Incidental Mutation 'R4610:Myo9a'
| ID |
344624 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo9a
|
| Ensembl Gene |
ENSMUSG00000039585 |
| Gene Name |
myosin IXa |
| Synonyms |
C130068I12Rik, 4732465J09Rik |
| MMRRC Submission |
041821-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4610 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
59658179-59836149 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 59779165 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 1640
(H1640Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122852
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000128341]
[ENSMUST00000135298]
[ENSMUST00000136740]
|
| AlphaFold |
Q8C170 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000128341
AA Change: H1640Q
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000119401
Gene: ENSMUSG00000039585
AA Change: H1640Q
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
14 |
112 |
5.57e-30 |
SMART |
|
low complexity region
|
129 |
137 |
N/A |
INTRINSIC |
|
MYSc
|
140 |
1018 |
N/A |
SMART |
|
IQ
|
1019 |
1041 |
1.79e1 |
SMART |
|
IQ
|
1042 |
1064 |
4.11e0 |
SMART |
|
IQ
|
1074 |
1096 |
1.9e-2 |
SMART |
|
IQ
|
1115 |
1137 |
1.01e-6 |
SMART |
|
IQ
|
1138 |
1160 |
8.71e-2 |
SMART |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
coiled coil region
|
1265 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1384 |
N/A |
INTRINSIC |
|
coiled coil region
|
1492 |
1539 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1685 |
1938 |
6e-89 |
BLAST |
|
low complexity region
|
1982 |
1993 |
N/A |
INTRINSIC |
|
C1
|
2002 |
2050 |
2.6e-9 |
SMART |
|
RhoGAP
|
2075 |
2250 |
3.36e-73 |
SMART |
|
coiled coil region
|
2320 |
2360 |
N/A |
INTRINSIC |
|
low complexity region
|
2419 |
2438 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135298
AA Change: H1640Q
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000117432
Gene: ENSMUSG00000039585
AA Change: H1640Q
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
14 |
112 |
5.57e-30 |
SMART |
|
low complexity region
|
129 |
137 |
N/A |
INTRINSIC |
|
MYSc
|
140 |
1018 |
N/A |
SMART |
|
IQ
|
1019 |
1041 |
1.79e1 |
SMART |
|
IQ
|
1042 |
1064 |
4.11e0 |
SMART |
|
IQ
|
1074 |
1096 |
1.9e-2 |
SMART |
|
IQ
|
1115 |
1137 |
1.01e-6 |
SMART |
|
IQ
|
1138 |
1160 |
8.71e-2 |
SMART |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
coiled coil region
|
1265 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1384 |
N/A |
INTRINSIC |
|
coiled coil region
|
1492 |
1539 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1759 |
N/A |
INTRINSIC |
|
low complexity region
|
2053 |
2064 |
N/A |
INTRINSIC |
|
C1
|
2073 |
2121 |
2.6e-9 |
SMART |
|
RhoGAP
|
2146 |
2321 |
3.36e-73 |
SMART |
|
coiled coil region
|
2391 |
2431 |
N/A |
INTRINSIC |
|
low complexity region
|
2490 |
2509 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136740
AA Change: H1640Q
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000122852
Gene: ENSMUSG00000039585
AA Change: H1640Q
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
14 |
112 |
5.57e-30 |
SMART |
|
low complexity region
|
129 |
137 |
N/A |
INTRINSIC |
|
MYSc
|
140 |
1018 |
N/A |
SMART |
|
IQ
|
1019 |
1041 |
1.79e1 |
SMART |
|
IQ
|
1042 |
1064 |
4.11e0 |
SMART |
|
IQ
|
1074 |
1096 |
1.9e-2 |
SMART |
|
IQ
|
1115 |
1137 |
1.01e-6 |
SMART |
|
IQ
|
1138 |
1160 |
8.71e-2 |
SMART |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
coiled coil region
|
1265 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1384 |
N/A |
INTRINSIC |
|
coiled coil region
|
1492 |
1539 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1759 |
N/A |
INTRINSIC |
|
low complexity region
|
2053 |
2064 |
N/A |
INTRINSIC |
|
C1
|
2073 |
2121 |
2.6e-9 |
SMART |
|
RhoGAP
|
2146 |
2321 |
3.36e-73 |
SMART |
|
coiled coil region
|
2409 |
2449 |
N/A |
INTRINSIC |
|
low complexity region
|
2508 |
2527 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147364
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215963
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
98% (121/124) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous KO leads to obstructive hydrocephaly caused by blockage of the third ventricle and the rostral aqueduct caused by developmental failures of their ependymal cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 117 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aars2 |
T |
A |
17: 45,827,847 (GRCm39) |
D555E |
probably damaging |
Het |
| Adgre1 |
C |
A |
17: 57,757,073 (GRCm39) |
Q777K |
possibly damaging |
Het |
| Agpat4 |
G |
A |
17: 12,429,264 (GRCm39) |
|
probably null |
Het |
| Ak7 |
G |
A |
12: 105,679,834 (GRCm39) |
V123M |
probably benign |
Het |
| Ankle1 |
AT |
A |
8: 71,859,851 (GRCm39) |
|
probably benign |
Het |
| Ankrd44 |
T |
G |
1: 54,805,907 (GRCm39) |
|
probably benign |
Het |
| Aprt |
A |
T |
8: 123,302,154 (GRCm39) |
|
probably null |
Het |
| Aptx |
T |
C |
4: 40,702,766 (GRCm39) |
|
probably null |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| AY358078 |
T |
A |
14: 52,063,532 (GRCm39) |
C393S |
possibly damaging |
Het |
| Bbip1 |
T |
C |
19: 53,920,606 (GRCm39) |
M1V |
probably null |
Het |
| Cacng7 |
T |
A |
7: 3,385,207 (GRCm39) |
M36K |
probably benign |
Het |
| Camta1 |
A |
G |
4: 151,169,284 (GRCm39) |
W156R |
probably damaging |
Het |
| Casd1 |
G |
A |
6: 4,631,165 (GRCm39) |
|
probably null |
Het |
| Casz1 |
T |
A |
4: 149,017,724 (GRCm39) |
Y338N |
probably damaging |
Het |
| Ccdc66 |
T |
C |
14: 27,222,377 (GRCm39) |
N122S |
probably damaging |
Het |
| Celf2 |
G |
T |
2: 6,590,831 (GRCm39) |
N279K |
possibly damaging |
Het |
| Cfap96 |
A |
T |
8: 46,423,505 (GRCm39) |
I69N |
probably damaging |
Het |
| Cit |
A |
G |
5: 116,132,146 (GRCm39) |
T1801A |
probably benign |
Het |
| Cnot2 |
A |
G |
10: 116,335,323 (GRCm39) |
I275T |
probably damaging |
Het |
| Ddx4 |
T |
C |
13: 112,748,594 (GRCm39) |
K435E |
probably damaging |
Het |
| Dnajc6 |
T |
C |
4: 101,468,461 (GRCm39) |
F166L |
probably damaging |
Het |
| Dst |
T |
C |
1: 34,208,937 (GRCm39) |
L820P |
probably damaging |
Het |
| Dusp11 |
T |
A |
6: 85,927,037 (GRCm39) |
N193Y |
probably damaging |
Het |
| Eif1ad7 |
T |
C |
12: 88,238,544 (GRCm39) |
N72S |
probably benign |
Het |
| Eif3m |
A |
T |
2: 104,843,633 (GRCm39) |
N116K |
probably benign |
Het |
| Epb41l1 |
A |
T |
2: 156,351,181 (GRCm39) |
E418D |
possibly damaging |
Het |
| Esyt2 |
T |
G |
12: 116,282,510 (GRCm39) |
N153K |
probably damaging |
Het |
| Exoc6b |
T |
G |
6: 84,980,141 (GRCm39) |
|
probably benign |
Het |
| Ezr |
C |
T |
17: 7,007,121 (GRCm39) |
E502K |
possibly damaging |
Het |
| Fbxw11 |
T |
A |
11: 32,661,859 (GRCm39) |
Y66N |
possibly damaging |
Het |
| Frem2 |
A |
G |
3: 53,455,228 (GRCm39) |
L2116S |
possibly damaging |
Het |
| Fry |
T |
C |
5: 150,309,569 (GRCm39) |
L671P |
probably damaging |
Het |
| Galnt7 |
A |
G |
8: 57,998,803 (GRCm39) |
I262T |
probably damaging |
Het |
| Glp1r |
T |
C |
17: 31,150,221 (GRCm39) |
F381S |
probably benign |
Het |
| Gm3867 |
T |
C |
9: 36,168,567 (GRCm39) |
|
noncoding transcript |
Het |
| Gm8741 |
G |
T |
17: 35,555,062 (GRCm39) |
|
noncoding transcript |
Het |
| Golgb1 |
A |
G |
16: 36,738,987 (GRCm39) |
D2442G |
probably damaging |
Het |
| Gp1bb |
A |
T |
16: 18,439,893 (GRCm39) |
L67Q |
probably damaging |
Het |
| Gstm7 |
G |
A |
3: 107,834,235 (GRCm39) |
T206I |
possibly damaging |
Het |
| H2bc7 |
A |
T |
13: 23,758,231 (GRCm39) |
V45E |
possibly damaging |
Het |
| Hs3st5 |
A |
T |
10: 36,704,802 (GRCm39) |
D35V |
probably benign |
Het |
| Hspa13 |
T |
C |
16: 75,558,190 (GRCm39) |
H125R |
probably benign |
Het |
| Hspa1a |
T |
G |
17: 35,190,156 (GRCm39) |
H249P |
probably damaging |
Het |
| Igkv10-95 |
A |
T |
6: 68,657,562 (GRCm39) |
Q6L |
probably damaging |
Het |
| Il1rap |
T |
A |
16: 26,533,526 (GRCm39) |
L474H |
probably benign |
Het |
| Ipo11 |
T |
A |
13: 107,016,245 (GRCm39) |
Y489F |
probably benign |
Het |
| Itga5 |
A |
G |
15: 103,259,259 (GRCm39) |
Y723H |
probably damaging |
Het |
| Itih2 |
T |
C |
2: 10,109,971 (GRCm39) |
N594S |
probably damaging |
Het |
| Itk |
T |
A |
11: 46,227,342 (GRCm39) |
Q427L |
probably benign |
Het |
| Kif26b |
A |
G |
1: 178,506,920 (GRCm39) |
Y332C |
probably damaging |
Het |
| Kmt2c |
G |
A |
5: 25,559,382 (GRCm39) |
R1086W |
probably damaging |
Het |
| Ktn1 |
T |
A |
14: 47,963,636 (GRCm39) |
|
probably benign |
Het |
| Lars2 |
T |
A |
9: 123,247,758 (GRCm39) |
I305N |
probably damaging |
Het |
| Lgmn |
G |
T |
12: 102,366,383 (GRCm39) |
|
probably benign |
Het |
| Ltbp4 |
C |
T |
7: 27,006,125 (GRCm39) |
E1453K |
probably damaging |
Het |
| Lypd8 |
G |
A |
11: 58,277,675 (GRCm39) |
M152I |
probably benign |
Het |
| Man2a1 |
T |
A |
17: 65,019,454 (GRCm39) |
S773T |
probably benign |
Het |
| Map2k6 |
T |
G |
11: 110,390,300 (GRCm39) |
L278R |
probably damaging |
Het |
| Mbtps1 |
A |
T |
8: 120,262,086 (GRCm39) |
D354E |
probably damaging |
Het |
| Mcpt9 |
C |
T |
14: 56,266,049 (GRCm39) |
V60M |
probably damaging |
Het |
| Mical3 |
C |
A |
6: 120,911,799 (GRCm39) |
E1083* |
probably null |
Het |
| Mms19 |
A |
G |
19: 41,933,935 (GRCm39) |
V811A |
possibly damaging |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Mslnl |
G |
A |
17: 25,961,908 (GRCm39) |
V128M |
probably damaging |
Het |
| Mtcl1 |
T |
A |
17: 66,684,882 (GRCm39) |
H520L |
probably benign |
Het |
| Mymk |
A |
T |
2: 26,952,719 (GRCm39) |
F130I |
probably damaging |
Het |
| Myo1f |
C |
T |
17: 33,801,306 (GRCm39) |
R333C |
probably damaging |
Het |
| Nav1 |
A |
G |
1: 135,520,186 (GRCm39) |
|
probably benign |
Het |
| Ncbp3 |
G |
T |
11: 72,969,844 (GRCm39) |
G564C |
probably damaging |
Het |
| Ncoa4 |
A |
T |
14: 31,898,682 (GRCm39) |
I501L |
probably benign |
Het |
| Ngp |
T |
A |
9: 110,249,883 (GRCm39) |
N60K |
possibly damaging |
Het |
| Npc1l1 |
G |
T |
11: 6,178,215 (GRCm39) |
D398E |
probably damaging |
Het |
| Nphs2 |
T |
A |
1: 156,153,701 (GRCm39) |
M264K |
probably damaging |
Het |
| Or4s2b |
G |
A |
2: 88,508,240 (GRCm39) |
V14I |
probably benign |
Het |
| Or4s2b |
T |
G |
2: 88,508,523 (GRCm39) |
V101G |
probably benign |
Het |
| Or7e165 |
T |
A |
9: 19,694,442 (GRCm39) |
Y4* |
probably null |
Het |
| Or8b8 |
T |
A |
9: 37,809,622 (GRCm39) |
S307R |
probably benign |
Het |
| Patz1 |
A |
G |
11: 3,256,241 (GRCm39) |
Y509C |
probably damaging |
Het |
| Pax8 |
G |
A |
2: 24,311,595 (GRCm39) |
P447S |
probably damaging |
Het |
| Pde11a |
A |
G |
2: 75,988,677 (GRCm39) |
V488A |
probably benign |
Het |
| Pex11g |
C |
T |
8: 3,515,899 (GRCm39) |
V45M |
probably benign |
Het |
| Pik3ip1 |
T |
A |
11: 3,283,327 (GRCm39) |
S142R |
probably damaging |
Het |
| Pitpnm2 |
C |
G |
5: 124,263,434 (GRCm39) |
A819P |
probably damaging |
Het |
| Pla2g4e |
T |
G |
2: 120,016,863 (GRCm39) |
H226P |
possibly damaging |
Het |
| Plin4 |
T |
A |
17: 56,412,418 (GRCm39) |
M538L |
probably benign |
Het |
| Ppp3cb |
T |
C |
14: 20,570,714 (GRCm39) |
N339S |
possibly damaging |
Het |
| Rev1 |
T |
C |
1: 38,092,730 (GRCm39) |
E1202G |
probably damaging |
Het |
| Rngtt |
T |
A |
4: 33,339,133 (GRCm39) |
|
probably benign |
Het |
| Serpinb12 |
T |
A |
1: 106,876,883 (GRCm39) |
D66E |
probably benign |
Het |
| Sgsm1 |
A |
T |
5: 113,403,173 (GRCm39) |
F958Y |
probably damaging |
Het |
| Slc35e2 |
T |
C |
4: 155,702,106 (GRCm39) |
F290S |
probably benign |
Het |
| Sorl1 |
C |
T |
9: 41,943,210 (GRCm39) |
V889M |
possibly damaging |
Het |
| Sptlc3 |
G |
A |
2: 139,478,600 (GRCm39) |
V520I |
probably benign |
Het |
| Stam |
A |
T |
2: 14,120,669 (GRCm39) |
H53L |
probably damaging |
Het |
| Stox2 |
A |
G |
8: 47,645,970 (GRCm39) |
S497P |
probably damaging |
Het |
| Tarbp1 |
A |
G |
8: 127,201,069 (GRCm39) |
Y246H |
probably damaging |
Het |
| Tbx15 |
A |
G |
3: 99,259,683 (GRCm39) |
Y518C |
probably damaging |
Het |
| Tdrd5 |
T |
A |
1: 156,111,944 (GRCm39) |
T479S |
probably benign |
Het |
| Tescl |
T |
C |
7: 24,032,683 (GRCm39) |
E214G |
probably damaging |
Het |
| Tex10 |
T |
C |
4: 48,452,946 (GRCm39) |
D671G |
probably benign |
Het |
| Tmem132d |
A |
G |
5: 128,061,360 (GRCm39) |
V414A |
probably benign |
Het |
| Tmem41b |
T |
A |
7: 109,573,941 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf18 |
A |
G |
4: 156,106,337 (GRCm39) |
|
probably benign |
Het |
| Tulp4 |
T |
A |
17: 6,249,108 (GRCm39) |
D42E |
probably damaging |
Het |
| Ubtd1 |
A |
G |
19: 42,022,103 (GRCm39) |
N125S |
probably damaging |
Het |
| Ubxn4 |
T |
A |
1: 128,183,186 (GRCm39) |
F68I |
probably benign |
Het |
| Urb1 |
A |
G |
16: 90,573,159 (GRCm39) |
S958P |
probably benign |
Het |
| Vash2 |
T |
C |
1: 190,692,498 (GRCm39) |
S226G |
probably benign |
Het |
| Vmn2r120 |
C |
T |
17: 57,816,120 (GRCm39) |
G745E |
probably damaging |
Het |
| Vmn2r58 |
T |
A |
7: 41,487,117 (GRCm39) |
I593F |
probably benign |
Het |
| Zfp398 |
T |
C |
6: 47,817,361 (GRCm39) |
L67P |
probably damaging |
Het |
| Zfp607b |
T |
A |
7: 27,403,120 (GRCm39) |
H525Q |
probably damaging |
Het |
| Zfp629 |
T |
C |
7: 127,211,492 (GRCm39) |
T106A |
probably benign |
Het |
| Zfp980 |
G |
A |
4: 145,428,653 (GRCm39) |
G461S |
probably benign |
Het |
| Zic5 |
T |
A |
14: 122,702,212 (GRCm39) |
D173V |
probably damaging |
Het |
| Zranb2 |
G |
A |
3: 157,247,521 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Myo9a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00427:Myo9a
|
APN |
9 |
59,750,342 (GRCm39) |
splice site |
probably benign |
|
|
IGL00510:Myo9a
|
APN |
9 |
59,739,464 (GRCm39) |
splice site |
probably benign |
|
|
IGL00710:Myo9a
|
APN |
9 |
59,782,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00963:Myo9a
|
APN |
9 |
59,807,655 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01087:Myo9a
|
APN |
9 |
59,697,361 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01145:Myo9a
|
APN |
9 |
59,762,658 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01403:Myo9a
|
APN |
9 |
59,778,846 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01528:Myo9a
|
APN |
9 |
59,686,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01608:Myo9a
|
APN |
9 |
59,778,119 (GRCm39) |
nonsense |
probably null |
|
|
IGL01701:Myo9a
|
APN |
9 |
59,791,877 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01918:Myo9a
|
APN |
9 |
59,686,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02026:Myo9a
|
APN |
9 |
59,813,245 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02139:Myo9a
|
APN |
9 |
59,687,275 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02176:Myo9a
|
APN |
9 |
59,777,836 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02272:Myo9a
|
APN |
9 |
59,791,883 (GRCm39) |
splice site |
probably benign |
|
|
IGL02283:Myo9a
|
APN |
9 |
59,778,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02499:Myo9a
|
APN |
9 |
59,722,669 (GRCm39) |
splice site |
probably benign |
|
|
IGL02652:Myo9a
|
APN |
9 |
59,771,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Myo9a
|
APN |
9 |
59,832,187 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02878:Myo9a
|
APN |
9 |
59,815,583 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02982:Myo9a
|
APN |
9 |
59,815,491 (GRCm39) |
nonsense |
probably null |
|
|
IGL03072:Myo9a
|
APN |
9 |
59,716,725 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL03090:Myo9a
|
APN |
9 |
59,801,418 (GRCm39) |
splice site |
probably benign |
|
|
IGL03111:Myo9a
|
APN |
9 |
59,734,526 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL03389:Myo9a
|
APN |
9 |
59,776,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
essentials
|
UTSW |
9 |
59,802,149 (GRCm39) |
missense |
probably benign |
0.09 |
|
necessities
|
UTSW |
9 |
59,722,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4402001:Myo9a
|
UTSW |
9 |
59,777,719 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0013:Myo9a
|
UTSW |
9 |
59,767,489 (GRCm39) |
splice site |
probably benign |
|
|
R0013:Myo9a
|
UTSW |
9 |
59,767,489 (GRCm39) |
splice site |
probably benign |
|
|
R0018:Myo9a
|
UTSW |
9 |
59,779,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0018:Myo9a
|
UTSW |
9 |
59,779,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0329:Myo9a
|
UTSW |
9 |
59,830,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0423:Myo9a
|
UTSW |
9 |
59,802,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Myo9a
|
UTSW |
9 |
59,801,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Myo9a
|
UTSW |
9 |
59,829,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0652:Myo9a
|
UTSW |
9 |
59,779,209 (GRCm39) |
missense |
probably benign |
|
|
R0653:Myo9a
|
UTSW |
9 |
59,832,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Myo9a
|
UTSW |
9 |
59,778,383 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0784:Myo9a
|
UTSW |
9 |
59,803,828 (GRCm39) |
splice site |
probably benign |
|
|
R0842:Myo9a
|
UTSW |
9 |
59,778,350 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1055:Myo9a
|
UTSW |
9 |
59,762,653 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1056:Myo9a
|
UTSW |
9 |
59,739,484 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1195:Myo9a
|
UTSW |
9 |
59,802,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Myo9a
|
UTSW |
9 |
59,802,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Myo9a
|
UTSW |
9 |
59,802,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1615:Myo9a
|
UTSW |
9 |
59,695,739 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1698:Myo9a
|
UTSW |
9 |
59,775,464 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1715:Myo9a
|
UTSW |
9 |
59,739,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1981:Myo9a
|
UTSW |
9 |
59,801,429 (GRCm39) |
missense |
probably benign |
|
|
R2228:Myo9a
|
UTSW |
9 |
59,801,463 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2272:Myo9a
|
UTSW |
9 |
59,722,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2327:Myo9a
|
UTSW |
9 |
59,687,048 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2990:Myo9a
|
UTSW |
9 |
59,832,172 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3161:Myo9a
|
UTSW |
9 |
59,739,598 (GRCm39) |
splice site |
probably benign |
|
|
R3721:Myo9a
|
UTSW |
9 |
59,775,463 (GRCm39) |
missense |
probably benign |
|
|
R3928:Myo9a
|
UTSW |
9 |
59,802,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Myo9a
|
UTSW |
9 |
59,802,149 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4212:Myo9a
|
UTSW |
9 |
59,813,349 (GRCm39) |
nonsense |
probably null |
|
|
R4616:Myo9a
|
UTSW |
9 |
59,728,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4621:Myo9a
|
UTSW |
9 |
59,778,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4623:Myo9a
|
UTSW |
9 |
59,778,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4632:Myo9a
|
UTSW |
9 |
59,776,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4657:Myo9a
|
UTSW |
9 |
59,782,699 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4892:Myo9a
|
UTSW |
9 |
59,731,525 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4897:Myo9a
|
UTSW |
9 |
59,803,800 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4966:Myo9a
|
UTSW |
9 |
59,779,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4993:Myo9a
|
UTSW |
9 |
59,768,755 (GRCm39) |
nonsense |
probably null |
|
|
R5160:Myo9a
|
UTSW |
9 |
59,779,085 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5233:Myo9a
|
UTSW |
9 |
59,817,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5271:Myo9a
|
UTSW |
9 |
59,814,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5308:Myo9a
|
UTSW |
9 |
59,771,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5367:Myo9a
|
UTSW |
9 |
59,807,732 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5432:Myo9a
|
UTSW |
9 |
59,772,953 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5459:Myo9a
|
UTSW |
9 |
59,791,803 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5511:Myo9a
|
UTSW |
9 |
59,687,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5568:Myo9a
|
UTSW |
9 |
59,781,911 (GRCm39) |
missense |
probably benign |
|
|
R5573:Myo9a
|
UTSW |
9 |
59,778,284 (GRCm39) |
missense |
probably benign |
|
|
R5589:Myo9a
|
UTSW |
9 |
59,802,527 (GRCm39) |
nonsense |
probably null |
|
|
R5607:Myo9a
|
UTSW |
9 |
59,771,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5633:Myo9a
|
UTSW |
9 |
59,775,467 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R5885:Myo9a
|
UTSW |
9 |
59,778,503 (GRCm39) |
missense |
probably benign |
|
|
R6024:Myo9a
|
UTSW |
9 |
59,762,671 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6086:Myo9a
|
UTSW |
9 |
59,697,340 (GRCm39) |
nonsense |
probably null |
|
|
R6146:Myo9a
|
UTSW |
9 |
59,778,512 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6194:Myo9a
|
UTSW |
9 |
59,777,033 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6213:Myo9a
|
UTSW |
9 |
59,734,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6368:Myo9a
|
UTSW |
9 |
59,832,231 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6550:Myo9a
|
UTSW |
9 |
59,775,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6612:Myo9a
|
UTSW |
9 |
59,734,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6665:Myo9a
|
UTSW |
9 |
59,779,155 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6951:Myo9a
|
UTSW |
9 |
59,802,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7026:Myo9a
|
UTSW |
9 |
59,722,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Myo9a
|
UTSW |
9 |
59,778,098 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7310:Myo9a
|
UTSW |
9 |
59,778,436 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7473:Myo9a
|
UTSW |
9 |
59,802,527 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7723:Myo9a
|
UTSW |
9 |
59,687,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7823:Myo9a
|
UTSW |
9 |
59,719,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7824:Myo9a
|
UTSW |
9 |
59,767,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Myo9a
|
UTSW |
9 |
59,695,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8031:Myo9a
|
UTSW |
9 |
59,687,374 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8055:Myo9a
|
UTSW |
9 |
59,814,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Myo9a
|
UTSW |
9 |
59,781,931 (GRCm39) |
missense |
probably benign |
|
|
R8250:Myo9a
|
UTSW |
9 |
59,767,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8260:Myo9a
|
UTSW |
9 |
59,817,961 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8355:Myo9a
|
UTSW |
9 |
59,817,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8432:Myo9a
|
UTSW |
9 |
59,687,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8470:Myo9a
|
UTSW |
9 |
59,739,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8528:Myo9a
|
UTSW |
9 |
59,767,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8681:Myo9a
|
UTSW |
9 |
59,775,394 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8690:Myo9a
|
UTSW |
9 |
59,782,657 (GRCm39) |
missense |
probably benign |
|
|
R8793:Myo9a
|
UTSW |
9 |
59,791,850 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8812:Myo9a
|
UTSW |
9 |
59,687,030 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9016:Myo9a
|
UTSW |
9 |
59,775,427 (GRCm39) |
nonsense |
probably null |
|
|
R9026:Myo9a
|
UTSW |
9 |
59,716,757 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9036:Myo9a
|
UTSW |
9 |
59,687,584 (GRCm39) |
nonsense |
probably null |
|
|
R9130:Myo9a
|
UTSW |
9 |
59,739,514 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9131:Myo9a
|
UTSW |
9 |
59,768,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9213:Myo9a
|
UTSW |
9 |
59,772,922 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9498:Myo9a
|
UTSW |
9 |
59,734,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9575:Myo9a
|
UTSW |
9 |
59,813,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9651:Myo9a
|
UTSW |
9 |
59,778,764 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9672:Myo9a
|
UTSW |
9 |
59,687,332 (GRCm39) |
missense |
probably benign |
0.16 |
|
RF018:Myo9a
|
UTSW |
9 |
59,776,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF019:Myo9a
|
UTSW |
9 |
59,829,055 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Myo9a
|
UTSW |
9 |
59,802,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGGTTCCCCATCAGCAGTC -3'
(R):5'- CAGCATTCATGTACACAGAGC -3'
Sequencing Primer
(F):5'- GTCACTAAAAGAGACGCAGCTCTTG -3'
(R):5'- TATGTGAGAAATTCCCCCACTTAAC -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation