Mutagenetix > Incidental Mutation

Incidental Mutation 'R7214:Dnah2'

561329

Institutional Source

Beutler Lab

Gene Symbol

Dnah2

Ensembl Gene

ENSMUSG00000005237

Gene Name

dynein, axonemal, heavy chain 2

Synonyms

Dnahc2, Dnhd3, D330014H01Rik, 2900022L05Rik

MMRRC Submission

045286-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7214 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

69420809-69549110 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 69431109 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 3795 (D3795G)

Ref Sequence

ENSEMBL: ENSMUSP00000104299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035539] [ENSMUST00000108659]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000035539
AA Change: D3789G

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000047329
Gene: ENSMUSG00000005237
AA Change: D3789G

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	273	429	6.6e-37	PFAM
Pfam:DHC_N1	432	761	1.3e-54	PFAM
Pfam:DHC_N2	1253	1668	3.4e-144	PFAM
AAA	1826	1962	2.95e-1	SMART
Pfam:AAA_5	2108	2251	1.3e-5	PFAM
AAA	2437	2584	3.63e-5	SMART
Pfam:AAA_8	2752	3022	1.1e-75	PFAM
Pfam:MT	3034	3370	8.7e-55	PFAM
Pfam:AAA_9	3386	3616	7.4e-68	PFAM
Pfam:Dynein_heavy	3748	4453	1.2e-220	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108659
AA Change: D3795G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104299
Gene: ENSMUSG00000005237
AA Change: D3795G

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	274	429	1.1e-47	PFAM
Pfam:DHC_N1	438	760	1.5e-75	PFAM
Pfam:DHC_N2	1255	1666	4.4e-144	PFAM
low complexity region	1711	1720	N/A	INTRINSIC
AAA	1832	1968	2.95e-1	SMART
Blast:AAA	2111	2251	2e-86	BLAST
AAA	2443	2590	3.63e-5	SMART
Pfam:AAA_8	2758	3028	5.5e-77	PFAM
Pfam:MT	3040	3376	7.6e-55	PFAM
Pfam:AAA_9	3396	3621	7.5e-94	PFAM
Pfam:Dynein_heavy	3759	4458	4.9e-264	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg5	C	T	8: 94,934,018 (GRCm38)	T95I		Het
Arap2	C	T	5: 62,749,338 (GRCm38)	V113I	probably benign	Het
Arntl	T	A	7: 113,299,403 (GRCm38)	I346K	probably benign	Het
Atraid	C	T	5: 31,052,246 (GRCm38)	Q85*	probably null	Het
BC005561	A	G	5: 104,522,363 (GRCm38)	T1584A	probably benign	Het
Bcdin3d	T	C	15: 99,470,463 (GRCm38)	D285G	probably benign	Het
Carmil3	T	C	14: 55,498,612 (GRCm38)	W604R	probably damaging	Het
Ccl6	C	T	11: 83,589,756 (GRCm38)		probably null	Het
Cct4	C	T	11: 22,990,616 (GRCm38)		probably benign	Het
Cd2ap	C	T	17: 42,845,394 (GRCm38)	R84Q	possibly damaging	Het
Cdt1	T	A	8: 122,568,273 (GRCm38)		probably null	Het
Cln3	C	T	7: 126,582,770 (GRCm38)	G40D	probably damaging	Het
Crlf3	T	C	11: 80,064,390 (GRCm38)	S47G	possibly damaging	Het
Csrp3	T	C	7: 48,830,637 (GRCm38)	K193R	probably benign	Het
Cxcl3	A	C	5: 90,786,360 (GRCm38)	E33A	probably damaging	Het
Cyp11b1	T	C	15: 74,836,859 (GRCm38)	D362G	probably benign	Het
Dnah3	G	A	7: 119,922,742 (GRCm38)	A4076V	probably damaging	Het
Dnaja3	T	A	16: 4,701,182 (GRCm38)	I380N	possibly damaging	Het
Dock10	T	A	1: 80,568,529 (GRCm38)	H785L	probably benign	Het
Dopey2	T	G	16: 93,810,135 (GRCm38)	F2226V	possibly damaging	Het
Dscaml1	A	T	9: 45,670,139 (GRCm38)	I419F	probably benign	Het
Dyrk4	T	A	6: 126,885,237 (GRCm38)	I431F	probably benign	Het
E430018J23Rik	A	G	7: 127,391,523 (GRCm38)	S431P	probably benign	Het
Endog	C	T	2: 30,172,890 (GRCm38)	R181C	probably damaging	Het
Fam90a1a	A	T	8: 21,963,625 (GRCm38)	Y332F	probably benign	Het
Fastkd3	T	C	13: 68,589,380 (GRCm38)	I588T	probably benign	Het
Galnt9	G	A	5: 110,589,828 (GRCm38)	V217I	probably benign	Het
Gm973	A	T	1: 59,562,729 (GRCm38)	R501*	probably null	Het
Gnptab	C	T	10: 88,379,157 (GRCm38)		probably benign	Het
Gpn1	T	C	5: 31,503,417 (GRCm38)	F184S	probably damaging	Het
Imp3	G	T	9: 56,937,723 (GRCm38)	V73L	probably benign	Het
Ipo11	T	C	13: 106,895,857 (GRCm38)	D259G	probably null	Het
Jag1	T	C	2: 137,106,882 (GRCm38)	S142G	probably benign	Het
Klhl5	A	T	5: 65,131,755 (GRCm38)	E120V	probably benign	Het
Lct	C	A	1: 128,300,460 (GRCm38)	V1099L	probably benign	Het
Lrba	G	C	3: 86,328,326 (GRCm38)	W912C	probably damaging	Het
Lss	C	T	10: 76,547,471 (GRCm38)	T535I	probably damaging	Het
Mcts2	T	C	2: 152,687,377 (GRCm38)	I36T	probably benign	Het
Meikin	T	A	11: 54,411,912 (GRCm38)	N383K	probably benign	Het
Myo1g	T	C	11: 6,511,055 (GRCm38)	Y663C	probably damaging	Het
Nadk2	T	A	15: 9,108,254 (GRCm38)	M419K	probably damaging	Het
Nbeal1	G	C	1: 60,237,151 (GRCm38)	V684L	probably benign	Het
Nfat5	T	C	8: 107,293,883 (GRCm38)	S20P	probably damaging	Het
Nlrp1a	C	T	11: 71,123,293 (GRCm38)	C377Y	probably damaging	Het
Nlrp9a	T	C	7: 26,551,038 (GRCm38)	V76A	probably damaging	Het
Nrap	C	A	19: 56,378,135 (GRCm38)	A341S	probably benign	Het
Ntng2	T	C	2: 29,227,720 (GRCm38)	S239G	probably damaging	Het
Nup188	T	A	2: 30,307,554 (GRCm38)	C207S	possibly damaging	Het
Olfr1077-ps1	C	T	2: 86,525,806 (GRCm38)	V124I	probably damaging	Het
Olfr1328	T	A	4: 118,933,949 (GRCm38)	I300F	possibly damaging	Het
Olfr1474	T	A	19: 13,470,973 (GRCm38)	M1K	probably null	Het
Olfr17	T	C	7: 107,098,412 (GRCm38)	*316R	probably null	Het
Olfr346	T	C	2: 36,688,095 (GRCm38)	I31T	probably benign	Het
Olfr705	T	C	7: 106,874,267 (GRCm38)		probably benign	Het
Olfr891	A	C	9: 38,180,022 (GRCm38)	V267G	probably damaging	Het
Pcdhgb2	C	A	18: 37,690,106 (GRCm38)	A50E	probably damaging	Het
Pgap1	A	T	1: 54,543,061 (GRCm38)	M209K	possibly damaging	Het
Plbd1	T	A	6: 136,612,831 (GRCm38)	D463V	probably damaging	Het
Plcg2	T	A	8: 117,583,549 (GRCm38)	I380N	probably damaging	Het
Pnpt1	T	C	11: 29,137,285 (GRCm38)	W184R	probably damaging	Het
Pptc7	G	A	5: 122,313,777 (GRCm38)	V202I	probably benign	Het
Prpf6	C	T	2: 181,640,596 (GRCm38)	A510V	probably damaging	Het
Prr5l	T	C	2: 101,729,432 (GRCm38)	Y235C	probably benign	Het
Ptprk	T	C	10: 28,574,909 (GRCm38)	V1022A	probably benign	Het
Rbl2	T	C	8: 91,083,429 (GRCm38)		probably null	Het
Rmnd1	T	C	10: 4,410,753 (GRCm38)	K348E	probably benign	Het
Rsf1	CGGCGGC	CGGCGGCGGGGGCGGC	7: 97,579,929 (GRCm38)		probably benign	Het
Sacs	T	A	14: 61,191,792 (GRCm38)	N433K	probably benign	Het
Scyl1	T	C	19: 5,760,029 (GRCm38)	T590A	probably benign	Het
Sdhd	A	G	9: 50,597,233 (GRCm38)	V111A	possibly damaging	Het
Sec24b	G	T	3: 130,033,860 (GRCm38)	P330Q	probably benign	Het
Serpinb6d	C	T	13: 33,664,145 (GRCm38)	P31S	probably damaging	Het
Slc26a9	A	T	1: 131,759,473 (GRCm38)	R457W	probably damaging	Het
Slc5a8	G	A	10: 88,919,502 (GRCm38)	M490I	probably benign	Het
Slx4	A	G	16: 3,988,980 (GRCm38)	I533T	probably benign	Het
Slx4ip	T	A	2: 137,046,730 (GRCm38)	F110L	probably benign	Het
Smchd1	T	C	17: 71,345,364 (GRCm38)	R2000G	probably benign	Het
Snx8	T	C	5: 140,360,253 (GRCm38)	E75G	possibly damaging	Het
Stab2	C	A	10: 86,899,841 (GRCm38)	C1292F	probably damaging	Het
Swt1	A	T	1: 151,394,613 (GRCm38)	M617K	possibly damaging	Het
Tiam2	T	A	17: 3,518,412 (GRCm38)	I1611N	possibly damaging	Het
Tmem63b	T	G	17: 45,661,822 (GRCm38)	N682T	probably benign	Het
Trio	C	T	15: 27,871,187 (GRCm38)	V674M	probably damaging	Het
Trpc3	G	A	3: 36,650,137 (GRCm38)	T557M	possibly damaging	Het
Vac14	T	G	8: 110,671,042 (GRCm38)	L463R	probably damaging	Het
Vmn2r43	C	T	7: 8,253,380 (GRCm38)		probably null	Het
Wdr49	A	T	3: 75,358,444 (GRCm38)	Y232N	possibly damaging	Het
Wdr90	T	C	17: 25,845,393 (GRCm38)	M1835V	probably benign	Het
Xpc	T	C	6: 91,492,338 (GRCm38)	E809G	probably damaging	Het
Zfhx3	A	T	8: 108,948,861 (GRCm38)	Q2181L	probably damaging	Het
Zfp442	T	C	2: 150,409,281 (GRCm38)	T234A	probably benign	Het
Zfp764	A	T	7: 127,405,278 (GRCm38)	M227K	probably benign	Het
Zfp957	A	G	14: 79,213,310 (GRCm38)	S350P	unknown	Het
Zscan29	T	A	2: 121,169,280 (GRCm38)	K147*	probably null	Het

Other mutations in Dnah2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00087:Dnah2	APN	11	69,492,672 (GRCm38)	missense	possibly damaging	0.93
IGL00418:Dnah2	APN	11	69,495,066 (GRCm38)	splice site	probably benign
IGL00772:Dnah2	APN	11	69,451,257 (GRCm38)	missense	probably damaging	0.97
IGL00819:Dnah2	APN	11	69,473,350 (GRCm38)	critical splice donor site	probably null
IGL00827:Dnah2	APN	11	69,448,457 (GRCm38)	missense	probably damaging	1.00
IGL01060:Dnah2	APN	11	69,478,092 (GRCm38)	missense	possibly damaging	0.86
IGL01340:Dnah2	APN	11	69,493,184 (GRCm38)	missense	probably damaging	0.99
IGL01349:Dnah2	APN	11	69,475,606 (GRCm38)	missense	probably damaging	0.99
IGL01413:Dnah2	APN	11	69,432,964 (GRCm38)	missense	probably damaging	0.99
IGL01451:Dnah2	APN	11	69,474,191 (GRCm38)	splice site	probably benign
IGL01480:Dnah2	APN	11	69,458,371 (GRCm38)	missense	possibly damaging	0.91
IGL01537:Dnah2	APN	11	69,516,080 (GRCm38)	missense	probably benign	0.17
IGL01592:Dnah2	APN	11	69,431,087 (GRCm38)	missense	probably benign	0.14
IGL01612:Dnah2	APN	11	69,465,063 (GRCm38)	splice site	probably benign
IGL01667:Dnah2	APN	11	69,544,395 (GRCm38)	missense	probably benign
IGL01667:Dnah2	APN	11	69,520,941 (GRCm38)	missense	probably damaging	0.98
IGL01691:Dnah2	APN	11	69,539,443 (GRCm38)	missense	probably benign
IGL02019:Dnah2	APN	11	69,474,285 (GRCm38)	missense	probably damaging	1.00
IGL02039:Dnah2	APN	11	69,499,212 (GRCm38)	missense	probably damaging	1.00
IGL02076:Dnah2	APN	11	69,422,559 (GRCm38)	missense	probably damaging	0.99
IGL02085:Dnah2	APN	11	69,458,185 (GRCm38)	missense	probably benign	0.07
IGL02158:Dnah2	APN	11	69,458,123 (GRCm38)	missense	probably benign
IGL02381:Dnah2	APN	11	69,446,292 (GRCm38)	missense	probably benign	0.25
IGL02681:Dnah2	APN	11	69,452,933 (GRCm38)	missense	probably benign	0.40
IGL02957:Dnah2	APN	11	69,448,507 (GRCm38)	missense	possibly damaging	0.96
IGL02961:Dnah2	APN	11	69,518,414 (GRCm38)	missense	probably damaging	1.00
IGL02969:Dnah2	APN	11	69,521,187 (GRCm38)	missense	possibly damaging	0.80
IGL03117:Dnah2	APN	11	69,436,291 (GRCm38)	splice site	probably benign
IGL03120:Dnah2	APN	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
IGL03183:Dnah2	APN	11	69,458,488 (GRCm38)	missense	possibly damaging	0.94
IGL03197:Dnah2	APN	11	69,459,263 (GRCm38)	missense	probably damaging	1.00
IGL03263:Dnah2	APN	11	69,529,381 (GRCm38)	critical splice donor site	probably null
IGL03333:Dnah2	APN	11	69,495,123 (GRCm38)	missense	probably damaging	1.00
IGL03338:Dnah2	APN	11	69,496,577 (GRCm38)	missense	probably benign	0.13
argyrios	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
Aureus	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
platinum	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R0334_dnah2_144	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R2150_dnah2_212	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
BB005:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
BB015:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
E0370:Dnah2	UTSW	11	69,515,615 (GRCm38)	splice site	probably null
P0026:Dnah2	UTSW	11	69,464,947 (GRCm38)	missense	probably damaging	1.00
R0133:Dnah2	UTSW	11	69,421,009 (GRCm38)	missense	probably damaging	1.00
R0190:Dnah2	UTSW	11	69,435,249 (GRCm38)	missense	probably damaging	1.00
R0334:Dnah2	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R0359:Dnah2	UTSW	11	69,529,531 (GRCm38)	missense	probably benign	0.00
R0386:Dnah2	UTSW	11	69,447,861 (GRCm38)	missense	probably damaging	1.00
R0414:Dnah2	UTSW	11	69,499,238 (GRCm38)	missense	probably benign	0.26
R0427:Dnah2	UTSW	11	69,452,879 (GRCm38)	missense	probably damaging	0.99
R0433:Dnah2	UTSW	11	69,459,288 (GRCm38)	missense	probably damaging	1.00
R0442:Dnah2	UTSW	11	69,448,542 (GRCm38)	missense	probably damaging	1.00
R0462:Dnah2	UTSW	11	69,459,201 (GRCm38)	missense	probably damaging	1.00
R0463:Dnah2	UTSW	11	69,423,126 (GRCm38)	missense	probably damaging	1.00
R0611:Dnah2	UTSW	11	69,499,194 (GRCm38)	missense	probably damaging	1.00
R0626:Dnah2	UTSW	11	69,477,683 (GRCm38)	missense	probably benign	0.07
R0924:Dnah2	UTSW	11	69,421,308 (GRCm38)	missense	probably damaging	1.00
R0968:Dnah2	UTSW	11	69,448,519 (GRCm38)	missense	possibly damaging	0.67
R1066:Dnah2	UTSW	11	69,447,819 (GRCm38)	missense	probably damaging	1.00
R1183:Dnah2	UTSW	11	69,446,648 (GRCm38)	missense	possibly damaging	0.95
R1184:Dnah2	UTSW	11	69,499,190 (GRCm38)	missense	probably damaging	1.00
R1186:Dnah2	UTSW	11	69,515,700 (GRCm38)	missense	probably damaging	0.99
R1453:Dnah2	UTSW	11	69,451,050 (GRCm38)	missense	probably damaging	0.99
R1498:Dnah2	UTSW	11	69,520,667 (GRCm38)	splice site	probably null
R1538:Dnah2	UTSW	11	69,477,202 (GRCm38)	missense	probably benign	0.17
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1590:Dnah2	UTSW	11	69,521,198 (GRCm38)	missense	probably benign	0.00
R1590:Dnah2	UTSW	11	69,422,754 (GRCm38)	critical splice donor site	probably null
R1655:Dnah2	UTSW	11	69,473,854 (GRCm38)	missense	probably damaging	1.00
R1695:Dnah2	UTSW	11	69,514,691 (GRCm38)	missense	possibly damaging	0.74
R1726:Dnah2	UTSW	11	69,497,889 (GRCm38)	missense	probably damaging	1.00
R1764:Dnah2	UTSW	11	69,423,543 (GRCm38)	missense	probably damaging	1.00
R1815:Dnah2	UTSW	11	69,475,574 (GRCm38)	missense	probably damaging	1.00
R1822:Dnah2	UTSW	11	69,514,804 (GRCm38)	missense	probably damaging	1.00
R1859:Dnah2	UTSW	11	69,437,886 (GRCm38)	missense	probably damaging	0.99
R1911:Dnah2	UTSW	11	69,515,752 (GRCm38)	missense	possibly damaging	0.64
R1913:Dnah2	UTSW	11	69,464,930 (GRCm38)	missense	probably damaging	1.00
R1981:Dnah2	UTSW	11	69,474,325 (GRCm38)	missense	probably damaging	1.00
R2010:Dnah2	UTSW	11	69,458,358 (GRCm38)	critical splice donor site	probably null
R2016:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2017:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2044:Dnah2	UTSW	11	69,524,240 (GRCm38)	missense	probably benign	0.14
R2077:Dnah2	UTSW	11	69,496,606 (GRCm38)	missense	possibly damaging	0.73
R2096:Dnah2	UTSW	11	69,455,916 (GRCm38)	missense	probably damaging	0.98
R2099:Dnah2	UTSW	11	69,493,237 (GRCm38)	missense	probably damaging	1.00
R2127:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2128:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2146:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2147:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2150:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2404:Dnah2	UTSW	11	69,437,221 (GRCm38)	missense	probably damaging	0.99
R2510:Dnah2	UTSW	11	69,524,206 (GRCm38)	nonsense	probably null
R2517:Dnah2	UTSW	11	69,516,644 (GRCm38)	missense	probably damaging	1.00
R3014:Dnah2	UTSW	11	69,430,478 (GRCm38)	missense	probably benign
R3741:Dnah2	UTSW	11	69,448,469 (GRCm38)	missense	probably damaging	1.00
R3814:Dnah2	UTSW	11	69,492,650 (GRCm38)	splice site	probably null
R3872:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3873:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3874:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3875:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3881:Dnah2	UTSW	11	69,451,347 (GRCm38)	missense	possibly damaging	0.94
R3953:Dnah2	UTSW	11	69,454,103 (GRCm38)	missense	probably damaging	1.00
R3956:Dnah2	UTSW	11	69,484,021 (GRCm38)	missense	probably benign	0.00
R4501:Dnah2	UTSW	11	69,477,659 (GRCm38)	missense	probably benign
R4515:Dnah2	UTSW	11	69,465,631 (GRCm38)	missense	possibly damaging	0.61
R4612:Dnah2	UTSW	11	69,483,367 (GRCm38)	missense	possibly damaging	0.93
R4625:Dnah2	UTSW	11	69,463,661 (GRCm38)	missense	probably damaging	1.00
R4627:Dnah2	UTSW	11	69,465,376 (GRCm38)	missense	probably damaging	1.00
R4642:Dnah2	UTSW	11	69,496,559 (GRCm38)	missense	probably benign	0.00
R4683:Dnah2	UTSW	11	69,458,942 (GRCm38)	missense	probably damaging	1.00
R4698:Dnah2	UTSW	11	69,498,532 (GRCm38)	missense	probably damaging	1.00
R4710:Dnah2	UTSW	11	69,478,077 (GRCm38)	missense	probably damaging	1.00
R4712:Dnah2	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
R4713:Dnah2	UTSW	11	69,476,688 (GRCm38)	missense	probably damaging	1.00
R4717:Dnah2	UTSW	11	69,429,357 (GRCm38)	missense	probably benign	0.00
R4740:Dnah2	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R4780:Dnah2	UTSW	11	69,473,871 (GRCm38)	missense	probably damaging	0.97
R4825:Dnah2	UTSW	11	69,423,205 (GRCm38)	missense	probably damaging	1.00
R4864:Dnah2	UTSW	11	69,422,590 (GRCm38)	missense	probably damaging	0.98
R4868:Dnah2	UTSW	11	69,463,648 (GRCm38)	missense	probably damaging	1.00
R4879:Dnah2	UTSW	11	69,476,691 (GRCm38)	missense	probably damaging	1.00
R4908:Dnah2	UTSW	11	69,521,147 (GRCm38)	missense	probably benign	0.00
R4911:Dnah2	UTSW	11	69,499,104 (GRCm38)	critical splice donor site	probably null
R4954:Dnah2	UTSW	11	69,539,496 (GRCm38)	missense	possibly damaging	0.61
R4962:Dnah2	UTSW	11	69,455,973 (GRCm38)	nonsense	probably null
R5015:Dnah2	UTSW	11	69,497,882 (GRCm38)	missense	possibly damaging	0.89
R5049:Dnah2	UTSW	11	69,448,166 (GRCm38)	missense	probably damaging	1.00
R5055:Dnah2	UTSW	11	69,520,773 (GRCm38)	missense	possibly damaging	0.67
R5153:Dnah2	UTSW	11	69,520,933 (GRCm38)	missense	possibly damaging	0.84
R5155:Dnah2	UTSW	11	69,422,536 (GRCm38)	missense	probably damaging	1.00
R5186:Dnah2	UTSW	11	69,435,884 (GRCm38)	missense	probably damaging	1.00
R5187:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5208:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5252:Dnah2	UTSW	11	69,529,469 (GRCm38)	missense	probably damaging	0.98
R5296:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5298:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5299:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5301:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5324:Dnah2	UTSW	11	69,457,993 (GRCm38)	missense	probably benign	0.07
R5350:Dnah2	UTSW	11	69,516,036 (GRCm38)	missense	possibly damaging	0.48
R5377:Dnah2	UTSW	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
R5393:Dnah2	UTSW	11	69,500,857 (GRCm38)	missense	probably benign
R5421:Dnah2	UTSW	11	69,435,636 (GRCm38)	missense	probably damaging	1.00
R5452:Dnah2	UTSW	11	69,524,383 (GRCm38)	missense	probably damaging	1.00
R5461:Dnah2	UTSW	11	69,473,351 (GRCm38)	critical splice donor site	probably null
R5474:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5476:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5477:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5510:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5527:Dnah2	UTSW	11	69,437,188 (GRCm38)	nonsense	probably null
R5566:Dnah2	UTSW	11	69,516,569 (GRCm38)	nonsense	probably null
R5587:Dnah2	UTSW	11	69,437,242 (GRCm38)	missense	probably damaging	1.00
R5628:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5688:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5690:Dnah2	UTSW	11	69,491,544 (GRCm38)	missense	probably benign	0.15
R5711:Dnah2	UTSW	11	69,435,390 (GRCm38)	missense	probably damaging	1.00
R5735:Dnah2	UTSW	11	69,430,817 (GRCm38)	missense	possibly damaging	0.93
R5826:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5913:Dnah2	UTSW	11	69,448,430 (GRCm38)	missense	probably damaging	1.00
R5914:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5960:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,431,148 (GRCm38)	missense	probably damaging	1.00
R5977:Dnah2	UTSW	11	69,520,881 (GRCm38)	missense	possibly damaging	0.79
R6020:Dnah2	UTSW	11	69,500,839 (GRCm38)	missense	probably benign
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6050:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6086:Dnah2	UTSW	11	69,516,008 (GRCm38)	missense	probably benign	0.30
R6115:Dnah2	UTSW	11	69,446,649 (GRCm38)	missense	probably damaging	1.00
R6123:Dnah2	UTSW	11	69,518,359 (GRCm38)	missense	probably benign	0.29
R6159:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6159:Dnah2	UTSW	11	69,458,542 (GRCm38)	missense	probably damaging	1.00
R6163:Dnah2	UTSW	11	69,520,903 (GRCm38)	nonsense	probably null
R6171:Dnah2	UTSW	11	69,423,042 (GRCm38)	missense	probably damaging	1.00
R6263:Dnah2	UTSW	11	69,457,412 (GRCm38)	missense	probably damaging	1.00
R6298:Dnah2	UTSW	11	69,491,641 (GRCm38)	missense	probably benign	0.25
R6352:Dnah2	UTSW	11	69,448,227 (GRCm38)	missense	probably damaging	1.00
R6399:Dnah2	UTSW	11	69,458,518 (GRCm38)	missense	probably damaging	0.98
R6466:Dnah2	UTSW	11	69,539,415 (GRCm38)	missense	probably benign
R6478:Dnah2	UTSW	11	69,516,010 (GRCm38)	missense	probably benign	0.01
R6516:Dnah2	UTSW	11	69,465,386 (GRCm38)	missense	probably benign	0.34
R6538:Dnah2	UTSW	11	69,437,197 (GRCm38)	missense	possibly damaging	0.87
R6802:Dnah2	UTSW	11	69,423,690 (GRCm38)	missense	probably damaging	1.00
R6861:Dnah2	UTSW	11	69,455,963 (GRCm38)	missense	possibly damaging	0.64
R6869:Dnah2	UTSW	11	69,429,471 (GRCm38)	missense	probably damaging	1.00
R6894:Dnah2	UTSW	11	69,484,260 (GRCm38)	missense	probably benign	0.12
R6935:Dnah2	UTSW	11	69,421,741 (GRCm38)	missense	probably damaging	1.00
R7017:Dnah2	UTSW	11	69,491,547 (GRCm38)	nonsense	probably null
R7073:Dnah2	UTSW	11	69,430,492 (GRCm38)	nonsense	probably null
R7111:Dnah2	UTSW	11	69,446,753 (GRCm38)	splice site	probably null
R7125:Dnah2	UTSW	11	69,436,182 (GRCm38)	missense	probably damaging	0.99
R7137:Dnah2	UTSW	11	69,491,555 (GRCm38)	missense	probably damaging	1.00
R7190:Dnah2	UTSW	11	69,549,097 (GRCm38)	splice site	probably null
R7227:Dnah2	UTSW	11	69,421,396 (GRCm38)	missense	probably damaging	0.99
R7238:Dnah2	UTSW	11	69,459,146 (GRCm38)	critical splice donor site	probably null
R7256:Dnah2	UTSW	11	69,431,094 (GRCm38)	missense	probably damaging	1.00
R7267:Dnah2	UTSW	11	69,500,817 (GRCm38)	missense	probably damaging	1.00
R7420:Dnah2	UTSW	11	69,478,797 (GRCm38)	missense	possibly damaging	0.94
R7421:Dnah2	UTSW	11	69,492,805 (GRCm38)	missense	probably benign	0.25
R7437:Dnah2	UTSW	11	69,498,627 (GRCm38)	missense	probably damaging	1.00
R7461:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7473:Dnah2	UTSW	11	69,491,658 (GRCm38)	missense	probably damaging	0.99
R7528:Dnah2	UTSW	11	69,500,796 (GRCm38)	missense	probably damaging	0.99
R7613:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7615:Dnah2	UTSW	11	69,435,304 (GRCm38)	missense	probably damaging	0.99
R7626:Dnah2	UTSW	11	69,498,685 (GRCm38)	missense	probably damaging	0.99
R7745:Dnah2	UTSW	11	69,451,318 (GRCm38)	nonsense	probably null
R7764:Dnah2	UTSW	11	69,458,158 (GRCm38)	missense	probably benign	0.29
R7793:Dnah2	UTSW	11	69,495,214 (GRCm38)	missense	probably benign	0.00
R7819:Dnah2	UTSW	11	69,516,593 (GRCm38)	missense	probably benign	0.01
R7881:Dnah2	UTSW	11	69,431,238 (GRCm38)	missense	probably damaging	1.00
R7900:Dnah2	UTSW	11	69,518,428 (GRCm38)	missense	probably damaging	1.00
R7916:Dnah2	UTSW	11	69,421,148 (GRCm38)	critical splice acceptor site	probably null
R7921:Dnah2	UTSW	11	69,520,834 (GRCm38)	missense	probably benign
R7928:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
R7937:Dnah2	UTSW	11	69,517,685 (GRCm38)	nonsense	probably null
R7995:Dnah2	UTSW	11	69,520,737 (GRCm38)	missense	possibly damaging	0.77
R8202:Dnah2	UTSW	11	69,478,823 (GRCm38)	missense	probably benign	0.00
R8208:Dnah2	UTSW	11	69,520,852 (GRCm38)	missense	probably benign	0.05
R8215:Dnah2	UTSW	11	69,435,367 (GRCm38)	missense	probably damaging	1.00
R8279:Dnah2	UTSW	11	69,475,573 (GRCm38)	missense	probably damaging	1.00
R8338:Dnah2	UTSW	11	69,487,296 (GRCm38)	missense	probably damaging	1.00
R8348:Dnah2	UTSW	11	69,429,447 (GRCm38)	missense	possibly damaging	0.95
R8405:Dnah2	UTSW	11	69,458,463 (GRCm38)	missense	probably damaging	1.00
R8407:Dnah2	UTSW	11	69,459,278 (GRCm38)	missense	probably benign	0.00
R8493:Dnah2	UTSW	11	69,452,978 (GRCm38)	missense	probably damaging	1.00
R8673:Dnah2	UTSW	11	69,514,697 (GRCm38)	missense	probably benign	0.23
R8725:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8727:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8730:Dnah2	UTSW	11	69,493,261 (GRCm38)	missense	possibly damaging	0.73
R8804:Dnah2	UTSW	11	69,465,685 (GRCm38)	missense	probably benign	0.01
R8876:Dnah2	UTSW	11	69,491,522 (GRCm38)	missense	probably damaging	1.00
R8894:Dnah2	UTSW	11	69,492,222 (GRCm38)	missense	probably benign	0.01
R8938:Dnah2	UTSW	11	69,437,928 (GRCm38)	missense	probably damaging	0.99
R9044:Dnah2	UTSW	11	69,529,421 (GRCm38)	missense	probably benign
R9085:Dnah2	UTSW	11	69,429,398 (GRCm38)	missense	possibly damaging	0.69
R9110:Dnah2	UTSW	11	69,544,382 (GRCm38)	missense	probably benign
R9156:Dnah2	UTSW	11	69,422,861 (GRCm38)	missense
R9251:Dnah2	UTSW	11	69,515,793 (GRCm38)	missense	probably damaging	1.00
R9258:Dnah2	UTSW	11	69,477,253 (GRCm38)	missense	probably damaging	1.00
R9279:Dnah2	UTSW	11	69,518,278 (GRCm38)	missense	probably benign	0.01
R9318:Dnah2	UTSW	11	69,484,329 (GRCm38)	missense	probably benign	0.07
R9321:Dnah2	UTSW	11	69,448,113 (GRCm38)	critical splice donor site	probably null
R9350:Dnah2	UTSW	11	69,493,247 (GRCm38)	missense	probably benign	0.10
R9358:Dnah2	UTSW	11	69,515,766 (GRCm38)	missense	probably damaging	0.99
R9417:Dnah2	UTSW	11	69,436,164 (GRCm38)	missense	probably damaging	1.00
R9420:Dnah2	UTSW	11	69,478,116 (GRCm38)	missense	probably benign	0.09
R9438:Dnah2	UTSW	11	69,473,394 (GRCm38)	missense	probably damaging	1.00
R9469:Dnah2	UTSW	11	69,431,070 (GRCm38)	missense	probably damaging	1.00
R9487:Dnah2	UTSW	11	69,515,791 (GRCm38)	missense	possibly damaging	0.47
R9495:Dnah2	UTSW	11	69,454,382 (GRCm38)	missense	possibly damaging	0.89
R9579:Dnah2	UTSW	11	69,477,215 (GRCm38)	missense	probably damaging	1.00
R9608:Dnah2	UTSW	11	69,454,062 (GRCm38)	missense	probably null	1.00
R9651:Dnah2	UTSW	11	69,450,998 (GRCm38)	critical splice donor site	probably null
R9662:Dnah2	UTSW	11	69,452,937 (GRCm38)	missense	probably benign
RF004:Dnah2	UTSW	11	69,437,187 (GRCm38)	missense	probably benign	0.24
U24488:Dnah2	UTSW	11	69,483,822 (GRCm38)	missense	probably damaging	0.99
X0021:Dnah2	UTSW	11	69,448,562 (GRCm38)	missense	possibly damaging	0.81
Z1088:Dnah2	UTSW	11	69,430,793 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,421,821 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,516,523 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,516,481 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,498,667 (GRCm38)	missense	probably benign	0.12
Z1176:Dnah2	UTSW	11	69,487,054 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,451,120 (GRCm38)	missense	probably benign
Z1177:Dnah2	UTSW	11	69,544,557 (GRCm38)	critical splice acceptor site	probably null
Z1177:Dnah2	UTSW	11	69,463,453 (GRCm38)	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- GCATCTCATTGCACGCATTC -3'
(R):5'- TGAGGGTTCTAGGCATCTTCTC -3'

Sequencing Primer
(F):5'- AGCCCTGAGAGTCAGTCAG -3'
(R):5'- CTCTCTTCCCCAAGGTCCTGG -3'

Posted On

2019-06-26