Incidental Mutation 'R0709:Vmn2r102'
| ID |
62680 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r102
|
| Ensembl Gene |
ENSMUSG00000095961 |
| Gene Name |
vomeronasal 2, receptor 102 |
| Synonyms |
EG224572 |
| MMRRC Submission |
038892-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0709 (G1)
|
| Quality Score |
127 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19660399-19694748 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 19677619 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 299
(M299L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126559
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171741]
|
| AlphaFold |
L7N279 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171741
AA Change: M299L
PolyPhen 2
Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: M299L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
448 |
5.2e-38 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
1.1e-21 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.8e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 95.8%
|
| Validation Efficiency |
98% (83/85) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A630010A05Rik |
A |
T |
16: 14,618,494 (GRCm38) |
D137V |
probably damaging |
Het |
| Aar2 |
C |
T |
2: 156,567,010 (GRCm38) |
P378L |
probably damaging |
Het |
| Abcc5 |
A |
T |
16: 20,376,592 (GRCm38) |
H718Q |
possibly damaging |
Het |
| Ace |
G |
T |
11: 105,981,538 (GRCm38) |
L319F |
probably damaging |
Het |
| Angpt4 |
C |
A |
2: 151,934,514 (GRCm38) |
P321T |
possibly damaging |
Het |
| Atrip |
T |
C |
9: 109,067,103 (GRCm38) |
N282S |
probably benign |
Het |
| AW554918 |
A |
C |
18: 25,463,654 (GRCm38) |
S525R |
probably damaging |
Het |
| Ccdc136 |
T |
A |
6: 29,414,970 (GRCm38) |
I644N |
possibly damaging |
Het |
| Ccdc178 |
A |
G |
18: 22,067,662 (GRCm38) |
Y413H |
probably damaging |
Het |
| Ccdc7b |
A |
G |
8: 129,136,646 (GRCm38) |
H223R |
probably benign |
Het |
| Cd109 |
T |
C |
9: 78,671,978 (GRCm38) |
V634A |
possibly damaging |
Het |
| Col7a1 |
T |
A |
9: 108,961,548 (GRCm38) |
|
probably benign |
Het |
| Copb2 |
A |
T |
9: 98,563,167 (GRCm38) |
|
probably benign |
Het |
| Csrnp3 |
C |
T |
2: 66,022,563 (GRCm38) |
S445L |
probably damaging |
Het |
| Cxcl13 |
G |
T |
5: 95,958,671 (GRCm38) |
C34F |
probably damaging |
Het |
| Dars2 |
T |
C |
1: 161,046,928 (GRCm38) |
E397G |
probably benign |
Het |
| Dlg5 |
C |
T |
14: 24,146,255 (GRCm38) |
V1625M |
probably damaging |
Het |
| Dnah12 |
T |
G |
14: 26,884,265 (GRCm38) |
|
probably benign |
Het |
| Eif4a1 |
C |
A |
11: 69,670,252 (GRCm38) |
A76S |
probably damaging |
Het |
| Fam162b |
T |
A |
10: 51,587,251 (GRCm38) |
I107L |
probably damaging |
Het |
| Fbxo30 |
G |
T |
10: 11,291,313 (GRCm38) |
C593F |
possibly damaging |
Het |
| Fut9 |
A |
G |
4: 25,620,359 (GRCm38) |
F152L |
probably damaging |
Het |
| Galnt2 |
G |
A |
8: 124,343,346 (GRCm38) |
G534D |
probably benign |
Het |
| Gm973 |
C |
T |
1: 59,558,234 (GRCm38) |
|
probably benign |
Het |
| Golm2 |
T |
A |
2: 121,867,425 (GRCm38) |
V74E |
probably damaging |
Het |
| Gprc5a |
T |
A |
6: 135,078,950 (GRCm38) |
S132T |
probably damaging |
Het |
| Hk3 |
G |
A |
13: 55,014,730 (GRCm38) |
R47C |
probably damaging |
Het |
| Hrnr |
A |
T |
3: 93,332,508 (GRCm38) |
Q3351L |
unknown |
Het |
| Icam1 |
T |
A |
9: 21,019,127 (GRCm38) |
F92L |
probably damaging |
Het |
| Ifi213 |
C |
T |
1: 173,589,800 (GRCm38) |
V349I |
possibly damaging |
Het |
| Il12rb2 |
T |
C |
6: 67,298,904 (GRCm38) |
|
probably benign |
Het |
| Irx3 |
A |
G |
8: 91,799,420 (GRCm38) |
V487A |
possibly damaging |
Het |
| Kalrn |
A |
G |
16: 34,035,554 (GRCm38) |
V204A |
probably damaging |
Het |
| Krt16 |
T |
C |
11: 100,246,454 (GRCm38) |
|
probably benign |
Het |
| Loxhd1 |
G |
A |
18: 77,404,969 (GRCm38) |
V1369I |
probably benign |
Het |
| Med13 |
T |
A |
11: 86,319,596 (GRCm38) |
K573N |
possibly damaging |
Het |
| Mnat1 |
A |
G |
12: 73,188,188 (GRCm38) |
R204G |
possibly damaging |
Het |
| Myt1l |
A |
T |
12: 29,827,733 (GRCm38) |
D461V |
unknown |
Het |
| Nek6 |
T |
A |
2: 38,557,846 (GRCm38) |
S41T |
probably damaging |
Het |
| Nudt22 |
T |
C |
19: 6,993,506 (GRCm38) |
E232G |
probably damaging |
Het |
| Numbl |
C |
A |
7: 27,273,990 (GRCm38) |
F192L |
probably damaging |
Het |
| Or4c105 |
C |
T |
2: 88,817,882 (GRCm38) |
T237I |
probably benign |
Het |
| Or7g12 |
T |
A |
9: 18,988,126 (GRCm38) |
I46K |
probably damaging |
Het |
| P2rx4 |
T |
C |
5: 122,714,404 (GRCm38) |
V47A |
probably damaging |
Het |
| Phka1 |
T |
A |
X: 102,586,104 (GRCm38) |
I478F |
probably damaging |
Het |
| Pkn2 |
G |
A |
3: 142,830,520 (GRCm38) |
T200I |
probably damaging |
Het |
| Plcg1 |
T |
A |
2: 160,751,778 (GRCm38) |
|
probably null |
Het |
| Polg2 |
C |
T |
11: 106,768,413 (GRCm38) |
G425R |
probably damaging |
Het |
| Ptprm |
G |
T |
17: 66,944,332 (GRCm38) |
|
probably null |
Het |
| Reg1 |
G |
A |
6: 78,428,118 (GRCm38) |
R108H |
possibly damaging |
Het |
| Slc19a2 |
T |
A |
1: 164,256,798 (GRCm38) |
F86I |
probably damaging |
Het |
| Slc26a11 |
T |
C |
11: 119,374,777 (GRCm38) |
L372P |
probably damaging |
Het |
| Slc2a4 |
C |
T |
11: 69,946,159 (GRCm38) |
V28M |
possibly damaging |
Het |
| Snap29 |
A |
G |
16: 17,406,148 (GRCm38) |
N9S |
probably damaging |
Het |
| Snd1 |
C |
G |
6: 28,545,470 (GRCm38) |
|
probably benign |
Het |
| Sorcs3 |
G |
A |
19: 48,487,406 (GRCm38) |
A235T |
probably benign |
Het |
| Sp100 |
T |
A |
1: 85,694,281 (GRCm38) |
N362K |
probably damaging |
Het |
| Sqor |
A |
T |
2: 122,799,855 (GRCm38) |
I32F |
probably benign |
Het |
| Stx6 |
C |
T |
1: 155,193,294 (GRCm38) |
R189C |
probably damaging |
Het |
| Tchp |
T |
C |
5: 114,717,453 (GRCm38) |
I298T |
probably damaging |
Het |
| Themis |
A |
G |
10: 28,761,574 (GRCm38) |
I225V |
probably benign |
Het |
| Timm50 |
A |
T |
7: 28,306,941 (GRCm38) |
V245E |
probably damaging |
Het |
| Tnxb |
A |
G |
17: 34,689,354 (GRCm38) |
E1327G |
probably damaging |
Het |
| Tpp1 |
C |
T |
7: 105,749,607 (GRCm38) |
R205H |
probably benign |
Het |
| Tradd |
T |
C |
8: 105,260,644 (GRCm38) |
E10G |
possibly damaging |
Het |
| Trim43a |
G |
A |
9: 88,582,146 (GRCm38) |
E37K |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,899,403 (GRCm38) |
|
probably benign |
Het |
| Ttr |
A |
T |
18: 20,669,977 (GRCm38) |
|
probably null |
Het |
| Ubp1 |
A |
G |
9: 113,944,931 (GRCm38) |
Y66C |
probably damaging |
Het |
| Vmn2r104 |
A |
T |
17: 20,042,904 (GRCm38) |
N98K |
probably damaging |
Het |
| Yipf5 |
A |
G |
18: 40,207,772 (GRCm38) |
S176P |
probably benign |
Het |
| Zpbp2 |
C |
T |
11: 98,553,937 (GRCm38) |
T97I |
probably damaging |
Het |
|
| Other mutations in Vmn2r102 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Vmn2r102
|
APN |
17 |
19,678,892 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00974:Vmn2r102
|
APN |
17 |
19,677,509 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL00978:Vmn2r102
|
APN |
17 |
19,678,923 (GRCm38) |
splice site |
probably null |
|
|
IGL01589:Vmn2r102
|
APN |
17 |
19,678,804 (GRCm38) |
missense |
probably benign |
|
|
IGL01738:Vmn2r102
|
APN |
17 |
19,677,758 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01994:Vmn2r102
|
APN |
17 |
19,660,469 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r102
|
APN |
17 |
19,693,929 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02525:Vmn2r102
|
APN |
17 |
19,681,185 (GRCm38) |
missense |
probably benign |
|
|
IGL02589:Vmn2r102
|
APN |
17 |
19,681,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02814:Vmn2r102
|
APN |
17 |
19,677,908 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03028:Vmn2r102
|
APN |
17 |
19,694,066 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL03162:Vmn2r102
|
APN |
17 |
19,694,024 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4431001:Vmn2r102
|
UTSW |
17 |
19,676,696 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R0042:Vmn2r102
|
UTSW |
17 |
19,660,589 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,678,763 (GRCm38) |
missense |
probably benign |
0.42 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,678,763 (GRCm38) |
missense |
probably benign |
0.42 |
|
R0132:Vmn2r102
|
UTSW |
17 |
19,678,763 (GRCm38) |
missense |
probably benign |
0.42 |
|
R0268:Vmn2r102
|
UTSW |
17 |
19,677,850 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0441:Vmn2r102
|
UTSW |
17 |
19,694,368 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0583:Vmn2r102
|
UTSW |
17 |
19,676,781 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0600:Vmn2r102
|
UTSW |
17 |
19,678,015 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0606:Vmn2r102
|
UTSW |
17 |
19,678,844 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R0674:Vmn2r102
|
UTSW |
17 |
19,677,867 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0879:Vmn2r102
|
UTSW |
17 |
19,694,192 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r102
|
UTSW |
17 |
19,660,625 (GRCm38) |
splice site |
probably benign |
|
|
R1473:Vmn2r102
|
UTSW |
17 |
19,694,581 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1630:Vmn2r102
|
UTSW |
17 |
19,678,770 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R1727:Vmn2r102
|
UTSW |
17 |
19,677,508 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1759:Vmn2r102
|
UTSW |
17 |
19,694,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r102
|
UTSW |
17 |
19,677,619 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2013:Vmn2r102
|
UTSW |
17 |
19,676,744 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2086:Vmn2r102
|
UTSW |
17 |
19,676,687 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2241:Vmn2r102
|
UTSW |
17 |
19,676,741 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2378:Vmn2r102
|
UTSW |
17 |
19,694,668 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3814:Vmn2r102
|
UTSW |
17 |
19,678,831 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3827:Vmn2r102
|
UTSW |
17 |
19,694,525 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4159:Vmn2r102
|
UTSW |
17 |
19,677,826 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4505:Vmn2r102
|
UTSW |
17 |
19,660,583 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4515:Vmn2r102
|
UTSW |
17 |
19,681,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4517:Vmn2r102
|
UTSW |
17 |
19,681,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4534:Vmn2r102
|
UTSW |
17 |
19,694,713 (GRCm38) |
missense |
probably benign |
|
|
R4535:Vmn2r102
|
UTSW |
17 |
19,694,713 (GRCm38) |
missense |
probably benign |
|
|
R4662:Vmn2r102
|
UTSW |
17 |
19,681,162 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r102
|
UTSW |
17 |
19,694,314 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r102
|
UTSW |
17 |
19,677,533 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4834:Vmn2r102
|
UTSW |
17 |
19,677,941 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4927:Vmn2r102
|
UTSW |
17 |
19,660,399 (GRCm38) |
start codon destroyed |
probably benign |
0.00 |
|
R5077:Vmn2r102
|
UTSW |
17 |
19,677,572 (GRCm38) |
missense |
probably benign |
0.20 |
|
R5181:Vmn2r102
|
UTSW |
17 |
19,676,741 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5277:Vmn2r102
|
UTSW |
17 |
19,694,131 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R5418:Vmn2r102
|
UTSW |
17 |
19,694,153 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5810:Vmn2r102
|
UTSW |
17 |
19,677,542 (GRCm38) |
missense |
probably benign |
0.20 |
|
R5864:Vmn2r102
|
UTSW |
17 |
19,694,681 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R6168:Vmn2r102
|
UTSW |
17 |
19,694,140 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R6266:Vmn2r102
|
UTSW |
17 |
19,678,745 (GRCm38) |
missense |
probably benign |
|
|
R6432:Vmn2r102
|
UTSW |
17 |
19,681,221 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R6487:Vmn2r102
|
UTSW |
17 |
19,677,907 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6597:Vmn2r102
|
UTSW |
17 |
19,694,188 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6797:Vmn2r102
|
UTSW |
17 |
19,660,432 (GRCm38) |
nonsense |
probably null |
|
|
R7009:Vmn2r102
|
UTSW |
17 |
19,694,194 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7098:Vmn2r102
|
UTSW |
17 |
19,694,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7134:Vmn2r102
|
UTSW |
17 |
19,677,487 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7463:Vmn2r102
|
UTSW |
17 |
19,676,624 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7511:Vmn2r102
|
UTSW |
17 |
19,681,143 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7512:Vmn2r102
|
UTSW |
17 |
19,694,101 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r102
|
UTSW |
17 |
19,677,831 (GRCm38) |
missense |
probably benign |
|
|
R8126:Vmn2r102
|
UTSW |
17 |
19,660,450 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8385:Vmn2r102
|
UTSW |
17 |
19,693,826 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R8410:Vmn2r102
|
UTSW |
17 |
19,677,934 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9045:Vmn2r102
|
UTSW |
17 |
19,660,579 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9267:Vmn2r102
|
UTSW |
17 |
19,676,666 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9325:Vmn2r102
|
UTSW |
17 |
19,677,296 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9363:Vmn2r102
|
UTSW |
17 |
19,677,352 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9524:Vmn2r102
|
UTSW |
17 |
19,677,302 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R9747:Vmn2r102
|
UTSW |
17 |
19,677,867 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r102
|
UTSW |
17 |
19,694,043 (GRCm38) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTCTCATACTCCCTGATGACCAC -3'
(R):5'- CATCCAAGGAAGCATTGGTTTGGC -3'
Sequencing Primer
(F):5'- GAGAAAAGGCATCTGCCTAGC -3'
(R):5'- TGTCAGCAAATGAGCACTTG -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation