Incidental Mutation 'R2117:Nav2'
| ID |
231074 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav2
|
| Ensembl Gene |
ENSMUSG00000052512 |
| Gene Name |
neuron navigator 2 |
| Synonyms |
Rainb1, Unc53H2, 5330421F07Rik, POMFIL2, HELAD1, RAINB2 |
| MMRRC Submission |
040121-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.550)
|
| Stock # |
R2117 (G1)
|
| Quality Score |
207 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
48608796-49259838 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 49114328 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 771
(I771V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139045
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064395]
[ENSMUST00000183659]
[ENSMUST00000184124]
[ENSMUST00000184945]
|
| AlphaFold |
E9Q842 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064395
AA Change: I771V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512
AA Change: I771V
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183659
AA Change: I710V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512
AA Change: I710V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
11 |
N/A |
INTRINSIC |
|
CH
|
23 |
126 |
6.19e-16 |
SMART |
|
low complexity region
|
141 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
249 |
N/A |
INTRINSIC |
|
low complexity region
|
276 |
287 |
N/A |
INTRINSIC |
|
low complexity region
|
351 |
363 |
N/A |
INTRINSIC |
|
coiled coil region
|
425 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
519 |
530 |
N/A |
INTRINSIC |
|
low complexity region
|
552 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
579 |
601 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
886 |
906 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
943 |
N/A |
INTRINSIC |
|
low complexity region
|
1001 |
1013 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1299 |
N/A |
INTRINSIC |
|
low complexity region
|
1307 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1356 |
1371 |
N/A |
INTRINSIC |
|
low complexity region
|
1393 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1465 |
1479 |
N/A |
INTRINSIC |
|
low complexity region
|
1553 |
1567 |
N/A |
INTRINSIC |
|
coiled coil region
|
1569 |
1656 |
N/A |
INTRINSIC |
|
low complexity region
|
1728 |
1739 |
N/A |
INTRINSIC |
|
coiled coil region
|
1780 |
1848 |
N/A |
INTRINSIC |
|
AAA
|
2032 |
2186 |
1.69e-5 |
SMART |
|
low complexity region
|
2343 |
2369 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184124
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184155
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184945
AA Change: I771V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512
AA Change: I771V
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrv1 |
A |
T |
13: 81,640,656 (GRCm39) |
C3357S |
probably benign |
Het |
| Ago1 |
T |
A |
4: 126,357,650 (GRCm39) |
|
probably null |
Het |
| Akap10 |
A |
T |
11: 61,781,129 (GRCm39) |
D562E |
possibly damaging |
Het |
| Akr1b7 |
G |
A |
6: 34,395,929 (GRCm39) |
A144T |
possibly damaging |
Het |
| Ankle1 |
A |
G |
8: 71,860,562 (GRCm39) |
T340A |
probably benign |
Het |
| Arf5 |
C |
T |
6: 28,424,783 (GRCm39) |
Q71* |
probably null |
Het |
| Arl15 |
C |
T |
13: 114,104,196 (GRCm39) |
S111F |
probably damaging |
Het |
| Asph |
G |
A |
4: 9,517,671 (GRCm39) |
Q468* |
probably null |
Het |
| Bcam |
G |
T |
7: 19,492,352 (GRCm39) |
A581E |
possibly damaging |
Het |
| Blvra |
G |
T |
2: 126,927,989 (GRCm39) |
E80* |
probably null |
Het |
| Ccr6 |
T |
C |
17: 8,474,914 (GRCm39) |
F40L |
possibly damaging |
Het |
| Cfap161 |
A |
T |
7: 83,425,184 (GRCm39) |
N302K |
possibly damaging |
Het |
| Ckmt2 |
T |
A |
13: 92,003,964 (GRCm39) |
I345F |
probably benign |
Het |
| Cpsf6 |
A |
G |
10: 117,202,025 (GRCm39) |
|
probably benign |
Het |
| Ctnna1 |
A |
G |
18: 35,285,678 (GRCm39) |
N8S |
possibly damaging |
Het |
| Cyp2d11 |
A |
G |
15: 82,275,954 (GRCm39) |
L209P |
probably damaging |
Het |
| Dab2 |
T |
C |
15: 6,465,096 (GRCm39) |
V628A |
probably damaging |
Het |
| Dcstamp |
C |
T |
15: 39,618,571 (GRCm39) |
Q327* |
probably null |
Het |
| Defb38 |
A |
T |
8: 19,073,483 (GRCm39) |
Y63* |
probably null |
Het |
| Dlg5 |
A |
T |
14: 24,227,826 (GRCm39) |
L365* |
probably null |
Het |
| Dnai7 |
C |
T |
6: 145,150,967 (GRCm39) |
|
probably null |
Het |
| Dnmt3l |
C |
A |
10: 77,899,130 (GRCm39) |
L110I |
probably damaging |
Het |
| Exoc3l2 |
G |
T |
7: 19,228,907 (GRCm39) |
L108F |
possibly damaging |
Het |
| Exoc4 |
T |
A |
6: 33,324,760 (GRCm39) |
N351K |
possibly damaging |
Het |
| Fam83h |
C |
A |
15: 75,876,582 (GRCm39) |
E252* |
probably null |
Het |
| Fancm |
A |
G |
12: 65,123,948 (GRCm39) |
D202G |
probably damaging |
Het |
| Fat1 |
T |
A |
8: 45,490,500 (GRCm39) |
V3804E |
probably benign |
Het |
| Fbxw28 |
T |
C |
9: 109,159,985 (GRCm39) |
T190A |
probably benign |
Het |
| Fer1l4 |
T |
C |
2: 155,881,038 (GRCm39) |
T843A |
probably benign |
Het |
| Fnip1 |
A |
T |
11: 54,391,450 (GRCm39) |
H461L |
probably damaging |
Het |
| Gcn1 |
A |
T |
5: 115,736,884 (GRCm39) |
M1276L |
probably benign |
Het |
| Gemin4 |
A |
G |
11: 76,101,827 (GRCm39) |
V978A |
possibly damaging |
Het |
| Gm7247 |
A |
T |
14: 51,602,792 (GRCm39) |
I43F |
probably damaging |
Het |
| Gm9978 |
C |
T |
10: 78,322,731 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr4 |
T |
C |
7: 18,957,070 (GRCm39) |
S331P |
probably damaging |
Het |
| Hspa1a |
T |
A |
17: 35,189,455 (GRCm39) |
N483Y |
probably damaging |
Het |
| Ift74 |
A |
G |
4: 94,515,496 (GRCm39) |
T138A |
probably benign |
Het |
| Ints14 |
T |
G |
9: 64,887,077 (GRCm39) |
L336R |
probably damaging |
Het |
| Irak1 |
G |
T |
X: 73,066,218 (GRCm39) |
P197Q |
possibly damaging |
Het |
| Kif4 |
A |
G |
X: 99,709,323 (GRCm39) |
S315G |
probably benign |
Het |
| L3mbtl1 |
T |
A |
2: 162,801,990 (GRCm39) |
|
probably null |
Het |
| Lamb3 |
A |
G |
1: 193,016,489 (GRCm39) |
R657G |
probably benign |
Het |
| Ldc1 |
C |
A |
4: 130,109,156 (GRCm39) |
V295L |
possibly damaging |
Het |
| Lrp2 |
A |
C |
2: 69,313,729 (GRCm39) |
V2334G |
probably benign |
Het |
| Lrwd1 |
T |
A |
5: 136,159,332 (GRCm39) |
Y431F |
probably damaging |
Het |
| Map3k21 |
A |
T |
8: 126,650,781 (GRCm39) |
H261L |
probably benign |
Het |
| Meis1 |
G |
T |
11: 18,831,679 (GRCm39) |
P453Q |
probably damaging |
Het |
| Mettl16 |
G |
T |
11: 74,693,755 (GRCm39) |
M255I |
probably benign |
Het |
| Mllt10 |
A |
G |
2: 18,167,380 (GRCm39) |
N435S |
probably benign |
Het |
| Mta2 |
T |
C |
19: 8,920,880 (GRCm39) |
I27T |
probably damaging |
Het |
| Nisch |
A |
T |
14: 30,899,242 (GRCm39) |
|
probably benign |
Het |
| Npc1 |
G |
A |
18: 12,329,613 (GRCm39) |
P990L |
probably damaging |
Het |
| Nrxn1 |
A |
T |
17: 91,011,705 (GRCm39) |
I308K |
probably damaging |
Het |
| Or13l2 |
C |
A |
3: 97,317,765 (GRCm39) |
C244F |
probably damaging |
Het |
| Or1ad6 |
A |
T |
11: 50,860,147 (GRCm39) |
I101F |
probably damaging |
Het |
| Or5h17 |
T |
C |
16: 58,820,783 (GRCm39) |
L245P |
possibly damaging |
Het |
| Otogl |
T |
C |
10: 107,694,779 (GRCm39) |
D823G |
probably benign |
Het |
| P2rx7 |
A |
G |
5: 122,819,329 (GRCm39) |
T584A |
probably benign |
Het |
| Pals1 |
T |
C |
12: 78,856,696 (GRCm39) |
F180L |
possibly damaging |
Het |
| Pank1 |
T |
A |
19: 34,818,486 (GRCm39) |
I18F |
probably damaging |
Het |
| Pgap3 |
A |
G |
11: 98,281,933 (GRCm39) |
L126P |
probably damaging |
Het |
| Pgap6 |
C |
T |
17: 26,336,858 (GRCm39) |
L259F |
possibly damaging |
Het |
| Phka1 |
C |
T |
X: 101,653,807 (GRCm39) |
R290H |
probably damaging |
Het |
| Pkd2 |
G |
A |
5: 104,631,042 (GRCm39) |
E489K |
probably damaging |
Het |
| Prdm16 |
T |
A |
4: 154,432,382 (GRCm39) |
S296C |
probably null |
Het |
| Prex2 |
T |
A |
1: 11,256,937 (GRCm39) |
N1216K |
probably damaging |
Het |
| Prmt7 |
A |
G |
8: 106,953,930 (GRCm39) |
T124A |
probably damaging |
Het |
| Ptpra |
G |
T |
2: 130,381,655 (GRCm39) |
R372L |
probably damaging |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Rap2b |
G |
T |
3: 61,272,512 (GRCm39) |
G12V |
probably damaging |
Het |
| Rapgef5 |
T |
A |
12: 117,677,799 (GRCm39) |
|
probably null |
Het |
| Rassf4 |
A |
G |
6: 116,622,088 (GRCm39) |
F168S |
possibly damaging |
Het |
| Rtf1 |
T |
A |
2: 119,535,999 (GRCm39) |
H184Q |
probably benign |
Het |
| Sacs |
A |
G |
14: 61,451,220 (GRCm39) |
K4422R |
probably benign |
Het |
| Sec11c |
A |
T |
18: 65,933,720 (GRCm39) |
T9S |
probably benign |
Het |
| Sema3d |
C |
T |
5: 12,613,240 (GRCm39) |
T439I |
probably benign |
Het |
| Sephs1 |
A |
G |
2: 4,904,351 (GRCm39) |
N243S |
probably benign |
Het |
| Setd2 |
TTGGGA |
T |
9: 110,433,212 (GRCm39) |
|
probably null |
Het |
| Setx |
A |
G |
2: 29,020,313 (GRCm39) |
D100G |
probably benign |
Het |
| Slc22a7 |
C |
A |
17: 46,744,898 (GRCm39) |
V383L |
possibly damaging |
Het |
| Slc25a40 |
T |
C |
5: 8,480,417 (GRCm39) |
C56R |
probably damaging |
Het |
| Stk38l |
T |
A |
6: 146,670,344 (GRCm39) |
L229I |
probably damaging |
Het |
| Sult2a5 |
T |
C |
7: 13,359,359 (GRCm39) |
S112P |
probably damaging |
Het |
| Syt4 |
A |
G |
18: 31,573,520 (GRCm39) |
Y332H |
probably damaging |
Het |
| Tcof1 |
T |
C |
18: 60,965,857 (GRCm39) |
E415G |
possibly damaging |
Het |
| Tenm2 |
A |
G |
11: 35,915,681 (GRCm39) |
L1951P |
probably damaging |
Het |
| Tlr9 |
A |
G |
9: 106,102,536 (GRCm39) |
N609S |
probably damaging |
Het |
| Tmem120a |
A |
T |
5: 135,764,977 (GRCm39) |
S266T |
possibly damaging |
Het |
| Tmem132b |
A |
G |
5: 125,699,615 (GRCm39) |
E92G |
probably damaging |
Het |
| Tnfrsf18 |
T |
A |
4: 156,112,973 (GRCm39) |
V196E |
probably damaging |
Het |
| Trpc1 |
A |
T |
9: 95,599,637 (GRCm39) |
L474H |
probably damaging |
Het |
| Trpm6 |
T |
C |
19: 18,807,316 (GRCm39) |
V1020A |
probably damaging |
Het |
| Usp20 |
T |
A |
2: 30,906,317 (GRCm39) |
C562S |
probably damaging |
Het |
| Usp47 |
T |
A |
7: 111,666,443 (GRCm39) |
|
probably null |
Het |
| Vgll1 |
A |
C |
X: 56,137,790 (GRCm39) |
K53T |
probably damaging |
Het |
| Vmn1r26 |
T |
C |
6: 57,985,335 (GRCm39) |
N285D |
possibly damaging |
Het |
| Zfp445 |
T |
A |
9: 122,682,502 (GRCm39) |
K480* |
probably null |
Het |
| Zfp786 |
A |
G |
6: 47,803,931 (GRCm39) |
V37A |
probably damaging |
Het |
| Zfp821 |
A |
G |
8: 110,447,851 (GRCm39) |
E64G |
probably damaging |
Het |
| Zfp994 |
T |
A |
17: 22,419,962 (GRCm39) |
D329V |
probably damaging |
Het |
| Zkscan8 |
T |
C |
13: 21,704,488 (GRCm39) |
S484G |
probably damaging |
Het |
|
| Other mutations in Nav2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Nav2
|
APN |
7 |
49,220,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01150:Nav2
|
APN |
7 |
49,102,269 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01649:Nav2
|
APN |
7 |
49,225,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01662:Nav2
|
APN |
7 |
49,220,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02297:Nav2
|
APN |
7 |
49,243,977 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02313:Nav2
|
APN |
7 |
49,208,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02441:Nav2
|
APN |
7 |
49,102,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Nav2
|
APN |
7 |
49,195,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02477:Nav2
|
APN |
7 |
49,232,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02725:Nav2
|
APN |
7 |
49,214,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02944:Nav2
|
APN |
7 |
49,070,004 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02953:Nav2
|
APN |
7 |
49,198,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03105:Nav2
|
APN |
7 |
49,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03234:Nav2
|
APN |
7 |
49,111,756 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03274:Nav2
|
APN |
7 |
49,011,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Nav2
|
APN |
7 |
49,141,205 (GRCm39) |
nonsense |
probably null |
|
|
R0006:Nav2
|
UTSW |
7 |
49,102,978 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0070:Nav2
|
UTSW |
7 |
49,220,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0113:Nav2
|
UTSW |
7 |
49,185,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0306:Nav2
|
UTSW |
7 |
49,195,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0346:Nav2
|
UTSW |
7 |
49,254,333 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0539:Nav2
|
UTSW |
7 |
49,111,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0669:Nav2
|
UTSW |
7 |
49,058,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0785:Nav2
|
UTSW |
7 |
49,070,081 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0970:Nav2
|
UTSW |
7 |
49,233,901 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1162:Nav2
|
UTSW |
7 |
49,185,788 (GRCm39) |
splice site |
probably benign |
|
|
R1274:Nav2
|
UTSW |
7 |
49,254,178 (GRCm39) |
nonsense |
probably null |
|
|
R1463:Nav2
|
UTSW |
7 |
49,185,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1464:Nav2
|
UTSW |
7 |
49,011,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1464:Nav2
|
UTSW |
7 |
49,011,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1536:Nav2
|
UTSW |
7 |
49,195,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1612:Nav2
|
UTSW |
7 |
49,220,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Nav2
|
UTSW |
7 |
49,102,213 (GRCm39) |
missense |
probably benign |
|
|
R1731:Nav2
|
UTSW |
7 |
49,197,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1734:Nav2
|
UTSW |
7 |
49,225,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Nav2
|
UTSW |
7 |
49,197,943 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1945:Nav2
|
UTSW |
7 |
49,114,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1997:Nav2
|
UTSW |
7 |
49,198,219 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2061:Nav2
|
UTSW |
7 |
49,248,645 (GRCm39) |
splice site |
probably benign |
|
|
R2174:Nav2
|
UTSW |
7 |
49,102,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2182:Nav2
|
UTSW |
7 |
49,247,002 (GRCm39) |
missense |
probably benign |
0.38 |
|
R2251:Nav2
|
UTSW |
7 |
49,103,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2283:Nav2
|
UTSW |
7 |
49,141,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2343:Nav2
|
UTSW |
7 |
49,248,565 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2472:Nav2
|
UTSW |
7 |
49,058,632 (GRCm39) |
missense |
probably benign |
|
|
R2568:Nav2
|
UTSW |
7 |
49,247,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2656:Nav2
|
UTSW |
7 |
49,195,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2964:Nav2
|
UTSW |
7 |
49,206,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2966:Nav2
|
UTSW |
7 |
49,206,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3817:Nav2
|
UTSW |
7 |
49,114,310 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3834:Nav2
|
UTSW |
7 |
49,195,606 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4207:Nav2
|
UTSW |
7 |
49,246,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4207:Nav2
|
UTSW |
7 |
49,222,046 (GRCm39) |
splice site |
probably null |
|
|
R4411:Nav2
|
UTSW |
7 |
49,047,857 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4413:Nav2
|
UTSW |
7 |
49,047,857 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4440:Nav2
|
UTSW |
7 |
49,225,011 (GRCm39) |
splice site |
probably benign |
|
|
R4440:Nav2
|
UTSW |
7 |
49,201,785 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4454:Nav2
|
UTSW |
7 |
49,198,292 (GRCm39) |
splice site |
probably null |
|
|
R4729:Nav2
|
UTSW |
7 |
49,102,567 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4801:Nav2
|
UTSW |
7 |
49,195,600 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4802:Nav2
|
UTSW |
7 |
49,195,600 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4824:Nav2
|
UTSW |
7 |
49,058,749 (GRCm39) |
intron |
probably benign |
|
|
R4887:Nav2
|
UTSW |
7 |
49,198,182 (GRCm39) |
nonsense |
probably null |
|
|
R4908:Nav2
|
UTSW |
7 |
49,254,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4952:Nav2
|
UTSW |
7 |
48,954,288 (GRCm39) |
intron |
probably benign |
|
|
R4965:Nav2
|
UTSW |
7 |
49,202,625 (GRCm39) |
nonsense |
probably null |
|
|
R5169:Nav2
|
UTSW |
7 |
49,198,231 (GRCm39) |
nonsense |
probably null |
|
|
R5224:Nav2
|
UTSW |
7 |
49,201,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5249:Nav2
|
UTSW |
7 |
49,185,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5285:Nav2
|
UTSW |
7 |
49,197,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5314:Nav2
|
UTSW |
7 |
49,058,440 (GRCm39) |
small deletion |
probably benign |
|
|
R5320:Nav2
|
UTSW |
7 |
49,141,121 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5377:Nav2
|
UTSW |
7 |
49,238,908 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5471:Nav2
|
UTSW |
7 |
49,197,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5754:Nav2
|
UTSW |
7 |
49,206,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Nav2
|
UTSW |
7 |
49,197,817 (GRCm39) |
splice site |
probably null |
|
|
R5884:Nav2
|
UTSW |
7 |
49,246,917 (GRCm39) |
nonsense |
probably null |
|
|
R5921:Nav2
|
UTSW |
7 |
48,954,324 (GRCm39) |
intron |
probably benign |
|
|
R6180:Nav2
|
UTSW |
7 |
49,107,915 (GRCm39) |
missense |
probably benign |
0.39 |
|
R6208:Nav2
|
UTSW |
7 |
49,213,851 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6373:Nav2
|
UTSW |
7 |
49,102,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6450:Nav2
|
UTSW |
7 |
49,244,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6522:Nav2
|
UTSW |
7 |
49,247,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6626:Nav2
|
UTSW |
7 |
49,244,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6695:Nav2
|
UTSW |
7 |
49,114,652 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6705:Nav2
|
UTSW |
7 |
49,201,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6842:Nav2
|
UTSW |
7 |
49,107,917 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6847:Nav2
|
UTSW |
7 |
49,141,204 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7287:Nav2
|
UTSW |
7 |
49,070,076 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7312:Nav2
|
UTSW |
7 |
49,111,672 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7315:Nav2
|
UTSW |
7 |
49,198,037 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7337:Nav2
|
UTSW |
7 |
49,201,521 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7366:Nav2
|
UTSW |
7 |
49,203,951 (GRCm39) |
splice site |
probably null |
|
|
R7451:Nav2
|
UTSW |
7 |
49,202,577 (GRCm39) |
splice site |
probably null |
|
|
R7545:Nav2
|
UTSW |
7 |
49,232,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7706:Nav2
|
UTSW |
7 |
49,244,067 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7730:Nav2
|
UTSW |
7 |
49,222,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Nav2
|
UTSW |
7 |
49,246,921 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8097:Nav2
|
UTSW |
7 |
49,237,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8110:Nav2
|
UTSW |
7 |
49,201,698 (GRCm39) |
nonsense |
probably null |
|
|
R8119:Nav2
|
UTSW |
7 |
49,103,232 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8298:Nav2
|
UTSW |
7 |
49,204,009 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8306:Nav2
|
UTSW |
7 |
49,195,765 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8331:Nav2
|
UTSW |
7 |
49,102,371 (GRCm39) |
missense |
probably benign |
|
|
R8402:Nav2
|
UTSW |
7 |
49,103,185 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8421:Nav2
|
UTSW |
7 |
49,102,269 (GRCm39) |
missense |
probably benign |
|
|
R8478:Nav2
|
UTSW |
7 |
49,111,733 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8724:Nav2
|
UTSW |
7 |
49,141,184 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8753:Nav2
|
UTSW |
7 |
49,102,320 (GRCm39) |
missense |
probably benign |
|
|
R8835:Nav2
|
UTSW |
7 |
49,248,551 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8933:Nav2
|
UTSW |
7 |
49,111,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8957:Nav2
|
UTSW |
7 |
49,220,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9069:Nav2
|
UTSW |
7 |
49,208,561 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9095:Nav2
|
UTSW |
7 |
49,254,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Nav2
|
UTSW |
7 |
49,202,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9261:Nav2
|
UTSW |
7 |
49,246,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Nav2
|
UTSW |
7 |
49,197,647 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Z1177:Nav2
|
UTSW |
7 |
49,243,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Nav2
|
UTSW |
7 |
49,102,509 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTGTAGGTAAACGCATAGCTTC -3'
(R):5'- TTCTCAGAGGGGCAGAGTAC -3'
Sequencing Primer
(F):5'- TCCTTGTTAATAAAGGAACGCCAGG -3'
(R):5'- AGAGTACACGTAGCGGCCTG -3'
|
| Posted On |
2014-09-18 |
Incidental Mutation