Incidental Mutation 'R4396:Usp32'
ID 325497
Institutional Source Beutler Lab
Gene Symbol Usp32
Ensembl Gene ENSMUSG00000000804
Gene Name ubiquitin specific peptidase 32
Synonyms 6430526O11Rik, 2900074J03Rik
MMRRC Submission 041129-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4396 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 84984442-85140161 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 85053975 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 296 (L296F)
Ref Sequence ENSEMBL: ENSMUSP00000103710 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108075]
AlphaFold F8VPZ3
Predicted Effect probably benign
Transcript: ENSMUST00000108075
AA Change: L296F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000103710
Gene: ENSMUSG00000000804
AA Change: L296F

DomainStartEndE-ValueType
EFh 232 260 4.66e0 SMART
EFh 268 296 5.8e-1 SMART
Blast:EFh 318 346 5e-7 BLAST
DUSP 389 588 2.32e-16 SMART
Pfam:Ubiquitin_3 628 711 2.4e-9 PFAM
Pfam:UCH 733 1564 2.4e-83 PFAM
Pfam:UCH_1 1202 1547 2.9e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172950
Meta Mutation Damage Score 0.1215 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm2 T C 7: 119,595,920 (GRCm38) F552L probably damaging Het
Actn2 A G 13: 12,310,879 (GRCm38) L70P probably damaging Het
Btbd7 A G 12: 102,785,293 (GRCm38) S1071P probably benign Het
Cd200r1 T A 16: 44,766,054 (GRCm38) W16R probably benign Het
Cdhr2 A G 13: 54,715,665 (GRCm38) N120D probably damaging Het
Col19a1 T C 1: 24,510,866 (GRCm38) T317A unknown Het
Dab1 C T 4: 104,731,751 (GRCm38) A524V probably benign Het
Dmbt1 T C 7: 131,116,632 (GRCm38) L1683P probably damaging Het
Dynll1 A T 5: 115,300,641 (GRCm38) C2S probably benign Het
Elp2 T A 18: 24,609,650 (GRCm38) S80T probably damaging Het
Fat1 T A 8: 44,952,346 (GRCm38) N711K probably damaging Het
Fzd3 A G 14: 65,235,605 (GRCm38) I238T probably damaging Het
Galnt7 A T 8: 57,538,181 (GRCm38) F432I probably damaging Het
Gemin5 T A 11: 58,139,549 (GRCm38) T817S probably benign Het
Gm5414 T G 15: 101,625,666 (GRCm38) E294A probably damaging Het
Gm8909 C A 17: 36,161,969 (GRCm38) probably benign Het
Homer3 G A 8: 70,290,143 (GRCm38) probably null Het
Kcnj4 C A 15: 79,484,673 (GRCm38) A369S probably benign Het
Llgl1 T C 11: 60,706,008 (GRCm38) V145A probably benign Het
Mdga1 T C 17: 29,850,517 (GRCm38) D185G probably damaging Het
Mettl2 A G 11: 105,126,778 (GRCm38) D38G probably damaging Het
Mfsd13a C T 19: 46,371,992 (GRCm38) R328C probably damaging Het
Mpp4 T C 1: 59,144,802 (GRCm38) I260V possibly damaging Het
Mtcl1 T C 17: 66,344,225 (GRCm38) E1112G probably damaging Het
Mtus2 T A 5: 148,203,938 (GRCm38) N871K possibly damaging Het
Mylk C T 16: 34,912,275 (GRCm38) Q642* probably null Het
Naip6 C T 13: 100,300,600 (GRCm38) A472T probably benign Het
Or4f57 A G 2: 111,960,215 (GRCm38) I286T probably damaging Het
Pdzd2 A T 15: 12,387,646 (GRCm38) D875E probably benign Het
Piezo1 G T 8: 122,498,674 (GRCm38) T557K probably damaging Het
Plxna2 C T 1: 194,749,317 (GRCm38) S538F probably damaging Het
Plxnb1 T C 9: 109,100,223 (GRCm38) V49A possibly damaging Het
Pramel6 A T 2: 87,508,530 (GRCm38) I25F probably damaging Het
Rreb1 C T 13: 37,930,443 (GRCm38) Q593* probably null Het
Scn8a A G 15: 100,972,830 (GRCm38) N254S probably damaging Het
Scnn1g T G 7: 121,740,427 (GRCm38) S150A probably benign Het
Sec24a A G 11: 51,715,164 (GRCm38) F686L possibly damaging Het
Sirt1 T C 10: 63,321,998 (GRCm38) T546A probably benign Het
Tns2 C T 15: 102,108,934 (GRCm38) R281C probably damaging Het
Traf5 A T 1: 191,997,845 (GRCm38) V415E probably benign Het
Traip C G 9: 107,959,487 (GRCm38) T110S probably benign Het
Treml2 T C 17: 48,308,114 (GRCm38) V209A probably benign Het
Trpv5 T C 6: 41,657,896 (GRCm38) S500G probably benign Het
Vmn2r79 A G 7: 87,001,891 (GRCm38) H166R possibly damaging Het
Zswim1 A G 2: 164,825,449 (GRCm38) D207G probably damaging Het
Other mutations in Usp32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00529:Usp32 APN 11 84,994,426 (GRCm38) missense probably damaging 1.00
IGL00701:Usp32 APN 11 85,059,125 (GRCm38) splice site probably null
IGL00848:Usp32 APN 11 85,051,181 (GRCm38) splice site probably benign
IGL00934:Usp32 APN 11 85,007,076 (GRCm38) missense probably damaging 1.00
IGL01019:Usp32 APN 11 85,039,265 (GRCm38) missense probably damaging 0.97
IGL01302:Usp32 APN 11 84,988,482 (GRCm38) missense probably benign 0.05
IGL01444:Usp32 APN 11 85,059,164 (GRCm38) missense probably damaging 0.97
IGL01575:Usp32 APN 11 85,022,802 (GRCm38) missense probably damaging 1.00
IGL01981:Usp32 APN 11 85,036,524 (GRCm38) missense probably benign 0.02
IGL02118:Usp32 APN 11 85,032,177 (GRCm38) nonsense probably null
IGL02159:Usp32 APN 11 85,005,802 (GRCm38) splice site probably null
IGL02227:Usp32 APN 11 84,986,481 (GRCm38) missense probably damaging 1.00
IGL02363:Usp32 APN 11 85,044,787 (GRCm38) missense probably benign 0.01
IGL02524:Usp32 APN 11 85,010,011 (GRCm38) nonsense probably null
IGL02613:Usp32 APN 11 85,040,070 (GRCm38) missense probably damaging 0.99
IGL02720:Usp32 APN 11 85,006,991 (GRCm38) critical splice donor site probably null
IGL02738:Usp32 APN 11 85,083,806 (GRCm38) missense probably damaging 1.00
IGL02929:Usp32 APN 11 84,988,372 (GRCm38) missense probably benign 0.01
IGL03303:Usp32 APN 11 85,022,832 (GRCm38) missense probably damaging 1.00
BB010:Usp32 UTSW 11 85,007,059 (GRCm38) missense probably damaging 1.00
BB020:Usp32 UTSW 11 85,007,059 (GRCm38) missense probably damaging 1.00
PIT4812001:Usp32 UTSW 11 85,010,074 (GRCm38) missense probably damaging 1.00
R0026:Usp32 UTSW 11 85,032,074 (GRCm38) missense possibly damaging 0.48
R0295:Usp32 UTSW 11 85,053,692 (GRCm38) missense probably damaging 0.98
R1320:Usp32 UTSW 11 85,017,793 (GRCm38) missense probably damaging 0.98
R1712:Usp32 UTSW 11 85,042,580 (GRCm38) missense probably benign 0.12
R1922:Usp32 UTSW 11 85,007,004 (GRCm38) nonsense probably null
R1973:Usp32 UTSW 11 85,103,931 (GRCm38) missense probably benign 0.09
R2010:Usp32 UTSW 11 85,040,004 (GRCm38) missense probably damaging 0.98
R2082:Usp32 UTSW 11 85,030,512 (GRCm38) missense probably damaging 0.99
R2355:Usp32 UTSW 11 85,005,909 (GRCm38) missense probably benign 0.34
R3147:Usp32 UTSW 11 85,029,087 (GRCm38) missense probably damaging 1.00
R3160:Usp32 UTSW 11 85,025,536 (GRCm38) missense probably damaging 0.97
R3162:Usp32 UTSW 11 85,025,536 (GRCm38) missense probably damaging 0.97
R3716:Usp32 UTSW 11 85,042,563 (GRCm38) missense probably damaging 1.00
R3816:Usp32 UTSW 11 84,994,384 (GRCm38) critical splice donor site probably null
R3870:Usp32 UTSW 11 85,007,055 (GRCm38) nonsense probably null
R3871:Usp32 UTSW 11 85,081,156 (GRCm38) missense probably null 0.81
R4041:Usp32 UTSW 11 85,017,739 (GRCm38) missense probably benign 0.40
R4079:Usp32 UTSW 11 85,039,229 (GRCm38) missense probably damaging 0.98
R4332:Usp32 UTSW 11 85,103,978 (GRCm38) missense possibly damaging 0.79
R4580:Usp32 UTSW 11 85,059,127 (GRCm38) critical splice donor site probably null
R4620:Usp32 UTSW 11 85,059,127 (GRCm38) critical splice donor site probably null
R4744:Usp32 UTSW 11 84,994,393 (GRCm38) missense probably damaging 1.00
R4909:Usp32 UTSW 11 85,055,772 (GRCm38) nonsense probably null
R5056:Usp32 UTSW 11 85,026,795 (GRCm38) missense probably benign 0.07
R5111:Usp32 UTSW 11 85,077,331 (GRCm38) missense possibly damaging 0.95
R5213:Usp32 UTSW 11 85,022,259 (GRCm38) missense probably damaging 1.00
R5308:Usp32 UTSW 11 85,017,718 (GRCm38) missense probably benign 0.12
R5381:Usp32 UTSW 11 85,059,127 (GRCm38) critical splice donor site probably benign
R5538:Usp32 UTSW 11 85,017,786 (GRCm38) missense possibly damaging 0.65
R5659:Usp32 UTSW 11 85,077,414 (GRCm38) missense possibly damaging 0.94
R6006:Usp32 UTSW 11 84,992,451 (GRCm38) critical splice donor site probably null
R6011:Usp32 UTSW 11 85,032,097 (GRCm38) missense possibly damaging 0.70
R6029:Usp32 UTSW 11 85,025,582 (GRCm38) missense probably damaging 0.99
R6074:Usp32 UTSW 11 84,994,573 (GRCm38) missense probably benign 0.00
R6331:Usp32 UTSW 11 84,986,576 (GRCm38) missense possibly damaging 0.92
R6353:Usp32 UTSW 11 85,022,281 (GRCm38) missense probably benign
R6714:Usp32 UTSW 11 85,026,870 (GRCm38) missense probably damaging 0.99
R6778:Usp32 UTSW 11 85,025,686 (GRCm38) missense probably benign 0.00
R6988:Usp32 UTSW 11 85,010,143 (GRCm38) missense probably benign 0.35
R6992:Usp32 UTSW 11 85,032,088 (GRCm38) missense probably damaging 0.99
R7182:Usp32 UTSW 11 85,040,170 (GRCm38) missense probably benign 0.34
R7186:Usp32 UTSW 11 85,051,234 (GRCm38) missense probably benign 0.45
R7198:Usp32 UTSW 11 85,022,855 (GRCm38) frame shift probably null
R7201:Usp32 UTSW 11 85,022,855 (GRCm38) frame shift probably null
R7469:Usp32 UTSW 11 84,988,553 (GRCm38) missense possibly damaging 0.94
R7502:Usp32 UTSW 11 85,022,898 (GRCm38) missense possibly damaging 0.48
R7513:Usp32 UTSW 11 85,027,112 (GRCm38) nonsense probably null
R7629:Usp32 UTSW 11 85,019,855 (GRCm38) frame shift probably null
R7703:Usp32 UTSW 11 85,077,327 (GRCm38) missense probably damaging 0.99
R7741:Usp32 UTSW 11 84,987,281 (GRCm38) missense probably damaging 0.99
R7765:Usp32 UTSW 11 84,994,408 (GRCm38) missense probably damaging 1.00
R7933:Usp32 UTSW 11 85,007,059 (GRCm38) missense probably damaging 1.00
R7973:Usp32 UTSW 11 85,022,808 (GRCm38) missense probably damaging 0.99
R7989:Usp32 UTSW 11 85,034,300 (GRCm38) missense
R7998:Usp32 UTSW 11 84,994,426 (GRCm38) missense probably damaging 1.00
R8292:Usp32 UTSW 11 85,077,401 (GRCm38) missense probably damaging 0.99
R8305:Usp32 UTSW 11 85,032,185 (GRCm38) missense possibly damaging 0.83
R8548:Usp32 UTSW 11 85,017,827 (GRCm38) missense possibly damaging 0.52
R8924:Usp32 UTSW 11 85,025,544 (GRCm38) missense probably damaging 0.98
R9002:Usp32 UTSW 11 85,053,951 (GRCm38) missense probably damaging 0.96
R9145:Usp32 UTSW 11 85,022,292 (GRCm38) missense probably damaging 1.00
R9209:Usp32 UTSW 11 85,040,012 (GRCm38) missense probably damaging 0.98
R9211:Usp32 UTSW 11 85,022,733 (GRCm38) missense probably damaging 1.00
R9296:Usp32 UTSW 11 85,017,652 (GRCm38) missense probably damaging 1.00
R9310:Usp32 UTSW 11 85,051,202 (GRCm38) missense probably benign 0.29
R9417:Usp32 UTSW 11 84,994,543 (GRCm38) missense probably damaging 1.00
R9514:Usp32 UTSW 11 85,022,734 (GRCm38) missense probably damaging 0.99
R9652:Usp32 UTSW 11 85,030,491 (GRCm38) missense probably damaging 0.97
R9723:Usp32 UTSW 11 85,044,710 (GRCm38) nonsense probably null
R9757:Usp32 UTSW 11 85,077,329 (GRCm38) nonsense probably null
X0028:Usp32 UTSW 11 84,992,606 (GRCm38) missense probably benign 0.05
Z1177:Usp32 UTSW 11 84,988,612 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAGACATTCATTCCATCTACCTAGC -3'
(R):5'- GAGGTCTGTTCACAATTCTACATG -3'

Sequencing Primer
(F):5'- TCAGAACTTCGCAGGACA -3'
(R):5'- CCTTATGGGAACTGCTACAGC -3'
Posted On 2015-07-06