Incidental Mutation 'R7250:Hfm1'
| ID |
563820 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hfm1
|
| Ensembl Gene |
ENSMUSG00000043410 |
| Gene Name |
HFM1, ATP-dependent DNA helicase homolog |
| Synonyms |
LOC381663, A330009G12Rik, Mer3, Sec63d1 |
| MMRRC Submission |
045350-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.080)
|
| Stock # |
R7250 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
106988058-107074187 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 107052197 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 300
(I300V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142727
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112690]
[ENSMUST00000117588]
[ENSMUST00000148686]
[ENSMUST00000200249]
|
| AlphaFold |
D3Z4R1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112690
AA Change: I300V
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000108310
Gene: ENSMUSG00000043410
AA Change: I300V
| Domain | Start | End | E-Value | Type |
|---|
|
DEXDc
|
276 |
490 |
3.66e-29 |
SMART |
|
HELICc
|
571 |
657 |
1.56e-14 |
SMART |
|
low complexity region
|
751 |
764 |
N/A |
INTRINSIC |
|
Sec63
|
775 |
1090 |
5.66e-60 |
SMART |
|
Blast:Sec63
|
1130 |
1188 |
2e-18 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117588
AA Change: I300V
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000112590
Gene: ENSMUSG00000043410
AA Change: I300V
| Domain | Start | End | E-Value | Type |
|---|
|
DEXDc
|
276 |
490 |
3.66e-29 |
SMART |
|
HELICc
|
571 |
657 |
1.56e-14 |
SMART |
|
low complexity region
|
751 |
764 |
N/A |
INTRINSIC |
|
Sec63
|
775 |
1090 |
5.66e-60 |
SMART |
|
Blast:Sec63
|
1130 |
1188 |
2e-18 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000148686
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200249
AA Change: I300V
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000142727
Gene: ENSMUSG00000043410
AA Change: I300V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ResIII
|
260 |
410 |
9.9e-7 |
PFAM |
|
Pfam:DEAD
|
281 |
410 |
1.5e-19 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014]
PHENOTYPE: Meiosis ais disrupted in homozygotes and bothe sexes are sterile [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930480E11Rik |
G |
T |
X: 77,414,311 (GRCm39) |
M345I |
probably benign |
Het |
| Actl7b |
T |
A |
4: 56,741,035 (GRCm39) |
M108L |
probably benign |
Het |
| Adgrf3 |
T |
A |
5: 30,400,680 (GRCm39) |
I934L |
probably damaging |
Het |
| Adprm |
A |
G |
11: 66,932,450 (GRCm39) |
V153A |
probably benign |
Het |
| Aif1l |
G |
A |
2: 31,859,764 (GRCm39) |
V109M |
probably damaging |
Het |
| Asphd1 |
T |
A |
7: 126,545,942 (GRCm39) |
E307V |
probably damaging |
Het |
| Ate1 |
T |
A |
7: 130,121,701 (GRCm39) |
|
probably benign |
Het |
| Borcs7 |
A |
G |
19: 46,688,047 (GRCm39) |
H64R |
probably damaging |
Het |
| C1qtnf1 |
A |
G |
11: 118,339,176 (GRCm39) |
*282W |
probably null |
Het |
| Cacna1c |
A |
G |
6: 118,574,966 (GRCm39) |
C1985R |
|
Het |
| Cacna1c |
A |
T |
6: 118,673,412 (GRCm39) |
V647E |
|
Het |
| Cacna1d |
A |
G |
14: 29,797,108 (GRCm39) |
S1497P |
probably damaging |
Het |
| Cacna1e |
T |
A |
1: 154,576,235 (GRCm39) |
I133F |
possibly damaging |
Het |
| Ccdc63 |
A |
T |
5: 122,260,906 (GRCm39) |
L206H |
probably damaging |
Het |
| Cenatac |
A |
G |
9: 44,323,748 (GRCm39) |
|
probably null |
Het |
| Cspg4b |
T |
G |
13: 113,455,349 (GRCm39) |
I465R |
|
Het |
| D430041D05Rik |
T |
C |
2: 104,086,961 (GRCm39) |
T672A |
possibly damaging |
Het |
| D630045J12Rik |
G |
T |
6: 38,119,546 (GRCm39) |
T1732K |
possibly damaging |
Het |
| D930020B18Rik |
T |
C |
10: 121,507,736 (GRCm39) |
I158T |
probably damaging |
Het |
| Ddx52 |
G |
A |
11: 83,835,392 (GRCm39) |
G106D |
probably benign |
Het |
| Dock2 |
A |
G |
11: 34,586,032 (GRCm39) |
V550A |
probably benign |
Het |
| Dock2 |
C |
T |
11: 34,586,120 (GRCm39) |
D521N |
probably damaging |
Het |
| F13b |
T |
C |
1: 139,444,227 (GRCm39) |
|
probably null |
Het |
| Fchsd2 |
A |
G |
7: 100,908,892 (GRCm39) |
K431R |
possibly damaging |
Het |
| Fez1 |
C |
T |
9: 36,779,090 (GRCm39) |
R256C |
probably damaging |
Het |
| Gjd4 |
T |
A |
18: 9,280,391 (GRCm39) |
Q229L |
probably benign |
Het |
| Gpr45 |
T |
A |
1: 43,071,531 (GRCm39) |
I58N |
probably damaging |
Het |
| Gstm1 |
T |
A |
3: 107,923,709 (GRCm39) |
I99F |
probably damaging |
Het |
| Gtpbp8 |
T |
A |
16: 44,564,225 (GRCm39) |
T149S |
probably damaging |
Het |
| H2-Ab1 |
A |
G |
17: 34,486,481 (GRCm39) |
D180G |
probably damaging |
Het |
| Hdhd5 |
A |
G |
6: 120,494,016 (GRCm39) |
I188T |
possibly damaging |
Het |
| Hnrnpr |
T |
G |
4: 136,059,746 (GRCm39) |
D283E |
probably benign |
Het |
| Hsp90b1 |
T |
C |
10: 86,527,572 (GRCm39) |
E768G |
unknown |
Het |
| Kcna4 |
C |
A |
2: 107,126,663 (GRCm39) |
Q466K |
possibly damaging |
Het |
| Kcnk6 |
A |
G |
7: 28,931,619 (GRCm39) |
L97P |
probably benign |
Het |
| Kics2 |
T |
C |
10: 121,581,376 (GRCm39) |
S126P |
possibly damaging |
Het |
| Klf5 |
A |
G |
14: 99,536,455 (GRCm39) |
S9G |
probably benign |
Het |
| Kmt2c |
C |
A |
5: 25,504,489 (GRCm39) |
K3606N |
probably damaging |
Het |
| Kmt2c |
T |
C |
5: 25,514,805 (GRCm39) |
T3013A |
probably benign |
Het |
| Lancl1 |
A |
G |
1: 67,048,458 (GRCm39) |
Y207H |
possibly damaging |
Het |
| Lipe |
G |
C |
7: 25,088,085 (GRCm39) |
|
probably benign |
Het |
| Lrrc66 |
T |
A |
5: 73,768,224 (GRCm39) |
H239L |
probably benign |
Het |
| Ltbp2 |
C |
T |
12: 84,834,166 (GRCm39) |
W1441* |
probably null |
Het |
| Man2a1 |
T |
C |
17: 64,943,583 (GRCm39) |
S213P |
probably benign |
Het |
| Mapre2 |
C |
T |
18: 23,991,119 (GRCm39) |
A171V |
possibly damaging |
Het |
| Mdn1 |
T |
A |
4: 32,695,427 (GRCm39) |
D1155E |
probably damaging |
Het |
| Mki67 |
T |
C |
7: 135,301,053 (GRCm39) |
D1327G |
possibly damaging |
Het |
| Mx2 |
T |
C |
16: 97,348,664 (GRCm39) |
I279T |
probably damaging |
Het |
| Myo5c |
A |
G |
9: 75,169,497 (GRCm39) |
T441A |
probably damaging |
Het |
| Nlrp9a |
T |
G |
7: 26,258,143 (GRCm39) |
V587G |
possibly damaging |
Het |
| Npas2 |
A |
T |
1: 39,377,188 (GRCm39) |
T517S |
probably damaging |
Het |
| Npy1r |
T |
C |
8: 67,157,712 (GRCm39) |
S341P |
probably benign |
Het |
| Ntm |
A |
G |
9: 29,322,988 (GRCm39) |
W11R |
probably benign |
Het |
| Nxpe2 |
A |
T |
9: 48,238,096 (GRCm39) |
I53N |
possibly damaging |
Het |
| Onecut2 |
T |
C |
18: 64,519,511 (GRCm39) |
F443L |
probably benign |
Het |
| Or10g6 |
T |
A |
9: 39,934,050 (GRCm39) |
Y120* |
probably null |
Het |
| Or2r2 |
A |
G |
6: 42,463,689 (GRCm39) |
V146A |
probably benign |
Het |
| Or52ac1 |
A |
T |
7: 104,245,738 (GRCm39) |
Y217N |
probably damaging |
Het |
| Parp2 |
T |
A |
14: 51,054,801 (GRCm39) |
V248E |
probably benign |
Het |
| Pcdh12 |
C |
A |
18: 38,415,029 (GRCm39) |
V699L |
probably benign |
Het |
| Pja2 |
G |
A |
17: 64,616,451 (GRCm39) |
P148L |
probably benign |
Het |
| Poglut3 |
C |
T |
9: 53,301,821 (GRCm39) |
Q158* |
probably null |
Het |
| Ppip5k2 |
T |
G |
1: 97,673,187 (GRCm39) |
D415A |
probably benign |
Het |
| Prss47 |
A |
G |
13: 65,200,355 (GRCm39) |
S74P |
probably benign |
Het |
| Ptprg |
G |
T |
14: 12,166,767 (GRCm38) |
M723I |
probably benign |
Het |
| Qsox2 |
A |
T |
2: 26,118,444 (GRCm39) |
I109N |
probably damaging |
Het |
| Ranbp3l |
A |
G |
15: 9,041,853 (GRCm39) |
E217G |
probably benign |
Het |
| Rgl2 |
C |
T |
17: 34,152,403 (GRCm39) |
R367W |
probably damaging |
Het |
| Rgs12 |
T |
A |
5: 35,122,841 (GRCm39) |
F208Y |
probably damaging |
Het |
| Rin3 |
C |
T |
12: 102,334,893 (GRCm39) |
T268I |
unknown |
Het |
| Rttn |
T |
A |
18: 89,007,647 (GRCm39) |
D427E |
probably benign |
Het |
| Samd13 |
G |
A |
3: 146,352,079 (GRCm39) |
P91S |
probably benign |
Het |
| Samd9l |
T |
C |
6: 3,374,201 (GRCm39) |
D1020G |
possibly damaging |
Het |
| Sec62 |
T |
G |
3: 30,866,496 (GRCm39) |
L201V |
possibly damaging |
Het |
| Setdb1 |
C |
T |
3: 95,261,852 (GRCm39) |
|
probably null |
Het |
| Sf3a3 |
A |
T |
4: 124,616,708 (GRCm39) |
T197S |
probably benign |
Het |
| Slc20a1 |
A |
T |
2: 129,051,844 (GRCm39) |
I618F |
possibly damaging |
Het |
| Slc38a3 |
A |
T |
9: 107,533,865 (GRCm39) |
M186K |
probably benign |
Het |
| Slc39a13 |
T |
C |
2: 90,893,503 (GRCm39) |
T319A |
probably benign |
Het |
| Slc44a4 |
T |
C |
17: 35,137,520 (GRCm39) |
|
probably null |
Het |
| St3gal1 |
A |
C |
15: 66,978,578 (GRCm39) |
D314E |
possibly damaging |
Het |
| Suclg1 |
A |
G |
6: 73,248,074 (GRCm39) |
N265S |
probably benign |
Het |
| Sult2b1 |
A |
T |
7: 45,433,361 (GRCm39) |
V2D |
unknown |
Het |
| Supv3l1 |
T |
A |
10: 62,280,846 (GRCm39) |
I182F |
probably damaging |
Het |
| Tcp11l2 |
T |
C |
10: 84,423,105 (GRCm39) |
|
probably null |
Het |
| Tenm2 |
C |
A |
11: 35,963,625 (GRCm39) |
L935F |
probably damaging |
Het |
| Tnks |
T |
A |
8: 35,318,912 (GRCm39) |
I790F |
probably damaging |
Het |
| Top2b |
C |
T |
14: 16,420,411 (GRCm38) |
T1274I |
probably benign |
Het |
| Tpi1 |
A |
T |
6: 124,789,441 (GRCm39) |
I178N |
probably damaging |
Het |
| Trav9d-1 |
A |
T |
14: 53,030,153 (GRCm39) |
S86C |
probably damaging |
Het |
| Treml2 |
A |
G |
17: 48,616,155 (GRCm39) |
E265G |
probably benign |
Het |
| Trpm7 |
A |
T |
2: 126,668,685 (GRCm39) |
S744T |
possibly damaging |
Het |
| Usp33 |
T |
A |
3: 152,097,999 (GRCm39) |
L909* |
probably null |
Het |
| Vcan |
A |
G |
13: 89,869,805 (GRCm39) |
I210T |
probably damaging |
Het |
| Vcan |
A |
T |
13: 89,879,576 (GRCm39) |
|
probably null |
Het |
| Vsig10l |
A |
T |
7: 43,113,099 (GRCm39) |
D17V |
probably benign |
Het |
| Zbtb7b |
T |
A |
3: 89,286,976 (GRCm39) |
T498S |
probably benign |
Het |
| Zfp366 |
T |
A |
13: 99,366,076 (GRCm39) |
H412Q |
probably damaging |
Het |
| Zfp53 |
C |
A |
17: 21,729,840 (GRCm39) |
D624E |
probably damaging |
Het |
| Zfp827 |
A |
T |
8: 79,916,721 (GRCm39) |
D432V |
|
Het |
| Zic1 |
T |
C |
9: 91,247,028 (GRCm39) |
T15A |
probably damaging |
Het |
| Zswim8 |
T |
C |
14: 20,770,036 (GRCm39) |
C1368R |
probably damaging |
Het |
|
| Other mutations in Hfm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Hfm1
|
APN |
5 |
107,049,996 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL01295:Hfm1
|
APN |
5 |
107,065,472 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01725:Hfm1
|
APN |
5 |
107,065,245 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01758:Hfm1
|
APN |
5 |
107,052,659 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01911:Hfm1
|
APN |
5 |
107,059,410 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02337:Hfm1
|
APN |
5 |
107,052,133 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02472:Hfm1
|
APN |
5 |
107,021,794 (GRCm39) |
splice site |
probably benign |
|
|
IGL02496:Hfm1
|
APN |
5 |
107,049,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02545:Hfm1
|
APN |
5 |
107,043,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02584:Hfm1
|
APN |
5 |
107,026,528 (GRCm39) |
splice site |
probably null |
|
|
IGL02728:Hfm1
|
APN |
5 |
107,026,689 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02881:Hfm1
|
APN |
5 |
107,022,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03108:Hfm1
|
APN |
5 |
107,043,800 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03351:Hfm1
|
APN |
5 |
107,059,441 (GRCm39) |
nonsense |
probably null |
|
|
IGL03353:Hfm1
|
APN |
5 |
107,004,795 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0024:Hfm1
|
UTSW |
5 |
107,004,790 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0024:Hfm1
|
UTSW |
5 |
107,004,790 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0094:Hfm1
|
UTSW |
5 |
107,065,344 (GRCm39) |
missense |
probably benign |
|
|
R0633:Hfm1
|
UTSW |
5 |
107,065,467 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0644:Hfm1
|
UTSW |
5 |
107,046,122 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1078:Hfm1
|
UTSW |
5 |
107,026,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1120:Hfm1
|
UTSW |
5 |
107,052,084 (GRCm39) |
splice site |
probably benign |
|
|
R1166:Hfm1
|
UTSW |
5 |
107,059,277 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1242:Hfm1
|
UTSW |
5 |
107,022,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1414:Hfm1
|
UTSW |
5 |
107,020,219 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1450:Hfm1
|
UTSW |
5 |
107,066,324 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1529:Hfm1
|
UTSW |
5 |
107,000,989 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1622:Hfm1
|
UTSW |
5 |
107,041,389 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1710:Hfm1
|
UTSW |
5 |
107,043,869 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1710:Hfm1
|
UTSW |
5 |
107,028,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1757:Hfm1
|
UTSW |
5 |
107,028,226 (GRCm39) |
splice site |
probably null |
|
|
R1856:Hfm1
|
UTSW |
5 |
106,995,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1984:Hfm1
|
UTSW |
5 |
107,046,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1985:Hfm1
|
UTSW |
5 |
107,046,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2040:Hfm1
|
UTSW |
5 |
107,049,684 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Hfm1
|
UTSW |
5 |
107,044,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Hfm1
|
UTSW |
5 |
106,995,519 (GRCm39) |
splice site |
probably null |
|
|
R2474:Hfm1
|
UTSW |
5 |
107,020,282 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2926:Hfm1
|
UTSW |
5 |
107,022,148 (GRCm39) |
nonsense |
probably null |
|
|
R2944:Hfm1
|
UTSW |
5 |
107,020,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3705:Hfm1
|
UTSW |
5 |
107,040,705 (GRCm39) |
unclassified |
probably benign |
|
|
R4256:Hfm1
|
UTSW |
5 |
107,052,663 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4455:Hfm1
|
UTSW |
5 |
107,034,374 (GRCm39) |
splice site |
probably null |
|
|
R4538:Hfm1
|
UTSW |
5 |
107,022,756 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4540:Hfm1
|
UTSW |
5 |
107,022,087 (GRCm39) |
nonsense |
probably null |
|
|
R4591:Hfm1
|
UTSW |
5 |
106,995,533 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4745:Hfm1
|
UTSW |
5 |
107,049,709 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4747:Hfm1
|
UTSW |
5 |
107,065,389 (GRCm39) |
missense |
probably benign |
|
|
R4765:Hfm1
|
UTSW |
5 |
106,990,405 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4821:Hfm1
|
UTSW |
5 |
107,002,606 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4842:Hfm1
|
UTSW |
5 |
107,040,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4944:Hfm1
|
UTSW |
5 |
107,022,079 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5093:Hfm1
|
UTSW |
5 |
107,049,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5399:Hfm1
|
UTSW |
5 |
107,065,428 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5414:Hfm1
|
UTSW |
5 |
107,049,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5436:Hfm1
|
UTSW |
5 |
107,040,638 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5459:Hfm1
|
UTSW |
5 |
107,052,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5485:Hfm1
|
UTSW |
5 |
106,995,528 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5585:Hfm1
|
UTSW |
5 |
107,059,305 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5631:Hfm1
|
UTSW |
5 |
107,052,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5705:Hfm1
|
UTSW |
5 |
107,059,319 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5804:Hfm1
|
UTSW |
5 |
107,026,455 (GRCm39) |
splice site |
probably null |
|
|
R5959:Hfm1
|
UTSW |
5 |
107,022,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6046:Hfm1
|
UTSW |
5 |
107,046,509 (GRCm39) |
splice site |
probably null |
|
|
R6191:Hfm1
|
UTSW |
5 |
107,034,419 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6345:Hfm1
|
UTSW |
5 |
106,989,504 (GRCm39) |
missense |
probably benign |
|
|
R6580:Hfm1
|
UTSW |
5 |
106,995,575 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6651:Hfm1
|
UTSW |
5 |
106,995,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6761:Hfm1
|
UTSW |
5 |
107,043,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Hfm1
|
UTSW |
5 |
107,026,681 (GRCm39) |
nonsense |
probably null |
|
|
R6891:Hfm1
|
UTSW |
5 |
107,065,240 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R6924:Hfm1
|
UTSW |
5 |
106,998,276 (GRCm39) |
splice site |
probably null |
|
|
R6980:Hfm1
|
UTSW |
5 |
107,028,343 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7054:Hfm1
|
UTSW |
5 |
107,043,909 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7058:Hfm1
|
UTSW |
5 |
107,059,306 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7189:Hfm1
|
UTSW |
5 |
107,049,569 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7376:Hfm1
|
UTSW |
5 |
107,043,084 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7577:Hfm1
|
UTSW |
5 |
107,043,909 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7636:Hfm1
|
UTSW |
5 |
107,065,332 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7639:Hfm1
|
UTSW |
5 |
107,046,341 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7639:Hfm1
|
UTSW |
5 |
107,037,791 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7763:Hfm1
|
UTSW |
5 |
107,029,727 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7828:Hfm1
|
UTSW |
5 |
107,029,657 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7905:Hfm1
|
UTSW |
5 |
107,046,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8160:Hfm1
|
UTSW |
5 |
107,043,899 (GRCm39) |
missense |
probably null |
0.00 |
|
R8477:Hfm1
|
UTSW |
5 |
107,029,684 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8739:Hfm1
|
UTSW |
5 |
107,046,371 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8968:Hfm1
|
UTSW |
5 |
107,065,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9072:Hfm1
|
UTSW |
5 |
107,046,146 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9073:Hfm1
|
UTSW |
5 |
107,046,146 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9152:Hfm1
|
UTSW |
5 |
106,989,611 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9234:Hfm1
|
UTSW |
5 |
107,041,334 (GRCm39) |
missense |
probably benign |
|
|
R9244:Hfm1
|
UTSW |
5 |
107,022,766 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9576:Hfm1
|
UTSW |
5 |
107,021,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9649:Hfm1
|
UTSW |
5 |
107,066,329 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9743:Hfm1
|
UTSW |
5 |
107,022,125 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9782:Hfm1
|
UTSW |
5 |
107,021,896 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9789:Hfm1
|
UTSW |
5 |
107,065,346 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Hfm1
|
UTSW |
5 |
107,019,686 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTCAGTGGTAAAGTGCTGTTTACAG -3'
(R):5'- CTAGAGCAGGACTACACGTAGG -3'
Sequencing Primer
(F):5'- CTGTTTACAGATTTAGTCAGAGCACC -3'
(R):5'- GAATCAGAGAGGTCAACATGCTTG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation