|Institutional Source||Beutler Lab|
|Gene Name||G protein-coupled receptor 39|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7887 (G1)|
|Chromosomal Location||125676995-125873862 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to A at 125677542 bp|
|Amino Acid Change||Threonine to Lysine at position 69 (T69K)|
|Ref Sequence||ENSEMBL: ENSMUSP00000027581 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027581]|
|Predicted Effect||probably damaging
AA Change: T69K
PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
AA Change: T69K
|Coding Region Coverage||
|Validation Efficiency||98% (48/49)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]
PHENOTYPE: Mice homozygous for a null mutation display abnormal glucose homeostasis when fed a high sugar diet. Mice homozygous for a different null allele have accelerated gastric emptying, decreased fasting-induced hyperphagia, and increasedbody weight after oneyear of age. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gpr39||
(F):5'- CTTCATCCAGTGGCTCCAAC -3'
(R):5'- GCAATGTAGCGCTCAAAGC -3'
(F):5'- AACCACATCTGCTCCCGTG -3'
(R):5'- TGAGGGTCAGCACGTGCAG -3'