Incidental Mutation 'R4953:Ube3b'
| ID |
446611 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ube3b
|
| Ensembl Gene |
ENSMUSG00000029577 |
| Gene Name |
ubiquitin protein ligase E3B |
| Synonyms |
|
| MMRRC Submission |
042550-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4953 (G1)
|
| Quality Score |
79 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
114518668-114559230 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 114539471 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 421
(S421P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073652
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074002]
[ENSMUST00000130169]
|
| AlphaFold |
Q9ES34 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000074002
AA Change: S421P
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000073652
Gene: ENSMUSG00000029577
AA Change: S421P
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
28 |
50 |
1.17e-2 |
SMART |
|
low complexity region
|
310 |
327 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
470 |
488 |
N/A |
INTRINSIC |
|
HECTc
|
697 |
1070 |
2.15e-110 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000130169
|
| SMART Domains |
Protein: ENSMUSP00000138723
Gene: ENSMUSG00000029577
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
28 |
50 |
1.17e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150630
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183408
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000196651
AA Change: S140P
|
| SMART Domains |
Protein: ENSMUSP00000143455
Gene: ENSMUSG00000029577
AA Change: S140P
| Domain | Start | End | E-Value | Type |
|---|
|
HECTc
|
122 |
495 |
1.1e-112 |
SMART |
|
| Meta Mutation Damage Score |
0.0618 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
97% (113/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit preweaning lethality, reduced fertility, decreased growth, reduced grip strength, impaired hearing, eye inflammation and decreased cholesterol level. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad9 |
T |
C |
3: 36,128,525 (GRCm39) |
Y129H |
probably damaging |
Het |
| Adcy4 |
C |
T |
14: 56,016,486 (GRCm39) |
D322N |
probably damaging |
Het |
| Adgre1 |
G |
A |
17: 57,748,321 (GRCm39) |
G507E |
probably damaging |
Het |
| Agpat5 |
G |
A |
8: 18,918,971 (GRCm39) |
V118I |
probably benign |
Het |
| Aif1 |
T |
C |
17: 35,390,074 (GRCm39) |
|
probably null |
Het |
| Akr1c6 |
A |
T |
13: 4,488,608 (GRCm39) |
|
probably null |
Het |
| Akt2 |
T |
A |
7: 27,337,597 (GRCm39) |
|
probably null |
Het |
| Ankrd35 |
T |
A |
3: 96,590,989 (GRCm39) |
L425Q |
possibly damaging |
Het |
| Arhgap40 |
A |
G |
2: 158,385,326 (GRCm39) |
T520A |
possibly damaging |
Het |
| Arhgef28 |
T |
A |
13: 98,066,062 (GRCm39) |
D1597V |
possibly damaging |
Het |
| Aspm |
A |
G |
1: 139,399,472 (GRCm39) |
D1079G |
probably benign |
Het |
| Atp1a2 |
A |
T |
1: 172,119,009 (GRCm39) |
|
probably benign |
Het |
| Cage1 |
C |
A |
13: 38,207,406 (GRCm39) |
E252D |
possibly damaging |
Het |
| Ccdc185 |
A |
G |
1: 182,576,582 (GRCm39) |
S36P |
possibly damaging |
Het |
| Cd300a |
T |
C |
11: 114,784,247 (GRCm39) |
V85A |
probably damaging |
Het |
| Cd38 |
A |
C |
5: 44,064,887 (GRCm39) |
D235A |
possibly damaging |
Het |
| Cdcp1 |
T |
C |
9: 123,009,088 (GRCm39) |
K530R |
probably benign |
Het |
| Ceacam20 |
T |
A |
7: 19,705,651 (GRCm39) |
L214Q |
probably damaging |
Het |
| Cntn4 |
G |
A |
6: 106,502,379 (GRCm39) |
A379T |
probably benign |
Het |
| Col4a2 |
A |
T |
8: 11,479,505 (GRCm39) |
E796V |
probably benign |
Het |
| Copa |
A |
G |
1: 171,910,453 (GRCm39) |
|
probably benign |
Het |
| Cpa5 |
A |
G |
6: 30,631,363 (GRCm39) |
T426A |
possibly damaging |
Het |
| Csmd1 |
A |
G |
8: 16,249,931 (GRCm39) |
F1016L |
probably damaging |
Het |
| Cyb5r3 |
A |
T |
15: 83,042,822 (GRCm39) |
L290* |
probably null |
Het |
| Ddx42 |
A |
G |
11: 106,133,766 (GRCm39) |
T581A |
probably damaging |
Het |
| Deaf1 |
C |
T |
7: 140,902,381 (GRCm39) |
G221S |
probably damaging |
Het |
| Dnah6 |
A |
G |
6: 73,165,366 (GRCm39) |
S580P |
probably benign |
Het |
| Dock1 |
A |
G |
7: 134,754,017 (GRCm39) |
E1598G |
probably benign |
Het |
| Drg2 |
T |
C |
11: 60,350,262 (GRCm39) |
|
probably benign |
Het |
| Eif3f |
C |
A |
7: 108,533,847 (GRCm39) |
|
probably benign |
Het |
| Fam184a |
G |
T |
10: 53,574,901 (GRCm39) |
T236K |
probably benign |
Het |
| Gas7 |
C |
T |
11: 67,550,876 (GRCm39) |
T126M |
possibly damaging |
Het |
| Gckr |
T |
G |
5: 31,465,608 (GRCm39) |
F408C |
probably damaging |
Het |
| Gm17472 |
A |
G |
6: 42,958,004 (GRCm39) |
D91G |
probably damaging |
Het |
| Gm5117 |
G |
A |
8: 32,228,608 (GRCm39) |
|
noncoding transcript |
Het |
| Gsto1 |
T |
A |
19: 47,843,759 (GRCm39) |
I47N |
probably damaging |
Het |
| Hck |
C |
T |
2: 152,976,597 (GRCm39) |
P244S |
probably damaging |
Het |
| Hif3a |
T |
C |
7: 16,784,490 (GRCm39) |
T250A |
probably damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,752,111 (GRCm39) |
|
probably benign |
Het |
| Impa1 |
G |
A |
3: 10,380,340 (GRCm39) |
S247F |
probably damaging |
Het |
| Ints14 |
G |
C |
9: 64,889,340 (GRCm39) |
R397P |
probably damaging |
Het |
| Iqgap1 |
T |
C |
7: 80,373,524 (GRCm39) |
|
probably null |
Het |
| Krt1c |
T |
C |
15: 101,722,377 (GRCm39) |
K436R |
probably damaging |
Het |
| Lama3 |
G |
A |
18: 12,581,362 (GRCm39) |
C607Y |
probably damaging |
Het |
| Loxl4 |
G |
T |
19: 42,599,133 (GRCm39) |
|
probably benign |
Het |
| Lrrc8d |
C |
T |
5: 105,961,234 (GRCm39) |
T548M |
probably damaging |
Het |
| Man1b1 |
T |
A |
2: 25,228,196 (GRCm39) |
D155E |
probably damaging |
Het |
| Mapk8ip2 |
C |
T |
15: 89,341,431 (GRCm39) |
P214L |
probably benign |
Het |
| Mast1 |
G |
A |
8: 85,645,357 (GRCm39) |
T696I |
probably damaging |
Het |
| Muc15 |
C |
T |
2: 110,561,617 (GRCm39) |
P18S |
probably damaging |
Het |
| Mybl2 |
T |
C |
2: 162,922,716 (GRCm39) |
S205P |
probably damaging |
Het |
| Mylk |
T |
C |
16: 34,809,331 (GRCm39) |
S1763P |
probably damaging |
Het |
| Nek10 |
T |
A |
14: 14,860,986 (GRCm38) |
L513M |
possibly damaging |
Het |
| Nfib |
A |
G |
4: 82,271,808 (GRCm39) |
M252T |
probably benign |
Het |
| Nid2 |
C |
A |
14: 19,828,146 (GRCm39) |
Y261* |
probably null |
Het |
| Nmd3 |
C |
T |
3: 69,638,970 (GRCm39) |
R187C |
possibly damaging |
Het |
| Nomo1 |
G |
T |
7: 45,700,155 (GRCm39) |
|
probably benign |
Het |
| Npy4r |
A |
G |
14: 33,868,437 (GRCm39) |
F284L |
probably damaging |
Het |
| Nt5dc2 |
T |
C |
14: 30,860,878 (GRCm39) |
V351A |
possibly damaging |
Het |
| Ofcc1 |
G |
A |
13: 40,168,864 (GRCm39) |
T841I |
probably damaging |
Het |
| Or5b121 |
T |
A |
19: 13,507,178 (GRCm39) |
L91Q |
probably null |
Het |
| Or5g27 |
T |
A |
2: 85,410,069 (GRCm39) |
L162* |
probably null |
Het |
| Pcdhb12 |
T |
A |
18: 37,569,209 (GRCm39) |
D118E |
probably damaging |
Het |
| Pdcd11 |
C |
T |
19: 47,116,404 (GRCm39) |
T1518I |
probably benign |
Het |
| Pde6a |
T |
A |
18: 61,364,434 (GRCm39) |
C163* |
probably null |
Het |
| Pign |
A |
T |
1: 105,572,227 (GRCm39) |
W314R |
probably benign |
Het |
| Pip5k1b |
T |
A |
19: 24,367,799 (GRCm39) |
H76L |
probably damaging |
Het |
| Plcz1 |
T |
C |
6: 139,974,277 (GRCm39) |
N55S |
possibly damaging |
Het |
| Pou5f1 |
A |
T |
17: 35,821,438 (GRCm39) |
H350L |
possibly damaging |
Het |
| Rchy1 |
A |
T |
5: 92,110,487 (GRCm39) |
|
probably null |
Het |
| Ric8b |
A |
G |
10: 84,793,946 (GRCm39) |
T270A |
possibly damaging |
Het |
| Rprml |
A |
G |
11: 103,540,644 (GRCm39) |
E13G |
probably benign |
Het |
| Secisbp2 |
T |
A |
13: 51,836,063 (GRCm39) |
I719N |
probably damaging |
Het |
| Sergef |
C |
T |
7: 46,283,259 (GRCm39) |
R148H |
probably benign |
Het |
| Serpina6 |
T |
A |
12: 103,618,221 (GRCm39) |
|
probably null |
Het |
| Sirpb1b |
C |
A |
3: 15,613,887 (GRCm39) |
W65L |
probably damaging |
Het |
| Slc32a1 |
A |
T |
2: 158,455,977 (GRCm39) |
I211F |
possibly damaging |
Het |
| Slc5a9 |
C |
A |
4: 111,748,941 (GRCm39) |
|
probably null |
Het |
| Smarce1 |
A |
G |
11: 99,105,977 (GRCm39) |
V226A |
probably benign |
Het |
| Spata31d1b |
A |
T |
13: 59,864,097 (GRCm39) |
E415V |
probably damaging |
Het |
| Speg |
G |
A |
1: 75,400,508 (GRCm39) |
R2556H |
possibly damaging |
Het |
| Suclg2 |
A |
C |
6: 95,543,417 (GRCm39) |
V338G |
probably damaging |
Het |
| Tarbp1 |
T |
C |
8: 127,174,184 (GRCm39) |
E874G |
possibly damaging |
Het |
| Tex14 |
G |
T |
11: 87,427,727 (GRCm39) |
|
probably null |
Het |
| Trim36 |
T |
A |
18: 46,329,245 (GRCm39) |
D53V |
possibly damaging |
Het |
| Tsga10ip |
T |
A |
19: 5,444,368 (GRCm39) |
Y21F |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,620,289 (GRCm39) |
V15849M |
probably damaging |
Het |
| Unc5a |
A |
T |
13: 55,147,683 (GRCm39) |
M498L |
probably benign |
Het |
| Vipr2 |
A |
G |
12: 116,107,876 (GRCm39) |
I420M |
probably benign |
Het |
| Vmn1r179 |
T |
A |
7: 23,628,515 (GRCm39) |
H235Q |
probably damaging |
Het |
| Vps35 |
T |
A |
8: 86,008,475 (GRCm39) |
I267F |
probably damaging |
Het |
| Wdr26 |
G |
A |
1: 181,025,216 (GRCm39) |
R279W |
probably damaging |
Het |
| Xpo6 |
C |
A |
7: 125,768,443 (GRCm39) |
R88L |
probably damaging |
Het |
| Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
| Zfp105 |
T |
A |
9: 122,758,880 (GRCm39) |
S184T |
probably benign |
Het |
| Zfp574 |
G |
A |
7: 24,780,388 (GRCm39) |
R470H |
probably damaging |
Het |
| Zswim9 |
T |
A |
7: 13,003,484 (GRCm39) |
H122L |
probably damaging |
Het |
|
| Other mutations in Ube3b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00754:Ube3b
|
APN |
5 |
114,553,348 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01154:Ube3b
|
APN |
5 |
114,544,313 (GRCm39) |
missense |
probably null |
0.86 |
|
IGL02632:Ube3b
|
APN |
5 |
114,536,902 (GRCm39) |
missense |
probably benign |
|
|
IGL02850:Ube3b
|
APN |
5 |
114,544,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02878:Ube3b
|
APN |
5 |
114,542,778 (GRCm39) |
splice site |
probably null |
|
|
IGL02881:Ube3b
|
APN |
5 |
114,550,945 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0003:Ube3b
|
UTSW |
5 |
114,536,912 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0071:Ube3b
|
UTSW |
5 |
114,557,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0071:Ube3b
|
UTSW |
5 |
114,557,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0076:Ube3b
|
UTSW |
5 |
114,546,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0076:Ube3b
|
UTSW |
5 |
114,546,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0111:Ube3b
|
UTSW |
5 |
114,528,437 (GRCm39) |
splice site |
probably benign |
|
|
R0309:Ube3b
|
UTSW |
5 |
114,557,530 (GRCm39) |
splice site |
probably benign |
|
|
R0718:Ube3b
|
UTSW |
5 |
114,540,616 (GRCm39) |
nonsense |
probably null |
|
|
R1344:Ube3b
|
UTSW |
5 |
114,556,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1350:Ube3b
|
UTSW |
5 |
114,544,198 (GRCm39) |
splice site |
probably null |
|
|
R1418:Ube3b
|
UTSW |
5 |
114,556,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1732:Ube3b
|
UTSW |
5 |
114,525,506 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1764:Ube3b
|
UTSW |
5 |
114,542,678 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1975:Ube3b
|
UTSW |
5 |
114,537,926 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2014:Ube3b
|
UTSW |
5 |
114,549,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2015:Ube3b
|
UTSW |
5 |
114,549,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2041:Ube3b
|
UTSW |
5 |
114,525,294 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2074:Ube3b
|
UTSW |
5 |
114,553,316 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2202:Ube3b
|
UTSW |
5 |
114,527,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2205:Ube3b
|
UTSW |
5 |
114,527,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3826:Ube3b
|
UTSW |
5 |
114,538,012 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3829:Ube3b
|
UTSW |
5 |
114,538,012 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3830:Ube3b
|
UTSW |
5 |
114,538,012 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3927:Ube3b
|
UTSW |
5 |
114,553,741 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3974:Ube3b
|
UTSW |
5 |
114,550,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4049:Ube3b
|
UTSW |
5 |
114,550,931 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4096:Ube3b
|
UTSW |
5 |
114,531,147 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4261:Ube3b
|
UTSW |
5 |
114,536,489 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4415:Ube3b
|
UTSW |
5 |
114,550,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Ube3b
|
UTSW |
5 |
114,531,139 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4779:Ube3b
|
UTSW |
5 |
114,542,778 (GRCm39) |
splice site |
probably null |
|
|
R4824:Ube3b
|
UTSW |
5 |
114,553,787 (GRCm39) |
splice site |
probably null |
|
|
R4868:Ube3b
|
UTSW |
5 |
114,536,488 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5013:Ube3b
|
UTSW |
5 |
114,545,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5057:Ube3b
|
UTSW |
5 |
114,544,318 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5117:Ube3b
|
UTSW |
5 |
114,557,692 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5131:Ube3b
|
UTSW |
5 |
114,545,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5498:Ube3b
|
UTSW |
5 |
114,556,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5564:Ube3b
|
UTSW |
5 |
114,527,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5572:Ube3b
|
UTSW |
5 |
114,544,240 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5580:Ube3b
|
UTSW |
5 |
114,553,384 (GRCm39) |
missense |
probably benign |
|
|
R5596:Ube3b
|
UTSW |
5 |
114,544,221 (GRCm39) |
splice site |
probably null |
|
|
R5843:Ube3b
|
UTSW |
5 |
114,550,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5910:Ube3b
|
UTSW |
5 |
114,553,370 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6591:Ube3b
|
UTSW |
5 |
114,546,185 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6691:Ube3b
|
UTSW |
5 |
114,546,185 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7148:Ube3b
|
UTSW |
5 |
114,544,313 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7334:Ube3b
|
UTSW |
5 |
114,553,742 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7438:Ube3b
|
UTSW |
5 |
114,556,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7438:Ube3b
|
UTSW |
5 |
114,553,345 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7640:Ube3b
|
UTSW |
5 |
114,553,384 (GRCm39) |
missense |
probably benign |
|
|
R7825:Ube3b
|
UTSW |
5 |
114,539,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7958:Ube3b
|
UTSW |
5 |
114,539,484 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8025:Ube3b
|
UTSW |
5 |
114,546,270 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8058:Ube3b
|
UTSW |
5 |
114,544,846 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8087:Ube3b
|
UTSW |
5 |
114,550,550 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8182:Ube3b
|
UTSW |
5 |
114,530,199 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8322:Ube3b
|
UTSW |
5 |
114,540,747 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8465:Ube3b
|
UTSW |
5 |
114,528,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8682:Ube3b
|
UTSW |
5 |
114,550,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8708:Ube3b
|
UTSW |
5 |
114,531,151 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8758:Ube3b
|
UTSW |
5 |
114,553,261 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R8784:Ube3b
|
UTSW |
5 |
114,526,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9058:Ube3b
|
UTSW |
5 |
114,553,300 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9072:Ube3b
|
UTSW |
5 |
114,542,607 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9116:Ube3b
|
UTSW |
5 |
114,542,837 (GRCm39) |
intron |
probably benign |
|
|
R9537:Ube3b
|
UTSW |
5 |
114,525,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9596:Ube3b
|
UTSW |
5 |
114,527,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9632:Ube3b
|
UTSW |
5 |
114,553,370 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9710:Ube3b
|
UTSW |
5 |
114,553,370 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0017:Ube3b
|
UTSW |
5 |
114,553,646 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACGAGAAATGCATTTGGGTTTTC -3'
(R):5'- GTGTTCACACAGGGAGAAGC -3'
Sequencing Primer
(F):5'- GGTTTTTGGCAAAAGCTCACATGC -3'
(R):5'- CAGGGGCTGCCCTCCTG -3'
|
| Posted On |
2016-11-23 |
Incidental Mutation