Incidental Mutation 'R1956:Adamts9'
| ID |
217787 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts9
|
| Ensembl Gene |
ENSMUSG00000030022 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 9 |
| Synonyms |
Mhdaund3, Mhdaund4, 1810011L16Rik, 8430403M15Rik, E030027K14Rik, Gsfund3, UND3, UND4 |
| MMRRC Submission |
039970-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1956 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
92749680-92920473 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 92836830 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 641
(C641S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126498
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000113438]
[ENSMUST00000167391]
|
| AlphaFold |
E9PUN6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113438
AA Change: C1222S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109065
Gene: ENSMUSG00000030022
AA Change: C1222S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
49 |
207 |
1.8e-37 |
PFAM |
|
low complexity region
|
234 |
247 |
N/A |
INTRINSIC |
|
Pfam:Reprolysin_5
|
291 |
476 |
7.6e-17 |
PFAM |
|
Pfam:Reprolysin_4
|
291 |
495 |
2e-11 |
PFAM |
|
Pfam:Reprolysin
|
293 |
499 |
7.4e-29 |
PFAM |
|
Pfam:Reprolysin_2
|
310 |
489 |
1e-13 |
PFAM |
|
Pfam:Reprolysin_3
|
314 |
445 |
1.7e-14 |
PFAM |
|
TSP1
|
591 |
643 |
2.15e-9 |
SMART |
|
Pfam:ADAM_spacer1
|
753 |
871 |
7.3e-35 |
PFAM |
|
TSP1
|
881 |
936 |
1.14e0 |
SMART |
|
Blast:TSP1
|
938 |
993 |
2e-28 |
BLAST |
|
TSP1
|
1000 |
1054 |
3.78e-5 |
SMART |
|
TSP1
|
1055 |
1109 |
5.64e-4 |
SMART |
|
TSP1
|
1110 |
1166 |
1.25e-5 |
SMART |
|
TSP1
|
1186 |
1240 |
1.45e-6 |
SMART |
|
TSP1
|
1242 |
1296 |
4.41e-6 |
SMART |
|
TSP1
|
1328 |
1380 |
7.06e-5 |
SMART |
|
TSP1
|
1381 |
1436 |
4.24e-8 |
SMART |
|
TSP1
|
1440 |
1495 |
8.23e-6 |
SMART |
|
TSP1
|
1496 |
1551 |
1.23e-4 |
SMART |
|
TSP1
|
1552 |
1609 |
2e-4 |
SMART |
|
TSP1
|
1611 |
1672 |
1.25e-5 |
SMART |
|
TSP1
|
1676 |
1730 |
3.47e-4 |
SMART |
|
Pfam:GON
|
1732 |
1930 |
1.6e-85 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125490
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130314
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167391
AA Change: C641S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126498
Gene: ENSMUSG00000030022
AA Change: C641S
| Domain | Start | End | E-Value | Type |
|---|
|
TSP1
|
10 |
62 |
2.15e-9 |
SMART |
|
Pfam:ADAM_spacer1
|
172 |
290 |
6.1e-35 |
PFAM |
|
TSP1
|
300 |
355 |
1.14e0 |
SMART |
|
Blast:TSP1
|
357 |
412 |
3e-28 |
BLAST |
|
TSP1
|
419 |
473 |
3.78e-5 |
SMART |
|
TSP1
|
474 |
528 |
5.64e-4 |
SMART |
|
TSP1
|
529 |
585 |
1.25e-5 |
SMART |
|
TSP1
|
605 |
659 |
1.45e-6 |
SMART |
|
TSP1
|
661 |
715 |
4.41e-6 |
SMART |
|
TSP1
|
747 |
799 |
7.06e-5 |
SMART |
|
TSP1
|
800 |
855 |
4.24e-8 |
SMART |
|
TSP1
|
859 |
914 |
8.23e-6 |
SMART |
|
TSP1
|
915 |
970 |
1.23e-4 |
SMART |
|
TSP1
|
971 |
1028 |
2e-4 |
SMART |
|
TSP1
|
1030 |
1091 |
1.25e-5 |
SMART |
|
TSP1
|
1095 |
1149 |
3.47e-4 |
SMART |
|
Pfam:GON
|
1150 |
1350 |
2.1e-86 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
PHENOTYPE: Homozygous null mice display embryonic lethality before somite formation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aard |
A |
T |
15: 51,908,316 (GRCm39) |
D157V |
probably damaging |
Het |
| Abcg5 |
A |
G |
17: 84,977,803 (GRCm39) |
V151A |
probably damaging |
Het |
| Acss3 |
A |
G |
10: 106,772,029 (GRCm39) |
V682A |
probably benign |
Het |
| Adipor1 |
T |
C |
1: 134,350,771 (GRCm39) |
S7P |
probably benign |
Het |
| Ankrd27 |
T |
A |
7: 35,303,264 (GRCm39) |
Y215N |
probably damaging |
Het |
| Arhgef7 |
T |
A |
8: 11,855,266 (GRCm39) |
L182Q |
probably damaging |
Het |
| Arnt |
C |
T |
3: 95,355,704 (GRCm39) |
S16L |
possibly damaging |
Het |
| Arrdc4 |
T |
C |
7: 68,391,547 (GRCm39) |
K240R |
probably benign |
Het |
| Atg2b |
T |
C |
12: 105,635,677 (GRCm39) |
Y197C |
probably damaging |
Het |
| Atp13a2 |
A |
G |
4: 140,731,572 (GRCm39) |
K907R |
possibly damaging |
Het |
| Cadps2 |
A |
T |
6: 23,287,685 (GRCm39) |
M1160K |
probably damaging |
Het |
| Cdk12 |
A |
G |
11: 98,110,042 (GRCm39) |
T688A |
probably benign |
Het |
| Cfap43 |
T |
A |
19: 47,885,649 (GRCm39) |
Y322F |
probably benign |
Het |
| Crabp2 |
T |
C |
3: 87,856,193 (GRCm39) |
F16L |
probably damaging |
Het |
| Creb3 |
A |
G |
4: 43,563,279 (GRCm39) |
|
probably null |
Het |
| Crk |
T |
C |
11: 75,583,496 (GRCm39) |
Y239H |
possibly damaging |
Het |
| Cyp3a13 |
A |
G |
5: 137,908,204 (GRCm39) |
I215T |
probably benign |
Het |
| D130043K22Rik |
A |
G |
13: 25,069,578 (GRCm39) |
Y879C |
probably damaging |
Het |
| Depdc5 |
T |
C |
5: 33,061,175 (GRCm39) |
V334A |
probably damaging |
Het |
| Dgkh |
T |
C |
14: 78,855,981 (GRCm39) |
N231S |
probably damaging |
Het |
| Disp2 |
T |
A |
2: 118,622,704 (GRCm39) |
H1145Q |
probably benign |
Het |
| Epb41l4b |
T |
C |
4: 57,038,553 (GRCm39) |
T563A |
possibly damaging |
Het |
| Ephb3 |
G |
A |
16: 21,040,132 (GRCm39) |
R498H |
probably damaging |
Het |
| F10 |
T |
C |
8: 13,105,422 (GRCm39) |
I329T |
probably damaging |
Het |
| Fam13b |
G |
T |
18: 34,578,382 (GRCm39) |
Q760K |
possibly damaging |
Het |
| Fmo4 |
G |
A |
1: 162,631,259 (GRCm39) |
T236I |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 48,186,796 (GRCm39) |
R378Q |
unknown |
Het |
| Fpr-rs4 |
A |
G |
17: 18,242,518 (GRCm39) |
Y175C |
probably damaging |
Het |
| Fzd8 |
T |
A |
18: 9,214,502 (GRCm39) |
M528K |
probably damaging |
Het |
| Gcc2 |
A |
G |
10: 58,121,965 (GRCm39) |
H1134R |
possibly damaging |
Het |
| Gdf10 |
G |
A |
14: 33,654,710 (GRCm39) |
A406T |
probably benign |
Het |
| Ggn |
T |
A |
7: 28,871,341 (GRCm39) |
S240R |
probably damaging |
Het |
| Git2 |
C |
T |
5: 114,887,398 (GRCm39) |
W299* |
probably null |
Het |
| Gm42669 |
A |
T |
5: 107,656,738 (GRCm39) |
E355D |
possibly damaging |
Het |
| Gm5134 |
T |
C |
10: 75,840,680 (GRCm39) |
F508S |
possibly damaging |
Het |
| Gm9923 |
G |
T |
10: 72,145,490 (GRCm39) |
V114L |
probably benign |
Het |
| Has3 |
A |
T |
8: 107,605,435 (GRCm39) |
Y547F |
probably benign |
Het |
| Heatr5a |
A |
G |
12: 51,992,202 (GRCm39) |
|
probably null |
Het |
| Hnrnpk |
A |
T |
13: 58,544,000 (GRCm39) |
|
probably null |
Het |
| Ifna4 |
A |
T |
4: 88,760,311 (GRCm39) |
I72F |
probably damaging |
Het |
| Ip6k3 |
A |
T |
17: 27,370,142 (GRCm39) |
L92Q |
probably benign |
Het |
| Itpripl1 |
T |
C |
2: 126,983,927 (GRCm39) |
E65G |
probably damaging |
Het |
| Kcnh5 |
G |
C |
12: 74,944,358 (GRCm39) |
Q964E |
probably benign |
Het |
| Kmt2d |
A |
G |
15: 98,757,471 (GRCm39) |
|
probably benign |
Het |
| Lrrc69 |
A |
G |
4: 14,665,986 (GRCm39) |
V324A |
possibly damaging |
Het |
| Mefv |
T |
C |
16: 3,535,691 (GRCm39) |
Q79R |
probably damaging |
Het |
| Mettl17 |
T |
C |
14: 52,126,254 (GRCm39) |
S168P |
probably damaging |
Het |
| Mpp4 |
A |
T |
1: 59,197,811 (GRCm39) |
S23T |
probably benign |
Het |
| Nabp1 |
A |
T |
1: 51,517,004 (GRCm39) |
V24D |
probably damaging |
Het |
| Nod2 |
T |
A |
8: 89,390,836 (GRCm39) |
F359Y |
probably damaging |
Het |
| Or10g1b |
C |
T |
14: 52,628,037 (GRCm39) |
M64I |
probably benign |
Het |
| Or1p1c |
A |
T |
11: 74,160,670 (GRCm39) |
T152S |
probably damaging |
Het |
| Or51b17 |
T |
G |
7: 103,542,925 (GRCm39) |
S6R |
probably benign |
Het |
| Or52d3 |
C |
A |
7: 104,229,116 (GRCm39) |
L88M |
probably damaging |
Het |
| Or5ak4 |
T |
C |
2: 85,161,444 (GRCm39) |
D266G |
probably benign |
Het |
| Or5b107 |
T |
C |
19: 13,142,560 (GRCm39) |
Y61H |
probably damaging |
Het |
| Or6a2 |
C |
T |
7: 106,600,342 (GRCm39) |
A242T |
probably damaging |
Het |
| Or7a39 |
A |
G |
10: 78,715,267 (GRCm39) |
Q87R |
probably benign |
Het |
| Pcdh18 |
T |
C |
3: 49,710,400 (GRCm39) |
H305R |
probably benign |
Het |
| Phf1 |
T |
A |
17: 27,154,719 (GRCm39) |
|
probably null |
Het |
| Pold3 |
T |
C |
7: 99,737,318 (GRCm39) |
K379R |
probably benign |
Het |
| Polr1f |
T |
A |
12: 33,487,817 (GRCm39) |
V244D |
probably benign |
Het |
| Pou2f3 |
T |
A |
9: 43,056,534 (GRCm39) |
T108S |
probably benign |
Het |
| Prdm5 |
C |
A |
6: 65,913,060 (GRCm39) |
T203K |
probably damaging |
Het |
| Psma5 |
A |
G |
3: 108,173,760 (GRCm39) |
S79G |
probably benign |
Het |
| Psme4 |
T |
A |
11: 30,782,424 (GRCm39) |
S889T |
probably damaging |
Het |
| Ptk2 |
A |
T |
15: 73,087,832 (GRCm39) |
V902D |
possibly damaging |
Het |
| Rad54l |
T |
A |
4: 115,967,554 (GRCm39) |
I243F |
probably damaging |
Het |
| Ralgapa2 |
A |
G |
2: 146,302,679 (GRCm39) |
F95L |
probably benign |
Het |
| Rassf6 |
G |
A |
5: 90,763,730 (GRCm39) |
Q71* |
probably null |
Het |
| Ryr2 |
A |
T |
13: 11,695,966 (GRCm39) |
L2967H |
probably damaging |
Het |
| Scn5a |
T |
C |
9: 119,346,479 (GRCm39) |
T1058A |
possibly damaging |
Het |
| Sdk1 |
T |
C |
5: 142,080,336 (GRCm39) |
L1276P |
probably damaging |
Het |
| Serpina12 |
T |
G |
12: 104,002,048 (GRCm39) |
T223P |
probably damaging |
Het |
| Sh3yl1 |
A |
G |
12: 30,992,787 (GRCm39) |
|
probably null |
Het |
| Spata31g1 |
A |
T |
4: 42,970,105 (GRCm39) |
|
probably null |
Het |
| St6galnac5 |
T |
A |
3: 152,552,120 (GRCm39) |
Q149L |
probably benign |
Het |
| Stam2 |
T |
C |
2: 52,598,239 (GRCm39) |
|
probably null |
Het |
| Tac2 |
A |
G |
10: 127,564,349 (GRCm39) |
|
probably null |
Het |
| Tbata |
G |
A |
10: 61,019,256 (GRCm39) |
D271N |
probably damaging |
Het |
| Tbx3 |
T |
C |
5: 119,819,018 (GRCm39) |
V531A |
probably benign |
Het |
| Tektl1 |
A |
G |
10: 78,586,373 (GRCm39) |
|
probably null |
Het |
| Thra |
T |
A |
11: 98,654,567 (GRCm39) |
D312E |
probably benign |
Het |
| Tlr1 |
T |
A |
5: 65,082,520 (GRCm39) |
I686F |
probably damaging |
Het |
| Tmem86b |
A |
T |
7: 4,631,706 (GRCm39) |
F115L |
probably benign |
Het |
| Tmem94 |
A |
G |
11: 115,679,500 (GRCm39) |
D259G |
possibly damaging |
Het |
| Trim69 |
G |
A |
2: 122,004,956 (GRCm39) |
|
probably null |
Het |
| Usp43 |
T |
A |
11: 67,795,159 (GRCm39) |
Q243L |
probably damaging |
Het |
| Vcam1 |
T |
C |
3: 115,919,606 (GRCm39) |
Y226C |
probably damaging |
Het |
| Vmn2r104 |
A |
T |
17: 20,262,313 (GRCm39) |
N272K |
probably damaging |
Het |
| Vmn2r26 |
G |
A |
6: 124,030,846 (GRCm39) |
C527Y |
probably damaging |
Het |
| Vmn2r84 |
G |
A |
10: 130,226,677 (GRCm39) |
A387V |
probably benign |
Het |
| Vps13b |
A |
T |
15: 35,869,553 (GRCm39) |
I2686F |
probably damaging |
Het |
| Vps8 |
C |
T |
16: 21,279,892 (GRCm39) |
T281M |
probably damaging |
Het |
| Wdfy3 |
A |
G |
5: 102,067,275 (GRCm39) |
V1219A |
probably benign |
Het |
| Wnt9b |
A |
G |
11: 103,621,638 (GRCm39) |
C340R |
probably damaging |
Het |
| Zfhx3 |
T |
C |
8: 109,520,774 (GRCm39) |
V632A |
probably benign |
Het |
| Zfp1006 |
A |
T |
8: 129,948,309 (GRCm39) |
D41E |
possibly damaging |
Het |
| Zfp341 |
A |
T |
2: 154,480,132 (GRCm39) |
T528S |
probably benign |
Het |
| Zfp990 |
G |
A |
4: 145,261,452 (GRCm39) |
A33T |
probably damaging |
Het |
| Zranb1 |
T |
G |
7: 132,584,458 (GRCm39) |
S601R |
probably damaging |
Het |
| Zyx |
A |
T |
6: 42,328,289 (GRCm39) |
K166I |
probably damaging |
Het |
|
| Other mutations in Adamts9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00565:Adamts9
|
APN |
6 |
92,836,883 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01352:Adamts9
|
APN |
6 |
92,837,155 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01462:Adamts9
|
APN |
6 |
92,871,247 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01551:Adamts9
|
APN |
6 |
92,784,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01577:Adamts9
|
APN |
6 |
92,835,128 (GRCm39) |
splice site |
probably benign |
|
|
IGL01638:Adamts9
|
APN |
6 |
92,849,409 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01757:Adamts9
|
APN |
6 |
92,773,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02102:Adamts9
|
APN |
6 |
92,754,420 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02379:Adamts9
|
APN |
6 |
92,774,014 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02419:Adamts9
|
APN |
6 |
92,773,978 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02554:Adamts9
|
APN |
6 |
92,857,828 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02832:Adamts9
|
APN |
6 |
92,784,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03164:Adamts9
|
APN |
6 |
92,866,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03347:Adamts9
|
APN |
6 |
92,864,413 (GRCm39) |
nonsense |
probably null |
|
|
IGL03401:Adamts9
|
APN |
6 |
92,763,849 (GRCm39) |
missense |
probably damaging |
0.97 |
|
basilisk
|
UTSW |
6 |
92,837,170 (GRCm39) |
missense |
probably benign |
0.35 |
|
bluebeard
|
UTSW |
6 |
92,856,940 (GRCm39) |
nonsense |
probably null |
|
|
Serpent
|
UTSW |
6 |
92,885,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4402001:Adamts9
|
UTSW |
6 |
92,849,328 (GRCm39) |
missense |
probably benign |
|
|
PIT4458001:Adamts9
|
UTSW |
6 |
92,866,886 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0047:Adamts9
|
UTSW |
6 |
92,882,287 (GRCm39) |
unclassified |
probably benign |
|
|
R0047:Adamts9
|
UTSW |
6 |
92,882,287 (GRCm39) |
unclassified |
probably benign |
|
|
R0067:Adamts9
|
UTSW |
6 |
92,867,148 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0141:Adamts9
|
UTSW |
6 |
92,920,066 (GRCm39) |
missense |
probably benign |
|
|
R0326:Adamts9
|
UTSW |
6 |
92,835,038 (GRCm39) |
nonsense |
probably null |
|
|
R0396:Adamts9
|
UTSW |
6 |
92,774,986 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0490:Adamts9
|
UTSW |
6 |
92,849,847 (GRCm39) |
missense |
probably benign |
|
|
R0504:Adamts9
|
UTSW |
6 |
92,889,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0620:Adamts9
|
UTSW |
6 |
92,835,094 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0669:Adamts9
|
UTSW |
6 |
92,857,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0682:Adamts9
|
UTSW |
6 |
92,880,783 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1412:Adamts9
|
UTSW |
6 |
92,773,414 (GRCm39) |
missense |
probably benign |
|
|
R1433:Adamts9
|
UTSW |
6 |
92,826,271 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1558:Adamts9
|
UTSW |
6 |
92,885,692 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1661:Adamts9
|
UTSW |
6 |
92,857,604 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1801:Adamts9
|
UTSW |
6 |
92,840,357 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1855:Adamts9
|
UTSW |
6 |
92,878,350 (GRCm39) |
splice site |
probably benign |
|
|
R1887:Adamts9
|
UTSW |
6 |
92,849,769 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1934:Adamts9
|
UTSW |
6 |
92,920,102 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1986:Adamts9
|
UTSW |
6 |
92,773,375 (GRCm39) |
missense |
probably benign |
|
|
R2370:Adamts9
|
UTSW |
6 |
92,837,184 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2376:Adamts9
|
UTSW |
6 |
92,889,812 (GRCm39) |
missense |
probably benign |
|
|
R2432:Adamts9
|
UTSW |
6 |
92,834,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2876:Adamts9
|
UTSW |
6 |
92,772,891 (GRCm39) |
splice site |
probably benign |
|
|
R3015:Adamts9
|
UTSW |
6 |
92,849,913 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3611:Adamts9
|
UTSW |
6 |
92,846,965 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4024:Adamts9
|
UTSW |
6 |
92,849,765 (GRCm39) |
splice site |
probably benign |
|
|
R4292:Adamts9
|
UTSW |
6 |
92,772,977 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4403:Adamts9
|
UTSW |
6 |
92,836,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4574:Adamts9
|
UTSW |
6 |
92,856,940 (GRCm39) |
nonsense |
probably null |
|
|
R4677:Adamts9
|
UTSW |
6 |
92,793,587 (GRCm39) |
start codon destroyed |
probably null |
|
|
R5114:Adamts9
|
UTSW |
6 |
92,867,254 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5260:Adamts9
|
UTSW |
6 |
92,784,118 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5384:Adamts9
|
UTSW |
6 |
92,774,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5423:Adamts9
|
UTSW |
6 |
92,857,678 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5497:Adamts9
|
UTSW |
6 |
92,831,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5629:Adamts9
|
UTSW |
6 |
92,775,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5943:Adamts9
|
UTSW |
6 |
92,880,767 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6039:Adamts9
|
UTSW |
6 |
92,885,527 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6039:Adamts9
|
UTSW |
6 |
92,885,527 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6051:Adamts9
|
UTSW |
6 |
92,867,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6051:Adamts9
|
UTSW |
6 |
92,836,907 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6082:Adamts9
|
UTSW |
6 |
92,866,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6192:Adamts9
|
UTSW |
6 |
92,774,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6291:Adamts9
|
UTSW |
6 |
92,867,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6502:Adamts9
|
UTSW |
6 |
92,849,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6818:Adamts9
|
UTSW |
6 |
92,882,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6848:Adamts9
|
UTSW |
6 |
92,840,335 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7028:Adamts9
|
UTSW |
6 |
92,886,774 (GRCm39) |
nonsense |
probably null |
|
|
R7095:Adamts9
|
UTSW |
6 |
92,864,672 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7287:Adamts9
|
UTSW |
6 |
92,866,984 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7294:Adamts9
|
UTSW |
6 |
92,871,270 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7313:Adamts9
|
UTSW |
6 |
92,835,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7581:Adamts9
|
UTSW |
6 |
92,914,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7682:Adamts9
|
UTSW |
6 |
92,857,679 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7691:Adamts9
|
UTSW |
6 |
92,773,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7791:Adamts9
|
UTSW |
6 |
92,849,366 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7851:Adamts9
|
UTSW |
6 |
92,885,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7974:Adamts9
|
UTSW |
6 |
92,886,668 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8224:Adamts9
|
UTSW |
6 |
92,773,351 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8328:Adamts9
|
UTSW |
6 |
92,866,993 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8334:Adamts9
|
UTSW |
6 |
92,914,225 (GRCm39) |
splice site |
probably null |
|
|
R8559:Adamts9
|
UTSW |
6 |
92,784,117 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8709:Adamts9
|
UTSW |
6 |
92,784,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8735:Adamts9
|
UTSW |
6 |
92,837,048 (GRCm39) |
intron |
probably benign |
|
|
R8739:Adamts9
|
UTSW |
6 |
92,831,261 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9108:Adamts9
|
UTSW |
6 |
92,857,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9171:Adamts9
|
UTSW |
6 |
92,849,381 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9198:Adamts9
|
UTSW |
6 |
92,837,170 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9299:Adamts9
|
UTSW |
6 |
92,773,976 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9300:Adamts9
|
UTSW |
6 |
92,864,371 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9308:Adamts9
|
UTSW |
6 |
92,857,875 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9325:Adamts9
|
UTSW |
6 |
92,849,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9397:Adamts9
|
UTSW |
6 |
92,878,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Adamts9
|
UTSW |
6 |
92,878,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9623:Adamts9
|
UTSW |
6 |
92,857,661 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9698:Adamts9
|
UTSW |
6 |
92,784,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9755:Adamts9
|
UTSW |
6 |
92,856,922 (GRCm39) |
missense |
probably benign |
0.15 |
|
RF013:Adamts9
|
UTSW |
6 |
92,920,126 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Z1177:Adamts9
|
UTSW |
6 |
92,831,327 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGGTTTGCAGTCAGTCCAG -3'
(R):5'- GCTAAGAACTGATAAGATACTGGGC -3'
Sequencing Primer
(F):5'- GTGTACTCCTTGGACATTTGACTAAG -3'
(R):5'- ACTGATAAGATACTGGGCTAAGTG -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation