Incidental Mutation 'R0827:Lrp4'
| ID |
78281 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp4
|
| Ensembl Gene |
ENSMUSG00000027253 |
| Gene Name |
low density lipoprotein receptor-related protein 4 |
| Synonyms |
6430526J12Rik, Megf7, mdig |
| MMRRC Submission |
039007-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.781)
|
| Stock # |
R0827 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
91287856-91344124 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 91325386 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 1404
(V1404M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028689]
|
| AlphaFold |
Q8VI56 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028689
AA Change: V1404M
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000028689
Gene: ENSMUSG00000027253
AA Change: V1404M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
LDLa
|
26 |
68 |
5.77e-10 |
SMART |
|
LDLa
|
70 |
107 |
4.05e-14 |
SMART |
|
LDLa
|
109 |
145 |
1.9e-10 |
SMART |
|
LDLa
|
147 |
184 |
1.51e-13 |
SMART |
|
LDLa
|
190 |
227 |
6.83e-12 |
SMART |
|
LDLa
|
230 |
267 |
2.45e-13 |
SMART |
|
LDLa
|
269 |
306 |
6.32e-16 |
SMART |
|
LDLa
|
311 |
351 |
3.24e-13 |
SMART |
|
EGF
|
357 |
394 |
1.4e0 |
SMART |
|
EGF_CA
|
395 |
434 |
1.05e-8 |
SMART |
|
LY
|
460 |
502 |
7.01e-10 |
SMART |
|
LY
|
503 |
545 |
4.41e-16 |
SMART |
|
LY
|
546 |
589 |
1.04e-12 |
SMART |
|
LY
|
590 |
632 |
5.07e-16 |
SMART |
|
LY
|
633 |
674 |
3.12e-7 |
SMART |
|
EGF
|
701 |
737 |
9.27e-1 |
SMART |
|
LY
|
765 |
807 |
7.29e-8 |
SMART |
|
LY
|
808 |
850 |
1.92e-16 |
SMART |
|
LY
|
851 |
894 |
3.05e-10 |
SMART |
|
LY
|
895 |
937 |
6.69e-16 |
SMART |
|
LY
|
938 |
979 |
8.71e-6 |
SMART |
|
EGF
|
1005 |
1044 |
1.64e-1 |
SMART |
|
LY
|
1073 |
1115 |
2.58e-8 |
SMART |
|
LY
|
1116 |
1158 |
1.57e-12 |
SMART |
|
LY
|
1159 |
1202 |
7.4e-9 |
SMART |
|
LY
|
1203 |
1245 |
9.39e-11 |
SMART |
|
LY
|
1246 |
1285 |
6.11e-1 |
SMART |
|
EGF
|
1312 |
1349 |
1.53e-1 |
SMART |
|
LY
|
1377 |
1419 |
4.42e-7 |
SMART |
|
LY
|
1420 |
1462 |
1.04e-12 |
SMART |
|
LY
|
1463 |
1506 |
2.11e-13 |
SMART |
|
LY
|
1507 |
1549 |
4.66e-15 |
SMART |
|
LY
|
1550 |
1590 |
2.02e-1 |
SMART |
|
EGF_like
|
1616 |
1649 |
5.79e1 |
SMART |
|
low complexity region
|
1674 |
1690 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1724 |
1746 |
N/A |
INTRINSIC |
|
low complexity region
|
1857 |
1870 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1233 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.1%
- 20x: 93.6%
|
| Validation Efficiency |
100% (88/88) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutations of this gene cause polysyndactyly. Additional phenotypes may include growth retardation, abnormal incisor development, kidney agenesis, and neonatal lethality associated with respiratory failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acan |
T |
C |
7: 78,749,419 (GRCm39) |
S1397P |
probably benign |
Het |
| Adamts15 |
T |
C |
9: 30,832,776 (GRCm39) |
Y253C |
probably damaging |
Het |
| Ankk1 |
A |
G |
9: 49,333,037 (GRCm39) |
I149T |
possibly damaging |
Het |
| Ankrd63 |
A |
G |
2: 118,533,034 (GRCm39) |
S296P |
possibly damaging |
Het |
| Arpc1b |
T |
G |
5: 145,062,566 (GRCm39) |
C227G |
probably benign |
Het |
| B4gat1 |
A |
G |
19: 5,089,725 (GRCm39) |
R241G |
possibly damaging |
Het |
| Ccar2 |
T |
C |
14: 70,377,287 (GRCm39) |
N751D |
probably benign |
Het |
| Cd55b |
T |
C |
1: 130,341,973 (GRCm39) |
I221M |
probably damaging |
Het |
| Cntn5 |
A |
G |
9: 9,666,943 (GRCm39) |
V1032A |
possibly damaging |
Het |
| Col11a1 |
G |
A |
3: 113,932,414 (GRCm39) |
R113H |
unknown |
Het |
| Colec10 |
G |
A |
15: 54,325,980 (GRCm39) |
C270Y |
probably damaging |
Het |
| Ctnnbl1 |
C |
T |
2: 157,641,337 (GRCm39) |
|
probably benign |
Het |
| Cyp2j12 |
T |
G |
4: 96,001,099 (GRCm39) |
|
probably benign |
Het |
| Dennd5a |
G |
A |
7: 109,498,938 (GRCm39) |
T999M |
probably damaging |
Het |
| Dusp13b |
C |
A |
14: 21,792,839 (GRCm39) |
V29L |
probably benign |
Het |
| Efr3a |
A |
C |
15: 65,725,400 (GRCm39) |
D83A |
possibly damaging |
Het |
| Elmod2 |
A |
G |
8: 84,043,424 (GRCm39) |
|
probably null |
Het |
| Eml3 |
C |
A |
19: 8,915,830 (GRCm39) |
T640K |
probably damaging |
Het |
| Eps8l1 |
T |
C |
7: 4,480,388 (GRCm39) |
V543A |
possibly damaging |
Het |
| Ermn |
T |
C |
2: 57,938,263 (GRCm39) |
K117E |
probably damaging |
Het |
| F830045P16Rik |
A |
G |
2: 129,314,696 (GRCm39) |
S194P |
probably benign |
Het |
| Faim2 |
A |
G |
15: 99,422,617 (GRCm39) |
V60A |
probably benign |
Het |
| Fancd2 |
G |
A |
6: 113,563,210 (GRCm39) |
|
probably null |
Het |
| Fbxo43 |
A |
T |
15: 36,163,115 (GRCm39) |
S31T |
possibly damaging |
Het |
| Gab2 |
G |
A |
7: 96,949,539 (GRCm39) |
R411Q |
probably damaging |
Het |
| Gpm6a |
A |
T |
8: 55,511,918 (GRCm39) |
D264V |
probably damaging |
Het |
| H1f6 |
A |
G |
13: 23,880,204 (GRCm39) |
D119G |
probably benign |
Het |
| Hsp90aa1 |
T |
C |
12: 110,659,129 (GRCm39) |
E556G |
probably benign |
Het |
| Ifi203 |
A |
T |
1: 173,756,029 (GRCm39) |
|
probably benign |
Het |
| Iqca1 |
C |
A |
1: 90,070,453 (GRCm39) |
G133V |
probably null |
Het |
| Kcnc3 |
A |
G |
7: 44,244,630 (GRCm39) |
T307A |
probably damaging |
Het |
| Kin |
C |
A |
2: 10,095,187 (GRCm39) |
|
probably benign |
Het |
| Knl1 |
T |
C |
2: 118,919,382 (GRCm39) |
|
probably benign |
Het |
| Lrrc71 |
T |
A |
3: 87,649,952 (GRCm39) |
|
probably null |
Het |
| Med13l |
T |
C |
5: 118,864,312 (GRCm39) |
|
probably benign |
Het |
| Mfap5 |
A |
G |
6: 122,497,879 (GRCm39) |
D39G |
probably damaging |
Het |
| Mlxipl |
T |
C |
5: 135,161,592 (GRCm39) |
S504P |
probably benign |
Het |
| Myo3a |
T |
G |
2: 22,448,227 (GRCm39) |
Y1D |
probably damaging |
Het |
| Nek1 |
A |
G |
8: 61,558,682 (GRCm39) |
|
probably benign |
Het |
| Nfkbiz |
T |
C |
16: 55,636,730 (GRCm39) |
R524G |
probably damaging |
Het |
| Npbwr1 |
T |
C |
1: 5,987,008 (GRCm39) |
T169A |
possibly damaging |
Het |
| Nuggc |
T |
C |
14: 65,846,340 (GRCm39) |
Y84H |
probably damaging |
Het |
| Nxph3 |
G |
A |
11: 95,402,252 (GRCm39) |
S54L |
probably benign |
Het |
| Or13a21 |
A |
G |
7: 139,999,380 (GRCm39) |
F102S |
probably damaging |
Het |
| Or9e1 |
T |
C |
11: 58,732,597 (GRCm39) |
I219T |
probably damaging |
Het |
| Ostn |
A |
G |
16: 27,143,381 (GRCm39) |
N70D |
probably damaging |
Het |
| Pate7 |
A |
T |
9: 35,689,147 (GRCm39) |
L12Q |
probably damaging |
Het |
| Pcdhb2 |
G |
A |
18: 37,428,710 (GRCm39) |
V228I |
possibly damaging |
Het |
| Pnpla6 |
A |
T |
8: 3,567,618 (GRCm39) |
M109L |
possibly damaging |
Het |
| Ppil6 |
T |
A |
10: 41,370,500 (GRCm39) |
|
probably benign |
Het |
| Prss46 |
A |
G |
9: 110,680,500 (GRCm39) |
N215S |
probably benign |
Het |
| Ptprd |
A |
T |
4: 76,047,152 (GRCm39) |
D371E |
probably damaging |
Het |
| Ripor2 |
T |
A |
13: 24,878,169 (GRCm39) |
F315I |
probably damaging |
Het |
| Rmi2 |
G |
A |
16: 10,653,104 (GRCm39) |
G51S |
probably damaging |
Het |
| Scg3 |
A |
G |
9: 75,590,979 (GRCm39) |
I10T |
possibly damaging |
Het |
| Scn9a |
T |
A |
2: 66,366,468 (GRCm39) |
K761* |
probably null |
Het |
| Scyl2 |
A |
G |
10: 89,493,727 (GRCm39) |
L347P |
possibly damaging |
Het |
| Sh3d21 |
A |
G |
4: 126,046,064 (GRCm39) |
|
probably benign |
Het |
| Shc1 |
T |
A |
3: 89,334,090 (GRCm39) |
|
probably null |
Het |
| Slbp |
A |
G |
5: 33,801,166 (GRCm39) |
S182P |
probably damaging |
Het |
| Slc24a1 |
C |
T |
9: 64,835,472 (GRCm39) |
G885D |
probably benign |
Het |
| Slc24a3 |
T |
C |
2: 145,360,412 (GRCm39) |
|
probably benign |
Het |
| Sowahb |
T |
G |
5: 93,191,145 (GRCm39) |
N525H |
probably damaging |
Het |
| Sppl3 |
T |
A |
5: 115,220,392 (GRCm39) |
C101* |
probably null |
Het |
| Srsf5 |
A |
G |
12: 80,996,314 (GRCm39) |
K163E |
probably damaging |
Het |
| Sult2a4 |
A |
G |
7: 13,718,886 (GRCm39) |
I119T |
probably benign |
Het |
| Svep1 |
A |
G |
4: 58,053,113 (GRCm39) |
|
probably benign |
Het |
| Tas1r3 |
G |
A |
4: 155,945,326 (GRCm39) |
R632W |
probably benign |
Het |
| Tlr4 |
T |
A |
4: 66,752,117 (GRCm39) |
|
probably null |
Het |
| Tmf1 |
A |
C |
6: 97,135,011 (GRCm39) |
L1001* |
probably null |
Het |
| Tnnt2 |
A |
G |
1: 135,771,534 (GRCm39) |
|
probably benign |
Het |
| Trank1 |
G |
A |
9: 111,178,485 (GRCm39) |
|
probably benign |
Het |
| Trdn |
A |
T |
10: 33,275,154 (GRCm39) |
|
probably benign |
Het |
| Trmt6 |
A |
T |
2: 132,657,754 (GRCm39) |
V34E |
probably damaging |
Het |
| Trrap |
T |
C |
5: 144,751,640 (GRCm39) |
F1699L |
probably benign |
Het |
| Ttk |
A |
G |
9: 83,725,968 (GRCm39) |
R250G |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,640,248 (GRCm39) |
I13787F |
probably damaging |
Het |
| Uggt1 |
T |
A |
1: 36,195,394 (GRCm39) |
|
probably null |
Het |
| Ugt2b35 |
T |
A |
5: 87,155,989 (GRCm39) |
|
probably benign |
Het |
| Ugt2b36 |
C |
A |
5: 87,214,234 (GRCm39) |
R470L |
possibly damaging |
Het |
| Unk |
A |
G |
11: 115,943,935 (GRCm39) |
D352G |
possibly damaging |
Het |
| Vmn2r77 |
G |
T |
7: 86,451,224 (GRCm39) |
C370F |
probably damaging |
Het |
| Vmn2r85 |
A |
G |
10: 130,265,387 (GRCm39) |
I32T |
possibly damaging |
Het |
| Zfp637 |
A |
G |
6: 117,822,405 (GRCm39) |
I178V |
possibly damaging |
Het |
| Zfp943 |
A |
G |
17: 22,211,071 (GRCm39) |
|
probably null |
Het |
| Zyg11a |
A |
G |
4: 108,067,239 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Lrp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00225:Lrp4
|
APN |
2 |
91,325,371 (GRCm39) |
missense |
probably benign |
|
|
IGL00509:Lrp4
|
APN |
2 |
91,316,519 (GRCm39) |
splice site |
probably benign |
|
|
IGL01145:Lrp4
|
APN |
2 |
91,317,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01287:Lrp4
|
APN |
2 |
91,304,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01531:Lrp4
|
APN |
2 |
91,341,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01534:Lrp4
|
APN |
2 |
91,303,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01544:Lrp4
|
APN |
2 |
91,307,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01761:Lrp4
|
APN |
2 |
91,312,326 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01885:Lrp4
|
APN |
2 |
91,331,452 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01909:Lrp4
|
APN |
2 |
91,324,529 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02111:Lrp4
|
APN |
2 |
91,336,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Lrp4
|
APN |
2 |
91,305,065 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02403:Lrp4
|
APN |
2 |
91,338,927 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02431:Lrp4
|
APN |
2 |
91,306,982 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02452:Lrp4
|
APN |
2 |
91,304,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Lrp4
|
APN |
2 |
91,307,055 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02828:Lrp4
|
APN |
2 |
91,305,639 (GRCm39) |
missense |
probably benign |
|
|
IGL02832:Lrp4
|
APN |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02893:Lrp4
|
APN |
2 |
91,305,161 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
artiodactyl
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bubalus
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
riverhorse
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wallow
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
F5770:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0137:Lrp4
|
UTSW |
2 |
91,325,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Lrp4
|
UTSW |
2 |
91,321,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0368:Lrp4
|
UTSW |
2 |
91,308,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0531:Lrp4
|
UTSW |
2 |
91,305,523 (GRCm39) |
splice site |
probably benign |
|
|
R1029:Lrp4
|
UTSW |
2 |
91,317,372 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Lrp4
|
UTSW |
2 |
91,307,864 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1587:Lrp4
|
UTSW |
2 |
91,306,650 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1693:Lrp4
|
UTSW |
2 |
91,322,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Lrp4
|
UTSW |
2 |
91,322,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1863:Lrp4
|
UTSW |
2 |
91,328,708 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1908:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1909:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1932:Lrp4
|
UTSW |
2 |
91,327,700 (GRCm39) |
nonsense |
probably null |
|
|
R1934:Lrp4
|
UTSW |
2 |
91,310,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2358:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2433:Lrp4
|
UTSW |
2 |
91,336,360 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2698:Lrp4
|
UTSW |
2 |
91,305,557 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2919:Lrp4
|
UTSW |
2 |
91,321,075 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3105:Lrp4
|
UTSW |
2 |
91,331,394 (GRCm39) |
missense |
probably benign |
|
|
R3709:Lrp4
|
UTSW |
2 |
91,320,811 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3711:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Lrp4
|
UTSW |
2 |
91,328,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Lrp4
|
UTSW |
2 |
91,307,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3894:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3895:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4397:Lrp4
|
UTSW |
2 |
91,342,015 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4741:Lrp4
|
UTSW |
2 |
91,341,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Lrp4
|
UTSW |
2 |
91,316,231 (GRCm39) |
missense |
probably benign |
|
|
R5050:Lrp4
|
UTSW |
2 |
91,322,767 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5096:Lrp4
|
UTSW |
2 |
91,316,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5110:Lrp4
|
UTSW |
2 |
91,327,417 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5141:Lrp4
|
UTSW |
2 |
91,309,023 (GRCm39) |
splice site |
probably benign |
|
|
R5439:Lrp4
|
UTSW |
2 |
91,327,418 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5725:Lrp4
|
UTSW |
2 |
91,325,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5795:Lrp4
|
UTSW |
2 |
91,304,816 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5820:Lrp4
|
UTSW |
2 |
91,322,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5883:Lrp4
|
UTSW |
2 |
91,318,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5919:Lrp4
|
UTSW |
2 |
91,303,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Lrp4
|
UTSW |
2 |
91,342,029 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6080:Lrp4
|
UTSW |
2 |
91,332,345 (GRCm39) |
missense |
probably benign |
|
|
R6189:Lrp4
|
UTSW |
2 |
91,305,579 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6192:Lrp4
|
UTSW |
2 |
91,338,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6319:Lrp4
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Lrp4
|
UTSW |
2 |
91,324,174 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6479:Lrp4
|
UTSW |
2 |
91,317,429 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6500:Lrp4
|
UTSW |
2 |
91,322,765 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6643:Lrp4
|
UTSW |
2 |
91,332,340 (GRCm39) |
missense |
probably benign |
|
|
R6657:Lrp4
|
UTSW |
2 |
91,322,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6696:Lrp4
|
UTSW |
2 |
91,327,690 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6714:Lrp4
|
UTSW |
2 |
91,306,710 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6734:Lrp4
|
UTSW |
2 |
91,316,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6770:Lrp4
|
UTSW |
2 |
91,327,648 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6774:Lrp4
|
UTSW |
2 |
91,341,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6957:Lrp4
|
UTSW |
2 |
91,317,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6978:Lrp4
|
UTSW |
2 |
91,322,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7065:Lrp4
|
UTSW |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7142:Lrp4
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7219:Lrp4
|
UTSW |
2 |
91,322,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7237:Lrp4
|
UTSW |
2 |
91,303,528 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7387:Lrp4
|
UTSW |
2 |
91,306,959 (GRCm39) |
missense |
probably benign |
|
|
R7585:Lrp4
|
UTSW |
2 |
91,322,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Lrp4
|
UTSW |
2 |
91,325,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7872:Lrp4
|
UTSW |
2 |
91,321,061 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7968:Lrp4
|
UTSW |
2 |
91,324,424 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8222:Lrp4
|
UTSW |
2 |
91,305,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Lrp4
|
UTSW |
2 |
91,322,713 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8342:Lrp4
|
UTSW |
2 |
91,318,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8435:Lrp4
|
UTSW |
2 |
91,307,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8720:Lrp4
|
UTSW |
2 |
91,324,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8774:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8774-TAIL:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8792:Lrp4
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8913:Lrp4
|
UTSW |
2 |
91,331,785 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9017:Lrp4
|
UTSW |
2 |
91,324,397 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9062:Lrp4
|
UTSW |
2 |
91,303,925 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9118:Lrp4
|
UTSW |
2 |
91,308,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9640:Lrp4
|
UTSW |
2 |
91,316,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9649:Lrp4
|
UTSW |
2 |
91,338,914 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9708:Lrp4
|
UTSW |
2 |
91,342,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9748:Lrp4
|
UTSW |
2 |
91,316,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Lrp4
|
UTSW |
2 |
91,316,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7580:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7581:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7582:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7583:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Lrp4
|
UTSW |
2 |
91,331,407 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGTGGCTCAAGAAATGGCGGC -3'
(R):5'- AGCAATGTAAGTGTGGACCACTGTG -3'
Sequencing Primer
(F):5'- GTCCCACTGGCATTCAGC -3'
(R):5'- GTGAAGTGGTCAGAAATCTAACTCC -3'
|
| Posted On |
2013-10-16 |
Incidental Mutation