Mutagenetix > Incidental Mutation

Incidental Mutation 'R8153:Vmn2r109'

633163

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r109

Ensembl Gene

ENSMUSG00000090572

Gene Name

vomeronasal 2, receptor 109

Synonyms

EG627814

MMRRC Submission

067579-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R8153 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20540517-20564756 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20564707 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 17 (V17A)

Ref Sequence

ENSEMBL: ENSMUSP00000132641 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167093]

AlphaFold

K7N747

Predicted Effect

probably benign
Transcript: ENSMUST00000167093
AA Change: V17A

PolyPhen 2 Score 0.107 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: V17A

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	1.4e-35	PFAM
Pfam:NCD3G	510	563	3.1e-21	PFAM
Pfam:7tm_3	596	831	7.4e-52	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.9%
10x: 99.5%
20x: 98.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610021A01Rik	T	A	7: 41,625,733	S287T	probably benign	Het
Abca15	T	C	7: 120,400,589	S1429P	probably damaging	Het
Arfgef2	GTGTGCAGAAACT	GT	2: 166,834,463	92	probably null	Het
C1qb	A	G	4: 136,880,566	V162A	possibly damaging	Het
Cachd1	G	T	4: 100,988,638		probably null	Het
Cfap61	T	C	2: 146,200,784	I1159T	probably benign	Het
Csf1	T	A	3: 107,748,704	D337V	probably damaging	Het
Ddhd2	T	A	8: 25,750,789	T251S	probably benign	Het
Dnah5	A	G	15: 28,384,430	T3107A	probably damaging	Het
Dnph1	T	C	17: 46,499,039	V169A	probably benign	Het
Ebf2	T	C	14: 67,390,465	V303A	probably damaging	Het
Enpp3	A	G	10: 24,809,879	F206S	probably damaging	Het
Fam151b	G	T	13: 92,477,902	T26K	probably damaging	Het
Fga	T	C	3: 83,030,857	S180P	probably damaging	Het
Fpr-rs3	A	G	17: 20,624,423	L152P	probably damaging	Het
Gen1	C	A	12: 11,260,947	G95W	probably damaging	Het
Ggta1	T	A	2: 35,423,321	T3S	possibly damaging	Het
Gm4884	T	A	7: 41,043,158	C184S	probably benign	Het
Gm5580	A	T	6: 116,552,007	I282F	probably damaging	Het
Gpr137b	T	C	13: 13,359,406	Y355C		Het
Gsx2	T	C	5: 75,077,055	S223P	probably damaging	Het
Hnf4g	C	T	3: 3,634,190		probably benign	Het
Iqub	A	C	6: 24,450,790	Y603*	probably null	Het
Klhl22	A	G	16: 17,792,550	N555S	probably damaging	Het
Lama5	T	C	2: 180,187,931	D1928G	probably benign	Het
Lamb2	C	T	9: 108,480,646	R123W	probably damaging	Het
Lamc2	CATCAGCTA	CA	1: 153,124,104		probably null	Het
Lgr4	T	A	2: 110,000,300	F255I	probably damaging	Het
Lnx2	T	C	5: 147,028,096	N439S	probably benign	Het
Lztr1	G	T	16: 17,518,575		probably null	Het
Nfkb2	G	T	19: 46,308,016	R241L	probably damaging	Het
Nrcam	T	C	12: 44,584,972	F1103L	probably benign	Het
Olfr123	A	G	17: 37,795,476	I11V	probably benign	Het
Olfr181	A	G	16: 58,925,786	S262P	possibly damaging	Het
Olfr924	A	G	9: 38,848,335	I74V	possibly damaging	Het
Olfr965	A	G	9: 39,719,658	M144V	possibly damaging	Het
Otof	C	A	5: 30,388,735	A425S	probably damaging	Het
Parg	T	A	14: 32,262,820	L774H	probably damaging	Het
Pcnx	C	T	12: 81,918,819	R59*	probably null	Het
Pcnx4	T	A	12: 72,556,243	F426L	probably benign	Het
Pde5a	T	G	3: 122,852,576	S805R	probably benign	Het
Pde5a	T	A	3: 122,852,578	M806K	probably damaging	Het
Plekhh1	T	C	12: 79,079,038	S1283P	probably benign	Het
Ppp1r12a	A	G	10: 108,162,442	K15E	probably damaging	Het
Prkdc	A	T	16: 15,664,244	M384L	probably damaging	Het
Ptchd4	A	G	17: 42,503,896	D896G	probably benign	Het
Rsf1	GGC	GGCTACGGCCGC	7: 97,579,906		probably benign	Het
Slmap	T	C	14: 26,533,333	S65G	probably benign	Het
Snta1	C	A	2: 154,380,802	L298F	probably damaging	Het
Soga3	G	T	10: 29,148,239	E384*	probably null	Het
Sphkap	T	G	1: 83,278,009	N673T	possibly damaging	Het
St8sia5	T	G	18: 77,253,111		probably null	Het
Tgm6	T	C	2: 130,145,055	V481A	probably benign	Het
Thada	T	C	17: 84,393,427	N1217S	possibly damaging	Het
Tia1	C	G	6: 86,420,332	H107D	probably damaging	Het
Ttn	A	G	2: 76,916,612	Y4698H	probably benign	Het
Ube3c	T	C	5: 29,606,931	Y390H	possibly damaging	Het
Ubqln5	A	G	7: 104,128,804	I271T	possibly damaging	Het
Xkr9	A	G	1: 13,684,139	D119G	probably benign	Het
Zfp236	C	T	18: 82,630,027	C1003Y	probably damaging	Het

Other mutations in Vmn2r109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01313:Vmn2r109	APN	17	20550157	missense	probably damaging	1.00
IGL01383:Vmn2r109	APN	17	20541121	missense	possibly damaging	0.89
IGL01469:Vmn2r109	APN	17	20541409	missense	probably damaging	1.00
IGL01762:Vmn2r109	APN	17	20554392	missense	probably benign
IGL01864:Vmn2r109	APN	17	20541134	missense	probably benign	0.28
IGL02028:Vmn2r109	APN	17	20541080	missense	probably benign	0.28
IGL02074:Vmn2r109	APN	17	20554341	missense	probably benign	0.05
IGL02162:Vmn2r109	APN	17	20554160	missense	probably benign	0.01
IGL02474:Vmn2r109	APN	17	20540888	missense	probably benign
IGL02490:Vmn2r109	APN	17	20540984	missense	possibly damaging	0.78
IGL02604:Vmn2r109	APN	17	20540701	missense	probably damaging	1.00
IGL02669:Vmn2r109	APN	17	20554256	missense	possibly damaging	0.64
IGL02705:Vmn2r109	APN	17	20553800	missense	probably benign
IGL02745:Vmn2r109	APN	17	20541250	missense	probably damaging	0.99
PIT4142001:Vmn2r109	UTSW	17	20554577	critical splice acceptor site	probably null
R0389:Vmn2r109	UTSW	17	20541074	missense	probably damaging	1.00
R0470:Vmn2r109	UTSW	17	20552886	missense	probably benign	0.06
R0570:Vmn2r109	UTSW	17	20540675	missense	probably damaging	0.99
R0855:Vmn2r109	UTSW	17	20541408	nonsense	probably null
R0882:Vmn2r109	UTSW	17	20554580	splice site	probably benign
R1241:Vmn2r109	UTSW	17	20555241	missense	possibly damaging	0.86
R1587:Vmn2r109	UTSW	17	20540740	missense	probably damaging	1.00
R1931:Vmn2r109	UTSW	17	20553810	nonsense	probably null
R1957:Vmn2r109	UTSW	17	20564707	missense	probably benign	0.11
R1962:Vmn2r109	UTSW	17	20553923	missense	probably damaging	0.99
R2020:Vmn2r109	UTSW	17	20541186	nonsense	probably null
R2073:Vmn2r109	UTSW	17	20564712	missense	probably benign	0.00
R2436:Vmn2r109	UTSW	17	20554536	missense	probably damaging	0.99
R3123:Vmn2r109	UTSW	17	20540986	missense	probably damaging	1.00
R3839:Vmn2r109	UTSW	17	20554442	missense	probably damaging	1.00
R4019:Vmn2r109	UTSW	17	20553812	missense	probably benign
R4428:Vmn2r109	UTSW	17	20553024	missense	probably benign
R4584:Vmn2r109	UTSW	17	20554558	nonsense	probably null
R4652:Vmn2r109	UTSW	17	20541394	missense	probably damaging	1.00
R4708:Vmn2r109	UTSW	17	20541343	missense	probably damaging	0.97
R4823:Vmn2r109	UTSW	17	20553891	missense	probably damaging	1.00
R4831:Vmn2r109	UTSW	17	20541232	missense	probably benign	0.01
R4907:Vmn2r109	UTSW	17	20550086	missense	probably damaging	1.00
R5011:Vmn2r109	UTSW	17	20555189	missense	probably damaging	1.00
R5296:Vmn2r109	UTSW	17	20554341	missense	possibly damaging	0.90
R5600:Vmn2r109	UTSW	17	20540927	missense	probably damaging	1.00
R5602:Vmn2r109	UTSW	17	20540671	missense	possibly damaging	0.94
R5652:Vmn2r109	UTSW	17	20540519	makesense	probably null
R5702:Vmn2r109	UTSW	17	20554145	missense	probably benign	0.42
R5706:Vmn2r109	UTSW	17	20554305	missense	probably benign	0.16
R5714:Vmn2r109	UTSW	17	20552859	missense	probably damaging	1.00
R5832:Vmn2r109	UTSW	17	20541056	missense	probably benign	0.10
R6008:Vmn2r109	UTSW	17	20540719	missense	probably damaging	1.00
R6334:Vmn2r109	UTSW	17	20541178	missense	probably benign	0.18
R6377:Vmn2r109	UTSW	17	20564534	critical splice donor site	probably null
R6738:Vmn2r109	UTSW	17	20554523	missense	possibly damaging	0.52
R6857:Vmn2r109	UTSW	17	20540670	missense	probably benign	0.45
R6953:Vmn2r109	UTSW	17	20540711	missense	possibly damaging	0.95
R7108:Vmn2r109	UTSW	17	20564744	missense	probably benign	0.03
R7229:Vmn2r109	UTSW	17	20540963	missense	possibly damaging	0.80
R7238:Vmn2r109	UTSW	17	20541074	missense	probably damaging	1.00
R7244:Vmn2r109	UTSW	17	20540683	missense	possibly damaging	0.70
R7292:Vmn2r109	UTSW	17	20541438	missense	probably benign	0.05
R7354:Vmn2r109	UTSW	17	20540781	missense	probably damaging	1.00
R7357:Vmn2r109	UTSW	17	20541274	missense	probably damaging	1.00
R7522:Vmn2r109	UTSW	17	20554403	missense	probably benign	0.11
R7596:Vmn2r109	UTSW	17	20540680	missense	probably damaging	0.98
R7728:Vmn2r109	UTSW	17	20552855	missense	probably damaging	0.99
R7859:Vmn2r109	UTSW	17	20541174	missense	probably damaging	1.00
R7871:Vmn2r109	UTSW	17	20540520	missense	probably benign	0.08
R8113:Vmn2r109	UTSW	17	20554467	missense	probably benign	0.01
R8977:Vmn2r109	UTSW	17	20554269	missense	possibly damaging	0.96
R9687:Vmn2r109	UTSW	17	20555070	missense
Z1176:Vmn2r109	UTSW	17	20552994	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CAAAGTCAGGCTGAGATTAAGTTAC -3'
(R):5'- TGAATACAGGGCCTCAGCTG -3'

Sequencing Primer
(F):5'- ATTTCATTCCCCCTGAGAGAGG -3'
(R):5'- TACAGGGCCTCAGCTGTAGAG -3'

Posted On

2020-06-30