Mutagenetix > Incidental Mutation

Incidental Mutation 'R8423:Dmxl1'

653330

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

MMRRC Submission

067899-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.953) question?

Stock #

R8423 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

49832670-49965473 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 49865116 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 761 (V761A)

Ref Sequence

ENSEMBL: ENSMUSP00000137871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000041772
AA Change: V761A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: V761A

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

probably damaging
Transcript: ENSMUST00000180611
AA Change: V761A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: V761A

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

98% (46/47)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam6b	A	G	12: 113,490,910 (GRCm38)	D449G	possibly damaging	Het
Ampd1	T	C	3: 103,080,989 (GRCm38)	S83P	probably benign	Het
Bub1	G	A	2: 127,807,830 (GRCm38)	L703F	probably benign	Het
C1rb	T	A	6: 124,574,658 (GRCm38)	D242E	probably damaging	Het
Carf	T	A	1: 60,150,593 (GRCm38)	L659Q	possibly damaging	Het
Carmil3	A	G	14: 55,499,065 (GRCm38)	N662S	probably damaging	Het
Ccno	A	G	13: 112,988,144 (GRCm38)	S83G	possibly damaging	Het
Chd3	A	T	11: 69,354,426 (GRCm38)	Y1155*	probably null	Het
Clec16a	A	G	16: 10,576,663 (GRCm38)	E295G	probably benign	Het
Clnk	A	G	5: 38,794,910 (GRCm38)		probably null	Het
Clvs2	T	C	10: 33,622,859 (GRCm38)	D25G	possibly damaging	Het
Cnr2	C	T	4: 135,917,516 (GRCm38)	R302W	probably damaging	Het
Col20a1	A	G	2: 180,998,705 (GRCm38)	T594A	probably damaging	Het
Dclk3	C	T	9: 111,468,719 (GRCm38)	R444W	possibly damaging	Het
Dnah7a	C	A	1: 53,472,904 (GRCm38)	K2999N	possibly damaging	Het
Dusp28	T	C	1: 92,907,184 (GRCm38)	S44P	probably damaging	Het
Enpep	T	G	3: 129,309,125 (GRCm38)	N394T	probably damaging	Het
Fam135a	A	T	1: 24,021,917 (GRCm38)	F1343I	probably damaging	Het
Fbxl12	C	A	9: 20,638,864 (GRCm38)	R165L	possibly damaging	Het
Fbxo40	A	T	16: 36,970,585 (GRCm38)	H54Q	probably damaging	Het
Galnt9	A	G	5: 110,596,245 (GRCm38)	D315G	probably benign	Het
Gbp4	T	A	5: 105,119,934 (GRCm38)	D482V	probably damaging	Het
Gm17175	T	A	14: 51,571,613 (GRCm38)	I99F	possibly damaging	Het
Gm340	T	C	19: 41,585,449 (GRCm38)	I881T	possibly damaging	Het
Heatr4	A	G	12: 83,980,330 (GRCm38)	F51S	probably benign	Het
Herc1	T	C	9: 66,508,160 (GRCm38)	S4806P	probably damaging	Het
Hoxc11	G	A	15: 102,954,742 (GRCm38)	V73I	possibly damaging	Het
Knl1	T	G	2: 119,070,032 (GRCm38)	I738S	probably damaging	Het
Lipt2	T	C	7: 100,160,243 (GRCm38)	F179S	probably damaging	Het
Lrrc8b	G	A	5: 105,480,756 (GRCm38)	V323M	probably damaging	Het
Ltbp1	T	C	17: 75,292,857 (GRCm38)	S665P	probably benign	Het
Miga1	A	T	3: 152,322,408 (GRCm38)	D161E	probably benign	Het
Mynn	A	G	3: 30,603,784 (GRCm38)	T84A	probably benign	Het
Or13c7d	T	C	4: 43,770,598 (GRCm38)	S138G	possibly damaging	Het
Or3a1b	T	C	11: 74,121,666 (GRCm38)	F126L	probably benign	Het
Or4a75	A	T	2: 89,617,987 (GRCm38)	D68E	probably damaging	Het
Pik3r3	C	T	4: 116,222,375 (GRCm38)	S23L	probably benign	Het
Plat	G	T	8: 22,772,232 (GRCm38)	G91W	probably damaging	Het
Plscr4	C	T	9: 92,490,790 (GRCm38)	R322*	probably null	Het
Ralgapa1	A	G	12: 55,659,062 (GRCm38)	S1892P	probably damaging	Het
Slc6a18	T	A	13: 73,665,574 (GRCm38)	Q540L	probably benign	Het
Tfap2a	A	T	13: 40,719,230 (GRCm38)	N323K	possibly damaging	Het
Tgm1	A	T	14: 55,705,643 (GRCm38)	M580K	probably benign	Het
Tnrc6b	G	A	15: 80,929,418 (GRCm38)	G1792D	unknown	Het
Trim66	T	A	7: 109,475,392 (GRCm38)	Q554L	possibly damaging	Het
Ttc28	G	A	5: 111,233,341 (GRCm38)	D1240N	probably benign	Het
Vmn1r238	G	T	18: 3,123,365 (GRCm38)	C16*	probably null	Het
Vmn1r6	G	A	6: 57,002,510 (GRCm38)	M52I	probably benign	Het
Zfp61	A	G	7: 24,292,034 (GRCm38)	F231L	probably benign	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49,851,467 (GRCm38)	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	49,939,553 (GRCm38)	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	49,917,668 (GRCm38)	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	49,912,725 (GRCm38)	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	49,912,751 (GRCm38)	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49,857,334 (GRCm38)	missense	probably benign
IGL01475:Dmxl1	APN	18	49,871,714 (GRCm38)	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	49,920,938 (GRCm38)	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	49,962,205 (GRCm38)	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49,863,025 (GRCm38)	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49,864,868 (GRCm38)	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	49,878,382 (GRCm38)	nonsense	probably null
IGL01933:Dmxl1	APN	18	49,877,785 (GRCm38)	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	49,890,654 (GRCm38)	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	49,894,178 (GRCm38)	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	49,961,163 (GRCm38)	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	49,877,674 (GRCm38)	splice site	probably benign
IGL02261:Dmxl1	APN	18	49,840,499 (GRCm38)	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49,864,895 (GRCm38)	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49,859,120 (GRCm38)	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	49,878,180 (GRCm38)	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	49,920,893 (GRCm38)	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49,864,818 (GRCm38)	missense	probably benign
capture	UTSW	18	49,962,261 (GRCm38)	missense	probably damaging	1.00
carnivora	UTSW	18	49,864,383 (GRCm38)	missense	probably damaging	0.99
digestion	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
drowning	UTSW	18	49,878,225 (GRCm38)	missense	possibly damaging	0.55
hibiscus	UTSW	18	49,889,467 (GRCm38)	missense	probably damaging	1.00
impound	UTSW	18	49,893,249 (GRCm38)	missense	probably benign
pitcher	UTSW	18	49,864,148 (GRCm38)	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	49,931,963 (GRCm38)	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	49,888,897 (GRCm38)	splice site	probably benign
R0027:Dmxl1	UTSW	18	49,957,295 (GRCm38)	splice site	probably benign
R0042:Dmxl1	UTSW	18	49,864,035 (GRCm38)	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49,864,035 (GRCm38)	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	49,878,082 (GRCm38)	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	49,878,082 (GRCm38)	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	49,955,803 (GRCm38)	splice site	probably benign
R0349:Dmxl1	UTSW	18	49,879,282 (GRCm38)	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	49,879,362 (GRCm38)	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	49,891,467 (GRCm38)	nonsense	probably null
R0539:Dmxl1	UTSW	18	49,857,430 (GRCm38)	splice site	probably benign
R0542:Dmxl1	UTSW	18	49,893,694 (GRCm38)	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	49,935,307 (GRCm38)	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49,851,423 (GRCm38)	splice site	probably benign
R0744:Dmxl1	UTSW	18	49,833,148 (GRCm38)	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49,833,148 (GRCm38)	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	49,893,402 (GRCm38)	missense	probably damaging	1.00
R1218:Dmxl1	UTSW	18	49,893,611 (GRCm38)	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	49,893,225 (GRCm38)	missense	probably benign
R1313:Dmxl1	UTSW	18	49,878,483 (GRCm38)	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	49,878,483 (GRCm38)	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	49,888,853 (GRCm38)	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49,857,249 (GRCm38)	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49,852,367 (GRCm38)	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49,859,286 (GRCm38)	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	49,890,767 (GRCm38)	nonsense	probably null
R1646:Dmxl1	UTSW	18	49,962,261 (GRCm38)	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	49,934,637 (GRCm38)	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	49,902,988 (GRCm38)	missense	probably benign
R1732:Dmxl1	UTSW	18	49,893,444 (GRCm38)	nonsense	probably null
R1886:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R1887:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	49,955,914 (GRCm38)	splice site	probably null
R1911:Dmxl1	UTSW	18	49,878,163 (GRCm38)	missense	probably benign	0.00
R2020:Dmxl1	UTSW	18	49,889,558 (GRCm38)	nonsense	probably null
R2116:Dmxl1	UTSW	18	49,878,817 (GRCm38)	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	49,917,631 (GRCm38)	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	49,894,094 (GRCm38)	missense	probably benign	0.12
R2216:Dmxl1	UTSW	18	49,893,923 (GRCm38)	missense	probably benign	0.00
R2255:Dmxl1	UTSW	18	49,846,639 (GRCm38)	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	49,919,976 (GRCm38)	splice site	probably null
R2343:Dmxl1	UTSW	18	49,890,678 (GRCm38)	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	49,880,791 (GRCm38)	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	49,935,317 (GRCm38)	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	49,935,317 (GRCm38)	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49,865,122 (GRCm38)	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	49,878,259 (GRCm38)	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49,863,962 (GRCm38)	missense	probably benign
R4033:Dmxl1	UTSW	18	49,851,431 (GRCm38)	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	49,961,197 (GRCm38)	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	49,878,017 (GRCm38)	nonsense	probably null
R4406:Dmxl1	UTSW	18	49,889,553 (GRCm38)	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49,848,761 (GRCm38)	missense	probably benign
R4454:Dmxl1	UTSW	18	49,893,332 (GRCm38)	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	49,961,216 (GRCm38)	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49,852,360 (GRCm38)	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49,852,360 (GRCm38)	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	49,962,181 (GRCm38)	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	49,878,631 (GRCm38)	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	49,878,021 (GRCm38)	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49,862,992 (GRCm38)	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49,851,476 (GRCm38)	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	49,889,467 (GRCm38)	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	49,957,281 (GRCm38)	intron	probably benign
R4885:Dmxl1	UTSW	18	49,878,795 (GRCm38)	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	49,877,697 (GRCm38)	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	49,895,127 (GRCm38)	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	49,870,923 (GRCm38)	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	49,893,584 (GRCm38)	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	49,951,235 (GRCm38)	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49,863,119 (GRCm38)	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	49,867,899 (GRCm38)	splice site	probably null
R5484:Dmxl1	UTSW	18	49,889,464 (GRCm38)	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49,864,478 (GRCm38)	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	49,877,697 (GRCm38)	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	49,891,626 (GRCm38)	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	49,894,257 (GRCm38)	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	49,931,941 (GRCm38)	nonsense	probably null
R5706:Dmxl1	UTSW	18	49,957,395 (GRCm38)	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49,846,586 (GRCm38)	missense	probably benign
R5876:Dmxl1	UTSW	18	49,870,984 (GRCm38)	missense	possibly damaging	0.70
R6054:Dmxl1	UTSW	18	49,857,386 (GRCm38)	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	49,912,766 (GRCm38)	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	49,893,335 (GRCm38)	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49,863,015 (GRCm38)	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	49,902,367 (GRCm38)	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	49,871,732 (GRCm38)	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49,846,586 (GRCm38)	missense	probably benign
R6319:Dmxl1	UTSW	18	49,852,300 (GRCm38)	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49,864,578 (GRCm38)	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49,859,179 (GRCm38)	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	49,878,246 (GRCm38)	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	49,880,780 (GRCm38)	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	49,893,974 (GRCm38)	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	49,921,024 (GRCm38)	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	49,955,823 (GRCm38)	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	49,955,823 (GRCm38)	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49,852,288 (GRCm38)	nonsense	probably null
R6857:Dmxl1	UTSW	18	49,864,835 (GRCm38)	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	49,935,305 (GRCm38)	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49,843,784 (GRCm38)	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	49,920,902 (GRCm38)	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49,863,057 (GRCm38)	missense	possibly damaging	0.51
R6897:Dmxl1	UTSW	18	49,851,495 (GRCm38)	missense	probably null	0.99
R6917:Dmxl1	UTSW	18	49,864,148 (GRCm38)	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	49,955,853 (GRCm38)	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49,864,614 (GRCm38)	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	49,878,612 (GRCm38)	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	49,893,957 (GRCm38)	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	49,902,794 (GRCm38)	missense	probably benign
R7629:Dmxl1	UTSW	18	49,859,270 (GRCm38)	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	49,893,552 (GRCm38)	missense	probably benign
R7688:Dmxl1	UTSW	18	49,955,871 (GRCm38)	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49,846,618 (GRCm38)	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	49,893,461 (GRCm38)	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	49,878,315 (GRCm38)	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	49,920,977 (GRCm38)	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49,840,490 (GRCm38)	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	49,961,147 (GRCm38)	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49,864,383 (GRCm38)	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	49,893,407 (GRCm38)	missense	possibly damaging	0.65
R8073:Dmxl1	UTSW	18	49,878,433 (GRCm38)	missense	probably damaging	1.00
R8089:Dmxl1	UTSW	18	49,888,830 (GRCm38)	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49,843,811 (GRCm38)	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	49,898,714 (GRCm38)	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	49,878,342 (GRCm38)	missense	probably benign
R8402:Dmxl1	UTSW	18	49,878,326 (GRCm38)	nonsense	probably null
R8402:Dmxl1	UTSW	18	49,878,327 (GRCm38)	missense	probably benign	0.09
R8678:Dmxl1	UTSW	18	49,871,692 (GRCm38)	nonsense	probably null
R8702:Dmxl1	UTSW	18	49,859,135 (GRCm38)	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	49,955,870 (GRCm38)	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	49,957,339 (GRCm38)	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	49,878,225 (GRCm38)	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,893,674 (GRCm38)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,864,508 (GRCm38)	missense	possibly damaging	0.96
R8978:Dmxl1	UTSW	18	49,922,612 (GRCm38)	missense	probably benign	0.37
R8987:Dmxl1	UTSW	18	49,893,852 (GRCm38)	missense
R9011:Dmxl1	UTSW	18	49,864,173 (GRCm38)	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	49,939,572 (GRCm38)	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	49,878,925 (GRCm38)	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	49,893,249 (GRCm38)	missense	probably benign
R9254:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49,843,852 (GRCm38)	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49,859,120 (GRCm38)	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	49,958,410 (GRCm38)	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	49,877,721 (GRCm38)	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	49,893,710 (GRCm38)	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	49,878,204 (GRCm38)	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	49,891,500 (GRCm38)	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49,865,161 (GRCm38)	missense	probably damaging	1.00
R9642:Dmxl1	UTSW	18	49,880,758 (GRCm38)	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	49,893,394 (GRCm38)	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49,864,368 (GRCm38)	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	49,919,899 (GRCm38)	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	49,920,965 (GRCm38)	missense	probably benign
Z1188:Dmxl1	UTSW	18	49,868,003 (GRCm38)	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	49,868,003 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TTCCAATGTGGCATGGCTCC -3'
(R):5'- GGTTGCAGGATCCATGAGTAC -3'

Sequencing Primer
(F):5'- AATGTGGCATGGCTCCCTACTC -3'
(R):5'- TTGCAGGATCCATGAGTACAAAAC -3'

Posted On

2020-10-20