Incidental Mutation 'R8153:Vmn2r109'
| ID |
633163 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r109
|
| Ensembl Gene |
ENSMUSG00000090572 |
| Gene Name |
vomeronasal 2, receptor 109 |
| Synonyms |
EG627814 |
| MMRRC Submission |
067579-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R8153 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20760779-20785018 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20784969 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 17
(V17A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132641
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167093]
|
| AlphaFold |
K7N747 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167093
AA Change: V17A
PolyPhen 2
Score 0.107 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: V17A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
1.4e-35 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
7.4e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610021A01Rik |
T |
A |
7: 41,275,157 (GRCm39) |
S287T |
probably benign |
Het |
| Abca15 |
T |
C |
7: 119,999,812 (GRCm39) |
S1429P |
probably damaging |
Het |
| Arfgef2 |
GTGTGCAGAAACT |
GT |
2: 166,676,383 (GRCm39) |
92 |
probably null |
Het |
| C1qb |
A |
G |
4: 136,607,877 (GRCm39) |
V162A |
possibly damaging |
Het |
| Cachd1 |
G |
T |
4: 100,845,835 (GRCm39) |
|
probably null |
Het |
| Cfap61 |
T |
C |
2: 146,042,704 (GRCm39) |
I1159T |
probably benign |
Het |
| Csf1 |
T |
A |
3: 107,656,020 (GRCm39) |
D337V |
probably damaging |
Het |
| Ddhd2 |
T |
A |
8: 26,240,816 (GRCm39) |
T251S |
probably benign |
Het |
| Dnah5 |
A |
G |
15: 28,384,576 (GRCm39) |
T3107A |
probably damaging |
Het |
| Dnph1 |
T |
C |
17: 46,809,965 (GRCm39) |
V169A |
probably benign |
Het |
| Ebf2 |
T |
C |
14: 67,627,914 (GRCm39) |
V303A |
probably damaging |
Het |
| Eif4a3l2 |
A |
T |
6: 116,528,968 (GRCm39) |
I282F |
probably damaging |
Het |
| Enpp3 |
A |
G |
10: 24,685,777 (GRCm39) |
F206S |
probably damaging |
Het |
| Fam151b |
G |
T |
13: 92,614,410 (GRCm39) |
T26K |
probably damaging |
Het |
| Fga |
T |
C |
3: 82,938,164 (GRCm39) |
S180P |
probably damaging |
Het |
| Fpr-rs3 |
A |
G |
17: 20,844,685 (GRCm39) |
L152P |
probably damaging |
Het |
| Gen1 |
C |
A |
12: 11,310,948 (GRCm39) |
G95W |
probably damaging |
Het |
| Ggta1 |
T |
A |
2: 35,313,333 (GRCm39) |
T3S |
possibly damaging |
Het |
| Gm4884 |
T |
A |
7: 40,692,582 (GRCm39) |
C184S |
probably benign |
Het |
| Gpr137b |
T |
C |
13: 13,533,991 (GRCm39) |
Y355C |
|
Het |
| Gsx2 |
T |
C |
5: 75,237,716 (GRCm39) |
S223P |
probably damaging |
Het |
| Hnf4g |
C |
T |
3: 3,699,250 (GRCm39) |
|
probably benign |
Het |
| Iqub |
A |
C |
6: 24,450,789 (GRCm39) |
Y603* |
probably null |
Het |
| Klhl22 |
A |
G |
16: 17,610,414 (GRCm39) |
N555S |
probably damaging |
Het |
| Lama5 |
T |
C |
2: 179,829,724 (GRCm39) |
D1928G |
probably benign |
Het |
| Lamb2 |
C |
T |
9: 108,357,845 (GRCm39) |
R123W |
probably damaging |
Het |
| Lamc2 |
CATCAGCTA |
CA |
1: 152,999,850 (GRCm39) |
|
probably null |
Het |
| Lgr4 |
T |
A |
2: 109,830,645 (GRCm39) |
F255I |
probably damaging |
Het |
| Lnx2 |
T |
C |
5: 146,964,906 (GRCm39) |
N439S |
probably benign |
Het |
| Lztr1 |
G |
T |
16: 17,336,439 (GRCm39) |
|
probably null |
Het |
| Mtcl3 |
G |
T |
10: 29,024,235 (GRCm39) |
E384* |
probably null |
Het |
| Nfkb2 |
G |
T |
19: 46,296,455 (GRCm39) |
R241L |
probably damaging |
Het |
| Nrcam |
T |
C |
12: 44,631,755 (GRCm39) |
F1103L |
probably benign |
Het |
| Or2g1 |
A |
G |
17: 38,106,367 (GRCm39) |
I11V |
probably benign |
Het |
| Or5k17 |
A |
G |
16: 58,746,149 (GRCm39) |
S262P |
possibly damaging |
Het |
| Or8d2 |
A |
G |
9: 38,759,631 (GRCm39) |
I74V |
possibly damaging |
Het |
| Or8g52 |
A |
G |
9: 39,630,954 (GRCm39) |
M144V |
possibly damaging |
Het |
| Otof |
C |
A |
5: 30,546,079 (GRCm39) |
A425S |
probably damaging |
Het |
| Parg |
T |
A |
14: 31,984,777 (GRCm39) |
L774H |
probably damaging |
Het |
| Pcnx1 |
C |
T |
12: 81,965,593 (GRCm39) |
R59* |
probably null |
Het |
| Pcnx4 |
T |
A |
12: 72,603,017 (GRCm39) |
F426L |
probably benign |
Het |
| Pde5a |
T |
G |
3: 122,646,225 (GRCm39) |
S805R |
probably benign |
Het |
| Pde5a |
T |
A |
3: 122,646,227 (GRCm39) |
M806K |
probably damaging |
Het |
| Plekhh1 |
T |
C |
12: 79,125,812 (GRCm39) |
S1283P |
probably benign |
Het |
| Ppp1r12a |
A |
G |
10: 107,998,303 (GRCm39) |
K15E |
probably damaging |
Het |
| Prkdc |
A |
T |
16: 15,482,108 (GRCm39) |
M384L |
probably damaging |
Het |
| Ptchd4 |
A |
G |
17: 42,814,787 (GRCm39) |
D896G |
probably benign |
Het |
| Rsf1 |
GGC |
GGCTACGGCCGC |
7: 97,229,113 (GRCm39) |
|
probably benign |
Het |
| Slmap |
T |
C |
14: 26,254,488 (GRCm39) |
S65G |
probably benign |
Het |
| Snta1 |
C |
A |
2: 154,222,722 (GRCm39) |
L298F |
probably damaging |
Het |
| Sphkap |
T |
G |
1: 83,255,730 (GRCm39) |
N673T |
possibly damaging |
Het |
| St8sia5 |
T |
G |
18: 77,340,807 (GRCm39) |
|
probably null |
Het |
| Tgm6 |
T |
C |
2: 129,986,975 (GRCm39) |
V481A |
probably benign |
Het |
| Thada |
T |
C |
17: 84,700,855 (GRCm39) |
N1217S |
possibly damaging |
Het |
| Tia1 |
C |
G |
6: 86,397,314 (GRCm39) |
H107D |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,746,956 (GRCm39) |
Y4698H |
probably benign |
Het |
| Ube3c |
T |
C |
5: 29,811,929 (GRCm39) |
Y390H |
possibly damaging |
Het |
| Ubqln5 |
A |
G |
7: 103,778,011 (GRCm39) |
I271T |
possibly damaging |
Het |
| Xkr9 |
A |
G |
1: 13,754,363 (GRCm39) |
D119G |
probably benign |
Het |
| Zfp236 |
C |
T |
18: 82,648,152 (GRCm39) |
C1003Y |
probably damaging |
Het |
|
| Other mutations in Vmn2r109 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01313:Vmn2r109
|
APN |
17 |
20,770,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01383:Vmn2r109
|
APN |
17 |
20,761,383 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01469:Vmn2r109
|
APN |
17 |
20,761,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01762:Vmn2r109
|
APN |
17 |
20,774,654 (GRCm39) |
missense |
probably benign |
|
|
IGL01864:Vmn2r109
|
APN |
17 |
20,761,396 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02028:Vmn2r109
|
APN |
17 |
20,761,342 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02074:Vmn2r109
|
APN |
17 |
20,774,603 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02162:Vmn2r109
|
APN |
17 |
20,774,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02474:Vmn2r109
|
APN |
17 |
20,761,150 (GRCm39) |
missense |
probably benign |
|
|
IGL02490:Vmn2r109
|
APN |
17 |
20,761,246 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02604:Vmn2r109
|
APN |
17 |
20,760,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02669:Vmn2r109
|
APN |
17 |
20,774,518 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02705:Vmn2r109
|
APN |
17 |
20,774,062 (GRCm39) |
missense |
probably benign |
|
|
IGL02745:Vmn2r109
|
APN |
17 |
20,761,512 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Vmn2r109
|
UTSW |
17 |
20,774,839 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0389:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0470:Vmn2r109
|
UTSW |
17 |
20,773,148 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0570:Vmn2r109
|
UTSW |
17 |
20,760,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0855:Vmn2r109
|
UTSW |
17 |
20,761,670 (GRCm39) |
nonsense |
probably null |
|
|
R0882:Vmn2r109
|
UTSW |
17 |
20,774,842 (GRCm39) |
splice site |
probably benign |
|
|
R1241:Vmn2r109
|
UTSW |
17 |
20,775,503 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1587:Vmn2r109
|
UTSW |
17 |
20,761,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Vmn2r109
|
UTSW |
17 |
20,774,072 (GRCm39) |
nonsense |
probably null |
|
|
R1957:Vmn2r109
|
UTSW |
17 |
20,784,969 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1962:Vmn2r109
|
UTSW |
17 |
20,774,185 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2020:Vmn2r109
|
UTSW |
17 |
20,761,448 (GRCm39) |
nonsense |
probably null |
|
|
R2073:Vmn2r109
|
UTSW |
17 |
20,784,974 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2436:Vmn2r109
|
UTSW |
17 |
20,774,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3123:Vmn2r109
|
UTSW |
17 |
20,761,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3839:Vmn2r109
|
UTSW |
17 |
20,774,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4019:Vmn2r109
|
UTSW |
17 |
20,774,074 (GRCm39) |
missense |
probably benign |
|
|
R4428:Vmn2r109
|
UTSW |
17 |
20,773,286 (GRCm39) |
missense |
probably benign |
|
|
R4584:Vmn2r109
|
UTSW |
17 |
20,774,820 (GRCm39) |
nonsense |
probably null |
|
|
R4652:Vmn2r109
|
UTSW |
17 |
20,761,656 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r109
|
UTSW |
17 |
20,761,605 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4823:Vmn2r109
|
UTSW |
17 |
20,774,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4831:Vmn2r109
|
UTSW |
17 |
20,761,494 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4907:Vmn2r109
|
UTSW |
17 |
20,770,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5011:Vmn2r109
|
UTSW |
17 |
20,775,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r109
|
UTSW |
17 |
20,774,603 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5600:Vmn2r109
|
UTSW |
17 |
20,761,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5602:Vmn2r109
|
UTSW |
17 |
20,760,933 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5652:Vmn2r109
|
UTSW |
17 |
20,760,781 (GRCm39) |
makesense |
probably null |
|
|
R5702:Vmn2r109
|
UTSW |
17 |
20,774,407 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5706:Vmn2r109
|
UTSW |
17 |
20,774,567 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5714:Vmn2r109
|
UTSW |
17 |
20,773,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Vmn2r109
|
UTSW |
17 |
20,761,318 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6008:Vmn2r109
|
UTSW |
17 |
20,760,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6334:Vmn2r109
|
UTSW |
17 |
20,761,440 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6377:Vmn2r109
|
UTSW |
17 |
20,784,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6738:Vmn2r109
|
UTSW |
17 |
20,774,785 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6857:Vmn2r109
|
UTSW |
17 |
20,760,932 (GRCm39) |
missense |
probably benign |
0.45 |
|
R6953:Vmn2r109
|
UTSW |
17 |
20,760,973 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7108:Vmn2r109
|
UTSW |
17 |
20,785,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7229:Vmn2r109
|
UTSW |
17 |
20,761,225 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7238:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7244:Vmn2r109
|
UTSW |
17 |
20,760,945 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7292:Vmn2r109
|
UTSW |
17 |
20,761,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7354:Vmn2r109
|
UTSW |
17 |
20,761,043 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7357:Vmn2r109
|
UTSW |
17 |
20,761,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7522:Vmn2r109
|
UTSW |
17 |
20,774,665 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7596:Vmn2r109
|
UTSW |
17 |
20,760,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7728:Vmn2r109
|
UTSW |
17 |
20,773,117 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7859:Vmn2r109
|
UTSW |
17 |
20,761,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7871:Vmn2r109
|
UTSW |
17 |
20,760,782 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8113:Vmn2r109
|
UTSW |
17 |
20,774,729 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8977:Vmn2r109
|
UTSW |
17 |
20,774,531 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R9687:Vmn2r109
|
UTSW |
17 |
20,775,332 (GRCm39) |
missense |
|
|
|
Z1176:Vmn2r109
|
UTSW |
17 |
20,773,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAAGTCAGGCTGAGATTAAGTTAC -3'
(R):5'- TGAATACAGGGCCTCAGCTG -3'
Sequencing Primer
(F):5'- ATTTCATTCCCCCTGAGAGAGG -3'
(R):5'- TACAGGGCCTCAGCTGTAGAG -3'
|
| Posted On |
2020-06-30 |
Incidental Mutation