|Institutional Source||Beutler Lab|
|Gene Name||ATP binding cassette subfamily G member 3|
|Is this an essential gene?||Probably non essential (E-score: 0.060)|
|Stock #||R8059 (G1)|
|Chromosomal Location||104935057-104982718 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to T at 104953082 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000031239 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031239] [ENSMUST00000130644]|
|Predicted Effect||probably null
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.9490|
|Coding Region Coverage||
|Validation Efficiency||100% (58/58)|
|MGI Phenotype||FUNCTION: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It lacks several highly conserved residues found in other ATP-binding proteins; this suggests that this protein may not bind ATP and may require dimerization with another subunit to form a functional ATP-transporter. The function of this gene has not yet been determined; however, high levels of expression in the thymus and spleen suggest a potential role in the transport of specific peptides or hydrophobic compounds from lymphocytes. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Abcg3||
(F):5'- CTGAGCTGCAGTTACCTCTG -3'
(R):5'- TCTACAGAGCAAGCTATGTTGGG -3'
(F):5'- GAATTCCCACATGTTTCTGCAG -3'
(R):5'- GTTGGGAGAAAACTGTCCTAACTTG -3'