Incidental Mutation 'R5587:Trmt1l'
ID 438787
Institutional Source Beutler Lab
Gene Symbol Trmt1l
Ensembl Gene ENSMUSG00000053286
Gene Name tRNA methyltransferase 1 like
Synonyms Trm1-like, 1190005F20Rik
MMRRC Submission 043141-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5587 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 151428542-151458161 bp(+) (GRCm38)
Type of Mutation intron
DNA Base Change (assembly) T to A at 151435704 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140009 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065625] [ENSMUST00000189655]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000065625
SMART Domains Protein: ENSMUSP00000068309
Gene: ENSMUSG00000053286

DomainStartEndE-ValueType
low complexity region 5 18 N/A INTRINSIC
low complexity region 25 70 N/A INTRINSIC
ZnF_C2H2 116 142 7.49e0 SMART
ZnF_C2H2 181 203 2.49e-1 SMART
Pfam:TRM 220 563 6.9e-60 PFAM
Pfam:TRM 595 684 6.8e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185230
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188179
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188679
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188843
Predicted Effect probably benign
Transcript: ENSMUST00000189655
SMART Domains Protein: ENSMUSP00000140009
Gene: ENSMUSG00000053286

DomainStartEndE-ValueType
ZnF_C2H2 28 50 1.1e-3 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.9%
Validation Efficiency 96% (78/81)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele are viable and anatomically normal but display significantly impaired motor coordination and aberrant exploratory behavior. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 138,065,409 R120G probably benign Het
4930548H24Rik G T 5: 31,486,084 G53W probably benign Het
Acad11 A G 9: 104,063,767 T3A probably benign Het
Adamts18 G A 8: 113,775,360 Q290* probably null Het
Ahnak A G 19: 9,009,476 D2708G possibly damaging Het
Asxl3 T A 18: 22,525,247 C2105S probably benign Het
Atp8b1 A T 18: 64,539,210 F1028I probably damaging Het
Axdnd1 C G 1: 156,351,412 W615C probably damaging Het
Bcl3 A T 7: 19,809,634 Y10* probably null Het
Bmp2 T A 2: 133,554,646 V74E possibly damaging Het
Ccdc78 C A 17: 25,786,677 P21Q probably benign Het
Cluap1 T A 16: 3,915,484 V199E probably damaging Het
Cntnap3 T C 13: 64,746,738 E1120G probably damaging Het
Col1a2 T A 6: 4,540,531 W1330R unknown Het
Coq4 A G 2: 29,795,514 probably null Het
Cwf19l1 G A 19: 44,120,877 T346I possibly damaging Het
Cyct T C 2: 76,354,203 Y68C probably damaging Het
Dnah10 T C 5: 124,793,913 L2368P probably benign Het
Dnah2 A T 11: 69,437,242 F3346I probably damaging Het
Dpp3 A T 19: 4,918,267 V259E probably damaging Het
Dpyd A C 3: 119,064,951 S605R probably damaging Het
Emc1 A G 4: 139,362,148 E209G probably damaging Het
Esrra A G 19: 6,920,207 S61P probably benign Het
Fam71d C A 12: 78,715,075 P171H probably damaging Het
Gbx2 T A 1: 89,933,122 probably benign Het
Hepacam A G 9: 37,384,684 H377R probably damaging Het
Igkv12-46 T C 6: 69,764,550 Y107C probably damaging Het
Intu A G 3: 40,675,308 D356G probably damaging Het
Izumo4 A T 10: 80,703,220 N113Y probably damaging Het
Krt86 G A 15: 101,473,593 A15T probably benign Het
Lhx8 A T 3: 154,311,679 S275R probably damaging Het
Lingo3 A T 10: 80,835,530 S189T probably damaging Het
Llgl1 T A 11: 60,710,342 M702K probably benign Het
Lpin1 T C 12: 16,573,714 Y223C Het
Lrit3 G T 3: 129,788,898 A359E probably benign Het
Lrp2 T C 2: 69,499,263 E1720G probably benign Het
Mcub A C 3: 129,916,970 V271G probably benign Het
Nktr C T 9: 121,748,489 probably benign Het
Olfr1342 T A 4: 118,689,870 D194V probably damaging Het
Olfr1502 G A 19: 13,862,576 R261H probably damaging Het
Olfr347 A T 2: 36,734,621 Q100L probably damaging Het
Olfr617 T A 7: 103,584,531 Y170N probably benign Het
Olfr979 A T 9: 40,000,621 I202N possibly damaging Het
Olfr984 A T 9: 40,101,244 L82Q probably damaging Het
Pcdha4 T C 18: 36,954,822 V686A probably benign Het
Pelo A G 13: 115,089,873 V16A possibly damaging Het
Plcd1 A G 9: 119,073,832 S539P probably benign Het
Prss1 A G 6: 41,463,265 I179V possibly damaging Het
Ptgs2 T C 1: 150,105,555 Y530H probably damaging Het
Rai1 T C 11: 60,189,859 V1583A probably damaging Het
Raph1 T G 1: 60,498,473 D508A probably damaging Het
Rmnd5a A G 6: 71,394,619 probably benign Het
Rsf1 T C 7: 97,662,121 L686P probably benign Het
Samd9l T C 6: 3,373,291 I1323M possibly damaging Het
Scn1a T C 2: 66,273,081 N1934S probably benign Het
Sec23ip C T 7: 128,750,427 H176Y probably benign Het
Sh3glb2 A G 2: 30,354,851 probably null Het
Sis A G 3: 72,914,576 I1384T possibly damaging Het
Spata31d1a A C 13: 59,702,618 C565W probably damaging Het
Srbd1 T A 17: 86,127,801 Q278L probably damaging Het
Sry T C Y: 2,662,625 H345R unknown Het
Suox A T 10: 128,671,825 D111E probably damaging Het
Taar7a A T 10: 23,992,828 F218L probably benign Het
Tfcp2l1 C A 1: 118,664,762 N288K possibly damaging Het
Tmem128 G T 5: 38,260,421 R7L possibly damaging Het
Tmem266 A G 9: 55,437,566 N494S probably damaging Het
Tmprss3 T A 17: 31,193,992 H80L probably benign Het
Tnrc6c C T 11: 117,749,271 Q1211* probably null Het
Tns1 T A 1: 73,920,596 D1671V possibly damaging Het
Tshz2 A T 2: 169,884,342 D286V probably damaging Het
Ttyh2 A G 11: 114,675,659 E39G probably benign Het
Vmn2r125 G A 4: 156,350,138 C73Y probably damaging Het
Vmn2r5 T C 3: 64,504,076 D357G probably damaging Het
Vmn2r61 T C 7: 42,300,487 F777S probably damaging Het
Vmn2r9 T C 5: 108,847,561 E407G probably damaging Het
Vwa3a A G 7: 120,780,235 N521S probably damaging Het
Zan C G 5: 137,391,762 S4816T unknown Het
Zc3h7b T C 15: 81,771,858 Y136H possibly damaging Het
Zfp101 T C 17: 33,381,321 K487R possibly damaging Het
Other mutations in Trmt1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00790:Trmt1l APN 1 151,442,712 (GRCm38) critical splice donor site probably null
IGL02175:Trmt1l APN 1 151,448,484 (GRCm38) missense probably benign 0.00
IGL02348:Trmt1l APN 1 151,450,006 (GRCm38) missense probably damaging 1.00
IGL02397:Trmt1l APN 1 151,439,531 (GRCm38) missense probably damaging 1.00
IGL02582:Trmt1l APN 1 151,433,785 (GRCm38) splice site probably benign
IGL03150:Trmt1l APN 1 151,453,892 (GRCm38) missense probably benign 0.00
IGL03220:Trmt1l APN 1 151,440,941 (GRCm38) splice site probably benign
Canyonlands UTSW 1 151,454,048 (GRCm38) nonsense probably null
splendiforous UTSW 1 151,453,148 (GRCm38) missense probably damaging 1.00
IGL03014:Trmt1l UTSW 1 151,457,930 (GRCm38) missense probably damaging 0.99
R0067:Trmt1l UTSW 1 151,448,380 (GRCm38) missense probably benign 0.16
R0067:Trmt1l UTSW 1 151,448,380 (GRCm38) missense probably benign 0.16
R0240:Trmt1l UTSW 1 151,457,454 (GRCm38) unclassified probably benign
R0267:Trmt1l UTSW 1 151,457,675 (GRCm38) unclassified probably benign
R2084:Trmt1l UTSW 1 151,440,854 (GRCm38) missense probably damaging 1.00
R2206:Trmt1l UTSW 1 151,435,843 (GRCm38) critical splice donor site probably null
R2338:Trmt1l UTSW 1 151,428,959 (GRCm38) intron probably benign
R2408:Trmt1l UTSW 1 151,439,516 (GRCm38) missense possibly damaging 0.48
R2429:Trmt1l UTSW 1 151,433,830 (GRCm38) missense probably damaging 1.00
R2520:Trmt1l UTSW 1 151,453,945 (GRCm38) missense probably benign 0.14
R3972:Trmt1l UTSW 1 151,433,883 (GRCm38) missense possibly damaging 0.91
R4092:Trmt1l UTSW 1 151,455,033 (GRCm38) missense probably benign 0.18
R4361:Trmt1l UTSW 1 151,435,875 (GRCm38) intron probably benign
R4411:Trmt1l UTSW 1 151,452,154 (GRCm38) missense probably benign 0.02
R4419:Trmt1l UTSW 1 151,440,808 (GRCm38) missense probably damaging 0.98
R4518:Trmt1l UTSW 1 151,448,343 (GRCm38) nonsense probably null
R4614:Trmt1l UTSW 1 151,454,048 (GRCm38) nonsense probably null
R4617:Trmt1l UTSW 1 151,454,048 (GRCm38) nonsense probably null
R4618:Trmt1l UTSW 1 151,454,048 (GRCm38) nonsense probably null
R4647:Trmt1l UTSW 1 151,457,881 (GRCm38) missense possibly damaging 0.86
R4653:Trmt1l UTSW 1 151,439,569 (GRCm38) missense probably benign 0.00
R4734:Trmt1l UTSW 1 151,442,637 (GRCm38) missense probably benign 0.32
R4873:Trmt1l UTSW 1 151,455,004 (GRCm38) missense probably benign 0.04
R4875:Trmt1l UTSW 1 151,455,004 (GRCm38) missense probably benign 0.04
R5026:Trmt1l UTSW 1 151,440,876 (GRCm38) missense probably damaging 1.00
R5528:Trmt1l UTSW 1 151,454,995 (GRCm38) missense probably benign
R5872:Trmt1l UTSW 1 151,440,843 (GRCm38) missense probably damaging 1.00
R6060:Trmt1l UTSW 1 151,457,580 (GRCm38) missense possibly damaging 0.78
R6169:Trmt1l UTSW 1 151,428,953 (GRCm38) intron probably benign
R6333:Trmt1l UTSW 1 151,453,934 (GRCm38) missense probably benign 0.15
R6906:Trmt1l UTSW 1 151,452,175 (GRCm38) missense probably benign 0.03
R7269:Trmt1l UTSW 1 151,457,788 (GRCm38) missense possibly damaging 0.81
R7574:Trmt1l UTSW 1 151,440,840 (GRCm38) missense possibly damaging 0.95
R7740:Trmt1l UTSW 1 151,440,888 (GRCm38) missense possibly damaging 0.47
R7760:Trmt1l UTSW 1 151,442,674 (GRCm38) missense possibly damaging 0.93
R7984:Trmt1l UTSW 1 151,435,738 (GRCm38) missense probably benign 0.02
R8257:Trmt1l UTSW 1 151,428,878 (GRCm38) start codon destroyed probably null
R8286:Trmt1l UTSW 1 151,457,792 (GRCm38) missense probably damaging 1.00
R8439:Trmt1l UTSW 1 151,449,976 (GRCm38) missense probably benign 0.10
R8451:Trmt1l UTSW 1 151,448,288 (GRCm38) missense unknown
R8514:Trmt1l UTSW 1 151,453,991 (GRCm38) missense probably damaging 0.98
R9287:Trmt1l UTSW 1 151,453,148 (GRCm38) missense probably damaging 1.00
R9423:Trmt1l UTSW 1 151,450,066 (GRCm38) missense possibly damaging 0.90
R9622:Trmt1l UTSW 1 151,428,959 (GRCm38) nonsense probably null
X0039:Trmt1l UTSW 1 151,454,990 (GRCm38) missense possibly damaging 0.88
Z1176:Trmt1l UTSW 1 151,453,113 (GRCm38) missense possibly damaging 0.72
Z1187:Trmt1l UTSW 1 151,457,580 (GRCm38) missense possibly damaging 0.78
Z1189:Trmt1l UTSW 1 151,457,580 (GRCm38) missense possibly damaging 0.78
Z1190:Trmt1l UTSW 1 151,457,580 (GRCm38) missense possibly damaging 0.78
Z1192:Trmt1l UTSW 1 151,457,580 (GRCm38) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- GCCACAGATAGCAGAGTCTCAG -3'
(R):5'- CATTGAGTGGGGACATTAAATCATC -3'

Sequencing Primer
(F):5'- CAGAGTCTCAGAGCTAAAGATAGTC -3'
(R):5'- TCCAAAGCTGGTACAAATGTTC -3'
Posted On 2016-10-26