Incidental Mutation 'R1848:Loxhd1'
| ID |
207963 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Loxhd1
|
| Ensembl Gene |
ENSMUSG00000032818 |
| Gene Name |
lipoxygenase homology domains 1 |
| Synonyms |
1700096C21Rik, sba |
| MMRRC Submission |
039873-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.163)
|
| Stock # |
R1848 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
18 |
| Chromosomal Location |
77369654-77530626 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 77369667 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 5
(K5R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094294
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096547]
|
| AlphaFold |
C8YR32 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000096547
AA Change: K5R
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000094294
Gene: ENSMUSG00000032818
AA Change: K5R
| Domain | Start | End | E-Value | Type |
|---|
|
LH2
|
43 |
158 |
5.64e-5 |
SMART |
|
LH2
|
172 |
290 |
1.64e-9 |
SMART |
|
LH2
|
296 |
409 |
1.1e-4 |
SMART |
|
LH2
|
425 |
539 |
4.02e-4 |
SMART |
|
LH2
|
553 |
675 |
3.79e-6 |
SMART |
|
LH2
|
684 |
800 |
5.92e-6 |
SMART |
|
LH2
|
814 |
936 |
6.91e-8 |
SMART |
|
low complexity region
|
945 |
954 |
N/A |
INTRINSIC |
|
LH2
|
970 |
1086 |
4.81e-7 |
SMART |
|
LH2
|
1101 |
1228 |
5.73e-3 |
SMART |
|
LH2
|
1255 |
1375 |
8.82e-5 |
SMART |
|
Pfam:PLAT
|
1424 |
1540 |
5.4e-10 |
PFAM |
|
LH2
|
1553 |
1666 |
6.41e-3 |
SMART |
|
LH2
|
1680 |
1799 |
6.76e-6 |
SMART |
|
Pfam:PLAT
|
1813 |
1929 |
3.8e-9 |
PFAM |
|
LH2
|
1949 |
2067 |
7.23e-11 |
SMART |
|
| Meta Mutation Damage Score |
0.0695 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.2%
- 20x: 92.2%
|
| Validation Efficiency |
98% (120/123) |
| MGI Phenotype |
PHENOTYPE: Mice honozygous for an ENU-induced mutation exhibit hearing loss associated with hair cell and spiral ganglion degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 120 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933402J07Rik |
C |
A |
8: 88,295,121 (GRCm39) |
Y86* |
probably null |
Het |
| Aadac |
A |
G |
3: 59,947,118 (GRCm39) |
E272G |
probably damaging |
Het |
| Abcc8 |
A |
T |
7: 45,816,326 (GRCm39) |
D271E |
probably benign |
Het |
| Acan |
T |
C |
7: 78,748,783 (GRCm39) |
F1185L |
probably benign |
Het |
| Adam1a |
A |
T |
5: 121,657,683 (GRCm39) |
C537S |
probably damaging |
Het |
| Ago2 |
A |
G |
15: 72,995,814 (GRCm39) |
V395A |
probably benign |
Het |
| Alox15 |
A |
G |
11: 70,241,578 (GRCm39) |
V101A |
probably damaging |
Het |
| Ankra2 |
T |
C |
13: 98,407,632 (GRCm39) |
I194T |
probably damaging |
Het |
| Apobec4 |
C |
A |
1: 152,631,981 (GRCm39) |
P3H |
probably damaging |
Het |
| Arid3b |
G |
T |
9: 57,703,960 (GRCm39) |
Y329* |
probably null |
Het |
| Atm |
A |
T |
9: 53,379,312 (GRCm39) |
S1993T |
probably benign |
Het |
| Bpgm |
T |
G |
6: 34,464,669 (GRCm39) |
S129A |
probably benign |
Het |
| Brat1 |
A |
G |
5: 140,704,264 (GRCm39) |
D839G |
possibly damaging |
Het |
| Ccdc15 |
A |
T |
9: 37,253,866 (GRCm39) |
S128T |
probably benign |
Het |
| Cd300lg |
A |
T |
11: 101,937,032 (GRCm39) |
|
probably benign |
Het |
| Cdc34b |
C |
A |
11: 94,633,303 (GRCm39) |
Q168K |
probably damaging |
Het |
| Celsr2 |
A |
T |
3: 108,308,626 (GRCm39) |
V1767E |
probably benign |
Het |
| Cep350 |
T |
C |
1: 155,829,397 (GRCm39) |
D169G |
probably benign |
Het |
| Col7a1 |
A |
T |
9: 108,798,633 (GRCm39) |
D1762V |
possibly damaging |
Het |
| Coro7 |
A |
G |
16: 4,448,298 (GRCm39) |
L724P |
probably damaging |
Het |
| Crb1 |
T |
A |
1: 139,164,750 (GRCm39) |
I1125F |
probably damaging |
Het |
| Ctif |
T |
A |
18: 75,653,012 (GRCm39) |
D415V |
probably damaging |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Dhrs2 |
A |
G |
14: 55,478,298 (GRCm39) |
D237G |
probably benign |
Het |
| Dhx9 |
T |
C |
1: 153,341,499 (GRCm39) |
Q582R |
probably damaging |
Het |
| Dnajc1 |
C |
T |
2: 18,224,524 (GRCm39) |
R443Q |
probably damaging |
Het |
| Dnm2 |
C |
T |
9: 21,416,977 (GRCm39) |
R837W |
possibly damaging |
Het |
| Dpf2 |
C |
A |
19: 5,956,643 (GRCm39) |
Q70H |
probably damaging |
Het |
| Dqx1 |
T |
A |
6: 83,043,088 (GRCm39) |
D608E |
probably damaging |
Het |
| Dync2h1 |
T |
A |
9: 7,049,166 (GRCm39) |
T3245S |
probably benign |
Het |
| Ect2l |
A |
G |
10: 18,075,781 (GRCm39) |
L35P |
probably damaging |
Het |
| Efcab5 |
A |
T |
11: 76,994,132 (GRCm39) |
L1285Q |
probably damaging |
Het |
| Eif4g1 |
G |
C |
16: 20,500,617 (GRCm39) |
R697P |
probably damaging |
Het |
| Emsy |
T |
A |
7: 98,250,028 (GRCm39) |
E753V |
probably damaging |
Het |
| Entpd3 |
A |
G |
9: 120,387,485 (GRCm39) |
I227M |
probably damaging |
Het |
| Epn1 |
T |
A |
7: 5,092,997 (GRCm39) |
V103E |
probably damaging |
Het |
| Esrra |
T |
C |
19: 6,889,378 (GRCm39) |
D337G |
probably benign |
Het |
| Fam83e |
A |
T |
7: 45,378,193 (GRCm39) |
K406* |
probably null |
Het |
| Fam83e |
A |
T |
7: 45,378,194 (GRCm39) |
K406M |
possibly damaging |
Het |
| Fat2 |
A |
G |
11: 55,202,384 (GRCm39) |
I230T |
probably damaging |
Het |
| Fbxl16 |
A |
G |
17: 26,035,420 (GRCm39) |
I6V |
probably benign |
Het |
| Fgf23 |
T |
C |
6: 127,050,156 (GRCm39) |
I55T |
probably damaging |
Het |
| Fibcd1 |
T |
A |
2: 31,711,561 (GRCm39) |
D288V |
probably damaging |
Het |
| Flnb |
T |
C |
14: 7,892,113 (GRCm38) |
I594T |
probably damaging |
Het |
| Gabbr2 |
T |
C |
4: 46,739,823 (GRCm39) |
E449G |
probably benign |
Het |
| Gbf1 |
T |
G |
19: 46,260,476 (GRCm39) |
S1130A |
possibly damaging |
Het |
| Gipc3 |
T |
C |
10: 81,177,099 (GRCm39) |
E157G |
probably damaging |
Het |
| Glra3 |
G |
T |
8: 56,393,942 (GRCm39) |
A18S |
probably benign |
Het |
| Gm6625 |
A |
C |
8: 89,873,462 (GRCm39) |
|
noncoding transcript |
Het |
| Gpx4 |
A |
G |
10: 79,891,870 (GRCm39) |
|
probably benign |
Het |
| Grb10 |
A |
G |
11: 11,896,029 (GRCm39) |
F264L |
possibly damaging |
Het |
| Grik3 |
T |
C |
4: 125,587,931 (GRCm39) |
Y684H |
probably damaging |
Het |
| Gstp1 |
C |
T |
19: 4,086,795 (GRCm39) |
|
probably benign |
Het |
| H2bc27 |
A |
T |
11: 58,839,928 (GRCm39) |
I55F |
possibly damaging |
Het |
| Haus8 |
G |
A |
8: 71,708,767 (GRCm39) |
|
probably benign |
Het |
| Hip1 |
G |
A |
5: 135,463,995 (GRCm39) |
|
probably null |
Het |
| Hspbap1 |
T |
A |
16: 35,639,134 (GRCm39) |
|
probably null |
Het |
| Htr2b |
T |
A |
1: 86,027,151 (GRCm39) |
I452F |
possibly damaging |
Het |
| Hydin |
T |
A |
8: 111,296,440 (GRCm39) |
H3656Q |
probably benign |
Het |
| Klb |
T |
A |
5: 65,506,180 (GRCm39) |
D142E |
probably benign |
Het |
| Lamb3 |
A |
T |
1: 193,016,924 (GRCm39) |
T777S |
possibly damaging |
Het |
| Lins1 |
C |
A |
7: 66,364,070 (GRCm39) |
T650K |
probably damaging |
Het |
| Lpp |
G |
A |
16: 24,580,405 (GRCm39) |
M40I |
probably damaging |
Het |
| Mia2 |
A |
T |
12: 59,217,037 (GRCm39) |
|
probably benign |
Het |
| Miip |
A |
C |
4: 147,947,549 (GRCm39) |
F204V |
probably damaging |
Het |
| Mmp21 |
T |
C |
7: 133,278,882 (GRCm39) |
R323G |
probably benign |
Het |
| Mta3 |
T |
A |
17: 84,062,980 (GRCm39) |
|
probably benign |
Het |
| Myh1 |
A |
G |
11: 67,104,456 (GRCm39) |
K1004R |
probably benign |
Het |
| Myh14 |
T |
A |
7: 44,281,853 (GRCm39) |
I810F |
probably damaging |
Het |
| Nbas |
A |
C |
12: 13,463,598 (GRCm39) |
D1295A |
probably damaging |
Het |
| Niban3 |
T |
C |
8: 72,056,413 (GRCm39) |
M371T |
possibly damaging |
Het |
| Npr2 |
T |
G |
4: 43,632,384 (GRCm39) |
V67G |
probably benign |
Het |
| Oas1f |
C |
A |
5: 120,993,492 (GRCm39) |
Q235K |
probably damaging |
Het |
| Or12d17 |
T |
A |
17: 37,777,938 (GRCm39) |
S280R |
probably damaging |
Het |
| Or13a27 |
T |
A |
7: 139,925,900 (GRCm39) |
M1L |
probably benign |
Het |
| Or1p1 |
G |
T |
11: 74,180,039 (GRCm39) |
C189F |
probably damaging |
Het |
| Or52ae9 |
T |
C |
7: 103,390,381 (GRCm39) |
N22S |
probably benign |
Het |
| Or7e166 |
C |
T |
9: 19,624,386 (GRCm39) |
H88Y |
probably benign |
Het |
| Pafah2 |
GCCCC |
GCCCCC |
4: 134,152,852 (GRCm39) |
|
probably null |
Het |
| Pde1b |
A |
G |
15: 103,433,767 (GRCm39) |
|
probably null |
Het |
| Pdilt |
T |
C |
7: 119,088,607 (GRCm39) |
T465A |
probably benign |
Het |
| Plxnd1 |
T |
C |
6: 115,943,507 (GRCm39) |
H1233R |
probably damaging |
Het |
| Ppm1b |
T |
A |
17: 85,301,552 (GRCm39) |
M144K |
probably benign |
Het |
| Prkdc |
T |
C |
16: 15,625,922 (GRCm39) |
L3316S |
probably benign |
Het |
| Prm2 |
T |
A |
16: 10,609,455 (GRCm39) |
|
probably benign |
Het |
| Prmt7 |
T |
C |
8: 106,963,640 (GRCm39) |
V240A |
probably benign |
Het |
| Prx |
C |
A |
7: 27,218,313 (GRCm39) |
A938E |
possibly damaging |
Het |
| Rbm7 |
A |
G |
9: 48,402,194 (GRCm39) |
V131A |
probably benign |
Het |
| Ric1 |
T |
A |
19: 29,578,213 (GRCm39) |
|
probably null |
Het |
| Rnf150 |
A |
T |
8: 83,590,639 (GRCm39) |
M1L |
possibly damaging |
Het |
| Rnf20 |
C |
T |
4: 49,644,628 (GRCm39) |
R298W |
probably damaging |
Het |
| Rp1 |
T |
A |
1: 4,417,455 (GRCm39) |
Y1219F |
possibly damaging |
Het |
| Scn7a |
A |
G |
2: 66,514,357 (GRCm39) |
|
probably null |
Het |
| Sdad1 |
A |
G |
5: 92,440,510 (GRCm39) |
|
probably null |
Het |
| Septin9 |
T |
C |
11: 117,243,909 (GRCm39) |
|
probably benign |
Het |
| Serinc3 |
T |
C |
2: 163,487,409 (GRCm39) |
|
probably benign |
Het |
| Shc3 |
C |
T |
13: 51,615,424 (GRCm39) |
G178R |
probably damaging |
Het |
| Slc4a10 |
A |
T |
2: 62,146,950 (GRCm39) |
K1090M |
probably damaging |
Het |
| Slco1a1 |
T |
C |
6: 141,868,837 (GRCm39) |
I376V |
probably benign |
Het |
| Slmap |
A |
T |
14: 26,143,729 (GRCm39) |
F719L |
probably benign |
Het |
| Smgc |
A |
G |
15: 91,743,956 (GRCm39) |
N573D |
possibly damaging |
Het |
| Spx |
G |
A |
6: 142,359,805 (GRCm39) |
|
probably null |
Het |
| Srrt |
C |
G |
5: 137,295,207 (GRCm39) |
E308Q |
probably damaging |
Het |
| Tas2r130 |
T |
A |
6: 131,607,560 (GRCm39) |
R78S |
probably benign |
Het |
| Tchhl1 |
A |
G |
3: 93,378,408 (GRCm39) |
R371G |
probably damaging |
Het |
| Teddm2 |
C |
T |
1: 153,726,194 (GRCm39) |
A174T |
probably benign |
Het |
| Tktl2 |
G |
A |
8: 66,964,999 (GRCm39) |
V186M |
probably damaging |
Het |
| Trim33 |
T |
C |
3: 103,231,956 (GRCm39) |
|
probably benign |
Het |
| Tspan31 |
A |
G |
10: 126,905,327 (GRCm39) |
V40A |
probably damaging |
Het |
| Uevld |
A |
G |
7: 46,594,975 (GRCm39) |
|
probably benign |
Het |
| Vcl |
G |
T |
14: 21,059,063 (GRCm39) |
A560S |
probably benign |
Het |
| Vmn2r24 |
T |
A |
6: 123,793,183 (GRCm39) |
C837S |
probably damaging |
Het |
| Vmn2r57 |
C |
T |
7: 41,077,531 (GRCm39) |
V212M |
probably damaging |
Het |
| Vps13c |
A |
G |
9: 67,843,622 (GRCm39) |
T1968A |
probably benign |
Het |
| Vtn |
A |
G |
11: 78,391,393 (GRCm39) |
R269G |
probably damaging |
Het |
| Wdcp |
G |
A |
12: 4,900,245 (GRCm39) |
V34I |
possibly damaging |
Het |
| Zc3h14 |
A |
G |
12: 98,719,091 (GRCm39) |
D152G |
possibly damaging |
Het |
| Zfp189 |
C |
T |
4: 49,529,266 (GRCm39) |
P123L |
probably benign |
Het |
| Zfp318 |
T |
C |
17: 46,716,981 (GRCm39) |
S1038P |
possibly damaging |
Het |
| Zfp873 |
A |
G |
10: 81,896,406 (GRCm39) |
D416G |
probably benign |
Het |
|
| Other mutations in Loxhd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00330:Loxhd1
|
APN |
18 |
77,483,146 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00490:Loxhd1
|
APN |
18 |
77,518,770 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL00507:Loxhd1
|
APN |
18 |
77,420,263 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00546:Loxhd1
|
APN |
18 |
77,493,672 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01369:Loxhd1
|
APN |
18 |
77,416,897 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL01767:Loxhd1
|
APN |
18 |
77,374,120 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02245:Loxhd1
|
APN |
18 |
77,427,797 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02388:Loxhd1
|
APN |
18 |
77,456,833 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02410:Loxhd1
|
APN |
18 |
77,490,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02593:Loxhd1
|
APN |
18 |
77,498,235 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02632:Loxhd1
|
APN |
18 |
77,493,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02692:Loxhd1
|
APN |
18 |
77,444,609 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02796:Loxhd1
|
APN |
18 |
77,456,811 (GRCm39) |
splice site |
probably benign |
|
|
IGL03032:Loxhd1
|
APN |
18 |
77,374,169 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03074:Loxhd1
|
APN |
18 |
77,529,480 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03094:Loxhd1
|
APN |
18 |
77,518,809 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03118:Loxhd1
|
APN |
18 |
77,468,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03232:Loxhd1
|
APN |
18 |
77,496,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03377:Loxhd1
|
APN |
18 |
77,529,369 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
H8562:Loxhd1
|
UTSW |
18 |
77,429,627 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
PIT4494001:Loxhd1
|
UTSW |
18 |
77,529,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0003:Loxhd1
|
UTSW |
18 |
77,427,196 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0003:Loxhd1
|
UTSW |
18 |
77,427,196 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0048:Loxhd1
|
UTSW |
18 |
77,496,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0049:Loxhd1
|
UTSW |
18 |
77,468,256 (GRCm39) |
splice site |
probably benign |
|
|
R0049:Loxhd1
|
UTSW |
18 |
77,468,256 (GRCm39) |
splice site |
probably benign |
|
|
R0206:Loxhd1
|
UTSW |
18 |
77,492,562 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0206:Loxhd1
|
UTSW |
18 |
77,492,562 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0208:Loxhd1
|
UTSW |
18 |
77,492,562 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0323:Loxhd1
|
UTSW |
18 |
77,456,833 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0332:Loxhd1
|
UTSW |
18 |
77,471,526 (GRCm39) |
splice site |
probably null |
|
|
R0367:Loxhd1
|
UTSW |
18 |
77,513,453 (GRCm39) |
splice site |
probably benign |
|
|
R0709:Loxhd1
|
UTSW |
18 |
77,492,665 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0783:Loxhd1
|
UTSW |
18 |
77,517,680 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1132:Loxhd1
|
UTSW |
18 |
77,517,639 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1232:Loxhd1
|
UTSW |
18 |
77,493,699 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1331:Loxhd1
|
UTSW |
18 |
77,490,632 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1465:Loxhd1
|
UTSW |
18 |
77,468,269 (GRCm39) |
splice site |
probably null |
|
|
R1465:Loxhd1
|
UTSW |
18 |
77,468,269 (GRCm39) |
splice site |
probably null |
|
|
R1501:Loxhd1
|
UTSW |
18 |
77,444,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1640:Loxhd1
|
UTSW |
18 |
77,490,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1656:Loxhd1
|
UTSW |
18 |
77,409,364 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1671:Loxhd1
|
UTSW |
18 |
77,492,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Loxhd1
|
UTSW |
18 |
77,380,937 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1735:Loxhd1
|
UTSW |
18 |
77,492,585 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1796:Loxhd1
|
UTSW |
18 |
77,513,335 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1796:Loxhd1
|
UTSW |
18 |
77,493,603 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1800:Loxhd1
|
UTSW |
18 |
77,490,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1912:Loxhd1
|
UTSW |
18 |
77,427,833 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1945:Loxhd1
|
UTSW |
18 |
77,492,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1978:Loxhd1
|
UTSW |
18 |
77,409,338 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1997:Loxhd1
|
UTSW |
18 |
77,383,465 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2086:Loxhd1
|
UTSW |
18 |
77,472,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2153:Loxhd1
|
UTSW |
18 |
77,443,862 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R3124:Loxhd1
|
UTSW |
18 |
77,518,774 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3896:Loxhd1
|
UTSW |
18 |
77,469,719 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R3907:Loxhd1
|
UTSW |
18 |
77,496,464 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3980:Loxhd1
|
UTSW |
18 |
77,501,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4165:Loxhd1
|
UTSW |
18 |
77,460,025 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4166:Loxhd1
|
UTSW |
18 |
77,460,025 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4176:Loxhd1
|
UTSW |
18 |
77,418,755 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4345:Loxhd1
|
UTSW |
18 |
77,486,697 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4354:Loxhd1
|
UTSW |
18 |
77,483,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Loxhd1
|
UTSW |
18 |
77,460,607 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4402:Loxhd1
|
UTSW |
18 |
77,529,456 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4404:Loxhd1
|
UTSW |
18 |
77,518,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4456:Loxhd1
|
UTSW |
18 |
77,486,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4525:Loxhd1
|
UTSW |
18 |
77,444,608 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4605:Loxhd1
|
UTSW |
18 |
77,493,642 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4661:Loxhd1
|
UTSW |
18 |
77,490,581 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4698:Loxhd1
|
UTSW |
18 |
77,459,987 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4725:Loxhd1
|
UTSW |
18 |
77,483,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4820:Loxhd1
|
UTSW |
18 |
77,472,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5163:Loxhd1
|
UTSW |
18 |
77,449,432 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5288:Loxhd1
|
UTSW |
18 |
77,451,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5328:Loxhd1
|
UTSW |
18 |
77,498,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5329:Loxhd1
|
UTSW |
18 |
77,420,378 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5347:Loxhd1
|
UTSW |
18 |
77,454,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5589:Loxhd1
|
UTSW |
18 |
77,429,751 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5616:Loxhd1
|
UTSW |
18 |
77,492,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5703:Loxhd1
|
UTSW |
18 |
77,444,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5837:Loxhd1
|
UTSW |
18 |
77,374,105 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5888:Loxhd1
|
UTSW |
18 |
77,490,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6021:Loxhd1
|
UTSW |
18 |
77,499,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6032:Loxhd1
|
UTSW |
18 |
77,469,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6032:Loxhd1
|
UTSW |
18 |
77,469,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Loxhd1
|
UTSW |
18 |
77,383,454 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6174:Loxhd1
|
UTSW |
18 |
77,499,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6265:Loxhd1
|
UTSW |
18 |
77,449,426 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6377:Loxhd1
|
UTSW |
18 |
77,468,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6530:Loxhd1
|
UTSW |
18 |
77,499,847 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6555:Loxhd1
|
UTSW |
18 |
77,380,965 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6782:Loxhd1
|
UTSW |
18 |
77,518,873 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6834:Loxhd1
|
UTSW |
18 |
77,529,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7000:Loxhd1
|
UTSW |
18 |
77,460,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7112:Loxhd1
|
UTSW |
18 |
77,476,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7203:Loxhd1
|
UTSW |
18 |
77,501,892 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7206:Loxhd1
|
UTSW |
18 |
77,529,513 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7260:Loxhd1
|
UTSW |
18 |
77,420,338 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7432:Loxhd1
|
UTSW |
18 |
77,383,547 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7475:Loxhd1
|
UTSW |
18 |
77,500,001 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7555:Loxhd1
|
UTSW |
18 |
77,483,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7590:Loxhd1
|
UTSW |
18 |
77,409,330 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7612:Loxhd1
|
UTSW |
18 |
77,517,671 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7626:Loxhd1
|
UTSW |
18 |
77,518,882 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7768:Loxhd1
|
UTSW |
18 |
77,472,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7791:Loxhd1
|
UTSW |
18 |
77,471,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7829:Loxhd1
|
UTSW |
18 |
77,496,483 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7884:Loxhd1
|
UTSW |
18 |
77,518,909 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7960:Loxhd1
|
UTSW |
18 |
77,472,746 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7986:Loxhd1
|
UTSW |
18 |
77,462,890 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8042:Loxhd1
|
UTSW |
18 |
77,518,888 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8084:Loxhd1
|
UTSW |
18 |
77,427,845 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8088:Loxhd1
|
UTSW |
18 |
77,429,709 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8100:Loxhd1
|
UTSW |
18 |
77,492,512 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8139:Loxhd1
|
UTSW |
18 |
77,468,192 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8152:Loxhd1
|
UTSW |
18 |
77,476,095 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8199:Loxhd1
|
UTSW |
18 |
77,469,334 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8246:Loxhd1
|
UTSW |
18 |
77,451,242 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8263:Loxhd1
|
UTSW |
18 |
77,462,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8324:Loxhd1
|
UTSW |
18 |
77,427,275 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8342:Loxhd1
|
UTSW |
18 |
77,493,681 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8401:Loxhd1
|
UTSW |
18 |
77,468,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8480:Loxhd1
|
UTSW |
18 |
77,518,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8490:Loxhd1
|
UTSW |
18 |
77,529,162 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8807:Loxhd1
|
UTSW |
18 |
77,444,468 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8961:Loxhd1
|
UTSW |
18 |
77,472,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8974:Loxhd1
|
UTSW |
18 |
77,518,899 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9079:Loxhd1
|
UTSW |
18 |
77,490,593 (GRCm39) |
missense |
probably benign |
|
|
R9284:Loxhd1
|
UTSW |
18 |
77,501,826 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9312:Loxhd1
|
UTSW |
18 |
77,498,285 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9619:Loxhd1
|
UTSW |
18 |
77,443,871 (GRCm39) |
missense |
probably benign |
0.32 |
|
X0020:Loxhd1
|
UTSW |
18 |
77,427,258 (GRCm39) |
nonsense |
probably null |
|
|
X0024:Loxhd1
|
UTSW |
18 |
77,483,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Loxhd1
|
UTSW |
18 |
77,529,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGAACTTTGGGATTGGGGAC -3'
(R):5'- TGCAAAGCTCTCCTCAGAAG -3'
Sequencing Primer
(F):5'- GACCCAGGAGACCCAGG -3'
(R):5'- GACAGATTCCGCAGCCC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation