Incidental Mutation 'R7687:Or2aj5'
ID 593177
Institutional Source Beutler Lab
Gene Symbol Or2aj5
Ensembl Gene ENSMUSG00000062245
Gene Name olfactory receptor family 2 subfamily AJ member 5
Synonyms Olfr170, MOR273-2, GA_x54KRFPKG5P-16052703-16051765
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R7687 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 19424475-19425416 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19424485 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 310 (N310S)
Ref Sequence ENSEMBL: ENSMUSP00000145775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078603] [ENSMUST00000206562] [ENSMUST00000218837]
AlphaFold Q8VGL6
Predicted Effect probably benign
Transcript: ENSMUST00000078603
AA Change: N310S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000077674
Gene: ENSMUSG00000062245
AA Change: N310S

DomainStartEndE-ValueType
Pfam:7tm_4 29 308 1.5e-43 PFAM
Pfam:7tm_1 41 290 2.4e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206562
AA Change: N310S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000218837
AA Change: N311S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,297,341 (GRCm39) K2383R probably benign Het
Acly C T 11: 100,395,680 (GRCm39) probably null Het
Baiap3 T A 17: 25,468,311 (GRCm39) I276F possibly damaging Het
Cdc14b A T 13: 64,357,007 (GRCm39) D419E probably benign Het
Celsr2 G T 3: 108,305,085 (GRCm39) P2165T probably benign Het
Clk4 A G 11: 51,172,225 (GRCm39) D476G probably benign Het
Dera A G 6: 137,813,878 (GRCm39) T10A Het
Dip2c A T 13: 9,654,617 (GRCm39) T742S probably benign Het
Dohh C A 10: 81,223,640 (GRCm39) A231E probably benign Het
Dot1l T G 10: 80,625,202 (GRCm39) S1150A possibly damaging Het
Eea1 T A 10: 95,862,460 (GRCm39) I794N probably benign Het
En2 T C 5: 28,375,287 (GRCm39) S277P probably damaging Het
Erich1 A G 8: 14,080,691 (GRCm39) L276P probably damaging Het
Flnb A G 14: 7,924,224 (GRCm38) N1779S probably damaging Het
Frzb T A 2: 80,254,979 (GRCm39) T186S probably benign Het
Gdf7 T A 12: 8,348,257 (GRCm39) R347* probably null Het
Ighv9-4 T C 12: 114,263,883 (GRCm39) I17V not run Het
Ipo13 G A 4: 117,769,088 (GRCm39) P235S probably benign Het
Itga2 C A 13: 115,002,796 (GRCm39) G565C probably damaging Het
Kcnc4 CCCGCCGCCGCCGCCGCCGCCGC CCCGCCGCCGCCGCCGCCGCCGCCGC 3: 107,365,925 (GRCm39) probably benign Het
Kcnk10 A G 12: 98,401,355 (GRCm39) I440T probably damaging Het
Kdm3a T A 6: 71,576,476 (GRCm39) K779N possibly damaging Het
Kmt2d C T 15: 98,760,001 (GRCm39) D1086N unknown Het
Kntc1 A G 5: 123,897,152 (GRCm39) I172V probably benign Het
Maip1 A G 1: 57,451,003 (GRCm39) E215G probably damaging Het
Mms19 A T 19: 41,943,607 (GRCm39) M417K possibly damaging Het
Mslnl T C 17: 25,962,157 (GRCm39) V185A probably damaging Het
Naa11 A T 5: 97,539,648 (GRCm39) V170E probably benign Het
Ncapg C T 5: 45,857,227 (GRCm39) P980S probably benign Het
Pbxip1 A G 3: 89,355,506 (GRCm39) D675G probably damaging Het
Pdlim5 A G 3: 141,983,608 (GRCm39) S382P probably benign Het
Pkd1l1 T A 11: 8,804,390 (GRCm39) I2184F Het
Plau A G 14: 20,889,866 (GRCm39) Y237C probably damaging Het
Ppl T C 16: 4,915,806 (GRCm39) T586A probably benign Het
Rapgef6 T G 11: 54,551,901 (GRCm39) I923S possibly damaging Het
Rbfox2 C T 15: 77,190,694 (GRCm39) G17D unknown Het
Sema3b T C 9: 107,481,013 (GRCm39) D108G probably damaging Het
Slc6a20a A G 9: 123,485,331 (GRCm39) I297T probably damaging Het
Slit1 A G 19: 41,639,128 (GRCm39) F261L probably benign Het
Tcp10a T A 17: 7,612,507 (GRCm39) V433D probably damaging Het
Tktl2 A G 8: 66,965,753 (GRCm39) E437G probably damaging Het
Tll1 G T 8: 64,574,526 (GRCm39) Y109* probably null Het
Tmem79 A G 3: 88,239,888 (GRCm39) V274A probably damaging Het
Tnfrsf23 G A 7: 143,235,199 (GRCm39) S55L probably benign Het
Ubd T C 17: 37,504,865 (GRCm39) probably null Het
Ubl3 C A 5: 148,442,985 (GRCm39) R105L possibly damaging Het
Ubl7 A T 9: 57,821,867 (GRCm39) D72V probably damaging Het
Wdr55 T C 18: 36,895,076 (GRCm39) S81P probably damaging Het
Wtip T C 7: 33,816,044 (GRCm39) Y344C probably damaging Het
Zfp488 A G 14: 33,692,357 (GRCm39) S269P possibly damaging Het
Zkscan2 A C 7: 123,099,085 (GRCm39) S36A probably benign Het
Other mutations in Or2aj5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01671:Or2aj5 APN 16 19,424,671 (GRCm39) missense probably benign 0.00
IGL02002:Or2aj5 APN 16 19,425,300 (GRCm39) missense possibly damaging 0.91
IGL02537:Or2aj5 APN 16 19,424,549 (GRCm39) missense probably damaging 1.00
IGL02881:Or2aj5 APN 16 19,425,050 (GRCm39) missense probably damaging 1.00
IGL03189:Or2aj5 APN 16 19,425,341 (GRCm39) missense probably benign
R0012:Or2aj5 UTSW 16 19,425,190 (GRCm39) missense probably benign 0.30
R0619:Or2aj5 UTSW 16 19,425,022 (GRCm39) missense probably damaging 1.00
R0764:Or2aj5 UTSW 16 19,425,182 (GRCm39) missense probably damaging 1.00
R1387:Or2aj5 UTSW 16 19,424,777 (GRCm39) missense probably damaging 1.00
R1430:Or2aj5 UTSW 16 19,424,752 (GRCm39) missense probably damaging 1.00
R1503:Or2aj5 UTSW 16 19,425,062 (GRCm39) missense probably benign 0.19
R1878:Or2aj5 UTSW 16 19,424,501 (GRCm39) missense probably benign
R1989:Or2aj5 UTSW 16 19,425,407 (GRCm39) missense probably benign 0.00
R2012:Or2aj5 UTSW 16 19,424,881 (GRCm39) missense probably benign 0.22
R3890:Or2aj5 UTSW 16 19,425,205 (GRCm39) missense probably damaging 1.00
R3891:Or2aj5 UTSW 16 19,425,205 (GRCm39) missense probably damaging 1.00
R5591:Or2aj5 UTSW 16 19,424,608 (GRCm39) missense probably damaging 1.00
R6158:Or2aj5 UTSW 16 19,424,675 (GRCm39) missense probably damaging 1.00
R6297:Or2aj5 UTSW 16 19,424,680 (GRCm39) missense possibly damaging 0.81
R6512:Or2aj5 UTSW 16 19,425,109 (GRCm39) missense probably damaging 1.00
R6962:Or2aj5 UTSW 16 19,424,672 (GRCm39) missense probably benign 0.00
R7252:Or2aj5 UTSW 16 19,425,249 (GRCm39) missense probably damaging 0.99
R7605:Or2aj5 UTSW 16 19,425,022 (GRCm39) missense probably damaging 1.00
R8302:Or2aj5 UTSW 16 19,425,116 (GRCm39) missense probably benign 0.05
R8991:Or2aj5 UTSW 16 19,424,511 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGACATCCCTGCTGTTCCTG -3'
(R):5'- GGCCAGTCATTTTCACATATATGAGAC -3'

Sequencing Primer
(F):5'- TGCTGTTCCTGCTACAGATATG -3'
(R):5'- CATTTTCACATATATGAGACCTCGC -3'
Posted On 2019-11-12