Mutagenetix > Incidental Mutation

Incidental Mutation 'R7814:Akap6'

601383

Institutional Source

Beutler Lab

Gene Symbol

Akap6

Ensembl Gene

ENSMUSG00000061603

Gene Name

A kinase (PRKA) anchor protein 6

Synonyms

MMRRC Submission

045869-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.868) question?

Stock #

R7814 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

52699383-53155599 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 53140961 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 1719 (N1719K)

Ref Sequence

ENSEMBL: ENSMUSP00000093406 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095737] [ENSMUST00000219786]

AlphaFold

E9Q9K8

Predicted Effect

probably benign
Transcript: ENSMUST00000095737
AA Change: N1719K

PolyPhen 2 Score 0.277 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000093406
Gene: ENSMUSG00000061603
AA Change: N1719K

Domain	Start	End	E-Value	Type
low complexity region	34	51	N/A	INTRINSIC
Blast:SPEC	66	168	2e-50	BLAST
low complexity region	441	455	N/A	INTRINSIC
low complexity region	544	555	N/A	INTRINSIC
low complexity region	569	587	N/A	INTRINSIC
low complexity region	640	651	N/A	INTRINSIC
low complexity region	694	708	N/A	INTRINSIC
SPEC	779	880	1.06e-1	SMART
SPEC	959	1057	1.45e0	SMART
SPEC	1078	1185	2.56e-2	SMART
low complexity region	1316	1332	N/A	INTRINSIC
low complexity region	1555	1568	N/A	INTRINSIC
low complexity region	1610	1622	N/A	INTRINSIC
low complexity region	1683	1698	N/A	INTRINSIC
low complexity region	1737	1781	N/A	INTRINSIC
low complexity region	1899	1910	N/A	INTRINSIC
low complexity region	2019	2031	N/A	INTRINSIC
low complexity region	2104	2115	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000219786

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

100% (90/90)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted disruption of this gene results in partial embryonic lethality; surviving homozygotes display a decreased body weight, craniofacial defects and reduced viability. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 93 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110065P20Rik	C	T	4: 124,850,602 (GRCm38)	G20R	not run	Het
4931409K22Rik	G	T	5: 24,545,422 (GRCm38)	Q626K	possibly damaging	Het
Adamts13	A	T	2: 26,996,549 (GRCm38)	M927L	probably benign	Het
Ank3	G	A	10: 69,986,904 (GRCm38)	V468M		Het
Aox1	A	G	1: 58,085,467 (GRCm38)	T956A	probably benign	Het
Ap4m1	T	C	5: 138,174,817 (GRCm38)	V140A	probably benign	Het
Apc	A	G	18: 34,272,539 (GRCm38)	T173A	probably damaging	Het
Bclaf1	A	G	10: 20,334,619 (GRCm38)	T839A	possibly damaging	Het
Btn2a2	T	A	13: 23,482,806 (GRCm38)	I210F	possibly damaging	Het
Cadps	A	G	14: 12,376,706 (GRCm38)	W1269R	probably damaging	Het
Capn2	G	C	1: 182,492,146 (GRCm38)	P159R	probably damaging	Het
Ccdc134	T	G	15: 82,131,523 (GRCm38)	V68G	probably damaging	Het
Cdh26	A	G	2: 178,470,035 (GRCm38)	T463A	probably damaging	Het
Cfap206	C	T	4: 34,716,347 (GRCm38)	V373I	probably benign	Het
Clpx	T	C	9: 65,324,301 (GRCm38)		probably null	Het
Ctnnd2	A	T	15: 31,020,728 (GRCm38)	Y1145F	probably benign	Het
Ctr9	T	A	7: 111,033,927 (GRCm38)	D127E	probably benign	Het
Cyp2f2	G	A	7: 27,129,253 (GRCm38)	V183I	probably benign	Het
Cyp7b1	G	A	3: 18,097,302 (GRCm38)	S249L	probably benign	Het
D630023F18Rik	T	A	1: 65,116,691 (GRCm38)	D125V	possibly damaging	Het
Dbh	A	T	2: 27,174,848 (GRCm38)	Y357F	probably damaging	Het
Dbp	T	A	7: 45,706,990 (GRCm38)	L175Q	probably benign	Het
Dmwd	A	T	7: 19,080,843 (GRCm38)	T473S	probably benign	Het
Dnah9	T	A	11: 66,005,660 (GRCm38)	Q2446L	probably damaging	Het
Dnmbp	T	C	19: 43,854,176 (GRCm38)	K498R	probably benign	Het
Dopey2	T	A	16: 93,799,971 (GRCm38)	I1924N	probably damaging	Het
Dsg1a	T	A	18: 20,338,515 (GRCm38)		probably null	Het
Dzank1	T	C	2: 144,522,564 (GRCm38)	T38A	probably damaging	Het
Egfem1	A	G	3: 29,686,791 (GRCm38)	H538R	probably damaging	Het
Entpd1	T	C	19: 40,727,447 (GRCm38)	C353R	probably damaging	Het
Ephx2	C	A	14: 66,110,229 (GRCm38)	C78F	probably benign	Het
Faf2	A	T	13: 54,660,961 (GRCm38)	H388L	probably benign	Het
Fam186a	G	A	15: 99,944,664 (GRCm38)	T1233I	possibly damaging	Het
Gfra2	C	A	14: 70,895,970 (GRCm38)	A80E	probably damaging	Het
Gif	C	A	19: 11,750,187 (GRCm38)	P125Q	probably benign	Het
Gm17175	T	A	14: 51,574,035 (GRCm38)		probably benign	Het
Gm8180	T	C	14: 43,783,646 (GRCm38)	D35G	possibly damaging	Het
Gm884	T	A	11: 103,614,173 (GRCm38)	H2323L	possibly damaging	Het
Gpr68	C	T	12: 100,879,043 (GRCm38)	V81M	probably damaging	Het
Hsd3b6	A	G	3: 98,810,943 (GRCm38)	L35P	probably damaging	Het
Hspd1	A	C	1: 55,078,644 (GRCm38)	V485G	possibly damaging	Het
Il16	A	G	7: 83,670,140 (GRCm38)	V381A	possibly damaging	Het
Il17rd	G	A	14: 27,100,117 (GRCm38)	C600Y	probably benign	Het
Ins2	C	A	7: 142,679,586 (GRCm38)		probably benign	Het
Itsn2	T	C	12: 4,658,561 (GRCm38)	I872T	probably benign	Het
Jakmip3	A	T	7: 139,019,129 (GRCm38)	D219V	probably damaging	Het
Jph4	T	C	14: 55,109,735 (GRCm38)	T452A	probably damaging	Het
Kazn	T	C	4: 142,210,170 (GRCm38)	E12G	unknown	Het
Kif20b	A	C	19: 34,950,955 (GRCm38)	S1206R	possibly damaging	Het
Lca5l	A	G	16: 96,162,557 (GRCm38)		probably null	Het
Lgals2	A	T	15: 78,851,333 (GRCm38)	S60R	probably benign	Het
Map10	A	G	8: 125,671,611 (GRCm38)	E581G	probably benign	Het
Map2k7	G	T	8: 4,243,744 (GRCm38)	R128L	probably benign	Het
Mapk8	G	C	14: 33,410,877 (GRCm38)	S34*	probably null	Het
Mcat	A	G	15: 83,547,909 (GRCm38)	Y253H	probably damaging	Het
Mmp2	T	C	8: 92,850,170 (GRCm38)	L607P	probably benign	Het
Ncor1	A	T	11: 62,333,926 (GRCm38)	V836E	probably damaging	Het
Neb	A	G	2: 52,137,380 (GRCm38)	S7113P	probably damaging	Het
Nphp4	G	T	4: 152,544,403 (GRCm38)	D749Y	probably damaging	Het
Nphp4	T	C	4: 152,524,272 (GRCm38)	F446L	possibly damaging	Het
Olfr115	T	A	17: 37,610,656 (GRCm38)	T32S	probably benign	Het
Olfr1185-ps1	A	G	2: 88,499,072 (GRCm38)		probably benign	Het
Olfr175-ps1	T	C	16: 58,824,002 (GRCm38)	K236E	probably damaging	Het
Olfr338	T	C	2: 36,376,809 (GRCm38)	I11T	possibly damaging	Het
Osbpl11	A	T	16: 33,210,061 (GRCm38)	R220*	probably null	Het
Plrg1	G	A	3: 83,056,837 (GRCm38)	V26M	probably damaging	Het
Polr1b	C	A	2: 129,125,544 (GRCm38)	F952L	probably damaging	Het
Ppfia3	A	C	7: 45,352,262 (GRCm38)	S560A	probably benign	Het
Ppp3cc	T	A	14: 70,225,015 (GRCm38)	N391I	possibly damaging	Het
Prdx6b	T	C	2: 80,292,960 (GRCm38)	S38P	possibly damaging	Het
Psg23	A	T	7: 18,606,914 (GRCm38)	*472R	probably null	Het
Rapgef4	A	T	2: 72,223,117 (GRCm38)	M587L	probably benign	Het
Rfx3	T	A	19: 27,826,070 (GRCm38)	M247L	probably benign	Het
Rgs7	T	A	1: 175,076,069 (GRCm38)	H463L	probably benign	Het
Riiad1	G	T	3: 94,465,855 (GRCm38)	S106R	probably benign	Het
Rims4	A	C	2: 163,918,628 (GRCm38)	I19S	probably benign	Het
Ros1	A	T	10: 52,096,137 (GRCm38)	M1648K	probably benign	Het
Rrn3	T	C	16: 13,811,589 (GRCm38)	F590L	probably benign	Het
Samd9l	T	A	6: 3,374,793 (GRCm38)	T823S	possibly damaging	Het
Sfxn1	C	A	13: 54,091,231 (GRCm38)	P115Q	possibly damaging	Het
Slc10a7	T	C	8: 78,698,573 (GRCm38)		probably null	Het
Slc25a16	A	T	10: 62,937,420 (GRCm38)	M142L	probably benign	Het
Stat2	CGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCCAGCCCCACAAGTCCAGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCTAGCCCCACAAGTCCTGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCTAGCCCCACAAGTCCAGCTGGAGCCAGC	CGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCCAGCCCCACAAGTCCAGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCTAGCCCCACAAGTCCTGCTGGAGCCAGCCCCACAAGTCCTGCTGGAGCTAGCCCCACAAGTCCAGCTGGAGCCAGC	10: 128,290,728 (GRCm38)		probably benign	Het
Stat5a	T	G	11: 100,875,027 (GRCm38)	L313R	probably damaging	Het
Strap	A	G	6: 137,741,978 (GRCm38)	E176G	possibly damaging	Het
Tlr4	T	G	4: 66,841,079 (GRCm38)	L703R	probably damaging	Het
Trim36	A	T	18: 46,167,624 (GRCm38)	V660D	possibly damaging	Het
Tspoap1	T	A	11: 87,775,524 (GRCm38)	D980E	probably damaging	Het
Usp28	T	C	9: 49,003,918 (GRCm38)	V157A	probably benign	Het
Vmn2r17	A	T	5: 109,427,873 (GRCm38)	R203S	probably benign	Het
Vmn2r66	T	C	7: 85,007,264 (GRCm38)	I181M	probably benign	Het
Zan	T	A	5: 137,463,579 (GRCm38)	T1113S	unknown	Het
Zfp442	C	T	2: 150,409,482 (GRCm38)	D167N	possibly damaging	Het

Other mutations in Akap6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Akap6	APN	12	53,140,980 (GRCm38)	missense	possibly damaging	0.79
IGL00505:Akap6	APN	12	52,887,102 (GRCm38)	missense	possibly damaging	0.92
IGL01134:Akap6	APN	12	52,937,217 (GRCm38)	missense	probably damaging	0.96
IGL01458:Akap6	APN	12	52,886,818 (GRCm38)	nonsense	probably null
IGL01589:Akap6	APN	12	53,139,664 (GRCm38)	missense	probably damaging	1.00
IGL01592:Akap6	APN	12	53,142,142 (GRCm38)	missense	probably damaging	1.00
IGL01738:Akap6	APN	12	52,886,817 (GRCm38)	missense	probably damaging	0.99
IGL01867:Akap6	APN	12	52,888,008 (GRCm38)	missense	probably damaging	1.00
IGL02025:Akap6	APN	12	53,140,335 (GRCm38)	missense	probably benign
IGL02041:Akap6	APN	12	53,140,653 (GRCm38)	missense	probably damaging	1.00
IGL02058:Akap6	APN	12	53,140,555 (GRCm38)	missense	probably damaging	1.00
IGL02194:Akap6	APN	12	52,886,823 (GRCm38)	missense	probably benign	0.00
IGL02226:Akap6	APN	12	53,010,467 (GRCm38)	splice site	probably benign
IGL02323:Akap6	APN	12	53,140,429 (GRCm38)	missense	probably benign	0.00
IGL02449:Akap6	APN	12	53,140,188 (GRCm38)	missense	probably damaging	1.00
IGL02475:Akap6	APN	12	53,139,494 (GRCm38)	missense	probably benign	0.03
IGL02546:Akap6	APN	12	52,880,738 (GRCm38)	missense	probably damaging	1.00
IGL02547:Akap6	APN	12	53,140,696 (GRCm38)	missense	probably damaging	1.00
IGL02588:Akap6	APN	12	52,886,499 (GRCm38)	nonsense	probably null
IGL02608:Akap6	APN	12	53,010,606 (GRCm38)	missense	probably benign	0.39
IGL02884:Akap6	APN	12	52,886,622 (GRCm38)	missense	probably benign	0.00
IGL02945:Akap6	APN	12	52,880,837 (GRCm38)	missense	probably damaging	1.00
IGL03029:Akap6	APN	12	52,886,412 (GRCm38)	missense	probably damaging	1.00
IGL03129:Akap6	APN	12	53,140,306 (GRCm38)	missense	probably damaging	1.00
R0133:Akap6	UTSW	12	53,139,471 (GRCm38)	nonsense	probably null
R0166:Akap6	UTSW	12	53,140,924 (GRCm38)	missense	probably benign	0.04
R0189:Akap6	UTSW	12	53,141,254 (GRCm38)	missense	probably benign	0.41
R0532:Akap6	UTSW	12	52,887,983 (GRCm38)	missense	probably benign	0.00
R0632:Akap6	UTSW	12	52,937,148 (GRCm38)	missense	probably damaging	1.00
R0666:Akap6	UTSW	12	52,911,808 (GRCm38)	missense	probably damaging	1.00
R0723:Akap6	UTSW	12	53,141,902 (GRCm38)	missense	probably damaging	1.00
R0763:Akap6	UTSW	12	53,142,214 (GRCm38)	missense	possibly damaging	0.93
R0785:Akap6	UTSW	12	52,886,622 (GRCm38)	missense	probably benign	0.00
R0879:Akap6	UTSW	12	52,880,799 (GRCm38)	missense	probably damaging	1.00
R0880:Akap6	UTSW	12	53,139,508 (GRCm38)	missense	possibly damaging	0.93
R1033:Akap6	UTSW	12	53,069,222 (GRCm38)	missense	probably damaging	0.97
R1055:Akap6	UTSW	12	52,880,672 (GRCm38)	nonsense	probably null
R1199:Akap6	UTSW	12	52,796,190 (GRCm38)	missense	probably damaging	1.00
R1295:Akap6	UTSW	12	52,887,029 (GRCm38)	missense	probably damaging	1.00
R1389:Akap6	UTSW	12	53,139,520 (GRCm38)	missense	probably benign	0.15
R1471:Akap6	UTSW	12	53,141,496 (GRCm38)	missense	probably benign	0.05
R1483:Akap6	UTSW	12	52,796,087 (GRCm38)	missense	probably damaging	1.00
R1512:Akap6	UTSW	12	52,937,154 (GRCm38)	missense	probably damaging	1.00
R1648:Akap6	UTSW	12	53,142,006 (GRCm38)	nonsense	probably null
R1791:Akap6	UTSW	12	53,069,125 (GRCm38)	missense	probably damaging	1.00
R1888:Akap6	UTSW	12	53,142,175 (GRCm38)	missense	possibly damaging	0.88
R1888:Akap6	UTSW	12	53,142,175 (GRCm38)	missense	possibly damaging	0.88
R1891:Akap6	UTSW	12	53,142,175 (GRCm38)	missense	possibly damaging	0.88
R1899:Akap6	UTSW	12	53,141,852 (GRCm38)	missense	possibly damaging	0.95
R1917:Akap6	UTSW	12	53,104,612 (GRCm38)	missense	probably benign	0.13
R1970:Akap6	UTSW	12	52,938,475 (GRCm38)	missense	probably damaging	0.96
R1987:Akap6	UTSW	12	53,140,795 (GRCm38)	missense	possibly damaging	0.78
R1988:Akap6	UTSW	12	53,140,795 (GRCm38)	missense	possibly damaging	0.78
R2153:Akap6	UTSW	12	53,141,404 (GRCm38)	missense	probably benign	0.03
R2567:Akap6	UTSW	12	52,938,373 (GRCm38)	missense	probably damaging	1.00
R2568:Akap6	UTSW	12	52,887,278 (GRCm38)	missense	possibly damaging	0.77
R3025:Akap6	UTSW	12	53,140,143 (GRCm38)	missense	probably benign
R3051:Akap6	UTSW	12	52,887,033 (GRCm38)	missense	probably damaging	1.00
R3195:Akap6	UTSW	12	53,072,457 (GRCm38)	nonsense	probably null
R3196:Akap6	UTSW	12	53,072,457 (GRCm38)	nonsense	probably null
R3426:Akap6	UTSW	12	52,888,034 (GRCm38)	missense	probably damaging	1.00
R3783:Akap6	UTSW	12	52,880,769 (GRCm38)	missense	probably damaging	1.00
R3934:Akap6	UTSW	12	53,140,444 (GRCm38)	missense	possibly damaging	0.92
R3936:Akap6	UTSW	12	53,140,444 (GRCm38)	missense	possibly damaging	0.92
R3967:Akap6	UTSW	12	53,141,453 (GRCm38)	missense	probably damaging	1.00
R3970:Akap6	UTSW	12	53,141,453 (GRCm38)	missense	probably damaging	1.00
R4042:Akap6	UTSW	12	53,139,379 (GRCm38)	critical splice acceptor site	probably null
R4095:Akap6	UTSW	12	53,139,462 (GRCm38)	missense	probably damaging	1.00
R4152:Akap6	UTSW	12	53,140,407 (GRCm38)	missense	probably benign	0.45
R4231:Akap6	UTSW	12	53,141,038 (GRCm38)	missense	probably damaging	1.00
R4232:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4233:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4234:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4235:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4236:Akap6	UTSW	12	53,139,671 (GRCm38)	missense	probably damaging	1.00
R4475:Akap6	UTSW	12	53,141,643 (GRCm38)	missense	probably benign	0.00
R4513:Akap6	UTSW	12	52,796,004 (GRCm38)	missense	probably benign	0.03
R4686:Akap6	UTSW	12	52,887,623 (GRCm38)	frame shift	probably null
R4724:Akap6	UTSW	12	52,795,885 (GRCm38)	missense	possibly damaging	0.80
R4782:Akap6	UTSW	12	52,887,623 (GRCm38)	frame shift	probably null
R4852:Akap6	UTSW	12	53,104,675 (GRCm38)	missense	probably damaging	1.00
R5024:Akap6	UTSW	12	53,142,562 (GRCm38)	missense	probably benign	0.01
R5116:Akap6	UTSW	12	53,141,515 (GRCm38)	missense	probably benign	0.01
R5164:Akap6	UTSW	12	53,142,466 (GRCm38)	missense	probably benign
R5225:Akap6	UTSW	12	52,886,546 (GRCm38)	missense	probably damaging	1.00
R5269:Akap6	UTSW	12	53,139,843 (GRCm38)	missense	probably damaging	0.99
R5352:Akap6	UTSW	12	52,796,097 (GRCm38)	missense	probably damaging	1.00
R5496:Akap6	UTSW	12	53,140,653 (GRCm38)	missense	possibly damaging	0.87
R5551:Akap6	UTSW	12	52,795,964 (GRCm38)	missense	probably damaging	1.00
R5997:Akap6	UTSW	12	52,937,233 (GRCm38)	critical splice donor site	probably null
R6137:Akap6	UTSW	12	53,140,354 (GRCm38)	missense	probably damaging	1.00
R6151:Akap6	UTSW	12	53,025,792 (GRCm38)	missense	probably damaging	1.00
R6169:Akap6	UTSW	12	53,142,358 (GRCm38)	missense	probably benign
R6307:Akap6	UTSW	12	53,141,568 (GRCm38)	missense	possibly damaging	0.85
R6351:Akap6	UTSW	12	53,142,025 (GRCm38)	missense	probably damaging	0.98
R6479:Akap6	UTSW	12	53,141,169 (GRCm38)	missense	probably damaging	1.00
R6502:Akap6	UTSW	12	53,140,215 (GRCm38)	missense	probably damaging	1.00
R6760:Akap6	UTSW	12	53,139,778 (GRCm38)	missense	probably damaging	1.00
R6778:Akap6	UTSW	12	53,025,816 (GRCm38)	missense	probably damaging	1.00
R6837:Akap6	UTSW	12	53,141,262 (GRCm38)	missense	probably damaging	1.00
R6896:Akap6	UTSW	12	52,887,494 (GRCm38)	missense	probably benign	0.06
R6917:Akap6	UTSW	12	53,069,168 (GRCm38)	missense	probably null	0.97
R6983:Akap6	UTSW	12	52,887,653 (GRCm38)	missense	probably damaging	1.00
R7142:Akap6	UTSW	12	52,887,364 (GRCm38)	missense	probably benign	0.02
R7143:Akap6	UTSW	12	52,887,364 (GRCm38)	missense	probably benign	0.02
R7216:Akap6	UTSW	12	53,140,457 (GRCm38)	missense	probably benign	0.02
R7297:Akap6	UTSW	12	52,887,364 (GRCm38)	missense	probably benign	0.02
R7356:Akap6	UTSW	12	52,911,864 (GRCm38)	missense	probably damaging	1.00
R7378:Akap6	UTSW	12	53,142,574 (GRCm38)	missense	probably benign	0.00
R7382:Akap6	UTSW	12	53,142,171 (GRCm38)	missense	probably benign	0.00
R7498:Akap6	UTSW	12	53,142,705 (GRCm38)	nonsense	probably null
R7542:Akap6	UTSW	12	53,069,234 (GRCm38)	missense	probably damaging	1.00
R7589:Akap6	UTSW	12	53,142,063 (GRCm38)	nonsense	probably null
R7676:Akap6	UTSW	12	52,886,850 (GRCm38)	missense	possibly damaging	0.94
R7971:Akap6	UTSW	12	53,139,795 (GRCm38)	missense	probably damaging	1.00
R8039:Akap6	UTSW	12	53,141,676 (GRCm38)	missense	probably benign	0.00
R8425:Akap6	UTSW	12	52,886,621 (GRCm38)	missense	probably benign	0.00
R8747:Akap6	UTSW	12	53,142,216 (GRCm38)	missense	probably benign	0.01
R8885:Akap6	UTSW	12	53,141,536 (GRCm38)	missense	probably benign
R8956:Akap6	UTSW	12	53,140,344 (GRCm38)	missense	probably benign	0.00
R8989:Akap6	UTSW	12	52,880,871 (GRCm38)	missense	probably damaging	1.00
R9014:Akap6	UTSW	12	53,139,620 (GRCm38)	missense	possibly damaging	0.60
R9031:Akap6	UTSW	12	53,142,048 (GRCm38)	missense	probably benign	0.36
R9216:Akap6	UTSW	12	52,880,885 (GRCm38)	missense	probably benign	0.05
R9220:Akap6	UTSW	12	53,140,449 (GRCm38)	missense	possibly damaging	0.49
R9243:Akap6	UTSW	12	53,141,252 (GRCm38)	missense	probably benign	0.08
R9286:Akap6	UTSW	12	53,072,471 (GRCm38)	missense	possibly damaging	0.90
R9347:Akap6	UTSW	12	53,069,111 (GRCm38)	missense	probably damaging	1.00
R9475:Akap6	UTSW	12	53,010,552 (GRCm38)	missense	probably damaging	1.00
R9509:Akap6	UTSW	12	53,142,238 (GRCm38)	missense	probably damaging	0.99
R9523:Akap6	UTSW	12	52,795,889 (GRCm38)	missense	probably benign	0.02
R9600:Akap6	UTSW	12	52,886,558 (GRCm38)	missense	probably benign	0.04
R9612:Akap6	UTSW	12	52,911,907 (GRCm38)	missense	probably damaging	1.00
R9627:Akap6	UTSW	12	53,104,630 (GRCm38)	missense
R9666:Akap6	UTSW	12	53,141,535 (GRCm38)	missense	probably benign
R9784:Akap6	UTSW	12	53,141,070 (GRCm38)	missense	probably damaging	1.00
X0062:Akap6	UTSW	12	53,142,361 (GRCm38)	missense	probably benign	0.43
Z1176:Akap6	UTSW	12	53,140,444 (GRCm38)	missense	possibly damaging	0.92

Predicted Primers

PCR Primer
(F):5'- AAGATGTCCTTCAGTGGCCAG -3'
(R):5'- TGTAGTCCAGCCCAGACATCAG -3'

Sequencing Primer
(F):5'- CAGATGTCACTGGATGTCGCATC -3'
(R):5'- CATCATCCGTTGCGATACTGGAG -3'

Posted On

2019-11-26