|Institutional Source||Beutler Lab|
|Gene Name||carbonic anhydrase 11|
|Is this an essential gene?||Probably non essential (E-score: 0.098)|
|Stock #||R7395 (G1)|
|Chromosomal Location||45699843-45704682 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 45701321 bp (GRCm38)|
|Amino Acid Change||Tyrosine to Stop codon at position 80 (Y80*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000003360 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000003360] [ENSMUST00000080885] [ENSMUST00000211357] [ENSMUST00000211513]|
AA Change: Y80*
AA Change: Y80*
AA Change: Y26*
|Coding Region Coverage||
|Validation Efficiency||99% (92/93)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Car11||
(F):5'- ACCCAAAGCTCCTGATTTCC -3'
(R):5'- GCTTGGGTAGACATTGGGAAGC -3'
(F):5'- CGTTTTCTTCCTTCAGCTGGGG -3'
(R):5'- CATTGGGAAGCTGAGGAAAGC -3'