Incidental Mutation 'R5394:Rnf123'
| ID |
426063 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rnf123
|
| Ensembl Gene |
ENSMUSG00000041528 |
| Gene Name |
ring finger protein 123 |
| Synonyms |
KPC1 |
| MMRRC Submission |
042966-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.171)
|
| Stock # |
R5394 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
107928869-107957183 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 107947930 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 131
(Y131C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136953
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047746]
[ENSMUST00000160249]
[ENSMUST00000160649]
[ENSMUST00000161828]
[ENSMUST00000162355]
[ENSMUST00000178267]
[ENSMUST00000174504]
[ENSMUST00000162516]
|
| AlphaFold |
Q5XPI3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047746
AA Change: Y131C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000040803
Gene: ENSMUSG00000041528
AA Change: Y131C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159136
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160249
AA Change: Y131C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000124548
Gene: ENSMUSG00000041528
AA Change: Y131C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160649
AA Change: Y131C
PolyPhen 2
Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000125495
Gene: ENSMUSG00000041528
AA Change: Y131C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161673
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161828
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162152
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000162355
AA Change: Y131C
PolyPhen 2
Score 0.628 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000125745
Gene: ENSMUSG00000041528
AA Change: Y131C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000178267
AA Change: Y131C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000136953
Gene: ENSMUSG00000041528
AA Change: Y131C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174504
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162516
|
| Meta Mutation Damage Score |
0.1966 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
97% (96/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930503B20Rik |
A |
G |
3: 146,356,363 (GRCm39) |
F182L |
probably damaging |
Het |
| 4930503B20Rik |
T |
C |
3: 146,356,713 (GRCm39) |
Y65C |
probably damaging |
Het |
| 4930590J08Rik |
A |
G |
6: 91,896,174 (GRCm39) |
T341A |
probably benign |
Het |
| Adamts13 |
G |
A |
2: 26,876,570 (GRCm39) |
V495I |
probably benign |
Het |
| Alms1 |
C |
A |
6: 85,600,070 (GRCm39) |
T2101K |
probably benign |
Het |
| Als2 |
T |
C |
1: 59,214,105 (GRCm39) |
D1361G |
probably benign |
Het |
| Ankdd1a |
A |
T |
9: 65,412,496 (GRCm39) |
M275K |
probably benign |
Het |
| Arfip2 |
A |
T |
7: 105,286,183 (GRCm39) |
Y161* |
probably null |
Het |
| Asap3 |
A |
T |
4: 135,968,570 (GRCm39) |
E707D |
probably benign |
Het |
| Atm |
C |
T |
9: 53,419,077 (GRCm39) |
|
probably null |
Het |
| Atp9b |
A |
T |
18: 80,820,052 (GRCm39) |
S577R |
probably benign |
Het |
| Bltp1 |
G |
T |
3: 36,971,817 (GRCm39) |
V517F |
probably damaging |
Het |
| Camk1d |
G |
C |
2: 5,308,177 (GRCm39) |
D274E |
probably benign |
Het |
| Cebpz |
C |
T |
17: 79,229,634 (GRCm39) |
D907N |
probably benign |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 105,036,102 (GRCm39) |
|
probably benign |
Het |
| Cnst |
T |
A |
1: 179,429,301 (GRCm39) |
|
probably benign |
Het |
| Cog2 |
G |
T |
8: 125,259,268 (GRCm39) |
V196L |
probably benign |
Het |
| Col11a1 |
A |
G |
3: 113,987,833 (GRCm39) |
|
probably null |
Het |
| Cops6 |
T |
A |
5: 138,161,762 (GRCm39) |
|
probably null |
Het |
| Cspg4 |
A |
G |
9: 56,797,484 (GRCm39) |
E1316G |
probably damaging |
Het |
| Cwc22 |
G |
C |
2: 77,759,683 (GRCm39) |
D122E |
possibly damaging |
Het |
| Dapk2 |
G |
A |
9: 66,176,000 (GRCm39) |
V300M |
probably benign |
Het |
| Dcp1b |
C |
A |
6: 119,152,328 (GRCm39) |
D25E |
probably damaging |
Het |
| Ddx10 |
A |
T |
9: 53,145,157 (GRCm39) |
Y273* |
probably null |
Het |
| Dhx58 |
T |
C |
11: 100,589,034 (GRCm39) |
E504G |
probably benign |
Het |
| Dync2h1 |
C |
T |
9: 7,120,899 (GRCm39) |
W2129* |
probably null |
Het |
| Egr4 |
A |
T |
6: 85,489,442 (GRCm39) |
L206Q |
probably damaging |
Het |
| Eif4g3 |
A |
G |
4: 137,830,709 (GRCm39) |
|
probably null |
Het |
| Fbxo46 |
A |
G |
7: 18,870,541 (GRCm39) |
N387D |
possibly damaging |
Het |
| Fpr-rs3 |
T |
G |
17: 20,844,470 (GRCm39) |
M224L |
probably benign |
Het |
| Gm14325 |
G |
A |
2: 177,474,777 (GRCm39) |
H102Y |
possibly damaging |
Het |
| Gxylt2 |
A |
G |
6: 100,682,075 (GRCm39) |
K91E |
probably benign |
Het |
| Hecw1 |
A |
T |
13: 14,497,174 (GRCm39) |
V278E |
probably damaging |
Het |
| Hydin |
A |
G |
8: 111,266,474 (GRCm39) |
|
probably null |
Het |
| Iars1 |
T |
C |
13: 49,875,641 (GRCm39) |
L776P |
probably damaging |
Het |
| Kcnh2 |
T |
A |
5: 24,537,039 (GRCm39) |
T182S |
probably benign |
Het |
| Kplce |
T |
C |
3: 92,776,005 (GRCm39) |
E226G |
probably damaging |
Het |
| Lats2 |
T |
G |
14: 57,928,810 (GRCm39) |
S1022R |
probably benign |
Het |
| Lef1 |
C |
T |
3: 130,988,308 (GRCm39) |
P264S |
probably damaging |
Het |
| Lyrm1 |
A |
C |
7: 119,513,471 (GRCm39) |
I79L |
possibly damaging |
Het |
| Macroh2a2 |
G |
A |
10: 61,587,466 (GRCm39) |
T156M |
possibly damaging |
Het |
| Man2b2 |
T |
G |
5: 36,971,862 (GRCm39) |
Q618P |
probably benign |
Het |
| Mei1 |
T |
C |
15: 81,976,957 (GRCm39) |
V180A |
possibly damaging |
Het |
| Mmp15 |
A |
T |
8: 96,093,032 (GRCm39) |
N137I |
probably damaging |
Het |
| Mms22l |
A |
G |
4: 24,517,115 (GRCm39) |
D222G |
possibly damaging |
Het |
| Mmut |
T |
A |
17: 41,258,075 (GRCm39) |
S414T |
probably benign |
Het |
| Myo18a |
T |
C |
11: 77,744,176 (GRCm39) |
M1846T |
probably benign |
Het |
| Neo1 |
A |
T |
9: 58,897,517 (GRCm39) |
N146K |
probably benign |
Het |
| Nos3 |
A |
G |
5: 24,588,888 (GRCm39) |
T1174A |
probably benign |
Het |
| Or10d4b |
A |
T |
9: 39,534,430 (GRCm39) |
T4S |
probably benign |
Het |
| Or10x1 |
T |
C |
1: 174,196,836 (GRCm39) |
Y118H |
probably damaging |
Het |
| Or4c125 |
A |
T |
2: 89,169,806 (GRCm39) |
I280N |
probably damaging |
Het |
| Or51f1 |
A |
T |
7: 102,505,686 (GRCm39) |
S268T |
probably damaging |
Het |
| Pax8 |
A |
T |
2: 24,332,922 (GRCm39) |
|
probably benign |
Het |
| Pde5a |
G |
A |
3: 122,611,658 (GRCm39) |
C532Y |
probably damaging |
Het |
| Pigq |
T |
C |
17: 26,150,446 (GRCm39) |
D442G |
possibly damaging |
Het |
| Pik3c2g |
T |
C |
6: 139,665,808 (GRCm39) |
V43A |
probably benign |
Het |
| Pik3cb |
T |
C |
9: 98,970,716 (GRCm39) |
N325S |
probably benign |
Het |
| Pot1b |
T |
C |
17: 56,007,063 (GRCm39) |
K18R |
probably benign |
Het |
| Ppp1r42 |
A |
T |
1: 10,069,630 (GRCm39) |
L144Q |
probably damaging |
Het |
| Prdm13 |
T |
A |
4: 21,679,455 (GRCm39) |
Q345L |
unknown |
Het |
| Pyroxd2 |
T |
A |
19: 42,728,898 (GRCm39) |
K167N |
probably benign |
Het |
| Rnf25 |
T |
C |
1: 74,634,411 (GRCm39) |
D204G |
probably damaging |
Het |
| Rpf2 |
G |
A |
10: 40,109,181 (GRCm39) |
T60I |
possibly damaging |
Het |
| Scaf11 |
T |
C |
15: 96,317,339 (GRCm39) |
N742D |
probably benign |
Het |
| Shank1 |
G |
A |
7: 44,002,075 (GRCm39) |
D1257N |
possibly damaging |
Het |
| Shc2 |
A |
G |
10: 79,465,933 (GRCm39) |
V168A |
probably damaging |
Het |
| Slc16a4 |
G |
A |
3: 107,199,758 (GRCm39) |
V2M |
probably benign |
Het |
| Slc24a3 |
T |
C |
2: 145,455,494 (GRCm39) |
V461A |
probably benign |
Het |
| Slc45a2 |
C |
T |
15: 11,027,871 (GRCm39) |
T480I |
probably damaging |
Het |
| Slc4a4 |
T |
A |
5: 89,345,623 (GRCm39) |
|
probably null |
Het |
| Snx30 |
T |
A |
4: 59,879,329 (GRCm39) |
D189E |
probably benign |
Het |
| Sspo |
A |
G |
6: 48,472,194 (GRCm39) |
Q4653R |
possibly damaging |
Het |
| Tpte |
G |
T |
8: 22,817,806 (GRCm39) |
R264I |
probably damaging |
Het |
| Tsc22d4 |
T |
A |
5: 137,757,036 (GRCm39) |
|
probably benign |
Het |
| Ubn1 |
T |
C |
16: 4,892,233 (GRCm39) |
L585P |
possibly damaging |
Het |
| Usp24 |
A |
T |
4: 106,265,210 (GRCm39) |
D1781V |
probably damaging |
Het |
| Utp20 |
A |
T |
10: 88,608,777 (GRCm39) |
Y1514* |
probably null |
Het |
| Vmn1r55 |
A |
T |
7: 5,149,995 (GRCm39) |
Y143N |
probably damaging |
Het |
| Vmn2r65 |
A |
G |
7: 84,595,862 (GRCm39) |
V274A |
probably benign |
Het |
| Wdr17 |
A |
G |
8: 55,092,524 (GRCm39) |
S1087P |
possibly damaging |
Het |
| Wnt5b |
C |
A |
6: 119,417,283 (GRCm39) |
R156L |
probably damaging |
Het |
| Zan |
T |
C |
5: 137,433,896 (GRCm39) |
D2279G |
unknown |
Het |
| Zan |
T |
C |
5: 137,462,336 (GRCm39) |
T948A |
unknown |
Het |
| Zfp758 |
T |
C |
17: 22,591,049 (GRCm39) |
S4P |
probably damaging |
Het |
| Zfp839 |
A |
G |
12: 110,822,020 (GRCm39) |
E278G |
probably benign |
Het |
| Zfp994 |
T |
A |
17: 22,419,506 (GRCm39) |
H481L |
probably damaging |
Het |
| Zswim9 |
G |
A |
7: 12,994,909 (GRCm39) |
R416C |
probably damaging |
Het |
|
| Other mutations in Rnf123 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00950:Rnf123
|
APN |
9 |
107,944,594 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01358:Rnf123
|
APN |
9 |
107,946,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01464:Rnf123
|
APN |
9 |
107,929,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01637:Rnf123
|
APN |
9 |
107,935,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01669:Rnf123
|
APN |
9 |
107,935,555 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01905:Rnf123
|
APN |
9 |
107,948,569 (GRCm39) |
splice site |
probably benign |
|
|
IGL02070:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02072:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02073:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02074:Rnf123
|
APN |
9 |
107,944,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02079:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02080:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02231:Rnf123
|
APN |
9 |
107,943,598 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02281:Rnf123
|
APN |
9 |
107,948,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02336:Rnf123
|
APN |
9 |
107,939,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02543:Rnf123
|
APN |
9 |
107,943,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02565:Rnf123
|
APN |
9 |
107,929,411 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02571:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02572:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02574:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02586:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02589:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02600:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02601:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02602:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02603:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02609:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02628:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02629:Rnf123
|
APN |
9 |
107,947,988 (GRCm39) |
splice site |
probably benign |
|
|
IGL02629:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02630:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02631:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02632:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02650:Rnf123
|
APN |
9 |
107,946,947 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL02690:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02691:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02692:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02693:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02713:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02736:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02929:Rnf123
|
APN |
9 |
107,946,275 (GRCm39) |
missense |
probably benign |
|
|
R1175:Rnf123
|
UTSW |
9 |
107,954,572 (GRCm39) |
missense |
probably benign |
|
|
R1465:Rnf123
|
UTSW |
9 |
107,948,665 (GRCm39) |
splice site |
probably benign |
|
|
R1502:Rnf123
|
UTSW |
9 |
107,945,709 (GRCm39) |
splice site |
probably null |
|
|
R1682:Rnf123
|
UTSW |
9 |
107,954,597 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1817:Rnf123
|
UTSW |
9 |
107,940,125 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1855:Rnf123
|
UTSW |
9 |
107,938,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2394:Rnf123
|
UTSW |
9 |
107,940,735 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2483:Rnf123
|
UTSW |
9 |
107,940,720 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3896:Rnf123
|
UTSW |
9 |
107,946,302 (GRCm39) |
splice site |
probably benign |
|
|
R3940:Rnf123
|
UTSW |
9 |
107,941,234 (GRCm39) |
splice site |
probably benign |
|
|
R4206:Rnf123
|
UTSW |
9 |
107,941,162 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4641:Rnf123
|
UTSW |
9 |
107,935,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Rnf123
|
UTSW |
9 |
107,929,638 (GRCm39) |
splice site |
probably null |
|
|
R4767:Rnf123
|
UTSW |
9 |
107,929,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Rnf123
|
UTSW |
9 |
107,933,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Rnf123
|
UTSW |
9 |
107,940,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5274:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5275:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5276:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5294:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5295:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5717:Rnf123
|
UTSW |
9 |
107,944,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6186:Rnf123
|
UTSW |
9 |
107,947,157 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6449:Rnf123
|
UTSW |
9 |
107,933,252 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6502:Rnf123
|
UTSW |
9 |
107,945,531 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6944:Rnf123
|
UTSW |
9 |
107,940,822 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7003:Rnf123
|
UTSW |
9 |
107,940,882 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7088:Rnf123
|
UTSW |
9 |
107,935,735 (GRCm39) |
missense |
probably null |
1.00 |
|
R7092:Rnf123
|
UTSW |
9 |
107,945,799 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7100:Rnf123
|
UTSW |
9 |
107,933,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Rnf123
|
UTSW |
9 |
107,946,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Rnf123
|
UTSW |
9 |
107,947,607 (GRCm39) |
splice site |
probably null |
|
|
R7468:Rnf123
|
UTSW |
9 |
107,946,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7517:Rnf123
|
UTSW |
9 |
107,947,473 (GRCm39) |
nonsense |
probably null |
|
|
R7577:Rnf123
|
UTSW |
9 |
107,947,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8296:Rnf123
|
UTSW |
9 |
107,940,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Rnf123
|
UTSW |
9 |
107,945,706 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8754:Rnf123
|
UTSW |
9 |
107,948,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Rnf123
|
UTSW |
9 |
107,946,272 (GRCm39) |
missense |
probably benign |
|
|
R9052:Rnf123
|
UTSW |
9 |
107,936,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9156:Rnf123
|
UTSW |
9 |
107,940,227 (GRCm39) |
splice site |
probably benign |
|
|
R9170:Rnf123
|
UTSW |
9 |
107,948,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9332:Rnf123
|
UTSW |
9 |
107,944,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9385:Rnf123
|
UTSW |
9 |
107,929,467 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9394:Rnf123
|
UTSW |
9 |
107,942,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9432:Rnf123
|
UTSW |
9 |
107,937,008 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9717:Rnf123
|
UTSW |
9 |
107,954,963 (GRCm39) |
missense |
probably benign |
0.43 |
|
Z1176:Rnf123
|
UTSW |
9 |
107,940,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Rnf123
|
UTSW |
9 |
107,935,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTGATTAAAGCGGCAGTTG -3'
(R):5'- ATCATGTCTGTCCCAGAAGCTC -3'
Sequencing Primer
(F):5'- ATTAAAGCGGCAGTTGATGGTGC -3'
(R):5'- CAGAAGCTCTGGACATGGATAC -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation