Incidental Mutation 'R9745:Mtus2'
ID |
732037 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Mtus2
|
Ensembl Gene |
ENSMUSG00000029651 |
Gene Name |
microtubule associated tumor suppressor candidate 2 |
Synonyms |
C130038G02Rik, A730013O20Rik, 5730592G18Rik |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.174)
|
Stock # |
R9745 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
5 |
Chromosomal Location |
147894130-148252875 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 148013311 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Serine
at position 35
(T35S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000082694
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085558]
[ENSMUST00000129092]
|
AlphaFold |
Q3UHD3 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000085558
AA Change: T35S
PolyPhen 2
Score 0.807 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000082694 Gene: ENSMUSG00000029651 AA Change: T35S
Domain | Start | End | E-Value | Type |
internal_repeat_1
|
57 |
290 |
2.46e-5 |
PROSPERO |
internal_repeat_1
|
312 |
525 |
2.46e-5 |
PROSPERO |
low complexity region
|
530 |
541 |
N/A |
INTRINSIC |
low complexity region
|
802 |
818 |
N/A |
INTRINSIC |
low complexity region
|
841 |
852 |
N/A |
INTRINSIC |
low complexity region
|
893 |
904 |
N/A |
INTRINSIC |
coiled coil region
|
1029 |
1080 |
N/A |
INTRINSIC |
SCOP:d1fxkc_
|
1167 |
1294 |
3e-4 |
SMART |
low complexity region
|
1332 |
1349 |
N/A |
INTRINSIC |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000129092
AA Change: T35S
PolyPhen 2
Score 0.807 (Sensitivity: 0.84; Specificity: 0.93)
|
Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.6%
- 10x: 99.1%
- 20x: 97.9%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 75 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Agap2 |
T |
A |
10: 126,919,380 (GRCm39) |
H488Q |
unknown |
Het |
Ces1b |
T |
C |
8: 93,790,625 (GRCm39) |
D388G |
probably benign |
Het |
Ces1f |
T |
C |
8: 93,989,740 (GRCm39) |
D392G |
probably benign |
Het |
Ces5a |
A |
G |
8: 94,228,814 (GRCm39) |
V472A |
probably damaging |
Het |
Chst1 |
A |
G |
2: 92,444,047 (GRCm39) |
D173G |
possibly damaging |
Het |
Cngb1 |
T |
G |
8: 95,967,919 (GRCm39) |
E1294A |
unknown |
Het |
Cnmd |
T |
C |
14: 79,887,850 (GRCm39) |
I124V |
possibly damaging |
Het |
Cntnap2 |
A |
T |
6: 46,211,100 (GRCm39) |
M505L |
probably benign |
Het |
Cntnap4 |
T |
A |
8: 113,391,808 (GRCm39) |
M91K |
possibly damaging |
Het |
Cstad |
A |
G |
2: 30,498,197 (GRCm39) |
T11A |
unknown |
Het |
Cyp2j6 |
A |
T |
4: 96,441,621 (GRCm39) |
V23E |
possibly damaging |
Het |
Dapk3 |
C |
A |
10: 81,028,594 (GRCm39) |
T388K |
unknown |
Het |
Dennd6a |
G |
A |
14: 26,320,818 (GRCm39) |
G120R |
possibly damaging |
Het |
Disp1 |
A |
C |
1: 182,869,310 (GRCm39) |
S1037A |
probably damaging |
Het |
Dpcd |
A |
T |
19: 45,560,881 (GRCm39) |
Q103L |
probably benign |
Het |
Egfem1 |
A |
T |
3: 29,716,532 (GRCm39) |
D334V |
probably damaging |
Het |
Egflam |
C |
T |
15: 7,333,419 (GRCm39) |
V178M |
probably benign |
Het |
Ehbp1 |
T |
C |
11: 22,096,692 (GRCm39) |
T291A |
probably benign |
Het |
Eif5b |
G |
T |
1: 38,084,729 (GRCm39) |
V859F |
probably damaging |
Het |
Fam161a |
A |
T |
11: 22,973,495 (GRCm39) |
Q459L |
possibly damaging |
Het |
Fcgrt |
A |
C |
7: 44,742,754 (GRCm39) |
D342E |
probably damaging |
Het |
Fchsd1 |
A |
C |
18: 38,102,425 (GRCm39) |
D34E |
probably benign |
Het |
Foxo4 |
G |
A |
X: 100,301,955 (GRCm39) |
S209N |
probably benign |
Het |
Galt |
A |
T |
4: 41,758,185 (GRCm39) |
M317L |
possibly damaging |
Het |
Gfm1 |
A |
G |
3: 67,358,657 (GRCm39) |
D416G |
possibly damaging |
Het |
Glcci1 |
A |
T |
6: 8,573,278 (GRCm39) |
I256L |
probably benign |
Het |
Ibtk |
C |
T |
9: 85,613,280 (GRCm39) |
G228S |
probably benign |
Het |
Ift70b |
T |
C |
2: 75,768,261 (GRCm39) |
Y164C |
probably benign |
Het |
Il2rb |
T |
A |
15: 78,372,399 (GRCm39) |
D106V |
probably benign |
Het |
Map3k6 |
A |
T |
4: 132,979,783 (GRCm39) |
I1261F |
probably damaging |
Het |
Mast2 |
A |
G |
4: 116,167,815 (GRCm39) |
L1014P |
probably benign |
Het |
Mcm2 |
G |
A |
6: 88,868,729 (GRCm39) |
Q343* |
probably null |
Het |
Megf8 |
A |
G |
7: 25,058,133 (GRCm39) |
T2136A |
possibly damaging |
Het |
Mmp28 |
G |
A |
11: 83,342,283 (GRCm39) |
T103I |
probably benign |
Het |
Mtif2 |
G |
A |
11: 29,476,587 (GRCm39) |
|
probably benign |
Het |
Ncoa2 |
A |
T |
1: 13,245,192 (GRCm39) |
I502N |
probably benign |
Het |
Nek5 |
A |
C |
8: 22,573,479 (GRCm39) |
D492E |
probably benign |
Het |
Nin |
T |
C |
12: 70,089,899 (GRCm39) |
E1172G |
|
Het |
Nsmaf |
T |
A |
4: 6,416,662 (GRCm39) |
I544F |
possibly damaging |
Het |
Oas3 |
T |
C |
5: 120,899,284 (GRCm39) |
D763G |
unknown |
Het |
Or2a20 |
G |
A |
6: 43,194,258 (GRCm39) |
W137* |
probably null |
Het |
Or4s2 |
T |
A |
2: 88,473,310 (GRCm39) |
F66L |
probably benign |
Het |
Or51r1 |
A |
T |
7: 102,227,861 (GRCm39) |
D53V |
probably damaging |
Het |
Or5al6 |
C |
T |
2: 85,976,251 (GRCm39) |
V276M |
probably damaging |
Het |
Or5aq1 |
T |
A |
2: 86,965,783 (GRCm39) |
N294I |
probably damaging |
Het |
Or5k15 |
A |
T |
16: 58,710,265 (GRCm39) |
L106Q |
probably damaging |
Het |
Or5t17 |
T |
C |
2: 86,832,487 (GRCm39) |
V58A |
probably benign |
Het |
Pcdh7 |
T |
C |
5: 57,879,622 (GRCm39) |
|
probably null |
Het |
Pitx3 |
A |
G |
19: 46,124,660 (GRCm39) |
S236P |
possibly damaging |
Het |
Plscr5 |
T |
A |
9: 92,087,502 (GRCm39) |
I157N |
probably damaging |
Het |
Potefam1 |
T |
C |
2: 111,000,008 (GRCm39) |
M201V |
unknown |
Het |
Preb |
T |
C |
5: 31,116,732 (GRCm39) |
N54D |
probably benign |
Het |
Pskh1 |
C |
T |
8: 106,656,404 (GRCm39) |
A360V |
possibly damaging |
Het |
Ptprk |
T |
C |
10: 28,139,608 (GRCm39) |
L111S |
possibly damaging |
Het |
Reln |
T |
A |
5: 22,152,525 (GRCm39) |
I2314F |
probably damaging |
Het |
Siglecg |
A |
G |
7: 43,067,476 (GRCm39) |
D681G |
probably damaging |
Het |
Snx5 |
A |
G |
2: 144,096,716 (GRCm39) |
V283A |
probably benign |
Het |
Srpk2 |
C |
A |
5: 23,880,874 (GRCm39) |
|
probably benign |
Het |
Tacr1 |
T |
C |
6: 82,469,619 (GRCm39) |
Y168H |
possibly damaging |
Het |
Tal1 |
G |
T |
4: 114,920,557 (GRCm39) |
R77L |
probably benign |
Het |
Tdrd12 |
T |
C |
7: 35,185,964 (GRCm39) |
|
probably null |
Het |
Tdrd7 |
A |
T |
4: 45,994,310 (GRCm39) |
N236I |
possibly damaging |
Het |
Tdrd9 |
T |
C |
12: 112,009,130 (GRCm39) |
F1012S |
probably damaging |
Het |
Tekt2 |
C |
T |
4: 126,217,444 (GRCm39) |
R207H |
probably damaging |
Het |
Tert |
T |
A |
13: 73,784,609 (GRCm39) |
L685Q |
probably damaging |
Het |
Th |
T |
G |
7: 142,448,851 (GRCm39) |
D342A |
probably damaging |
Het |
Tpsg1 |
G |
T |
17: 25,591,492 (GRCm39) |
V31L |
probably damaging |
Het |
Traf3ip1 |
C |
G |
1: 91,439,095 (GRCm39) |
S337* |
probably null |
Het |
Trpv6 |
A |
G |
6: 41,600,003 (GRCm39) |
F551S |
probably damaging |
Het |
Urah |
A |
G |
7: 140,415,531 (GRCm39) |
N23D |
probably benign |
Het |
Vangl1 |
A |
C |
3: 102,072,669 (GRCm39) |
|
probably null |
Het |
Zc3h6 |
A |
G |
2: 128,859,155 (GRCm39) |
E1062G |
probably benign |
Het |
Zfp37 |
A |
T |
4: 62,110,644 (GRCm39) |
V181E |
possibly damaging |
Het |
Zfp638 |
T |
A |
6: 83,921,795 (GRCm39) |
S641T |
probably benign |
Het |
Zkscan16 |
A |
T |
4: 58,957,473 (GRCm39) |
H585L |
possibly damaging |
Het |
|
Other mutations in Mtus2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01104:Mtus2
|
APN |
5 |
148,013,819 (GRCm39) |
splice site |
probably null |
|
IGL01911:Mtus2
|
APN |
5 |
148,015,030 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01973:Mtus2
|
APN |
5 |
148,240,286 (GRCm39) |
splice site |
probably benign |
|
IGL02452:Mtus2
|
APN |
5 |
148,014,473 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02476:Mtus2
|
APN |
5 |
148,014,748 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02716:Mtus2
|
APN |
5 |
148,173,120 (GRCm39) |
missense |
probably benign |
0.05 |
IGL03194:Mtus2
|
APN |
5 |
148,043,913 (GRCm39) |
missense |
probably damaging |
1.00 |
rumblado
|
UTSW |
5 |
148,243,518 (GRCm39) |
nonsense |
probably null |
|
IGL02991:Mtus2
|
UTSW |
5 |
148,250,310 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4431001:Mtus2
|
UTSW |
5 |
148,013,515 (GRCm39) |
missense |
probably benign |
0.01 |
R0101:Mtus2
|
UTSW |
5 |
148,019,845 (GRCm39) |
missense |
probably damaging |
1.00 |
R0101:Mtus2
|
UTSW |
5 |
148,019,845 (GRCm39) |
missense |
probably damaging |
1.00 |
R0310:Mtus2
|
UTSW |
5 |
148,043,829 (GRCm39) |
missense |
probably benign |
0.17 |
R0729:Mtus2
|
UTSW |
5 |
148,014,097 (GRCm39) |
missense |
probably benign |
0.08 |
R0968:Mtus2
|
UTSW |
5 |
148,014,994 (GRCm39) |
missense |
probably benign |
0.09 |
R1231:Mtus2
|
UTSW |
5 |
148,014,198 (GRCm39) |
missense |
probably benign |
0.01 |
R1253:Mtus2
|
UTSW |
5 |
148,240,380 (GRCm39) |
nonsense |
probably null |
|
R1556:Mtus2
|
UTSW |
5 |
148,014,198 (GRCm39) |
missense |
probably benign |
0.01 |
R1561:Mtus2
|
UTSW |
5 |
148,013,362 (GRCm39) |
missense |
probably benign |
0.07 |
R1574:Mtus2
|
UTSW |
5 |
148,013,362 (GRCm39) |
missense |
probably benign |
0.07 |
R1750:Mtus2
|
UTSW |
5 |
148,214,443 (GRCm39) |
missense |
probably damaging |
0.97 |
R2318:Mtus2
|
UTSW |
5 |
148,043,892 (GRCm39) |
nonsense |
probably null |
|
R2327:Mtus2
|
UTSW |
5 |
148,014,725 (GRCm39) |
missense |
probably benign |
0.00 |
R3153:Mtus2
|
UTSW |
5 |
148,019,870 (GRCm39) |
missense |
probably damaging |
1.00 |
R3154:Mtus2
|
UTSW |
5 |
148,240,083 (GRCm39) |
intron |
probably benign |
|
R3158:Mtus2
|
UTSW |
5 |
148,168,637 (GRCm39) |
missense |
probably damaging |
1.00 |
R3548:Mtus2
|
UTSW |
5 |
148,232,316 (GRCm39) |
missense |
probably damaging |
1.00 |
R3861:Mtus2
|
UTSW |
5 |
148,250,223 (GRCm39) |
missense |
probably damaging |
1.00 |
R4395:Mtus2
|
UTSW |
5 |
148,013,432 (GRCm39) |
missense |
probably benign |
0.17 |
R4396:Mtus2
|
UTSW |
5 |
148,140,748 (GRCm39) |
missense |
possibly damaging |
0.81 |
R4667:Mtus2
|
UTSW |
5 |
148,235,070 (GRCm39) |
missense |
possibly damaging |
0.64 |
R4887:Mtus2
|
UTSW |
5 |
148,013,913 (GRCm39) |
nonsense |
probably null |
|
R4931:Mtus2
|
UTSW |
5 |
148,014,226 (GRCm39) |
missense |
probably benign |
0.09 |
R5097:Mtus2
|
UTSW |
5 |
148,232,392 (GRCm39) |
missense |
probably damaging |
0.99 |
R5318:Mtus2
|
UTSW |
5 |
148,013,382 (GRCm39) |
missense |
probably benign |
0.05 |
R5372:Mtus2
|
UTSW |
5 |
148,250,222 (GRCm39) |
missense |
probably damaging |
1.00 |
R5388:Mtus2
|
UTSW |
5 |
148,243,518 (GRCm39) |
nonsense |
probably null |
|
R5622:Mtus2
|
UTSW |
5 |
148,015,244 (GRCm39) |
missense |
probably benign |
0.09 |
R6009:Mtus2
|
UTSW |
5 |
148,243,462 (GRCm39) |
missense |
probably damaging |
1.00 |
R6379:Mtus2
|
UTSW |
5 |
148,014,008 (GRCm39) |
missense |
probably benign |
0.00 |
R6409:Mtus2
|
UTSW |
5 |
148,014,425 (GRCm39) |
missense |
probably benign |
|
R6527:Mtus2
|
UTSW |
5 |
148,214,408 (GRCm39) |
critical splice acceptor site |
probably null |
|
R6853:Mtus2
|
UTSW |
5 |
148,043,821 (GRCm39) |
missense |
probably damaging |
1.00 |
R7001:Mtus2
|
UTSW |
5 |
148,214,438 (GRCm39) |
missense |
probably damaging |
1.00 |
R7187:Mtus2
|
UTSW |
5 |
148,013,515 (GRCm39) |
missense |
probably benign |
0.01 |
R7276:Mtus2
|
UTSW |
5 |
148,013,368 (GRCm39) |
missense |
probably benign |
|
R7594:Mtus2
|
UTSW |
5 |
148,014,216 (GRCm39) |
missense |
probably benign |
0.44 |
R7790:Mtus2
|
UTSW |
5 |
148,014,998 (GRCm39) |
missense |
probably benign |
0.09 |
R7967:Mtus2
|
UTSW |
5 |
148,014,656 (GRCm39) |
missense |
probably benign |
0.32 |
R7987:Mtus2
|
UTSW |
5 |
148,168,836 (GRCm39) |
splice site |
probably null |
|
R8112:Mtus2
|
UTSW |
5 |
148,013,713 (GRCm39) |
nonsense |
probably null |
|
R8273:Mtus2
|
UTSW |
5 |
148,043,815 (GRCm39) |
missense |
probably damaging |
1.00 |
R8527:Mtus2
|
UTSW |
5 |
148,240,408 (GRCm39) |
missense |
probably damaging |
1.00 |
R8542:Mtus2
|
UTSW |
5 |
148,240,408 (GRCm39) |
missense |
probably damaging |
1.00 |
R8783:Mtus2
|
UTSW |
5 |
148,019,861 (GRCm39) |
missense |
probably damaging |
1.00 |
R8805:Mtus2
|
UTSW |
5 |
148,015,303 (GRCm39) |
missense |
possibly damaging |
0.58 |
R9204:Mtus2
|
UTSW |
5 |
148,238,293 (GRCm39) |
missense |
probably damaging |
1.00 |
R9210:Mtus2
|
UTSW |
5 |
148,014,124 (GRCm39) |
missense |
probably benign |
0.00 |
R9261:Mtus2
|
UTSW |
5 |
148,243,453 (GRCm39) |
nonsense |
probably null |
|
R9419:Mtus2
|
UTSW |
5 |
148,243,451 (GRCm39) |
missense |
probably damaging |
1.00 |
R9477:Mtus2
|
UTSW |
5 |
148,014,740 (GRCm39) |
missense |
probably benign |
|
R9483:Mtus2
|
UTSW |
5 |
148,232,300 (GRCm39) |
missense |
possibly damaging |
0.80 |
R9563:Mtus2
|
UTSW |
5 |
148,250,217 (GRCm39) |
missense |
|
|
R9643:Mtus2
|
UTSW |
5 |
148,014,025 (GRCm39) |
missense |
probably benign |
0.04 |
R9716:Mtus2
|
UTSW |
5 |
148,013,464 (GRCm39) |
missense |
possibly damaging |
0.82 |
X0017:Mtus2
|
UTSW |
5 |
148,214,410 (GRCm39) |
missense |
possibly damaging |
0.83 |
X0028:Mtus2
|
UTSW |
5 |
148,014,128 (GRCm39) |
missense |
probably benign |
0.03 |
Z1088:Mtus2
|
UTSW |
5 |
148,240,073 (GRCm39) |
intron |
probably benign |
|
Z1176:Mtus2
|
UTSW |
5 |
148,014,068 (GRCm39) |
missense |
probably benign |
0.05 |
Z1176:Mtus2
|
UTSW |
5 |
148,013,552 (GRCm39) |
missense |
probably benign |
0.31 |
Z1177:Mtus2
|
UTSW |
5 |
148,140,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGTGACATCGTCAGAGGAGG -3'
(R):5'- TCAGAGAAGCCTGAGACTCC -3'
Sequencing Primer
(F):5'- CAGAGAAGGTGACAGTGGCCTG -3'
(R):5'- AGAGAAGCCTGAGACTCCCTCTG -3'
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Posted On |
2022-11-14 |