Incidental Mutation 'R9717:Rnf123'
| ID |
730544 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rnf123
|
| Ensembl Gene |
ENSMUSG00000041528 |
| Gene Name |
ring finger protein 123 |
| Synonyms |
KPC1 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.171)
|
| Stock # |
R9717 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
107928869-107957183 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 107954963 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 14
(S14G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125745
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035211]
[ENSMUST00000047746]
[ENSMUST00000159372]
[ENSMUST00000160249]
[ENSMUST00000160649]
[ENSMUST00000161828]
[ENSMUST00000162355]
[ENSMUST00000162516]
[ENSMUST00000162886]
[ENSMUST00000174504]
[ENSMUST00000178267]
|
| AlphaFold |
Q5XPI3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000035211
|
| SMART Domains |
Protein: ENSMUSP00000035211
Gene: ENSMUSG00000032591
| Domain | Start | End | E-Value | Type |
|---|
|
PAN_AP
|
21 |
104 |
2.65e-9 |
SMART |
|
KR
|
108 |
188 |
3.13e-39 |
SMART |
|
KR
|
189 |
270 |
8.57e-46 |
SMART |
|
KR
|
290 |
372 |
7.94e-41 |
SMART |
|
KR
|
377 |
459 |
6.59e-47 |
SMART |
|
Tryp_SPc
|
488 |
709 |
2.27e-55 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047746
AA Change: S14G
PolyPhen 2
Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000040803
Gene: ENSMUSG00000041528
AA Change: S14G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159372
AA Change: S14G
PolyPhen 2
Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160184
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160249
AA Change: S14G
PolyPhen 2
Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000124548
Gene: ENSMUSG00000041528
AA Change: S14G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160649
AA Change: S14G
PolyPhen 2
Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000125495
Gene: ENSMUSG00000041528
AA Change: S14G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161828
AA Change: S14G
PolyPhen 2
Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162355
AA Change: S14G
PolyPhen 2
Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000125745
Gene: ENSMUSG00000041528
AA Change: S14G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162516
AA Change: S14G
PolyPhen 2
Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162886
|
| SMART Domains |
Protein: ENSMUSP00000125175
Gene: ENSMUSG00000032591
| Domain | Start | End | E-Value | Type |
|---|
|
PAN_AP
|
21 |
104 |
2.65e-9 |
SMART |
|
KR
|
108 |
188 |
3.13e-39 |
SMART |
|
KR
|
189 |
270 |
1.07e-46 |
SMART |
|
KR
|
281 |
363 |
7.94e-41 |
SMART |
|
KR
|
368 |
450 |
6.59e-47 |
SMART |
|
Tryp_SPc
|
479 |
700 |
2.27e-55 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174504
AA Change: S14G
PolyPhen 2
Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178267
AA Change: S14G
PolyPhen 2
Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000136953
Gene: ENSMUSG00000041528
AA Change: S14G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrv1 |
T |
A |
13: 81,668,900 (GRCm39) |
N2552I |
probably damaging |
Het |
| Amph |
G |
T |
13: 19,309,253 (GRCm39) |
A444S |
probably benign |
Het |
| Ankrd52 |
A |
G |
10: 128,216,457 (GRCm39) |
N157S |
probably benign |
Het |
| Arhgap29 |
T |
C |
3: 121,797,920 (GRCm39) |
F537L |
probably benign |
Het |
| Asic1 |
A |
C |
15: 99,590,657 (GRCm39) |
T136P |
probably damaging |
Het |
| Atg2b |
T |
C |
12: 105,605,561 (GRCm39) |
Y1468C |
probably benign |
Het |
| Atm |
A |
G |
9: 53,427,817 (GRCm39) |
L431P |
probably damaging |
Het |
| Atosb |
T |
C |
4: 43,036,050 (GRCm39) |
H227R |
probably damaging |
Het |
| Btaf1 |
A |
G |
19: 36,922,646 (GRCm39) |
T17A |
probably benign |
Het |
| Car10 |
A |
G |
11: 93,195,367 (GRCm39) |
N58S |
probably benign |
Het |
| Cd79b |
A |
T |
11: 106,202,845 (GRCm39) |
D252E |
probably damaging |
Het |
| Cdipt |
C |
T |
7: 126,576,202 (GRCm39) |
|
probably benign |
Het |
| Cebpe |
T |
C |
14: 54,949,165 (GRCm39) |
D84G |
probably damaging |
Het |
| Cenpj |
T |
C |
14: 56,790,453 (GRCm39) |
E532G |
probably benign |
Het |
| Cherp |
A |
G |
8: 73,216,920 (GRCm39) |
|
probably null |
Het |
| Chuk |
T |
C |
19: 44,071,109 (GRCm39) |
D532G |
possibly damaging |
Het |
| Clec1b |
C |
T |
6: 129,374,603 (GRCm39) |
T9I |
probably benign |
Het |
| Clspn |
G |
T |
4: 126,458,756 (GRCm39) |
A280S |
possibly damaging |
Het |
| Cts3 |
T |
G |
13: 61,712,799 (GRCm39) |
Y307S |
probably benign |
Het |
| Cyp2c39 |
T |
C |
19: 39,556,493 (GRCm39) |
M443T |
possibly damaging |
Het |
| Dhx57 |
C |
T |
17: 80,582,447 (GRCm39) |
R386H |
probably damaging |
Het |
| Dhx58 |
A |
T |
11: 100,592,133 (GRCm39) |
M305K |
probably benign |
Het |
| Dlgap3 |
T |
C |
4: 127,129,287 (GRCm39) |
L894P |
probably damaging |
Het |
| Dnah3 |
A |
T |
7: 119,574,299 (GRCm39) |
N2164K |
probably damaging |
Het |
| Dnajb14 |
A |
G |
3: 137,608,044 (GRCm39) |
N183S |
probably benign |
Het |
| Drd5 |
G |
T |
5: 38,478,090 (GRCm39) |
R361L |
probably damaging |
Het |
| Duoxa1 |
T |
C |
2: 122,135,622 (GRCm39) |
E159G |
probably damaging |
Het |
| Exoc1 |
T |
A |
5: 76,711,079 (GRCm39) |
S659R |
probably benign |
Het |
| Fbln7 |
T |
C |
2: 128,719,314 (GRCm39) |
I37T |
probably benign |
Het |
| Fcgrt |
T |
G |
7: 44,744,853 (GRCm39) |
E205A |
possibly damaging |
Het |
| Fcho2 |
A |
T |
13: 98,900,202 (GRCm39) |
S304T |
probably damaging |
Het |
| Gbp9 |
C |
A |
5: 105,253,587 (GRCm39) |
G43* |
probably null |
Het |
| Gucy2d |
A |
G |
7: 98,123,868 (GRCm39) |
K151R |
probably benign |
Het |
| Heatr4 |
T |
A |
12: 84,024,829 (GRCm39) |
I331F |
probably damaging |
Het |
| Hmcn1 |
G |
A |
1: 150,485,378 (GRCm39) |
T4408I |
probably damaging |
Het |
| Hoxc9 |
C |
T |
15: 102,890,551 (GRCm39) |
T156M |
probably benign |
Het |
| Hrnr |
A |
T |
3: 93,227,987 (GRCm39) |
E35V |
probably damaging |
Het |
| Idua |
C |
T |
5: 108,818,037 (GRCm39) |
Q70* |
probably null |
Het |
| Klf5 |
A |
T |
14: 99,539,189 (GRCm39) |
I201F |
probably damaging |
Het |
| Lonrf1 |
T |
C |
8: 36,701,164 (GRCm39) |
K349E |
probably damaging |
Het |
| Lrp1b |
A |
T |
2: 41,158,395 (GRCm39) |
D1721E |
|
Het |
| Mdh1 |
T |
A |
11: 21,521,870 (GRCm39) |
|
probably benign |
Het |
| Mllt11 |
T |
C |
3: 95,127,521 (GRCm39) |
H83R |
probably benign |
Het |
| Mrgprb4 |
A |
C |
7: 47,848,583 (GRCm39) |
I115S |
possibly damaging |
Het |
| Mrpl38 |
A |
G |
11: 116,023,296 (GRCm39) |
F319S |
probably damaging |
Het |
| Naif1 |
A |
T |
2: 32,344,907 (GRCm39) |
M204L |
probably benign |
Het |
| Ncan |
T |
A |
8: 70,554,628 (GRCm39) |
D1063V |
probably damaging |
Het |
| Noto |
A |
T |
6: 85,401,327 (GRCm39) |
R119W |
possibly damaging |
Het |
| Or4c115 |
G |
A |
2: 88,927,573 (GRCm39) |
L233F |
probably benign |
Het |
| Or51h7 |
A |
T |
7: 102,591,165 (GRCm39) |
D206E |
probably damaging |
Het |
| Or6c69 |
T |
A |
10: 129,748,048 (GRCm39) |
Y33F |
probably damaging |
Het |
| Or8b3 |
A |
T |
9: 38,314,841 (GRCm39) |
I224F |
probably damaging |
Het |
| Ovch2 |
A |
G |
7: 107,393,584 (GRCm39) |
W181R |
probably damaging |
Het |
| Palm |
G |
C |
10: 79,655,117 (GRCm39) |
G292R |
probably damaging |
Het |
| Pdgfrb |
T |
A |
18: 61,205,787 (GRCm39) |
L591* |
probably null |
Het |
| Pik3c2g |
T |
C |
6: 139,841,910 (GRCm39) |
S772P |
|
Het |
| Prx |
C |
A |
7: 27,217,411 (GRCm39) |
D776E |
probably benign |
Het |
| Ptpra |
A |
G |
2: 130,384,366 (GRCm39) |
E562G |
possibly damaging |
Het |
| Rbm4b |
A |
G |
19: 4,807,359 (GRCm39) |
Y25C |
probably damaging |
Het |
| Reln |
T |
C |
5: 22,136,427 (GRCm39) |
T2534A |
probably benign |
Het |
| Rock2 |
A |
G |
12: 17,015,602 (GRCm39) |
H833R |
probably benign |
Het |
| Rxfp3 |
A |
G |
15: 11,037,111 (GRCm39) |
V87A |
possibly damaging |
Het |
| S100b |
G |
A |
10: 76,092,936 (GRCm39) |
G23D |
probably damaging |
Het |
| Scn9a |
T |
A |
2: 66,357,002 (GRCm39) |
M1100L |
probably benign |
Het |
| Septin11 |
T |
A |
5: 93,296,266 (GRCm39) |
S55T |
possibly damaging |
Het |
| Speer4a3 |
T |
C |
5: 26,154,829 (GRCm39) |
E257G |
probably damaging |
Het |
| Sv2b |
T |
A |
7: 74,769,676 (GRCm39) |
Q622L |
probably benign |
Het |
| Taar7a |
T |
C |
10: 23,868,799 (GRCm39) |
D194G |
probably benign |
Het |
| Trappc3 |
T |
C |
4: 126,169,014 (GRCm39) |
I168T |
probably benign |
Het |
| Trim27 |
T |
C |
13: 21,374,296 (GRCm39) |
|
probably null |
Het |
| Wdr49 |
G |
A |
3: 75,304,359 (GRCm39) |
T109I |
probably benign |
Het |
| Wdr64 |
T |
C |
1: 175,544,854 (GRCm39) |
Y96H |
probably damaging |
Het |
| Zfp219 |
A |
T |
14: 52,247,049 (GRCm39) |
L26Q |
probably damaging |
Het |
| Zfp758 |
T |
A |
17: 22,593,829 (GRCm39) |
V105D |
possibly damaging |
Het |
| Zfp975 |
C |
G |
7: 42,312,332 (GRCm39) |
E94Q |
possibly damaging |
Het |
| Zfyve9 |
C |
T |
4: 108,539,334 (GRCm39) |
A289T |
probably benign |
Het |
| Zscan5b |
T |
C |
7: 6,234,525 (GRCm39) |
S184P |
possibly damaging |
Het |
|
| Other mutations in Rnf123 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00950:Rnf123
|
APN |
9 |
107,944,594 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01358:Rnf123
|
APN |
9 |
107,946,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01464:Rnf123
|
APN |
9 |
107,929,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01637:Rnf123
|
APN |
9 |
107,935,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01669:Rnf123
|
APN |
9 |
107,935,555 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01905:Rnf123
|
APN |
9 |
107,948,569 (GRCm39) |
splice site |
probably benign |
|
|
IGL02070:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02072:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02073:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02074:Rnf123
|
APN |
9 |
107,944,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02079:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02080:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02231:Rnf123
|
APN |
9 |
107,943,598 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02281:Rnf123
|
APN |
9 |
107,948,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02336:Rnf123
|
APN |
9 |
107,939,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02543:Rnf123
|
APN |
9 |
107,943,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02565:Rnf123
|
APN |
9 |
107,929,411 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02571:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02572:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02574:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02586:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02589:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02600:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02601:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02602:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02603:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02609:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02628:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02629:Rnf123
|
APN |
9 |
107,947,988 (GRCm39) |
splice site |
probably benign |
|
|
IGL02629:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02630:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02631:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02632:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02650:Rnf123
|
APN |
9 |
107,946,947 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL02690:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02691:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02692:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02693:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02713:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02736:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02929:Rnf123
|
APN |
9 |
107,946,275 (GRCm39) |
missense |
probably benign |
|
|
R1175:Rnf123
|
UTSW |
9 |
107,954,572 (GRCm39) |
missense |
probably benign |
|
|
R1465:Rnf123
|
UTSW |
9 |
107,948,665 (GRCm39) |
splice site |
probably benign |
|
|
R1502:Rnf123
|
UTSW |
9 |
107,945,709 (GRCm39) |
splice site |
probably null |
|
|
R1682:Rnf123
|
UTSW |
9 |
107,954,597 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1817:Rnf123
|
UTSW |
9 |
107,940,125 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1855:Rnf123
|
UTSW |
9 |
107,938,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2394:Rnf123
|
UTSW |
9 |
107,940,735 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2483:Rnf123
|
UTSW |
9 |
107,940,720 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3896:Rnf123
|
UTSW |
9 |
107,946,302 (GRCm39) |
splice site |
probably benign |
|
|
R3940:Rnf123
|
UTSW |
9 |
107,941,234 (GRCm39) |
splice site |
probably benign |
|
|
R4206:Rnf123
|
UTSW |
9 |
107,941,162 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4641:Rnf123
|
UTSW |
9 |
107,935,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Rnf123
|
UTSW |
9 |
107,929,638 (GRCm39) |
splice site |
probably null |
|
|
R4767:Rnf123
|
UTSW |
9 |
107,929,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Rnf123
|
UTSW |
9 |
107,933,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Rnf123
|
UTSW |
9 |
107,940,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5274:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5275:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5276:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5294:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5295:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5394:Rnf123
|
UTSW |
9 |
107,947,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5717:Rnf123
|
UTSW |
9 |
107,944,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6186:Rnf123
|
UTSW |
9 |
107,947,157 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6449:Rnf123
|
UTSW |
9 |
107,933,252 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6502:Rnf123
|
UTSW |
9 |
107,945,531 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6944:Rnf123
|
UTSW |
9 |
107,940,822 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7003:Rnf123
|
UTSW |
9 |
107,940,882 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7088:Rnf123
|
UTSW |
9 |
107,935,735 (GRCm39) |
missense |
probably null |
1.00 |
|
R7092:Rnf123
|
UTSW |
9 |
107,945,799 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7100:Rnf123
|
UTSW |
9 |
107,933,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Rnf123
|
UTSW |
9 |
107,946,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Rnf123
|
UTSW |
9 |
107,947,607 (GRCm39) |
splice site |
probably null |
|
|
R7468:Rnf123
|
UTSW |
9 |
107,946,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7517:Rnf123
|
UTSW |
9 |
107,947,473 (GRCm39) |
nonsense |
probably null |
|
|
R7577:Rnf123
|
UTSW |
9 |
107,947,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8296:Rnf123
|
UTSW |
9 |
107,940,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Rnf123
|
UTSW |
9 |
107,945,706 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8754:Rnf123
|
UTSW |
9 |
107,948,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Rnf123
|
UTSW |
9 |
107,946,272 (GRCm39) |
missense |
probably benign |
|
|
R9052:Rnf123
|
UTSW |
9 |
107,936,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9156:Rnf123
|
UTSW |
9 |
107,940,227 (GRCm39) |
splice site |
probably benign |
|
|
R9170:Rnf123
|
UTSW |
9 |
107,948,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9332:Rnf123
|
UTSW |
9 |
107,944,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9385:Rnf123
|
UTSW |
9 |
107,929,467 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9394:Rnf123
|
UTSW |
9 |
107,942,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9432:Rnf123
|
UTSW |
9 |
107,937,008 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Rnf123
|
UTSW |
9 |
107,940,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Rnf123
|
UTSW |
9 |
107,935,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCACACTGAGCGCACTTTTC -3'
(R):5'- ATATGCATGGTTCAGTCTTACCTG -3'
Sequencing Primer
(F):5'- GTGTCAGCAAAGAACTGGTCCC -3'
(R):5'- GGTTCAGTCTTACCTGCTCCCAAG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation