Mutagenetix > Incidental Mutation

Incidental Mutation 'R1956:Vmn2r26'

217788

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

039970-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R1956 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

124024758-124062035 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 124053887 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 527 (C527Y)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably damaging
Transcript: ENSMUST00000032238
AA Change: C527Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: C527Y

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158682

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.2%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 102 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700022I11Rik	A	T	4: 42,970,105 (GRCm38)		probably null	Het
2610044O15Rik8	A	T	8: 129,221,828 (GRCm38)	D41E	possibly damaging	Het
Aard	A	T	15: 52,044,920 (GRCm38)	D157V	probably damaging	Het
Abcg5	A	G	17: 84,670,375 (GRCm38)	V151A	probably damaging	Het
Acss3	A	G	10: 106,936,168 (GRCm38)	V682A	probably benign	Het
Adamts9	A	T	6: 92,859,849 (GRCm38)	C641S	probably damaging	Het
Adipor1	T	C	1: 134,423,033 (GRCm38)	S7P	probably benign	Het
Ankrd27	T	A	7: 35,603,839 (GRCm38)	Y215N	probably damaging	Het
Arhgef7	T	A	8: 11,805,266 (GRCm38)	L182Q	probably damaging	Het
Arnt	C	T	3: 95,448,393 (GRCm38)	S16L	possibly damaging	Het
Arrdc4	T	C	7: 68,741,799 (GRCm38)	K240R	probably benign	Het
Atg2b	T	C	12: 105,669,418 (GRCm38)	Y197C	probably damaging	Het
Atp13a2	A	G	4: 141,004,261 (GRCm38)	K907R	possibly damaging	Het
Cadps2	A	T	6: 23,287,686 (GRCm38)	M1160K	probably damaging	Het
Ccdc105	A	G	10: 78,750,539 (GRCm38)		probably null	Het
Cdk12	A	G	11: 98,219,216 (GRCm38)	T688A	probably benign	Het
Cfap43	T	A	19: 47,897,210 (GRCm38)	Y322F	probably benign	Het
Crabp2	T	C	3: 87,948,886 (GRCm38)	F16L	probably damaging	Het
Creb3	A	G	4: 43,563,279 (GRCm38)		probably null	Het
Crk	T	C	11: 75,692,670 (GRCm38)	Y239H	possibly damaging	Het
Cyp3a13	A	G	5: 137,909,942 (GRCm38)	I215T	probably benign	Het
D130043K22Rik	A	G	13: 24,885,595 (GRCm38)	Y879C	probably damaging	Het
Depdc5	T	C	5: 32,903,831 (GRCm38)	V334A	probably damaging	Het
Dgkh	T	C	14: 78,618,541 (GRCm38)	N231S	probably damaging	Het
Disp2	T	A	2: 118,792,223 (GRCm38)	H1145Q	probably benign	Het
Epb41l4b	T	C	4: 57,038,553 (GRCm38)	T563A	possibly damaging	Het
Ephb3	G	A	16: 21,221,382 (GRCm38)	R498H	probably damaging	Het
F10	T	C	8: 13,055,422 (GRCm38)	I329T	probably damaging	Het
Fam13b	G	T	18: 34,445,329 (GRCm38)	Q760K	possibly damaging	Het
Fmo4	G	A	1: 162,803,690 (GRCm38)	T236I	probably benign	Het
Foxp4	C	T	17: 47,875,871 (GRCm38)	R378Q	unknown	Het
Fpr-rs4	A	G	17: 18,022,256 (GRCm38)	Y175C	probably damaging	Het
Fzd8	T	A	18: 9,214,502 (GRCm38)	M528K	probably damaging	Het
Gcc2	A	G	10: 58,286,143 (GRCm38)	H1134R	possibly damaging	Het
Gdf10	G	A	14: 33,932,753 (GRCm38)	A406T	probably benign	Het
Ggn	T	A	7: 29,171,916 (GRCm38)	S240R	probably damaging	Het
Git2	C	T	5: 114,749,337 (GRCm38)	W299*	probably null	Het
Gm42669	A	T	5: 107,508,872 (GRCm38)	E355D	possibly damaging	Het
Gm5134	T	C	10: 76,004,846 (GRCm38)	F508S	possibly damaging	Het
Gm9923	G	T	10: 72,309,660 (GRCm38)	V114L	probably benign	Het
Has3	A	T	8: 106,878,803 (GRCm38)	Y547F	probably benign	Het
Heatr5a	A	G	12: 51,945,419 (GRCm38)		probably null	Het
Hnrnpk	A	T	13: 58,396,186 (GRCm38)		probably null	Het
Ifna4	A	T	4: 88,842,074 (GRCm38)	I72F	probably damaging	Het
Ip6k3	A	T	17: 27,151,168 (GRCm38)	L92Q	probably benign	Het
Itpripl1	T	C	2: 127,142,007 (GRCm38)	E65G	probably damaging	Het
Kcnh5	G	C	12: 74,897,584 (GRCm38)	Q964E	probably benign	Het
Kmt2d	A	G	15: 98,859,590 (GRCm38)		probably benign	Het
Lrrc69	A	G	4: 14,665,986 (GRCm38)	V324A	possibly damaging	Het
Mefv	T	C	16: 3,717,827 (GRCm38)	Q79R	probably damaging	Het
Mettl17	T	C	14: 51,888,797 (GRCm38)	S168P	probably damaging	Het
Mpp4	A	T	1: 59,158,652 (GRCm38)	S23T	probably benign	Het
Nabp1	A	T	1: 51,477,845 (GRCm38)	V24D	probably damaging	Het
Nod2	T	A	8: 88,664,208 (GRCm38)	F359Y	probably damaging	Het
Olfr1355	A	G	10: 78,879,433 (GRCm38)	Q87R	probably benign	Het
Olfr1461	T	C	19: 13,165,196 (GRCm38)	Y61H	probably damaging	Het
Olfr1511	C	T	14: 52,390,580 (GRCm38)	M64I	probably benign	Het
Olfr2	C	T	7: 107,001,135 (GRCm38)	A242T	probably damaging	Het
Olfr406	A	T	11: 74,269,844 (GRCm38)	T152S	probably damaging	Het
Olfr64	T	G	7: 103,893,718 (GRCm38)	S6R	probably benign	Het
Olfr653	C	A	7: 104,579,909 (GRCm38)	L88M	probably damaging	Het
Olfr987	T	C	2: 85,331,100 (GRCm38)	D266G	probably benign	Het
Pcdh18	T	C	3: 49,755,951 (GRCm38)	H305R	probably benign	Het
Phf1	T	A	17: 26,935,745 (GRCm38)		probably null	Het
Pold3	T	C	7: 100,088,111 (GRCm38)	K379R	probably benign	Het
Pou2f3	T	A	9: 43,145,237 (GRCm38)	T108S	probably benign	Het
Prdm5	C	A	6: 65,936,076 (GRCm38)	T203K	probably damaging	Het
Psma5	A	G	3: 108,266,444 (GRCm38)	S79G	probably benign	Het
Psme4	T	A	11: 30,832,424 (GRCm38)	S889T	probably damaging	Het
Ptk2	A	T	15: 73,215,983 (GRCm38)	V902D	possibly damaging	Het
Rad54l	T	A	4: 116,110,357 (GRCm38)	I243F	probably damaging	Het
Ralgapa2	A	G	2: 146,460,759 (GRCm38)	F95L	probably benign	Het
Rassf6	G	A	5: 90,615,871 (GRCm38)	Q71*	probably null	Het
Ryr2	A	T	13: 11,681,080 (GRCm38)	L2967H	probably damaging	Het
Scn5a	T	C	9: 119,517,413 (GRCm38)	T1058A	possibly damaging	Het
Sdk1	T	C	5: 142,094,581 (GRCm38)	L1276P	probably damaging	Het
Serpina12	T	G	12: 104,035,789 (GRCm38)	T223P	probably damaging	Het
Sh3yl1	A	G	12: 30,942,788 (GRCm38)		probably null	Het
St6galnac5	T	A	3: 152,846,483 (GRCm38)	Q149L	probably benign	Het
Stam2	T	C	2: 52,708,227 (GRCm38)		probably null	Het
Tac2	A	G	10: 127,728,480 (GRCm38)		probably null	Het
Tbata	G	A	10: 61,183,477 (GRCm38)	D271N	probably damaging	Het
Tbx3	T	C	5: 119,680,953 (GRCm38)	V531A	probably benign	Het
Thra	T	A	11: 98,763,741 (GRCm38)	D312E	probably benign	Het
Tlr1	T	A	5: 64,925,177 (GRCm38)	I686F	probably damaging	Het
Tmem86b	A	T	7: 4,628,707 (GRCm38)	F115L	probably benign	Het
Tmem94	A	G	11: 115,788,674 (GRCm38)	D259G	possibly damaging	Het
Trim69	G	A	2: 122,174,475 (GRCm38)		probably null	Het
Twistnb	T	A	12: 33,437,818 (GRCm38)	V244D	probably benign	Het
Usp43	T	A	11: 67,904,333 (GRCm38)	Q243L	probably damaging	Het
Vcam1	T	C	3: 116,125,957 (GRCm38)	Y226C	probably damaging	Het
Vmn2r104	A	T	17: 20,042,051 (GRCm38)	N272K	probably damaging	Het
Vmn2r84	G	A	10: 130,390,808 (GRCm38)	A387V	probably benign	Het
Vps13b	A	T	15: 35,869,407 (GRCm38)	I2686F	probably damaging	Het
Vps8	C	T	16: 21,461,142 (GRCm38)	T281M	probably damaging	Het
Wdfy3	A	G	5: 101,919,409 (GRCm38)	V1219A	probably benign	Het
Wnt9b	A	G	11: 103,730,812 (GRCm38)	C340R	probably damaging	Het
Zfhx3	T	C	8: 108,794,142 (GRCm38)	V632A	probably benign	Het
Zfp341	A	T	2: 154,638,212 (GRCm38)	T528S	probably benign	Het
Zfp990	G	A	4: 145,534,882 (GRCm38)	A33T	probably damaging	Het
Zranb1	T	G	7: 132,982,729 (GRCm38)	S601R	probably damaging	Het
Zyx	A	T	6: 42,351,355 (GRCm38)	K166I	probably damaging	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124,061,607 (GRCm38)	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124,061,756 (GRCm38)	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124,053,874 (GRCm38)	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124,050,673 (GRCm38)	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124,061,625 (GRCm38)	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124,061,818 (GRCm38)	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124,026,141 (GRCm38)	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124,026,132 (GRCm38)	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124,039,795 (GRCm38)	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124,050,819 (GRCm38)	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124,039,899 (GRCm38)	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124,062,033 (GRCm38)	makesense	probably null
R0083:Vmn2r26	UTSW	6	124,053,981 (GRCm38)	splice site	probably null
R0682:Vmn2r26	UTSW	6	124,061,170 (GRCm38)	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124,061,644 (GRCm38)	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124,053,913 (GRCm38)	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124,050,708 (GRCm38)	missense	probably benign
R1579:Vmn2r26	UTSW	6	124,039,747 (GRCm38)	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124,061,472 (GRCm38)	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124,061,410 (GRCm38)	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124,024,771 (GRCm38)	missense	probably benign
R1996:Vmn2r26	UTSW	6	124,061,185 (GRCm38)	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124,061,237 (GRCm38)	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124,039,749 (GRCm38)	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124,061,350 (GRCm38)	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124,025,979 (GRCm38)	missense	probably benign
R4490:Vmn2r26	UTSW	6	124,050,738 (GRCm38)	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124,061,191 (GRCm38)	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124,061,416 (GRCm38)	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124,053,965 (GRCm38)	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124,026,111 (GRCm38)	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124,061,873 (GRCm38)	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124,061,326 (GRCm38)	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124,050,717 (GRCm38)	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124,039,449 (GRCm38)	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124,025,966 (GRCm38)	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124,061,674 (GRCm38)	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124,039,871 (GRCm38)	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124,039,560 (GRCm38)	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124,061,485 (GRCm38)	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124,061,389 (GRCm38)	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124,026,080 (GRCm38)	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124,061,691 (GRCm38)	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124,039,098 (GRCm38)	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124,039,782 (GRCm38)	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124,061,296 (GRCm38)	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124,039,768 (GRCm38)	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124,061,989 (GRCm38)	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124,025,955 (GRCm38)	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124,039,741 (GRCm38)	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124,039,647 (GRCm38)	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124,039,362 (GRCm38)	missense	probably benign
R7696:Vmn2r26	UTSW	6	124,061,535 (GRCm38)	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124,061,745 (GRCm38)	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124,039,799 (GRCm38)	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124,024,955 (GRCm38)	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124,061,928 (GRCm38)	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124,039,618 (GRCm38)	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124,026,036 (GRCm38)	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124,039,618 (GRCm38)	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124,024,918 (GRCm38)	missense	probably benign	0.00
R8914:Vmn2r26	UTSW	6	124,062,024 (GRCm38)	missense	probably benign
R9333:Vmn2r26	UTSW	6	124,026,050 (GRCm38)	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124,039,374 (GRCm38)	missense	probably benign
R9436:Vmn2r26	UTSW	6	124,025,867 (GRCm38)	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124,061,178 (GRCm38)	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124,039,489 (GRCm38)	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- GAGTACTTGGACAGGCATGG -3'
(R):5'- GTGCATCATTTCCACATTCAGAATC -3'

Sequencing Primer
(F):5'- ATATAGGCGAACATCACAATTGG -3'
(R):5'- TCTTCTAATTCACACAATCAAAACCC -3'

Posted On

2014-08-01