Het |
| Prdm9 |
A |
T |
17: 15,544,956 (GRCm38) |
Y521N |
probably benign |
Het |
| Prex2 |
A |
G |
1: 11,184,456 (GRCm38) |
S1105G |
probably damaging |
Het |
| Prss35 |
T |
A |
9: 86,756,100 (GRCm38) |
F308I |
probably damaging |
Het |
| Rab22a |
C |
T |
2: 173,701,055 (GRCm38) |
A167V |
probably benign |
Het |
| Rorb |
A |
T |
19: 18,957,247 (GRCm38) |
M253K |
probably benign |
Het |
| Ryr3 |
T |
C |
2: 112,652,610 (GRCm38) |
D4269G |
probably damaging |
Het |
| Snx11 |
T |
C |
11: 96,769,906 (GRCm38) |
|
probably benign |
Het |
| Son |
A |
G |
16: 91,657,188 (GRCm38) |
Q941R |
probably damaging |
Het |
| Sptbn2 |
G |
T |
19: 4,747,785 (GRCm38) |
R1880L |
probably benign |
Het |
| Sun1 |
G |
A |
5: 139,215,259 (GRCm38) |
|
probably null |
Het |
| Tprn |
A |
G |
2: 25,264,038 (GRCm38) |
R451G |
probably benign |
Het |
| Trbv30 |
T |
A |
6: 41,281,377 (GRCm38) |
M1K |
probably null |
Het |
| Ttn |
C |
A |
2: 76,738,221 (GRCm38) |
G25697W |
probably damaging |
Het |
| Ubb |
T |
G |
11: 62,551,527 (GRCm38) |
|
probably null |
Het |
| Unc13b |
C |
T |
4: 43,239,331 (GRCm38) |
R1038C |
probably damaging |
Het |
| Usp7 |
T |
C |
16: 8,696,911 (GRCm38) |
M687V |
probably benign |
Het |
| Zfp160 |
G |
A |
17: 21,020,734 (GRCm38) |
M21I |
probably benign |
Het |
| Zfp868 |
T |
C |
8: 69,612,096 (GRCm38) |
N196S |
probably benign |
Het |
| Zufsp |
A |
T |
10: 33,928,029 (GRCm38) |
I483N |
probably damaging |
Het |
|
| Other mutations in Rims2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:Rims2
|
APN |
15 |
39,459,615 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL00502:Rims2
|
APN |
15 |
39,506,984 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00556:Rims2
|
APN |
15 |
39,456,674 (GRCm38) |
splice site |
probably null |
|
|
IGL00811:Rims2
|
APN |
15 |
39,292,149 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00827:Rims2
|
APN |
15 |
39,472,359 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01642:Rims2
|
APN |
15 |
39,457,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02951:Rims2
|
APN |
15 |
39,534,938 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03009:Rims2
|
APN |
15 |
39,566,997 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
IGL03080:Rims2
|
APN |
15 |
39,535,903 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03102:Rims2
|
APN |
15 |
39,459,593 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL03252:Rims2
|
APN |
15 |
39,452,352 (GRCm38) |
missense |
probably benign |
|
|
IGL03365:Rims2
|
APN |
15 |
39,476,541 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03393:Rims2
|
APN |
15 |
39,462,613 (GRCm38) |
splice site |
probably null |
|
|
IGL03409:Rims2
|
APN |
15 |
39,456,733 (GRCm38) |
missense |
probably damaging |
1.00 |
|
rhyme
|
UTSW |
15 |
39,452,328 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4486001:Rims2
|
UTSW |
15 |
39,476,520 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R0009:Rims2
|
UTSW |
15 |
39,534,966 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0009:Rims2
|
UTSW |
15 |
39,534,966 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0078:Rims2
|
UTSW |
15 |
39,534,855 (GRCm38) |
missense |
probably benign |
0.42 |
|
R0367:Rims2
|
UTSW |
15 |
39,462,615 (GRCm38) |
splice site |
probably null |
|
|
R0401:Rims2
|
UTSW |
15 |
39,509,632 (GRCm38) |
splice site |
probably benign |
|
|
R0531:Rims2
|
UTSW |
15 |
39,567,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0791:Rims2
|
UTSW |
15 |
39,679,625 (GRCm38) |
splice site |
probably benign |
|
|
R0838:Rims2
|
UTSW |
15 |
39,681,025 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1201:Rims2
|
UTSW |
15 |
39,616,324 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R1318:Rims2
|
UTSW |
15 |
39,517,826 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1457:Rims2
|
UTSW |
15 |
39,511,314 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R1619:Rims2
|
UTSW |
15 |
39,506,986 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1672:Rims2
|
UTSW |
15 |
39,292,189 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1743:Rims2
|
UTSW |
15 |
39,679,650 (GRCm38) |
missense |
probably benign |
0.10 |
|
R1766:Rims2
|
UTSW |
15 |
39,462,580 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1779:Rims2
|
UTSW |
15 |
39,681,702 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1804:Rims2
|
UTSW |
15 |
39,437,043 (GRCm38) |
nonsense |
probably null |
|
|
R1985:Rims2
|
UTSW |
15 |
39,345,314 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1986:Rims2
|
UTSW |
15 |
39,345,314 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2113:Rims2
|
UTSW |
15 |
39,511,326 (GRCm38) |
missense |
probably benign |
0.17 |
|
R2260:Rims2
|
UTSW |
15 |
39,478,566 (GRCm38) |
nonsense |
probably null |
|
|
R2510:Rims2
|
UTSW |
15 |
39,585,652 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3693:Rims2
|
UTSW |
15 |
39,478,575 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3937:Rims2
|
UTSW |
15 |
39,437,845 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4425:Rims2
|
UTSW |
15 |
39,437,924 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4453:Rims2
|
UTSW |
15 |
39,292,208 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4474:Rims2
|
UTSW |
15 |
39,462,560 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4518:Rims2
|
UTSW |
15 |
39,437,526 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4526:Rims2
|
UTSW |
15 |
39,437,717 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4833:Rims2
|
UTSW |
15 |
39,535,914 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4936:Rims2
|
UTSW |
15 |
39,437,728 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4993:Rims2
|
UTSW |
15 |
39,454,445 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R5001:Rims2
|
UTSW |
15 |
39,452,428 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5054:Rims2
|
UTSW |
15 |
39,517,869 (GRCm38) |
splice site |
probably null |
|
|
R5072:Rims2
|
UTSW |
15 |
39,462,590 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5171:Rims2
|
UTSW |
15 |
39,437,103 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5429:Rims2
|
UTSW |
15 |
39,345,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5623:Rims2
|
UTSW |
15 |
39,478,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5624:Rims2
|
UTSW |
15 |
39,345,413 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R5685:Rims2
|
UTSW |
15 |
39,437,206 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R5784:Rims2
|
UTSW |
15 |
39,535,987 (GRCm38) |
splice site |
probably null |
|
|
R5790:Rims2
|
UTSW |
15 |
39,681,045 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5822:Rims2
|
UTSW |
15 |
39,476,490 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5963:Rims2
|
UTSW |
15 |
39,437,182 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5988:Rims2
|
UTSW |
15 |
39,292,182 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6057:Rims2
|
UTSW |
15 |
39,675,020 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6239:Rims2
|
UTSW |
15 |
39,198,363 (GRCm38) |
start codon destroyed |
unknown |
|
|
R6407:Rims2
|
UTSW |
15 |
39,452,328 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6418:Rims2
|
UTSW |
15 |
39,509,696 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6495:Rims2
|
UTSW |
15 |
39,517,812 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6502:Rims2
|
UTSW |
15 |
39,534,855 (GRCm38) |
missense |
probably benign |
0.42 |
|
R6855:Rims2
|
UTSW |
15 |
39,345,515 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6948:Rims2
|
UTSW |
15 |
39,511,341 (GRCm38) |
missense |
probably benign |
|
|
R7058:Rims2
|
UTSW |
15 |
39,585,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7167:Rims2
|
UTSW |
15 |
39,437,077 (GRCm38) |
missense |
probably benign |
|
|
R7217:Rims2
|
UTSW |
15 |
39,476,489 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7223:Rims2
|
UTSW |
15 |
39,437,032 (GRCm38) |
missense |
probably benign |
0.30 |
|
R7289:Rims2
|
UTSW |
15 |
39,437,718 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7459:Rims2
|
UTSW |
15 |
39,517,839 (GRCm38) |
missense |
probably benign |
|
|
R7663:Rims2
|
UTSW |
15 |
39,507,026 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7792:Rims2
|
UTSW |
15 |
39,198,528 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R7836:Rims2
|
UTSW |
15 |
39,681,079 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8082:Rims2
|
UTSW |
15 |
39,476,523 (GRCm38) |
missense |
probably benign |
0.34 |
|
R8489:Rims2
|
UTSW |
15 |
39,616,450 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8730:Rims2
|
UTSW |
15 |
39,517,843 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8830:Rims2
|
UTSW |
15 |
39,437,362 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R8857:Rims2
|
UTSW |
15 |
39,679,648 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8893:Rims2
|
UTSW |
15 |
39,534,954 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9010:Rims2
|
UTSW |
15 |
39,452,390 (GRCm38) |
nonsense |
probably null |
|
|
R9030:Rims2
|
UTSW |
15 |
39,476,477 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9287:Rims2
|
UTSW |
15 |
39,679,690 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9395:Rims2
|
UTSW |
15 |
39,292,269 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9451:Rims2
|
UTSW |
15 |
39,437,328 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9506:Rims2
|
UTSW |
15 |
39,472,436 (GRCm38) |
missense |
probably damaging |
0.97 |
|
X0034:Rims2
|
UTSW |
15 |
39,437,534 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,681,114 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Rims2
|
UTSW |
15 |
39,478,690 (GRCm38) |
frame shift |
probably null |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,437,769 (GRCm38) |
missense |
probably benign |
0.24 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACAGATGGGCCAATGTTTTC -3'
(R):5'- CTGTAGAATTTAATATCACTGGGCC -3'
Sequencing Primer
(F):5'- ACAGATGGGCCAATGTTTTCTTCTAG -3'
(R):5'- CACTGGGCCATTACATTATATGTTTG -3'
|
| Posted On |
2018-08-01 |
Incidental Mutation