Incidental Mutation 'R4795:Mroh2a'
| ID |
401879 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mroh2a
|
| Ensembl Gene |
ENSMUSG00000079429 |
| Gene Name |
maestro heat-like repeat family member 2A |
| Synonyms |
ENSMUSG00000044873, Heatr7b1, OTTMUSG00000020804 |
| MMRRC Submission |
041996-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.937)
|
| Stock # |
R4795 (G1)
|
| Quality Score |
61 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
88154713-88190011 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 88186386 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 64
(S64G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118971
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054674]
[ENSMUST00000061013]
[ENSMUST00000113130]
[ENSMUST00000135948]
|
| AlphaFold |
D3Z750 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054674
|
| SMART Domains |
Protein: ENSMUSP00000054263
Gene: ENSMUSG00000044783
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Scm3
|
11 |
68 |
1.5e-10 |
PFAM |
|
low complexity region
|
159 |
175 |
N/A |
INTRINSIC |
|
low complexity region
|
215 |
232 |
N/A |
INTRINSIC |
|
Pfam:HJURP_mid
|
254 |
370 |
7.6e-54 |
PFAM |
|
Pfam:HJURP_C
|
385 |
446 |
3.1e-26 |
PFAM |
|
low complexity region
|
496 |
515 |
N/A |
INTRINSIC |
|
Pfam:HJURP_C
|
527 |
585 |
7.1e-21 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061013
AA Change: S1567G
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000130508
Gene: ENSMUSG00000079429
AA Change: S1567G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
26 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
1235 |
1248 |
N/A |
INTRINSIC |
|
SCOP:d1jdha_
|
1371 |
1669 |
9e-8 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113130
AA Change: S1559G
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000108755
Gene: ENSMUSG00000079429
AA Change: S1559G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
26 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
1232 |
1245 |
N/A |
INTRINSIC |
|
SCOP:d1gw5a_
|
1446 |
1671 |
6e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135948
AA Change: S64G
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000118971
Gene: ENSMUSG00000079429
AA Change: S64G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1gw5a_
|
15 |
174 |
5e-6 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
98% (123/125) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a HEAT-domain-containing protein. The function of the encoded protein has not been characterized. [provided by RefSeq, Aug 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca4 |
T |
G |
3: 121,969,772 (GRCm39) |
L2259R |
probably damaging |
Het |
| Acd |
A |
G |
8: 106,427,647 (GRCm39) |
S2P |
possibly damaging |
Het |
| Acsf3 |
A |
G |
8: 123,506,896 (GRCm39) |
Y63C |
possibly damaging |
Het |
| Adam21 |
T |
C |
12: 81,607,748 (GRCm39) |
I5V |
probably benign |
Het |
| Adamts6 |
C |
A |
13: 104,580,636 (GRCm39) |
S783* |
probably null |
Het |
| Adamtsl1 |
T |
C |
4: 86,162,006 (GRCm39) |
|
probably null |
Het |
| Adck2 |
T |
A |
6: 39,553,327 (GRCm39) |
S313T |
probably benign |
Het |
| Adgb |
A |
G |
10: 10,233,616 (GRCm39) |
I1285T |
probably benign |
Het |
| Angptl1 |
T |
A |
1: 156,688,153 (GRCm39) |
M485K |
possibly damaging |
Het |
| Ank3 |
G |
A |
10: 69,694,095 (GRCm39) |
V289I |
probably benign |
Het |
| Atp13a4 |
A |
G |
16: 29,308,826 (GRCm39) |
|
probably null |
Het |
| Atp1a1 |
A |
G |
3: 101,491,091 (GRCm39) |
L648P |
probably benign |
Het |
| Atp2a3 |
A |
G |
11: 72,863,855 (GRCm39) |
I194V |
probably benign |
Het |
| Bglap |
A |
C |
3: 88,291,712 (GRCm39) |
I4S |
unknown |
Het |
| Cacna1b |
T |
A |
2: 24,527,499 (GRCm39) |
T1621S |
possibly damaging |
Het |
| Ccdc112 |
T |
A |
18: 46,420,739 (GRCm39) |
Q337L |
probably benign |
Het |
| Ccdc121rt3 |
A |
G |
5: 112,503,165 (GRCm39) |
S180P |
possibly damaging |
Het |
| Cd34 |
T |
G |
1: 194,633,319 (GRCm39) |
S194A |
probably damaging |
Het |
| Cdh20 |
A |
G |
1: 104,868,989 (GRCm39) |
D160G |
probably damaging |
Het |
| Clock |
T |
C |
5: 76,413,763 (GRCm39) |
K44R |
probably damaging |
Het |
| Commd9 |
A |
G |
2: 101,729,241 (GRCm39) |
N116D |
probably benign |
Het |
| Dab2 |
C |
A |
15: 6,459,092 (GRCm39) |
P335T |
probably benign |
Het |
| Epb41l3 |
T |
A |
17: 69,555,714 (GRCm39) |
|
probably null |
Het |
| Epha2 |
A |
G |
4: 141,049,727 (GRCm39) |
|
probably null |
Het |
| Fam78b |
T |
C |
1: 166,906,216 (GRCm39) |
V125A |
probably benign |
Het |
| Fars2 |
A |
T |
13: 36,721,400 (GRCm39) |
E448V |
probably damaging |
Het |
| Fkbpl |
G |
A |
17: 34,864,303 (GRCm39) |
A24T |
probably benign |
Het |
| Glyr1 |
A |
C |
16: 4,865,622 (GRCm39) |
V44G |
probably benign |
Het |
| Gm1527 |
A |
G |
3: 28,974,812 (GRCm39) |
I542V |
possibly damaging |
Het |
| Gm18856 |
C |
A |
13: 14,139,793 (GRCm39) |
|
probably benign |
Het |
| Gm44501 |
A |
G |
17: 40,889,605 (GRCm39) |
K40E |
probably benign |
Het |
| Hdhd5 |
T |
C |
6: 120,500,407 (GRCm39) |
H97R |
probably benign |
Het |
| Hmcn1 |
A |
G |
1: 150,629,362 (GRCm39) |
V965A |
probably benign |
Het |
| Hsf5 |
A |
G |
11: 87,526,446 (GRCm39) |
M373V |
probably benign |
Het |
| Igbp1b |
C |
T |
6: 138,634,803 (GRCm39) |
E214K |
probably benign |
Het |
| Iigp1 |
T |
A |
18: 60,522,964 (GRCm39) |
F27L |
probably benign |
Het |
| Isl1 |
T |
C |
13: 116,441,966 (GRCm39) |
N89S |
probably benign |
Het |
| Itga1 |
C |
A |
13: 115,171,921 (GRCm39) |
W61C |
probably damaging |
Het |
| Itga5 |
T |
C |
15: 103,256,187 (GRCm39) |
R922G |
probably benign |
Het |
| Kbtbd3 |
G |
A |
9: 4,331,073 (GRCm39) |
W482* |
probably null |
Het |
| Kcnq1 |
A |
G |
7: 142,736,494 (GRCm39) |
T168A |
probably benign |
Het |
| Lrch3 |
A |
G |
16: 32,826,074 (GRCm39) |
N631S |
probably damaging |
Het |
| Lrrk1 |
T |
A |
7: 65,912,413 (GRCm39) |
I1716F |
possibly damaging |
Het |
| Ly75 |
T |
C |
2: 60,180,284 (GRCm39) |
E631G |
probably benign |
Het |
| Map4 |
T |
C |
9: 109,864,331 (GRCm39) |
S519P |
probably benign |
Het |
| Mrtfa |
C |
T |
15: 80,901,234 (GRCm39) |
S419N |
probably damaging |
Het |
| Muc5b |
A |
G |
7: 141,403,304 (GRCm39) |
E755G |
unknown |
Het |
| Ncaph2 |
T |
G |
15: 89,255,010 (GRCm39) |
V478G |
probably damaging |
Het |
| Ncbp1 |
A |
G |
4: 46,152,967 (GRCm39) |
R247G |
possibly damaging |
Het |
| Necab1 |
G |
T |
4: 15,111,208 (GRCm39) |
D73E |
possibly damaging |
Het |
| Nedd9 |
T |
C |
13: 41,471,376 (GRCm39) |
K208E |
probably benign |
Het |
| Nfyb |
A |
T |
10: 82,588,202 (GRCm39) |
|
probably benign |
Het |
| Nol4 |
T |
C |
18: 23,054,944 (GRCm39) |
Q162R |
probably damaging |
Het |
| Nwd2 |
G |
A |
5: 63,962,776 (GRCm39) |
D787N |
probably benign |
Het |
| Olfr908 |
T |
A |
9: 38,427,799 (GRCm39) |
M157K |
probably damaging |
Het |
| Or10a5 |
A |
T |
7: 106,636,121 (GRCm39) |
Y253F |
probably benign |
Het |
| Or11g7 |
A |
C |
14: 50,690,874 (GRCm39) |
M122L |
probably damaging |
Het |
| Or13a22 |
A |
G |
7: 140,072,920 (GRCm39) |
D123G |
probably damaging |
Het |
| Or5ac23 |
C |
T |
16: 59,149,213 (GRCm39) |
V220I |
probably benign |
Het |
| Or6a2 |
C |
T |
7: 106,600,542 (GRCm39) |
G175D |
probably damaging |
Het |
| Or6e1 |
A |
G |
14: 54,520,004 (GRCm39) |
M116T |
probably damaging |
Het |
| Orai3 |
T |
C |
7: 127,373,060 (GRCm39) |
V187A |
probably benign |
Het |
| Parn |
T |
C |
16: 13,424,066 (GRCm39) |
T444A |
probably benign |
Het |
| Pcdh11x |
A |
C |
X: 119,309,937 (GRCm39) |
N460T |
probably damaging |
Het |
| Pcnt |
C |
T |
10: 76,205,858 (GRCm39) |
R2516H |
probably benign |
Het |
| Pde4d |
T |
A |
13: 110,074,705 (GRCm39) |
|
probably benign |
Het |
| Pdgfra |
A |
G |
5: 75,349,972 (GRCm39) |
N952S |
probably benign |
Het |
| Pgm2 |
A |
G |
5: 64,261,217 (GRCm39) |
Y237C |
probably damaging |
Het |
| Plcb2 |
A |
G |
2: 118,541,605 (GRCm39) |
V975A |
probably benign |
Het |
| Polk |
T |
C |
13: 96,625,764 (GRCm39) |
T347A |
probably benign |
Het |
| Ppp6r1 |
C |
T |
7: 4,644,053 (GRCm39) |
V430M |
possibly damaging |
Het |
| Ptges2 |
C |
A |
2: 32,286,334 (GRCm39) |
C16* |
probably null |
Het |
| Relb |
A |
T |
7: 19,353,764 (GRCm39) |
I38N |
probably damaging |
Het |
| Runx1t1 |
T |
A |
4: 13,837,767 (GRCm39) |
N51K |
probably damaging |
Het |
| Samsn1 |
A |
G |
16: 75,680,733 (GRCm39) |
|
probably benign |
Het |
| Scrn1 |
A |
G |
6: 54,497,754 (GRCm39) |
V279A |
possibly damaging |
Het |
| Sec31b |
A |
G |
19: 44,520,185 (GRCm39) |
S200P |
probably benign |
Het |
| Selp |
A |
G |
1: 163,972,475 (GRCm39) |
T705A |
probably benign |
Het |
| Slc2a1 |
G |
A |
4: 118,989,642 (GRCm39) |
R61Q |
probably damaging |
Het |
| Slit3 |
G |
A |
11: 35,542,647 (GRCm39) |
|
probably null |
Het |
| Smo |
T |
A |
6: 29,755,573 (GRCm39) |
V415E |
probably damaging |
Het |
| Spag8 |
C |
A |
4: 43,652,035 (GRCm39) |
V350L |
possibly damaging |
Het |
| Tbck |
T |
G |
3: 132,413,559 (GRCm39) |
L132R |
possibly damaging |
Het |
| Thnsl1 |
T |
A |
2: 21,216,856 (GRCm39) |
C203* |
probably null |
Het |
| Tm9sf2 |
T |
A |
14: 122,387,252 (GRCm39) |
|
probably null |
Het |
| Tmem131 |
A |
G |
1: 36,880,757 (GRCm39) |
V171A |
probably damaging |
Het |
| Tmem209 |
T |
C |
6: 30,501,954 (GRCm39) |
T83A |
probably benign |
Het |
| Tmem63a |
T |
C |
1: 180,782,416 (GRCm39) |
Y138H |
probably damaging |
Het |
| Trim80 |
A |
G |
11: 115,338,769 (GRCm39) |
Y533C |
probably damaging |
Het |
| Trpv2 |
A |
G |
11: 62,472,006 (GRCm39) |
D66G |
possibly damaging |
Het |
| Trrap |
T |
A |
5: 144,769,298 (GRCm39) |
I2620N |
probably benign |
Het |
| Ttyh3 |
A |
T |
5: 140,620,541 (GRCm39) |
I232N |
probably damaging |
Het |
| Ube2dnl1 |
G |
A |
X: 113,815,482 (GRCm39) |
C119Y |
possibly damaging |
Het |
| Unc13c |
T |
A |
9: 73,839,469 (GRCm39) |
S461C |
probably damaging |
Het |
| Unc80 |
T |
G |
1: 66,567,100 (GRCm39) |
I902S |
probably damaging |
Het |
| Usp42 |
C |
A |
5: 143,709,692 (GRCm39) |
G170W |
probably damaging |
Het |
| Vldlr |
T |
C |
19: 27,216,252 (GRCm39) |
|
probably null |
Het |
| Ywhab |
A |
G |
2: 163,857,265 (GRCm39) |
Y180C |
probably damaging |
Het |
| Zan |
A |
T |
5: 137,379,112 (GRCm39) |
C5329* |
probably null |
Het |
| Zbtb40 |
C |
T |
4: 136,725,953 (GRCm39) |
M535I |
probably benign |
Het |
| Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
| Zfp318 |
A |
G |
17: 46,722,988 (GRCm39) |
T1664A |
probably benign |
Het |
| Zfp7 |
T |
A |
15: 76,775,546 (GRCm39) |
C529* |
probably null |
Het |
| Zfp768 |
T |
C |
7: 126,942,547 (GRCm39) |
Q527R |
possibly damaging |
Het |
| Zfp975 |
T |
A |
7: 42,314,570 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Mroh2a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00990:Mroh2a
|
APN |
1 |
88,172,692 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00990:Mroh2a
|
APN |
1 |
88,161,842 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL00990:Mroh2a
|
APN |
1 |
88,158,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03097:Mroh2a
|
UTSW |
1 |
88,163,098 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0032:Mroh2a
|
UTSW |
1 |
88,183,888 (GRCm39) |
frame shift |
probably null |
|
|
R0068:Mroh2a
|
UTSW |
1 |
88,183,888 (GRCm39) |
frame shift |
probably null |
|
|
R0139:Mroh2a
|
UTSW |
1 |
88,185,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0197:Mroh2a
|
UTSW |
1 |
88,173,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0242:Mroh2a
|
UTSW |
1 |
88,170,142 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0322:Mroh2a
|
UTSW |
1 |
88,158,402 (GRCm39) |
nonsense |
probably null |
|
|
R0374:Mroh2a
|
UTSW |
1 |
88,170,142 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0387:Mroh2a
|
UTSW |
1 |
88,173,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0412:Mroh2a
|
UTSW |
1 |
88,162,938 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0536:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0548:Mroh2a
|
UTSW |
1 |
88,170,142 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0580:Mroh2a
|
UTSW |
1 |
88,171,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0581:Mroh2a
|
UTSW |
1 |
88,183,888 (GRCm39) |
frame shift |
probably null |
|
|
R0583:Mroh2a
|
UTSW |
1 |
88,183,888 (GRCm39) |
frame shift |
probably null |
|
|
R0613:Mroh2a
|
UTSW |
1 |
88,171,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Mroh2a
|
UTSW |
1 |
88,158,402 (GRCm39) |
nonsense |
probably null |
|
|
R0657:Mroh2a
|
UTSW |
1 |
88,183,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0659:Mroh2a
|
UTSW |
1 |
88,170,142 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0659:Mroh2a
|
UTSW |
1 |
88,178,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0671:Mroh2a
|
UTSW |
1 |
88,170,142 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0675:Mroh2a
|
UTSW |
1 |
88,156,102 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0675:Mroh2a
|
UTSW |
1 |
88,178,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0689:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0689:Mroh2a
|
UTSW |
1 |
88,158,402 (GRCm39) |
nonsense |
probably null |
|
|
R0735:Mroh2a
|
UTSW |
1 |
88,171,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0761:Mroh2a
|
UTSW |
1 |
88,171,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0766:Mroh2a
|
UTSW |
1 |
88,158,402 (GRCm39) |
nonsense |
probably null |
|
|
R0845:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0853:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0959:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R0960:Mroh2a
|
UTSW |
1 |
88,170,142 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1004:Mroh2a
|
UTSW |
1 |
88,170,142 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1013:Mroh2a
|
UTSW |
1 |
88,162,334 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1028:Mroh2a
|
UTSW |
1 |
88,163,098 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1268:Mroh2a
|
UTSW |
1 |
88,158,402 (GRCm39) |
nonsense |
probably null |
|
|
R1281:Mroh2a
|
UTSW |
1 |
88,183,889 (GRCm39) |
frame shift |
probably null |
|
|
R1414:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1439:Mroh2a
|
UTSW |
1 |
88,185,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1441:Mroh2a
|
UTSW |
1 |
88,169,353 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1442:Mroh2a
|
UTSW |
1 |
88,160,075 (GRCm39) |
splice site |
probably benign |
|
|
R1442:Mroh2a
|
UTSW |
1 |
88,170,142 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1465:Mroh2a
|
UTSW |
1 |
88,185,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1662:Mroh2a
|
UTSW |
1 |
88,169,340 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1686:Mroh2a
|
UTSW |
1 |
88,158,402 (GRCm39) |
nonsense |
probably null |
|
|
R1686:Mroh2a
|
UTSW |
1 |
88,162,334 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1780:Mroh2a
|
UTSW |
1 |
88,158,402 (GRCm39) |
nonsense |
probably null |
|
|
R1846:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1899:Mroh2a
|
UTSW |
1 |
88,163,098 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1958:Mroh2a
|
UTSW |
1 |
88,165,213 (GRCm39) |
nonsense |
probably null |
|
|
R2122:Mroh2a
|
UTSW |
1 |
88,184,476 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2248:Mroh2a
|
UTSW |
1 |
88,184,476 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2306:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2869:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R2870:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R2871:Mroh2a
|
UTSW |
1 |
88,183,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R3408:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R3608:Mroh2a
|
UTSW |
1 |
88,172,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3730:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R3937:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4022:Mroh2a
|
UTSW |
1 |
88,173,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4049:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4133:Mroh2a
|
UTSW |
1 |
88,182,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4361:Mroh2a
|
UTSW |
1 |
88,182,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4392:Mroh2a
|
UTSW |
1 |
88,187,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4401:Mroh2a
|
UTSW |
1 |
88,182,657 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4402:Mroh2a
|
UTSW |
1 |
88,182,657 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4575:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4625:Mroh2a
|
UTSW |
1 |
88,182,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4631:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4665:Mroh2a
|
UTSW |
1 |
88,169,340 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4701:Mroh2a
|
UTSW |
1 |
88,162,334 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4701:Mroh2a
|
UTSW |
1 |
88,169,340 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4771:Mroh2a
|
UTSW |
1 |
88,179,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4839:Mroh2a
|
UTSW |
1 |
88,165,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4873:Mroh2a
|
UTSW |
1 |
88,182,657 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4875:Mroh2a
|
UTSW |
1 |
88,182,657 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4896:Mroh2a
|
UTSW |
1 |
88,184,476 (GRCm39) |
missense |
probably benign |
0.37 |
|
R5007:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R5031:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R5062:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R5301:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5367:Mroh2a
|
UTSW |
1 |
88,182,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5371:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5446:Mroh2a
|
UTSW |
1 |
88,182,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5484:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5506:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5561:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R5615:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R5825:Mroh2a
|
UTSW |
1 |
88,158,402 (GRCm39) |
nonsense |
probably null |
|
|
R5891:Mroh2a
|
UTSW |
1 |
88,169,337 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5906:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5928:Mroh2a
|
UTSW |
1 |
88,169,340 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6004:Mroh2a
|
UTSW |
1 |
88,176,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6035:Mroh2a
|
UTSW |
1 |
88,158,390 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6064:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R6074:Mroh2a
|
UTSW |
1 |
88,186,386 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6091:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R6127:Mroh2a
|
UTSW |
1 |
88,162,334 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6234:Mroh2a
|
UTSW |
1 |
88,184,476 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6234:Mroh2a
|
UTSW |
1 |
88,162,334 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6244:Mroh2a
|
UTSW |
1 |
88,184,476 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6464:Mroh2a
|
UTSW |
1 |
88,185,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6465:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R6575:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
R6809:Mroh2a
|
UTSW |
1 |
88,162,938 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6819:Mroh2a
|
UTSW |
1 |
88,170,142 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6854:Mroh2a
|
UTSW |
1 |
88,171,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6860:Mroh2a
|
UTSW |
1 |
88,182,657 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7126:Mroh2a
|
UTSW |
1 |
88,182,657 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7818:Mroh2a
|
UTSW |
1 |
88,162,334 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8350:Mroh2a
|
UTSW |
1 |
88,171,805 (GRCm39) |
splice site |
probably null |
|
|
R9414:Mroh2a
|
UTSW |
1 |
88,179,096 (GRCm39) |
missense |
probably benign |
0.26 |
|
RF024:Mroh2a
|
UTSW |
1 |
88,170,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V5622:Mroh2a
|
UTSW |
1 |
88,154,813 (GRCm39) |
start gained |
probably benign |
|
|
V8831:Mroh2a
|
UTSW |
1 |
88,183,889 (GRCm39) |
frame shift |
probably null |
|
|
X0027:Mroh2a
|
UTSW |
1 |
88,176,335 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0028:Mroh2a
|
UTSW |
1 |
88,183,888 (GRCm39) |
frame shift |
probably null |
|
|
X0028:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
X0033:Mroh2a
|
UTSW |
1 |
88,183,888 (GRCm39) |
frame shift |
probably null |
|
|
X0034:Mroh2a
|
UTSW |
1 |
88,183,888 (GRCm39) |
frame shift |
probably null |
|
|
X0034:Mroh2a
|
UTSW |
1 |
88,160,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0034:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
X0039:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
X0057:Mroh2a
|
UTSW |
1 |
88,183,888 (GRCm39) |
frame shift |
probably null |
|
|
X0057:Mroh2a
|
UTSW |
1 |
88,183,377 (GRCm39) |
missense |
probably benign |
0.25 |
|
X0057:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
X0063:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
Z1188:Mroh2a
|
UTSW |
1 |
88,162,938 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1190:Mroh2a
|
UTSW |
1 |
88,159,979 (GRCm39) |
frame shift |
probably null |
|
|
Z1192:Mroh2a
|
UTSW |
1 |
88,162,938 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTGTAGAGCCCTTTCTGG -3'
(R):5'- CATTCCTTCCTGTCAGGGAC -3'
Sequencing Primer
(F):5'- TGGGGCTGCTCTCTCTC -3'
(R):5'- ACCTTCCTGGACTTTGAAGATTG -3'
|
| Posted On |
2016-07-15 |
Incidental Mutation