Mutagenetix > Incidental Mutation

Incidental Mutation 'R7798:Tex15'

600366

Institutional Source

Beutler Lab

Gene Symbol

Tex15

Ensembl Gene

ENSMUSG00000009628

Gene Name

testis expressed gene 15

Synonyms

2210014E14Rik

MMRRC Submission

045648-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.291) question?

Stock #

R7798 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

34006766-34075610 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 34071875 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Phenylalanine at position 2474 (S2474F)

Ref Sequence

ENSEMBL: ENSMUSP00000009772 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000009772] [ENSMUST00000124501]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000009772
AA Change: S2474F

PolyPhen 2 Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000009772
Gene: ENSMUSG00000009628
AA Change: S2474F

Domain	Start	End	E-Value	Type
low complexity region	262	274	N/A	INTRINSIC
low complexity region	302	313	N/A	INTRINSIC
low complexity region	524	536	N/A	INTRINSIC
low complexity region	665	674	N/A	INTRINSIC
low complexity region	713	725	N/A	INTRINSIC
low complexity region	946	961	N/A	INTRINSIC
low complexity region	1497	1508	N/A	INTRINSIC
Pfam:TEX15	1572	1788	1.3e-109	PFAM
Pfam:TEX15	1901	2119	1.1e-16	PFAM
low complexity region	2758	2770	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124501

SMART Domains

Protein: ENSMUSP00000138070
Gene: ENSMUSG00000009628

Domain	Start	End	E-Value	Type
Pfam:DUF3715	96	251	2.4e-52	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700088E04Rik	T	A	15: 79,019,932 (GRCm39)	N128I	probably damaging	Het
Abca13	A	G	11: 9,241,664 (GRCm39)	T1176A	probably benign	Het
Abca9	A	G	11: 110,029,005 (GRCm39)	V851A	probably benign	Het
Abcc6	C	A	7: 45,626,277 (GRCm39)	E1494*	probably null	Het
Adamts14	A	T	10: 61,106,952 (GRCm39)	V56E	probably damaging	Het
Adamts15	G	A	9: 30,815,939 (GRCm39)	T639M	probably damaging	Het
Albfm1	T	C	5: 90,745,370 (GRCm39)	S608P	possibly damaging	Het
Arhgap11a	A	C	2: 113,673,680 (GRCm39)	V70G	probably damaging	Het
BC051665	A	T	13: 60,932,249 (GRCm39)	D113E	probably benign	Het
Best1	T	C	19: 9,969,035 (GRCm39)	Y227C	probably damaging	Het
Camk2b	A	G	11: 5,928,399 (GRCm39)	S447P	probably benign	Het
Ccdc88a	C	A	11: 29,427,348 (GRCm39)	Q1018K	probably benign	Het
Cdhr17	T	C	5: 17,061,656 (GRCm39)	F801L	possibly damaging	Het
Cfap74	T	A	4: 155,507,079 (GRCm39)	V180D		Het
Clca3a1	T	A	3: 144,463,723 (GRCm39)	T185S	probably damaging	Het
Clca3b	T	C	3: 144,533,891 (GRCm39)	S495G	probably damaging	Het
Cyb5r2	A	T	7: 107,353,155 (GRCm39)	Y96N	possibly damaging	Het
Cyp21a1	T	C	17: 35,023,295 (GRCm39)	K27E	probably benign	Het
Cyp2ab1	T	C	16: 20,131,166 (GRCm39)	E321G	probably benign	Het
Des	T	C	1: 75,339,003 (GRCm39)	I228T	probably damaging	Het
Dis3l	G	T	9: 64,248,299 (GRCm39)	P39T	probably benign	Het
Disp2	A	C	2: 118,622,360 (GRCm39)	I1031L	probably benign	Het
Ell3	TCTCCTC	TCTC	2: 121,269,937 (GRCm39)		probably benign	Het
Etl4	G	A	2: 20,786,757 (GRCm39)		probably null	Het
Fgf23	A	T	6: 127,050,177 (GRCm39)	D62V	probably damaging	Het
Galnt15	C	T	14: 31,751,862 (GRCm39)	T138I	possibly damaging	Het
Ggt6	A	T	11: 72,326,367 (GRCm39)		probably benign	Het
Gpr180	T	A	14: 118,391,098 (GRCm39)	V209D	probably damaging	Het
Gzma	A	T	13: 113,232,858 (GRCm39)	F78Y	probably benign	Het
Igkv8-30	A	T	6: 70,094,355 (GRCm39)	C19S	probably benign	Het
Il1r1	G	A	1: 40,349,526 (GRCm39)	V361I	probably benign	Het
Intu	T	C	3: 40,646,359 (GRCm39)	V598A	probably damaging	Het
Itpr2	A	G	6: 146,287,513 (GRCm39)	F471L	probably benign	Het
Kntc1	T	A	5: 123,924,357 (GRCm39)	V1081E	probably benign	Het
Kntc1	T	A	5: 123,957,180 (GRCm39)	V2163E	possibly damaging	Het
Macf1	T	C	4: 123,271,893 (GRCm39)	K6552E	probably damaging	Het
Marf1	T	C	16: 13,956,315 (GRCm39)	H842R	probably benign	Het
Mgat4b	A	G	11: 50,116,497 (GRCm39)	T10A	possibly damaging	Het
Muc21	C	G	17: 35,932,146 (GRCm39)	G680A	unknown	Het
Muc5ac	T	C	7: 141,347,778 (GRCm39)		probably null	Het
Nrk	CGCAGCAGCAGCAGCAGCAGC	CGCAGCAGCAGCAGCAGC	X: 137,883,426 (GRCm39)		probably benign	Het
Nsun4	T	G	4: 115,908,371 (GRCm39)	S730R	possibly damaging	Het
Or12e1	A	T	2: 87,022,636 (GRCm39)	I202L	probably benign	Het
Or12k7	A	T	2: 36,959,186 (GRCm39)	S290C	probably damaging	Het
Or1n1	T	C	2: 36,750,348 (GRCm39)	E4G	probably benign	Het
Or4f6	A	G	2: 111,838,617 (GRCm39)	F305L	probably benign	Het
Or4k15	A	T	14: 50,364,895 (GRCm39)	Y287F	probably damaging	Het
Padi3	C	T	4: 140,513,750 (GRCm39)	E653K	probably benign	Het
Pde4a	A	G	9: 21,109,959 (GRCm39)	E280G	possibly damaging	Het
Phactr3	G	A	2: 177,925,703 (GRCm39)	R326H	probably benign	Het
Prob1	G	A	18: 35,786,397 (GRCm39)	P619L	possibly damaging	Het
Ptk2	G	A	15: 73,167,224 (GRCm39)	R368W	probably damaging	Het
Rgs6	A	G	12: 83,116,293 (GRCm39)	T240A	probably benign	Het
Rpa1	A	T	11: 75,203,635 (GRCm39)	Y356N	probably damaging	Het
Rxrb	T	A	17: 34,252,579 (GRCm39)	D165E	probably damaging	Het
Sco1	A	G	11: 66,944,628 (GRCm39)	T84A	possibly damaging	Het
Sepsecs	T	C	5: 52,804,531 (GRCm39)	I380V	probably benign	Het
Sfmbt1	T	A	14: 30,538,759 (GRCm39)	W793R	probably damaging	Het
Slco3a1	A	G	7: 73,968,344 (GRCm39)	S459P	probably benign	Het
Smg1	A	T	7: 117,771,162 (GRCm39)	S1503R	possibly damaging	Het
Sox2	G	A	3: 34,704,791 (GRCm39)	R76H	probably damaging	Het
Spty2d1	G	A	7: 46,645,804 (GRCm39)	S613F	probably damaging	Het
Stab2	A	T	10: 86,793,776 (GRCm39)	Y440N	probably damaging	Het
Syn3	A	G	10: 85,916,117 (GRCm39)	Y290H	probably damaging	Het
Tgtp1	A	G	11: 48,878,159 (GRCm39)	F182S	probably benign	Het
Tmcc1	A	T	6: 116,020,539 (GRCm39)	S304R		Het
Tmem130	T	G	5: 144,680,580 (GRCm39)	K275Q	probably damaging	Het
Tmem9	C	A	1: 135,961,927 (GRCm39)	T174K	probably damaging	Het
Ttyh3	C	T	5: 140,620,538 (GRCm39)	R233Q	probably damaging	Het
Tut7	A	T	13: 59,963,389 (GRCm39)	M323K	possibly damaging	Het
Twnk	T	C	19: 44,996,107 (GRCm39)	M180T	probably benign	Het
Ube4a	A	G	9: 44,844,629 (GRCm39)	V874A	probably damaging	Het
Ugt2a3	T	C	5: 87,475,582 (GRCm39)	N350S	probably damaging	Het
Vegfa	C	T	17: 46,342,761 (GRCm39)	G19D	probably damaging	Het
Vmn2r2	C	A	3: 64,041,518 (GRCm39)	C399F	possibly damaging	Het
Vmn2r65	G	T	7: 84,595,530 (GRCm39)	P385T	probably benign	Het
Vmn2r65	A	G	7: 84,596,192 (GRCm39)	F164S	probably damaging	Het

Other mutations in Tex15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00639:Tex15	APN	8	34,065,339 (GRCm39)	missense	probably benign	0.18
IGL00705:Tex15	APN	8	34,071,620 (GRCm39)	missense	probably damaging	1.00
IGL00820:Tex15	APN	8	34,069,034 (GRCm39)	splice site	probably benign
IGL01288:Tex15	APN	8	34,061,412 (GRCm39)	missense	probably benign	0.02
IGL01328:Tex15	APN	8	34,061,424 (GRCm39)	nonsense	probably null
IGL01359:Tex15	APN	8	34,071,926 (GRCm39)	missense	probably damaging	0.99
IGL01603:Tex15	APN	8	34,063,575 (GRCm39)	missense	possibly damaging	0.93
IGL01861:Tex15	APN	8	34,060,717 (GRCm39)	missense	probably damaging	1.00
IGL02052:Tex15	APN	8	34,072,493 (GRCm39)	missense	probably benign	0.28
IGL02560:Tex15	APN	8	34,071,779 (GRCm39)	missense	probably benign	0.00
IGL02677:Tex15	APN	8	34,061,108 (GRCm39)	missense	probably benign	0.03
IGL02739:Tex15	APN	8	34,071,721 (GRCm39)	missense	possibly damaging	0.68
Big_gulp	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
P0005:Tex15	UTSW	8	34,060,896 (GRCm39)	missense	probably benign	0.00
P0037:Tex15	UTSW	8	34,071,608 (GRCm39)	missense	probably benign	0.00
PIT4377001:Tex15	UTSW	8	34,061,129 (GRCm39)	missense	probably damaging	1.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0595:Tex15	UTSW	8	34,062,645 (GRCm39)	missense	probably damaging	1.00
R0646:Tex15	UTSW	8	34,072,354 (GRCm39)	missense	possibly damaging	0.83
R0688:Tex15	UTSW	8	34,063,528 (GRCm39)	missense	probably damaging	1.00
R0842:Tex15	UTSW	8	34,061,575 (GRCm39)	missense	possibly damaging	0.95
R0987:Tex15	UTSW	8	34,066,875 (GRCm39)	missense	probably damaging	1.00
R1084:Tex15	UTSW	8	34,067,032 (GRCm39)	missense	probably benign	0.28
R1183:Tex15	UTSW	8	34,064,893 (GRCm39)	missense	probably benign	0.35
R1186:Tex15	UTSW	8	34,061,661 (GRCm39)	missense	probably benign	0.19
R1378:Tex15	UTSW	8	34,065,244 (GRCm39)	missense	probably damaging	0.99
R1500:Tex15	UTSW	8	34,065,120 (GRCm39)	missense	probably damaging	0.96
R1508:Tex15	UTSW	8	34,066,880 (GRCm39)	missense	probably damaging	1.00
R1597:Tex15	UTSW	8	34,061,511 (GRCm39)	missense	probably damaging	0.96
R1636:Tex15	UTSW	8	34,066,415 (GRCm39)	nonsense	probably null
R1639:Tex15	UTSW	8	34,060,845 (GRCm39)	missense	possibly damaging	0.94
R1809:Tex15	UTSW	8	34,064,262 (GRCm39)	missense	probably benign
R1843:Tex15	UTSW	8	34,066,682 (GRCm39)	missense	probably benign	0.27
R2029:Tex15	UTSW	8	34,061,302 (GRCm39)	missense	probably damaging	0.99
R2228:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2229:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2245:Tex15	UTSW	8	34,061,524 (GRCm39)	missense	possibly damaging	0.77
R2246:Tex15	UTSW	8	34,072,540 (GRCm39)	missense	possibly damaging	0.49
R2880:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2881:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2882:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R3001:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3002:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3020:Tex15	UTSW	8	34,066,698 (GRCm39)	missense	probably damaging	1.00
R3084:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3085:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3701:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3702:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3752:Tex15	UTSW	8	34,061,443 (GRCm39)	missense	probably benign
R4162:Tex15	UTSW	8	34,071,586 (GRCm39)	missense	probably damaging	1.00
R4231:Tex15	UTSW	8	34,062,165 (GRCm39)	missense	probably damaging	0.99
R4589:Tex15	UTSW	8	34,047,401 (GRCm39)	missense	probably damaging	1.00
R4707:Tex15	UTSW	8	34,072,525 (GRCm39)	missense	probably benign	0.00
R4773:Tex15	UTSW	8	34,072,760 (GRCm39)	missense	probably benign	0.42
R4967:Tex15	UTSW	8	34,064,498 (GRCm39)	missense	probably benign	0.34
R5063:Tex15	UTSW	8	34,072,638 (GRCm39)	missense	possibly damaging	0.59
R5121:Tex15	UTSW	8	34,061,794 (GRCm39)	missense	probably damaging	1.00
R5147:Tex15	UTSW	8	34,062,340 (GRCm39)	nonsense	probably null
R5166:Tex15	UTSW	8	34,066,420 (GRCm39)	missense	probably benign	0.07
R5173:Tex15	UTSW	8	34,061,768 (GRCm39)	missense	possibly damaging	0.73
R5439:Tex15	UTSW	8	34,064,199 (GRCm39)	missense	possibly damaging	0.93
R5537:Tex15	UTSW	8	34,061,641 (GRCm39)	missense	probably damaging	1.00
R5580:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R5588:Tex15	UTSW	8	34,067,215 (GRCm39)	missense	probably damaging	1.00
R5696:Tex15	UTSW	8	34,063,220 (GRCm39)	missense	probably benign	0.01
R5734:Tex15	UTSW	8	34,036,364 (GRCm39)	missense	probably benign	0.01
R5756:Tex15	UTSW	8	34,065,861 (GRCm39)	missense	probably benign	0.17
R5823:Tex15	UTSW	8	34,060,962 (GRCm39)	missense	possibly damaging	0.67
R6126:Tex15	UTSW	8	34,063,591 (GRCm39)	missense	probably benign	0.19
R6129:Tex15	UTSW	8	34,064,158 (GRCm39)	missense	possibly damaging	0.90
R6276:Tex15	UTSW	8	34,067,217 (GRCm39)	missense	possibly damaging	0.93
R6374:Tex15	UTSW	8	34,065,940 (GRCm39)	missense	probably damaging	1.00
R6430:Tex15	UTSW	8	34,061,329 (GRCm39)	missense	probably benign	0.01
R6452:Tex15	UTSW	8	34,062,844 (GRCm39)	missense	probably damaging	1.00
R6471:Tex15	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
R6700:Tex15	UTSW	8	34,064,917 (GRCm39)	missense	possibly damaging	0.93
R6918:Tex15	UTSW	8	34,063,212 (GRCm39)	missense	probably benign	0.27
R6958:Tex15	UTSW	8	34,060,899 (GRCm39)	missense	probably benign	0.01
R6970:Tex15	UTSW	8	34,047,456 (GRCm39)	missense	probably benign	0.03
R7059:Tex15	UTSW	8	34,064,758 (GRCm39)	missense	possibly damaging	0.57
R7069:Tex15	UTSW	8	34,060,748 (GRCm39)	missense	probably benign
R7072:Tex15	UTSW	8	34,065,459 (GRCm39)	missense	possibly damaging	0.85
R7212:Tex15	UTSW	8	34,063,023 (GRCm39)	missense	probably damaging	1.00
R7212:Tex15	UTSW	8	34,060,854 (GRCm39)	nonsense	probably null
R7216:Tex15	UTSW	8	34,063,014 (GRCm39)	missense	possibly damaging	0.93
R7219:Tex15	UTSW	8	34,036,268 (GRCm39)	missense	probably benign	0.40
R7313:Tex15	UTSW	8	34,064,845 (GRCm39)	missense	possibly damaging	0.82
R7315:Tex15	UTSW	8	34,071,544 (GRCm39)	missense	probably benign	0.01
R7444:Tex15	UTSW	8	34,066,590 (GRCm39)	missense	possibly damaging	0.92
R7455:Tex15	UTSW	8	34,067,025 (GRCm39)	missense	possibly damaging	0.91
R7643:Tex15	UTSW	8	34,065,148 (GRCm39)	missense	probably damaging	1.00
R7644:Tex15	UTSW	8	34,064,445 (GRCm39)	missense	probably benign	0.01
R7724:Tex15	UTSW	8	34,036,291 (GRCm39)	missense	possibly damaging	0.60
R7779:Tex15	UTSW	8	34,065,309 (GRCm39)	missense	probably damaging	1.00
R7816:Tex15	UTSW	8	34,071,683 (GRCm39)	missense	probably benign	0.14
R7820:Tex15	UTSW	8	34,065,090 (GRCm39)	missense	probably damaging	0.98
R8041:Tex15	UTSW	8	34,065,874 (GRCm39)	missense	probably damaging	1.00
R8150:Tex15	UTSW	8	34,063,534 (GRCm39)	missense	probably benign	0.06
R8152:Tex15	UTSW	8	34,062,921 (GRCm39)	missense	possibly damaging	0.82
R8237:Tex15	UTSW	8	34,067,427 (GRCm39)	missense	possibly damaging	0.72
R8250:Tex15	UTSW	8	34,055,233 (GRCm39)	missense	probably null	0.27
R8264:Tex15	UTSW	8	34,072,390 (GRCm39)	missense	probably benign	0.18
R8279:Tex15	UTSW	8	34,061,765 (GRCm39)	missense	probably damaging	0.96
R8353:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8388:Tex15	UTSW	8	34,065,237 (GRCm39)	missense	probably benign	0.00
R8432:Tex15	UTSW	8	34,066,572 (GRCm39)	missense	probably damaging	0.99
R8453:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8489:Tex15	UTSW	8	34,067,574 (GRCm39)	missense	probably benign	0.02
R8670:Tex15	UTSW	8	34,064,746 (GRCm39)	missense	probably benign	0.19
R8703:Tex15	UTSW	8	34,062,724 (GRCm39)	missense	probably benign	0.00
R8871:Tex15	UTSW	8	34,066,992 (GRCm39)	missense	possibly damaging	0.62
R8945:Tex15	UTSW	8	34,064,724 (GRCm39)	missense	probably benign	0.00
R9104:Tex15	UTSW	8	34,060,950 (GRCm39)	missense	possibly damaging	0.86
R9132:Tex15	UTSW	8	34,067,554 (GRCm39)	missense	possibly damaging	0.84
R9207:Tex15	UTSW	8	34,065,784 (GRCm39)	missense	probably damaging	1.00
R9210:Tex15	UTSW	8	34,064,319 (GRCm39)	missense	possibly damaging	0.91
R9330:Tex15	UTSW	8	34,065,143 (GRCm39)	missense	probably benign	0.01
R9354:Tex15	UTSW	8	34,063,344 (GRCm39)	missense	possibly damaging	0.86
R9365:Tex15	UTSW	8	34,064,564 (GRCm39)	missense	possibly damaging	0.56
R9440:Tex15	UTSW	8	34,072,273 (GRCm39)	missense	possibly damaging	0.90
R9534:Tex15	UTSW	8	34,060,999 (GRCm39)	missense	probably benign	0.45
R9570:Tex15	UTSW	8	34,067,309 (GRCm39)	missense	probably damaging	0.96
R9574:Tex15	UTSW	8	34,064,509 (GRCm39)	missense	probably benign	0.09
R9618:Tex15	UTSW	8	34,062,397 (GRCm39)	missense	probably benign	0.35
R9655:Tex15	UTSW	8	34,066,784 (GRCm39)	nonsense	probably null
R9786:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R9798:Tex15	UTSW	8	34,062,721 (GRCm39)	missense	probably damaging	0.98
RF005:Tex15	UTSW	8	34,066,705 (GRCm39)	missense	probably benign	0.05
X0020:Tex15	UTSW	8	34,066,607 (GRCm39)	missense	probably benign	0.03
X0065:Tex15	UTSW	8	34,065,545 (GRCm39)	nonsense	probably null
Z1088:Tex15	UTSW	8	34,061,343 (GRCm39)	missense	possibly damaging	0.89
Z1088:Tex15	UTSW	8	34,064,898 (GRCm39)	missense	probably benign
Z1088:Tex15	UTSW	8	34,061,838 (GRCm39)	missense	possibly damaging	0.68
Z1176:Tex15	UTSW	8	34,064,754 (GRCm39)	missense	possibly damaging	0.84

Predicted Primers

PCR Primer
(F):5'- TGTCACCTGCTGAAAGTGTAC -3'
(R):5'- TGGTGAAAGTCTGTGCCACTC -3'

Sequencing Primer
(F):5'- GTCACCTGCTGAAAGTGTACAAGAC -3'
(R):5'- CAAATAAACGTCCTTCTCTGACTGGG -3'

Posted On

2019-11-26