Incidental Mutation 'R4077:Erbb4'
| ID |
316587 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| MMRRC Submission |
041622-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4077 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
68071345-69147218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 68079496 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 1195
(T1195A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114123
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119142
AA Change: T1211A
PolyPhen 2
Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
AA Change: T1211A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121473
AA Change: T1195A
PolyPhen 2
Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
AA Change: T1195A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0578 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
99% (81/82) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd12 |
T |
A |
2: 150,690,379 (GRCm39) |
|
probably null |
Het |
| Adam33 |
T |
C |
2: 130,905,444 (GRCm39) |
|
probably benign |
Het |
| Adrm1b |
A |
C |
3: 92,336,195 (GRCm39) |
|
probably benign |
Het |
| Akap8 |
C |
T |
17: 32,531,272 (GRCm39) |
R380Q |
probably damaging |
Het |
| Arhgef12 |
T |
C |
9: 42,886,588 (GRCm39) |
M1131V |
probably damaging |
Het |
| Atrn |
T |
C |
2: 130,806,850 (GRCm39) |
|
probably null |
Het |
| Btaf1 |
A |
G |
19: 36,963,879 (GRCm39) |
T817A |
probably benign |
Het |
| C3 |
C |
T |
17: 57,512,303 (GRCm39) |
D1542N |
possibly damaging |
Het |
| Cadm3 |
A |
G |
1: 173,169,236 (GRCm39) |
V293A |
probably benign |
Het |
| Cdk11b |
C |
T |
4: 155,724,204 (GRCm39) |
|
probably benign |
Het |
| Cdnf |
A |
G |
2: 3,522,060 (GRCm39) |
Y84C |
probably damaging |
Het |
| Chdh |
T |
C |
14: 29,757,297 (GRCm39) |
S407P |
probably damaging |
Het |
| Cmtr1 |
C |
A |
17: 29,904,949 (GRCm39) |
T300K |
probably damaging |
Het |
| Dennd2d |
A |
T |
3: 106,389,939 (GRCm39) |
|
probably benign |
Het |
| Diaph1 |
T |
A |
18: 37,986,636 (GRCm39) |
E1116D |
possibly damaging |
Het |
| Eif1ad3 |
A |
G |
12: 87,843,401 (GRCm39) |
K16R |
unknown |
Het |
| Eif1ad3 |
A |
T |
12: 87,843,710 (GRCm39) |
D119V |
possibly damaging |
Het |
| Enpp1 |
A |
G |
10: 24,544,905 (GRCm39) |
|
probably null |
Het |
| Ermard |
T |
A |
17: 15,273,638 (GRCm39) |
S408T |
probably benign |
Het |
| Etl4 |
A |
T |
2: 20,812,772 (GRCm39) |
R1442S |
probably damaging |
Het |
| F13b |
T |
A |
1: 139,429,508 (GRCm39) |
F9I |
unknown |
Het |
| Fnbp4 |
C |
T |
2: 90,588,821 (GRCm39) |
R531* |
probably null |
Het |
| Gdf6 |
A |
G |
4: 9,844,776 (GRCm39) |
Y100C |
probably damaging |
Het |
| Gpr3 |
T |
C |
4: 132,938,226 (GRCm39) |
T149A |
probably damaging |
Het |
| Grm8 |
T |
C |
6: 27,760,208 (GRCm39) |
H374R |
probably benign |
Het |
| Hbs1l |
T |
C |
10: 21,228,501 (GRCm39) |
V493A |
probably damaging |
Het |
| Hgs |
A |
G |
11: 120,368,202 (GRCm39) |
K277E |
probably damaging |
Het |
| Hnrnpul1 |
C |
T |
7: 25,426,300 (GRCm39) |
R517Q |
probably damaging |
Het |
| Hoxa11 |
A |
T |
6: 52,222,504 (GRCm39) |
Y66N |
probably damaging |
Het |
| Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
| Igdcc4 |
T |
A |
9: 65,039,047 (GRCm39) |
L944Q |
probably damaging |
Het |
| Ighv3-1 |
C |
A |
12: 113,928,107 (GRCm39) |
S84I |
probably damaging |
Het |
| Iqgap2 |
T |
C |
13: 95,794,375 (GRCm39) |
D1199G |
probably damaging |
Het |
| Kcnk10 |
A |
T |
12: 98,401,205 (GRCm39) |
M490K |
probably benign |
Het |
| Kirrel1 |
A |
G |
3: 86,992,387 (GRCm39) |
|
probably null |
Het |
| Lias |
A |
T |
5: 65,552,768 (GRCm39) |
T124S |
probably benign |
Het |
| Lrig3 |
A |
C |
10: 125,845,656 (GRCm39) |
E695A |
probably damaging |
Het |
| Lrpap1 |
A |
G |
5: 35,253,381 (GRCm39) |
I261T |
possibly damaging |
Het |
| Lrrc37a |
T |
A |
11: 103,388,808 (GRCm39) |
T2206S |
unknown |
Het |
| Macf1 |
T |
A |
4: 123,365,884 (GRCm39) |
Q2959L |
probably benign |
Het |
| Mis12 |
A |
G |
11: 70,916,134 (GRCm39) |
T56A |
probably benign |
Het |
| Or10ag56 |
T |
A |
2: 87,139,208 (GRCm39) |
M25K |
probably null |
Het |
| Or1l4 |
T |
A |
2: 37,092,024 (GRCm39) |
I257N |
possibly damaging |
Het |
| Or4k41 |
A |
G |
2: 111,279,848 (GRCm39) |
D121G |
probably damaging |
Het |
| Or5b99 |
T |
C |
19: 12,977,235 (GRCm39) |
V295A |
probably damaging |
Het |
| Otof |
A |
T |
5: 30,576,850 (GRCm39) |
L134Q |
possibly damaging |
Het |
| Pds5b |
T |
A |
5: 150,717,824 (GRCm39) |
V1155E |
possibly damaging |
Het |
| Pdss2 |
A |
T |
10: 43,278,518 (GRCm39) |
M342L |
probably benign |
Het |
| Phyhipl |
C |
T |
10: 70,404,903 (GRCm39) |
V57I |
probably damaging |
Het |
| Plekha5 |
T |
A |
6: 140,501,647 (GRCm39) |
|
probably null |
Het |
| Pnck |
A |
T |
X: 72,701,761 (GRCm39) |
V93E |
probably damaging |
Het |
| Proser1 |
A |
G |
3: 53,385,962 (GRCm39) |
T615A |
probably damaging |
Het |
| Ptprk |
G |
A |
10: 28,139,508 (GRCm39) |
V78I |
probably benign |
Het |
| Ptprv |
A |
G |
1: 135,038,168 (GRCm39) |
|
noncoding transcript |
Het |
| Ranbp3l |
A |
G |
15: 9,060,838 (GRCm39) |
N233S |
probably damaging |
Het |
| Rassf2 |
G |
A |
2: 131,854,522 (GRCm39) |
P7S |
probably benign |
Het |
| Sart1 |
A |
T |
19: 5,432,771 (GRCm39) |
L521Q |
possibly damaging |
Het |
| Scgb1b21 |
T |
A |
7: 33,227,118 (GRCm39) |
|
noncoding transcript |
Het |
| Scyl2 |
A |
T |
10: 89,476,458 (GRCm39) |
M889K |
probably benign |
Het |
| Secisbp2l |
A |
G |
2: 125,593,785 (GRCm39) |
|
probably benign |
Het |
| Svil |
A |
G |
18: 5,063,522 (GRCm39) |
E931G |
probably benign |
Het |
| Syce1 |
C |
A |
7: 140,359,809 (GRCm39) |
L83F |
probably damaging |
Het |
| Tdrd1 |
A |
G |
19: 56,819,505 (GRCm39) |
M2V |
probably benign |
Het |
| Tjp2 |
A |
T |
19: 24,086,182 (GRCm39) |
V780E |
possibly damaging |
Het |
| Tram1 |
A |
G |
1: 13,636,599 (GRCm39) |
V358A |
probably benign |
Het |
| Unc13c |
C |
T |
9: 73,643,821 (GRCm39) |
W1214* |
probably null |
Het |
| Vps13b |
T |
C |
15: 35,455,274 (GRCm39) |
C728R |
probably damaging |
Het |
| Wwox |
A |
G |
8: 115,166,481 (GRCm39) |
|
probably benign |
Het |
| Zbtb41 |
G |
A |
1: 139,357,064 (GRCm39) |
V440I |
probably benign |
Het |
| Zfp777 |
T |
C |
6: 48,002,456 (GRCm39) |
S589G |
probably benign |
Het |
| Zfp955a |
A |
G |
17: 33,460,675 (GRCm39) |
Y486H |
probably benign |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,110,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,337,608 (GRCm39) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,385,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,383,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,367,404 (GRCm39) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,329,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,293,722 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,293,725 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,119,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,081,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,329,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,081,596 (GRCm39) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,345,023 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,081,878 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,367,281 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,110,835 (GRCm39) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,114,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,083,119 (GRCm39) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,337,439 (GRCm39) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,298,418 (GRCm39) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,369,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,081,621 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0730:Erbb4
|
UTSW |
1 |
68,298,449 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1029:Erbb4
|
UTSW |
1 |
68,348,773 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,293,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,385,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,435,411 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,117,741 (GRCm39) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,385,728 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,079,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,370,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,114,569 (GRCm39) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,337,482 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,385,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,081,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,117,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,345,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,779,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4196:Erbb4
|
UTSW |
1 |
68,383,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,385,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,383,080 (GRCm39) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,289,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4739:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,337,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Erbb4
|
UTSW |
1 |
68,293,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Erbb4
|
UTSW |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5068:Erbb4
|
UTSW |
1 |
68,083,061 (GRCm39) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,337,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,599,678 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6189:Erbb4
|
UTSW |
1 |
68,083,075 (GRCm39) |
missense |
probably benign |
|
|
R6257:Erbb4
|
UTSW |
1 |
68,435,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,081,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,409,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,079,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,779,650 (GRCm39) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,378,619 (GRCm39) |
missense |
probably benign |
|
|
R7356:Erbb4
|
UTSW |
1 |
68,378,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7593:Erbb4
|
UTSW |
1 |
68,293,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7743:Erbb4
|
UTSW |
1 |
68,367,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,114,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,081,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,298,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,435,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,337,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,348,785 (GRCm39) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,079,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,382,997 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,289,779 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,388,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,081,601 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,329,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,081,773 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,238,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,112,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,367,418 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,337,561 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,348,802 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,329,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,298,342 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATTCTCTGCCACAATGGGG -3'
(R):5'- GGCTCTCTTGTTCTAAAGAAGTTAACC -3'
Sequencing Primer
(F):5'- GCGGATCCGTCCATTCTG -3'
(R):5'- CTTGTTCTAAAGAAGTTAACCACTGC -3'
|
| Posted On |
2015-05-15 |
Incidental Mutation