Incidental Mutation 'R5495:Or8g36'
ID 432296
Institutional Source Beutler Lab
Gene Symbol Or8g36
Ensembl Gene ENSMUSG00000095322
Gene Name olfactory receptor family 8 subfamily G member 36
Synonyms Olfr957, MOR171-12, GA_x6K02T2PVTD-33208209-33207274
MMRRC Submission 043056-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R5495 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39422079-39423014 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39422441 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 192 (T192A)
Ref Sequence ENSEMBL: ENSMUSP00000149559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051653] [ENSMUST00000216177]
AlphaFold Q9EQB7
Predicted Effect probably benign
Transcript: ENSMUST00000051653
AA Change: T192A

PolyPhen 2 Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000054536
Gene: ENSMUSG00000095322
AA Change: T192A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.8e-50 PFAM
Pfam:7tm_1 41 290 3.8e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216177
AA Change: T192A

PolyPhen 2 Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 98.4%
  • 3x: 97.3%
  • 10x: 95.3%
  • 20x: 91.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akt2 T C 7: 27,335,594 (GRCm39) probably null Het
Arhgap29 T G 3: 121,808,578 (GRCm39) M844R probably damaging Het
Atp1a1 T G 3: 101,498,741 (GRCm39) D184A probably benign Het
Bcl11a T A 11: 24,115,042 (GRCm39) V795E possibly damaging Het
Casp12 T A 9: 5,353,797 (GRCm39) I277N possibly damaging Het
Ccdc59 A G 10: 105,681,239 (GRCm39) K164E probably damaging Het
D630003M21Rik C T 2: 158,062,431 (GRCm39) G30S possibly damaging Het
Dgkd A G 1: 87,854,594 (GRCm39) D632G probably damaging Het
Efr3a A G 15: 65,687,258 (GRCm39) K56E possibly damaging Het
Egflam T A 15: 7,280,722 (GRCm39) R434S probably damaging Het
Fancl C G 11: 26,347,801 (GRCm39) A51G probably damaging Het
Fkbp7 T C 2: 76,493,638 (GRCm39) Y185C probably damaging Het
Galc A G 12: 98,197,673 (GRCm39) probably null Het
Galnt15 A G 14: 31,751,774 (GRCm39) S109G probably damaging Het
Gramd2b T C 18: 56,615,694 (GRCm39) I163T probably damaging Het
Impa1 A G 3: 10,391,230 (GRCm39) V80A probably benign Het
Itga10 T C 3: 96,554,687 (GRCm39) M56T possibly damaging Het
Larp1b G T 3: 40,990,257 (GRCm39) R135I probably damaging Het
Lgals12 C T 19: 7,581,495 (GRCm39) A71T probably damaging Het
Lmbr1 A T 5: 29,551,851 (GRCm39) L78* probably null Het
Lrat C A 3: 82,804,289 (GRCm39) M229I probably benign Het
Mug2 A T 6: 122,056,609 (GRCm39) M1185L probably damaging Het
Naprt T C 15: 75,765,696 (GRCm39) probably null Het
Nfat5 A G 8: 108,095,079 (GRCm39) I1107V probably benign Het
Nr4a2 T C 2: 57,002,387 (GRCm39) Y22C probably damaging Het
Ogfod1 C A 8: 94,790,906 (GRCm39) Q526K probably benign Het
Or2d4 C A 7: 106,543,699 (GRCm39) G170* probably null Het
Or3a10 G A 11: 73,935,611 (GRCm39) T163I probably damaging Het
Or4p21 T C 2: 88,276,401 (GRCm39) T294A probably benign Het
Parp10 T G 15: 76,127,366 (GRCm39) I24L probably benign Het
Pcdha11 A G 18: 37,144,079 (GRCm39) T57A probably benign Het
Prdm8 A G 5: 98,333,165 (GRCm39) E244G possibly damaging Het
Prl6a1 T C 13: 27,496,654 (GRCm39) S3P possibly damaging Het
Rab11fip3 T A 17: 26,235,117 (GRCm39) T18S probably damaging Het
Rfc4 T C 16: 22,941,004 (GRCm39) probably benign Het
Rubcnl G T 14: 75,279,777 (GRCm39) V387F possibly damaging Het
S100a7l2 A T 3: 90,997,602 (GRCm39) L38M possibly damaging Het
Serpinb12 T C 1: 106,884,151 (GRCm39) L299P probably damaging Het
Sptbn5 G A 2: 119,876,965 (GRCm39) probably benign Het
Taar4 A T 10: 23,837,181 (GRCm39) I264F possibly damaging Het
Tdpoz4 A T 3: 93,704,806 (GRCm39) T368S probably benign Het
Thsd7b T A 1: 129,523,570 (GRCm39) H124Q probably damaging Het
Ugt1a6a A T 1: 88,066,746 (GRCm39) Q184L probably benign Het
Vnn1 T A 10: 23,774,462 (GRCm39) F168L probably damaging Het
Zan A G 5: 137,468,670 (GRCm39) L267P probably damaging Het
Zswim8 A G 14: 20,772,354 (GRCm39) S1621G probably damaging Het
Other mutations in Or8g36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01520:Or8g36 APN 9 39,422,342 (GRCm39) missense possibly damaging 0.64
R0603:Or8g36 UTSW 9 39,422,810 (GRCm39) missense possibly damaging 0.76
R1642:Or8g36 UTSW 9 39,422,650 (GRCm39) missense possibly damaging 0.78
R2044:Or8g36 UTSW 9 39,422,674 (GRCm39) missense probably damaging 0.99
R2182:Or8g36 UTSW 9 39,422,722 (GRCm39) missense probably damaging 1.00
R2290:Or8g36 UTSW 9 39,422,974 (GRCm39) missense possibly damaging 0.87
R4246:Or8g36 UTSW 9 39,422,899 (GRCm39) missense probably benign 0.31
R4248:Or8g36 UTSW 9 39,422,899 (GRCm39) missense probably benign 0.31
R5273:Or8g36 UTSW 9 39,422,795 (GRCm39) missense possibly damaging 0.95
R5718:Or8g36 UTSW 9 39,422,338 (GRCm39) missense probably damaging 1.00
R5827:Or8g36 UTSW 9 39,422,354 (GRCm39) missense probably damaging 1.00
R6261:Or8g36 UTSW 9 39,422,105 (GRCm39) missense probably benign
R6917:Or8g36 UTSW 9 39,422,495 (GRCm39) missense probably damaging 1.00
R7965:Or8g36 UTSW 9 39,422,810 (GRCm39) missense probably benign 0.00
R8357:Or8g36 UTSW 9 39,422,442 (GRCm39) missense probably benign 0.38
R8457:Or8g36 UTSW 9 39,422,442 (GRCm39) missense probably benign 0.38
R8896:Or8g36 UTSW 9 39,422,770 (GRCm39) missense probably damaging 1.00
R8938:Or8g36 UTSW 9 39,422,910 (GRCm39) nonsense probably null
R9249:Or8g36 UTSW 9 39,422,149 (GRCm39) missense probably damaging 1.00
R9629:Or8g36 UTSW 9 39,422,497 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACAGCAACAGCCAAGATGTG -3'
(R):5'- TCACATGCTGGCTGTCATGG -3'

Sequencing Primer
(F):5'- CCAAGATGTGGGAGCTGC -3'
(R):5'- ATGATCGCTATGTTGCCATCTGTAAC -3'
Posted On 2016-10-05