Incidental Mutation 'R8906:Adamts3'
| ID |
680101 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts3
|
| Ensembl Gene |
ENSMUSG00000043635 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 3 |
| Synonyms |
1100001H14Rik, 6330442E02Rik |
| MMRRC Submission |
068699-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R8906 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
89824946-90031193 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 89825575 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 1088
(T1088I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132219
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061427]
[ENSMUST00000163159]
|
| AlphaFold |
E9Q287 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000061427
AA Change: T1087I
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000058552
Gene: ENSMUSG00000043635
AA Change: T1087I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
42 |
201 |
5.1e-40 |
PFAM |
|
Pfam:Reprolysin_5
|
254 |
439 |
5.4e-15 |
PFAM |
|
Pfam:Reprolysin_4
|
256 |
454 |
1.9e-10 |
PFAM |
|
Pfam:Reprolysin
|
257 |
460 |
3.6e-22 |
PFAM |
|
Pfam:Reprolysin_2
|
274 |
451 |
7.7e-13 |
PFAM |
|
Pfam:Reprolysin_3
|
278 |
409 |
1.5e-12 |
PFAM |
|
TSP1
|
554 |
606 |
1.26e-15 |
SMART |
|
Pfam:ADAM_spacer1
|
713 |
827 |
3e-34 |
PFAM |
|
TSP1
|
848 |
905 |
4.35e-2 |
SMART |
|
TSP1
|
908 |
967 |
4.95e-2 |
SMART |
|
TSP1
|
969 |
1016 |
6.58e-5 |
SMART |
|
low complexity region
|
1114 |
1128 |
N/A |
INTRINSIC |
|
low complexity region
|
1157 |
1177 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163159
AA Change: T1088I
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000132219
Gene: ENSMUSG00000043635
AA Change: T1088I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
43 |
201 |
1.5e-40 |
PFAM |
|
Pfam:Reprolysin_5
|
254 |
439 |
2.2e-15 |
PFAM |
|
Pfam:Reprolysin_4
|
256 |
454 |
7.7e-11 |
PFAM |
|
Pfam:Reprolysin
|
257 |
460 |
3.7e-21 |
PFAM |
|
Pfam:Reprolysin_2
|
274 |
451 |
4.3e-14 |
PFAM |
|
Pfam:Reprolysin_3
|
278 |
409 |
1.3e-12 |
PFAM |
|
TSP1
|
554 |
606 |
1.26e-15 |
SMART |
|
Pfam:ADAM_spacer1
|
713 |
828 |
3.6e-28 |
PFAM |
|
TSP1
|
849 |
906 |
4.35e-2 |
SMART |
|
TSP1
|
909 |
968 |
4.95e-2 |
SMART |
|
TSP1
|
970 |
1017 |
6.58e-5 |
SMART |
|
low complexity region
|
1115 |
1129 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1178 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.4%
|
| Validation Efficiency |
100% (88/88) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810055G02Rik |
A |
C |
19: 3,766,686 (GRCm39) |
N91T |
possibly damaging |
Het |
| 2510009E07Rik |
CCGGAAGGGGAGGAGCAGTGACCCAGTTTCGGA |
CCGGA |
16: 21,472,148 (GRCm39) |
|
probably null |
Het |
| 4932414N04Rik |
A |
G |
2: 68,562,498 (GRCm39) |
D375G |
possibly damaging |
Het |
| Adad2 |
C |
A |
8: 120,339,725 (GRCm39) |
P69Q |
probably benign |
Het |
| Ank2 |
A |
G |
3: 126,726,720 (GRCm39) |
V858A |
probably benign |
Het |
| Ankrd13a |
A |
G |
5: 114,939,798 (GRCm39) |
N475S |
probably benign |
Het |
| Barhl2 |
G |
A |
5: 106,603,352 (GRCm39) |
T269I |
probably benign |
Het |
| Boc |
G |
A |
16: 44,323,931 (GRCm39) |
R157W |
|
Het |
| Bsn |
G |
T |
9: 107,984,752 (GRCm39) |
P3101T |
unknown |
Het |
| Catsperb |
C |
A |
12: 101,486,904 (GRCm39) |
A477E |
possibly damaging |
Het |
| Ccser1 |
T |
A |
6: 61,787,842 (GRCm39) |
I220K |
probably benign |
Het |
| Cd200r3 |
A |
T |
16: 44,778,102 (GRCm39) |
I242F |
possibly damaging |
Het |
| Cdc34b |
A |
C |
11: 94,632,911 (GRCm39) |
D37A |
probably damaging |
Het |
| Chek2 |
A |
G |
5: 111,013,458 (GRCm39) |
|
probably benign |
Het |
| Cngb1 |
A |
T |
8: 95,989,736 (GRCm39) |
V792D |
probably damaging |
Het |
| Cops7a |
T |
C |
6: 124,939,371 (GRCm39) |
K93E |
possibly damaging |
Het |
| Crispld1 |
T |
C |
1: 17,820,995 (GRCm39) |
I345T |
possibly damaging |
Het |
| Dgkd |
A |
G |
1: 87,869,157 (GRCm39) |
D1170G |
probably damaging |
Het |
| Dhx35 |
A |
G |
2: 158,648,918 (GRCm39) |
T115A |
possibly damaging |
Het |
| Dnai1 |
G |
A |
4: 41,625,125 (GRCm39) |
R363H |
probably benign |
Het |
| Dnmbp |
T |
A |
19: 43,878,681 (GRCm39) |
Q130L |
probably benign |
Het |
| Egfr |
A |
G |
11: 16,861,635 (GRCm39) |
Y1138C |
probably damaging |
Het |
| Elf3 |
A |
T |
1: 135,182,678 (GRCm39) |
L329Q |
probably damaging |
Het |
| Enkur |
A |
G |
2: 21,201,568 (GRCm39) |
M39T |
probably benign |
Het |
| Epha7 |
T |
C |
4: 28,821,615 (GRCm39) |
I260T |
probably damaging |
Het |
| Fbxo28 |
A |
T |
1: 182,144,634 (GRCm39) |
I310K |
probably damaging |
Het |
| Fga |
C |
A |
3: 82,939,111 (GRCm39) |
N495K |
probably benign |
Het |
| Galnt6 |
T |
C |
15: 100,601,247 (GRCm39) |
D344G |
probably damaging |
Het |
| Gm572 |
A |
G |
4: 148,751,290 (GRCm39) |
Q221R |
probably benign |
Het |
| Gpa33 |
G |
A |
1: 165,974,216 (GRCm39) |
A18T |
probably benign |
Het |
| Gpatch11 |
C |
T |
17: 79,145,289 (GRCm39) |
T6I |
probably benign |
Het |
| Gpr84 |
T |
A |
15: 103,217,625 (GRCm39) |
S151C |
probably damaging |
Het |
| H2-M11 |
T |
A |
17: 36,859,851 (GRCm39) |
Y281* |
probably null |
Het |
| Hadh |
T |
C |
3: 131,038,891 (GRCm39) |
N155S |
probably benign |
Het |
| Hoxd13 |
A |
G |
2: 74,500,266 (GRCm39) |
Y269C |
|
Het |
| Iars1 |
T |
A |
13: 49,882,177 (GRCm39) |
C1074S |
probably benign |
Het |
| Ibtk |
G |
T |
9: 85,625,457 (GRCm39) |
H98N |
possibly damaging |
Het |
| Igsf10 |
C |
T |
3: 59,233,739 (GRCm39) |
G1665R |
probably benign |
Het |
| Inpp5d |
A |
G |
1: 87,625,337 (GRCm39) |
|
probably benign |
Het |
| Ipo9 |
A |
C |
1: 135,321,951 (GRCm39) |
V593G |
probably damaging |
Het |
| Irx3 |
T |
C |
8: 92,526,915 (GRCm39) |
D263G |
possibly damaging |
Het |
| Kif13a |
A |
G |
13: 46,927,154 (GRCm39) |
V1179A |
probably benign |
Het |
| Lrrc4c |
T |
C |
2: 97,460,393 (GRCm39) |
Y340H |
probably benign |
Het |
| Lysmd1 |
A |
G |
3: 95,045,219 (GRCm39) |
D155G |
probably damaging |
Het |
| Mical2 |
T |
A |
7: 111,980,671 (GRCm39) |
I105N |
probably damaging |
Het |
| Mob2 |
A |
T |
7: 141,563,261 (GRCm39) |
L66Q |
probably damaging |
Het |
| Myh1 |
A |
G |
11: 67,096,739 (GRCm39) |
S337G |
probably benign |
Het |
| Neb |
T |
C |
2: 52,096,259 (GRCm39) |
D1002G |
probably benign |
Het |
| Nebl |
A |
T |
2: 17,382,928 (GRCm39) |
N116K |
probably benign |
Het |
| Nkx2-6 |
T |
C |
14: 69,412,623 (GRCm39) |
S264P |
probably benign |
Het |
| Nlgn3 |
T |
C |
X: 100,352,390 (GRCm39) |
V179A |
probably damaging |
Het |
| Nlrp4e |
A |
G |
7: 23,020,556 (GRCm39) |
T348A |
possibly damaging |
Het |
| Nomo1 |
A |
T |
7: 45,722,004 (GRCm39) |
I982F |
probably benign |
Het |
| Or10j5 |
A |
G |
1: 172,784,186 (GRCm39) |
|
probably benign |
Het |
| Or11g24 |
T |
G |
14: 50,662,291 (GRCm39) |
F105C |
probably damaging |
Het |
| Or1j19 |
A |
T |
2: 36,676,621 (GRCm39) |
Y28F |
probably benign |
Het |
| Or8g22 |
A |
G |
9: 38,958,077 (GRCm39) |
F213L |
possibly damaging |
Het |
| Palld |
A |
G |
8: 62,003,198 (GRCm39) |
|
probably null |
Het |
| Pcdh7 |
A |
G |
5: 57,879,154 (GRCm39) |
Y903C |
probably damaging |
Het |
| Pknox2 |
G |
A |
9: 36,804,167 (GRCm39) |
T460M |
possibly damaging |
Het |
| Ppm1h |
C |
T |
10: 122,714,451 (GRCm39) |
T330I |
probably damaging |
Het |
| Ppp2r2b |
C |
T |
18: 42,821,399 (GRCm39) |
R253H |
probably damaging |
Het |
| Pramel58 |
G |
T |
5: 94,831,413 (GRCm39) |
R140L |
possibly damaging |
Het |
| Prr18 |
G |
A |
17: 8,560,476 (GRCm39) |
A211T |
probably benign |
Het |
| Ptgs2 |
A |
G |
1: 149,979,859 (GRCm39) |
I321M |
|
Het |
| Rara |
G |
T |
11: 98,860,989 (GRCm39) |
R159L |
probably damaging |
Het |
| Rasa4 |
T |
A |
5: 136,133,446 (GRCm39) |
I635N |
probably benign |
Het |
| Rxfp2 |
A |
T |
5: 149,989,888 (GRCm39) |
H423L |
possibly damaging |
Het |
| Scn4b |
A |
G |
9: 45,059,169 (GRCm39) |
I147V |
possibly damaging |
Het |
| Scrn3 |
G |
A |
2: 73,161,352 (GRCm39) |
V313I |
probably benign |
Het |
| Scrn3 |
C |
A |
2: 73,161,355 (GRCm39) |
P314T |
possibly damaging |
Het |
| Sh2b1 |
A |
G |
7: 126,070,292 (GRCm39) |
|
probably null |
Het |
| Slc26a10 |
T |
C |
10: 127,016,459 (GRCm39) |
Q3R |
probably benign |
Het |
| Slitrk1 |
A |
G |
14: 109,149,139 (GRCm39) |
I524T |
probably damaging |
Het |
| Smcp |
T |
A |
3: 92,491,530 (GRCm39) |
N106Y |
unknown |
Het |
| Spata31h1 |
T |
C |
10: 82,122,379 (GRCm39) |
T3544A |
probably benign |
Het |
| St8sia5 |
G |
A |
18: 77,336,172 (GRCm39) |
V202M |
probably damaging |
Het |
| Stxbp5l |
A |
T |
16: 37,028,526 (GRCm39) |
D512E |
probably damaging |
Het |
| Tas1r2 |
A |
G |
4: 139,397,046 (GRCm39) |
E795G |
probably damaging |
Het |
| Tdrd1 |
T |
A |
19: 56,831,145 (GRCm39) |
V320D |
probably damaging |
Het |
| Tmem71 |
T |
A |
15: 66,404,606 (GRCm39) |
I261L |
probably benign |
Het |
| Tns2 |
T |
C |
15: 102,020,039 (GRCm39) |
L643P |
probably damaging |
Het |
| Upf1 |
G |
A |
8: 70,786,815 (GRCm39) |
Q890* |
probably null |
Het |
| Usp43 |
A |
T |
11: 67,782,307 (GRCm39) |
H370Q |
possibly damaging |
Het |
| Vmn1r236 |
T |
A |
17: 21,507,356 (GRCm39) |
I158N |
possibly damaging |
Het |
| Vmn2r98 |
T |
A |
17: 19,286,532 (GRCm39) |
N343K |
probably benign |
Het |
| Vwa8 |
T |
C |
14: 79,329,815 (GRCm39) |
S1216P |
probably benign |
Het |
| Yars1 |
A |
C |
4: 129,090,747 (GRCm39) |
D97A |
probably damaging |
Het |
| Zer1 |
G |
A |
2: 30,001,035 (GRCm39) |
H129Y |
probably benign |
Het |
| Zfat |
C |
T |
15: 67,956,404 (GRCm39) |
D1143N |
possibly damaging |
Het |
|
| Other mutations in Adamts3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00160:Adamts3
|
APN |
5 |
90,009,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00340:Adamts3
|
APN |
5 |
89,849,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00923:Adamts3
|
APN |
5 |
89,832,235 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01420:Adamts3
|
APN |
5 |
89,850,916 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL01522:Adamts3
|
APN |
5 |
89,850,802 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01676:Adamts3
|
APN |
5 |
90,029,402 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01676:Adamts3
|
APN |
5 |
89,825,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01678:Adamts3
|
APN |
5 |
89,855,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01936:Adamts3
|
APN |
5 |
90,009,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01956:Adamts3
|
APN |
5 |
89,825,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02342:Adamts3
|
APN |
5 |
89,839,332 (GRCm39) |
splice site |
probably null |
|
|
IGL02415:Adamts3
|
APN |
5 |
89,854,506 (GRCm39) |
splice site |
probably null |
|
|
IGL03261:Adamts3
|
APN |
5 |
90,030,756 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL03301:Adamts3
|
APN |
5 |
89,855,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0041:Adamts3
|
UTSW |
5 |
89,832,326 (GRCm39) |
missense |
probably benign |
|
|
R0079:Adamts3
|
UTSW |
5 |
89,840,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0096:Adamts3
|
UTSW |
5 |
89,849,576 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Adamts3
|
UTSW |
5 |
89,849,576 (GRCm39) |
nonsense |
probably null |
|
|
R0477:Adamts3
|
UTSW |
5 |
89,832,366 (GRCm39) |
missense |
probably benign |
|
|
R0605:Adamts3
|
UTSW |
5 |
90,009,334 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1036:Adamts3
|
UTSW |
5 |
89,843,952 (GRCm39) |
splice site |
probably benign |
|
|
R1462:Adamts3
|
UTSW |
5 |
90,009,208 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1462:Adamts3
|
UTSW |
5 |
90,009,208 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1621:Adamts3
|
UTSW |
5 |
89,869,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1799:Adamts3
|
UTSW |
5 |
89,923,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2163:Adamts3
|
UTSW |
5 |
89,856,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2412:Adamts3
|
UTSW |
5 |
89,849,630 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2420:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2421:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2422:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2921:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2922:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2923:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3402:Adamts3
|
UTSW |
5 |
89,849,592 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3431:Adamts3
|
UTSW |
5 |
89,855,312 (GRCm39) |
splice site |
probably benign |
|
|
R3432:Adamts3
|
UTSW |
5 |
89,855,312 (GRCm39) |
splice site |
probably benign |
|
|
R3813:Adamts3
|
UTSW |
5 |
89,825,785 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R3816:Adamts3
|
UTSW |
5 |
89,853,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3905:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3906:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3907:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3908:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4557:Adamts3
|
UTSW |
5 |
89,848,346 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4684:Adamts3
|
UTSW |
5 |
89,850,866 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4844:Adamts3
|
UTSW |
5 |
89,825,675 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4925:Adamts3
|
UTSW |
5 |
89,832,182 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5097:Adamts3
|
UTSW |
5 |
89,840,909 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5100:Adamts3
|
UTSW |
5 |
89,856,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5237:Adamts3
|
UTSW |
5 |
89,923,236 (GRCm39) |
missense |
probably benign |
|
|
R5265:Adamts3
|
UTSW |
5 |
90,009,411 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5322:Adamts3
|
UTSW |
5 |
89,855,159 (GRCm39) |
splice site |
probably null |
|
|
R5413:Adamts3
|
UTSW |
5 |
89,856,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5459:Adamts3
|
UTSW |
5 |
89,839,332 (GRCm39) |
splice site |
probably null |
|
|
R5738:Adamts3
|
UTSW |
5 |
89,856,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5979:Adamts3
|
UTSW |
5 |
90,009,528 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5992:Adamts3
|
UTSW |
5 |
89,839,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6364:Adamts3
|
UTSW |
5 |
89,869,673 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6572:Adamts3
|
UTSW |
5 |
90,009,468 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7098:Adamts3
|
UTSW |
5 |
90,009,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7172:Adamts3
|
UTSW |
5 |
90,030,860 (GRCm39) |
start gained |
probably benign |
|
|
R7263:Adamts3
|
UTSW |
5 |
89,825,601 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7401:Adamts3
|
UTSW |
5 |
89,855,309 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7599:Adamts3
|
UTSW |
5 |
90,009,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7829:Adamts3
|
UTSW |
5 |
90,009,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Adamts3
|
UTSW |
5 |
89,848,299 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7892:Adamts3
|
UTSW |
5 |
90,009,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8021:Adamts3
|
UTSW |
5 |
89,831,043 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8289:Adamts3
|
UTSW |
5 |
89,923,282 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Adamts3
|
UTSW |
5 |
89,850,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8468:Adamts3
|
UTSW |
5 |
89,842,627 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8827:Adamts3
|
UTSW |
5 |
89,839,324 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8864:Adamts3
|
UTSW |
5 |
89,854,981 (GRCm39) |
intron |
probably benign |
|
|
R9000:Adamts3
|
UTSW |
5 |
89,854,570 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9005:Adamts3
|
UTSW |
5 |
89,825,693 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9378:Adamts3
|
UTSW |
5 |
89,848,269 (GRCm39) |
nonsense |
probably null |
|
|
R9505:Adamts3
|
UTSW |
5 |
89,855,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Adamts3
|
UTSW |
5 |
89,834,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0064:Adamts3
|
UTSW |
5 |
89,850,901 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
Z1088:Adamts3
|
UTSW |
5 |
89,832,308 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Adamts3
|
UTSW |
5 |
89,923,210 (GRCm39) |
missense |
not run |
|
|
Z1177:Adamts3
|
UTSW |
5 |
89,923,210 (GRCm39) |
missense |
not run |
|
|
Z1177:Adamts3
|
UTSW |
5 |
89,855,723 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGACGAAGGTGATCAGTCTTTATG -3'
(R):5'- CCATGTTTGGGTGACAAGTCC -3'
Sequencing Primer
(F):5'- AGGAGGATGGCACTGACTCC -3'
(R):5'- CCATATTCTGTCAAATGGAGGTGC -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation