Incidental Mutation 'R7871:Vmn2r109'
| ID |
608140 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r109
|
| Ensembl Gene |
ENSMUSG00000090572 |
| Gene Name |
vomeronasal 2, receptor 109 |
| Synonyms |
EG627814 |
| MMRRC Submission |
045923-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R7871 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20540517-20564756 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 20540520 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Methionine
at position 858
(I858M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132641
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167093]
|
| AlphaFold |
K7N747 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167093
AA Change: I858M
PolyPhen 2
Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: I858M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
1.4e-35 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
7.4e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
97% (64/66) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900026A02Rik |
A |
G |
5: 113,183,226 (GRCm38) |
S1041P |
probably benign |
Het |
| Aatf |
ACACACACACACACACACACACACACACACACACACACACACACACACAC |
ACACACACACACACACACACACACACACACACACACACACACACACACACAC |
11: 84,471,038 (GRCm38) |
|
probably null |
Het |
| Arpin |
A |
T |
7: 79,927,715 (GRCm38) |
W195R |
probably damaging |
Het |
| Asap1 |
A |
G |
15: 64,092,076 (GRCm38) |
V1091A |
probably damaging |
Het |
| Asxl3 |
A |
G |
18: 22,524,224 (GRCm38) |
T1764A |
not run |
Het |
| Bmp7 |
C |
A |
2: 172,939,991 (GRCm38) |
A27S |
probably benign |
Het |
| Ccnh |
T |
A |
13: 85,211,872 (GRCm38) |
Y297* |
probably null |
Het |
| Ccno |
C |
A |
13: 112,988,113 (GRCm38) |
D72E |
probably benign |
Het |
| Cd70 |
T |
G |
17: 57,148,770 (GRCm38) |
T67P |
probably damaging |
Het |
| Chml |
CTGTTTG |
CTG |
1: 175,687,400 (GRCm38) |
|
probably null |
Het |
| Chst4 |
A |
G |
8: 110,030,913 (GRCm38) |
F106S |
probably damaging |
Het |
| Cntnap3 |
A |
C |
13: 64,903,773 (GRCm38) |
L23R |
probably benign |
Het |
| Crybg2 |
T |
A |
4: 134,087,599 (GRCm38) |
L1288H |
probably damaging |
Het |
| Cse1l |
T |
A |
2: 166,935,671 (GRCm38) |
|
probably null |
Het |
| Cyfip2 |
T |
C |
11: 46,242,350 (GRCm38) |
H841R |
probably damaging |
Het |
| Cyp2c39 |
T |
C |
19: 39,560,961 (GRCm38) |
Y308H |
possibly damaging |
Het |
| Cyp4f18 |
G |
A |
8: 71,988,643 (GRCm38) |
P498S |
possibly damaging |
Het |
| Dennd1b |
G |
A |
1: 139,062,873 (GRCm38) |
E192K |
probably damaging |
Het |
| Dnah3 |
T |
A |
7: 119,967,552 (GRCm38) |
I97F |
|
Het |
| Entpd3 |
A |
G |
9: 120,560,586 (GRCm38) |
R313G |
possibly damaging |
Het |
| Erg28 |
G |
A |
12: 85,819,479 (GRCm38) |
T75I |
probably damaging |
Het |
| Fam171a1 |
A |
G |
2: 3,225,384 (GRCm38) |
H518R |
probably benign |
Het |
| Fam50b |
G |
A |
13: 34,747,101 (GRCm38) |
E187K |
possibly damaging |
Het |
| Galntl6 |
T |
C |
8: 57,837,188 (GRCm38) |
E457G |
probably damaging |
Het |
| Glt8d1 |
A |
T |
14: 31,010,339 (GRCm38) |
H192L |
probably damaging |
Het |
| Gm15446 |
T |
A |
5: 109,943,299 (GRCm38) |
C472* |
probably null |
Het |
| Gm28363 |
A |
T |
1: 117,697,498 (GRCm38) |
M1L |
unknown |
Het |
| Gm40460 |
CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
7: 142,240,817 (GRCm38) |
|
probably benign |
Het |
| Gstp3 |
T |
A |
19: 4,058,746 (GRCm38) |
K45* |
probably null |
Het |
| Hsd17b13 |
A |
G |
5: 103,965,815 (GRCm38) |
F258L |
possibly damaging |
Het |
| Htt |
T |
C |
5: 34,864,649 (GRCm38) |
S1646P |
probably benign |
Het |
| Ipo11 |
T |
C |
13: 106,892,468 (GRCm38) |
M326V |
probably benign |
Het |
| Itpr3 |
T |
A |
17: 27,117,179 (GRCm38) |
I2293N |
probably damaging |
Het |
| Klk8 |
A |
G |
7: 43,799,326 (GRCm38) |
|
probably null |
Het |
| Kntc1 |
T |
A |
5: 123,784,227 (GRCm38) |
L963H |
probably damaging |
Het |
| Lyst |
T |
A |
13: 13,636,052 (GRCm38) |
L769* |
probably null |
Het |
| Map3k13 |
A |
G |
16: 21,921,596 (GRCm38) |
S558G |
probably benign |
Het |
| Mbd1 |
G |
A |
18: 74,274,057 (GRCm38) |
|
probably null |
Het |
| Mep1a |
T |
C |
17: 43,479,235 (GRCm38) |
N408D |
probably benign |
Het |
| Mtrf1 |
A |
G |
14: 79,406,938 (GRCm38) |
T229A |
probably benign |
Het |
| Muc4 |
C |
T |
16: 32,754,935 (GRCm38) |
S1603L |
unknown |
Het |
| Myo1b |
A |
C |
1: 51,779,580 (GRCm38) |
I512S |
possibly damaging |
Het |
| N4bp2 |
A |
G |
5: 65,807,103 (GRCm38) |
I832V |
probably benign |
Het |
| Nadsyn1 |
T |
A |
7: 143,798,496 (GRCm38) |
K618* |
probably null |
Het |
| Ncstn |
T |
C |
1: 172,075,456 (GRCm38) |
D87G |
probably benign |
Het |
| Neurl4 |
T |
C |
11: 69,903,186 (GRCm38) |
V156A |
probably benign |
Het |
| Nfasc |
C |
A |
1: 132,600,013 (GRCm38) |
G885V |
not run |
Het |
| Nox4 |
A |
T |
7: 87,314,127 (GRCm38) |
Y180F |
possibly damaging |
Het |
| Nuggc |
A |
G |
14: 65,623,251 (GRCm38) |
T449A |
probably benign |
Het |
| Olfr799 |
A |
G |
10: 129,647,412 (GRCm38) |
I95V |
probably benign |
Het |
| Pik3r4 |
T |
C |
9: 105,663,117 (GRCm38) |
S735P |
probably damaging |
Het |
| Ppp1r9b |
T |
C |
11: 95,001,909 (GRCm38) |
I645T |
probably damaging |
Het |
| Rras2 |
G |
A |
7: 114,117,548 (GRCm38) |
|
probably benign |
Het |
| Rtel1 |
T |
C |
2: 181,321,029 (GRCm38) |
M25T |
probably damaging |
Het |
| Serpinb3c |
T |
A |
1: 107,273,153 (GRCm38) |
Y178F |
possibly damaging |
Het |
| Sh3bp2 |
A |
G |
5: 34,559,085 (GRCm38) |
H280R |
not run |
Het |
| Six4 |
CT |
C |
12: 73,104,239 (GRCm38) |
|
probably benign |
Het |
| Skor1 |
T |
C |
9: 63,146,501 (GRCm38) |
E62G |
probably damaging |
Het |
| Slc22a22 |
T |
A |
15: 57,263,355 (GRCm38) |
N106I |
possibly damaging |
Het |
| Slc44a4 |
T |
A |
17: 34,923,852 (GRCm38) |
|
probably null |
Het |
| Sppl2c |
A |
G |
11: 104,188,516 (GRCm38) |
|
probably null |
Het |
| Sptbn2 |
C |
G |
19: 4,749,012 (GRCm38) |
R2037G |
probably benign |
Het |
| Stx5a |
T |
A |
19: 8,755,118 (GRCm38) |
W384R |
unknown |
Het |
| Topaz1 |
A |
G |
9: 122,780,700 (GRCm38) |
Y1111C |
possibly damaging |
Het |
| Ttbk1 |
T |
A |
17: 46,446,238 (GRCm38) |
M1157L |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,965,137 (GRCm38) |
E632G |
unknown |
Het |
| Ttn |
T |
C |
2: 76,748,145 (GRCm38) |
T24135A |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,717,215 (GRCm38) |
T32204A |
probably benign |
Het |
| Vmn2r71 |
A |
T |
7: 85,623,661 (GRCm38) |
Q561L |
possibly damaging |
Het |
| Yme1l1 |
A |
G |
2: 23,181,065 (GRCm38) |
D271G |
probably damaging |
Het |
| Zfp629 |
A |
G |
7: 127,611,995 (GRCm38) |
F214S |
probably damaging |
Het |
| Zfp709 |
A |
G |
8: 71,889,464 (GRCm38) |
I246V |
probably benign |
Het |
|
| Other mutations in Vmn2r109 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01313:Vmn2r109
|
APN |
17 |
20,550,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01383:Vmn2r109
|
APN |
17 |
20,541,121 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
IGL01469:Vmn2r109
|
APN |
17 |
20,541,409 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01762:Vmn2r109
|
APN |
17 |
20,554,392 (GRCm38) |
missense |
probably benign |
|
|
IGL01864:Vmn2r109
|
APN |
17 |
20,541,134 (GRCm38) |
missense |
probably benign |
0.28 |
|
IGL02028:Vmn2r109
|
APN |
17 |
20,541,080 (GRCm38) |
missense |
probably benign |
0.28 |
|
IGL02074:Vmn2r109
|
APN |
17 |
20,554,341 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL02162:Vmn2r109
|
APN |
17 |
20,554,160 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02474:Vmn2r109
|
APN |
17 |
20,540,888 (GRCm38) |
missense |
probably benign |
|
|
IGL02490:Vmn2r109
|
APN |
17 |
20,540,984 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL02604:Vmn2r109
|
APN |
17 |
20,540,701 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02669:Vmn2r109
|
APN |
17 |
20,554,256 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
IGL02705:Vmn2r109
|
APN |
17 |
20,553,800 (GRCm38) |
missense |
probably benign |
|
|
IGL02745:Vmn2r109
|
APN |
17 |
20,541,250 (GRCm38) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Vmn2r109
|
UTSW |
17 |
20,554,577 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R0389:Vmn2r109
|
UTSW |
17 |
20,541,074 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0470:Vmn2r109
|
UTSW |
17 |
20,552,886 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0570:Vmn2r109
|
UTSW |
17 |
20,540,675 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0855:Vmn2r109
|
UTSW |
17 |
20,541,408 (GRCm38) |
nonsense |
probably null |
|
|
R0882:Vmn2r109
|
UTSW |
17 |
20,554,580 (GRCm38) |
splice site |
probably benign |
|
|
R1241:Vmn2r109
|
UTSW |
17 |
20,555,241 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1587:Vmn2r109
|
UTSW |
17 |
20,540,740 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1931:Vmn2r109
|
UTSW |
17 |
20,553,810 (GRCm38) |
nonsense |
probably null |
|
|
R1957:Vmn2r109
|
UTSW |
17 |
20,564,707 (GRCm38) |
missense |
probably benign |
0.11 |
|
R1962:Vmn2r109
|
UTSW |
17 |
20,553,923 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2020:Vmn2r109
|
UTSW |
17 |
20,541,186 (GRCm38) |
nonsense |
probably null |
|
|
R2073:Vmn2r109
|
UTSW |
17 |
20,564,712 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2436:Vmn2r109
|
UTSW |
17 |
20,554,536 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3123:Vmn2r109
|
UTSW |
17 |
20,540,986 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3839:Vmn2r109
|
UTSW |
17 |
20,554,442 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4019:Vmn2r109
|
UTSW |
17 |
20,553,812 (GRCm38) |
missense |
probably benign |
|
|
R4428:Vmn2r109
|
UTSW |
17 |
20,553,024 (GRCm38) |
missense |
probably benign |
|
|
R4584:Vmn2r109
|
UTSW |
17 |
20,554,558 (GRCm38) |
nonsense |
probably null |
|
|
R4652:Vmn2r109
|
UTSW |
17 |
20,541,394 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r109
|
UTSW |
17 |
20,541,343 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4823:Vmn2r109
|
UTSW |
17 |
20,553,891 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4831:Vmn2r109
|
UTSW |
17 |
20,541,232 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4907:Vmn2r109
|
UTSW |
17 |
20,550,086 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5011:Vmn2r109
|
UTSW |
17 |
20,555,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r109
|
UTSW |
17 |
20,554,341 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R5600:Vmn2r109
|
UTSW |
17 |
20,540,927 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5602:Vmn2r109
|
UTSW |
17 |
20,540,671 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5652:Vmn2r109
|
UTSW |
17 |
20,540,519 (GRCm38) |
makesense |
probably null |
|
|
R5702:Vmn2r109
|
UTSW |
17 |
20,554,145 (GRCm38) |
missense |
probably benign |
0.42 |
|
R5706:Vmn2r109
|
UTSW |
17 |
20,554,305 (GRCm38) |
missense |
probably benign |
0.16 |
|
R5714:Vmn2r109
|
UTSW |
17 |
20,552,859 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5832:Vmn2r109
|
UTSW |
17 |
20,541,056 (GRCm38) |
missense |
probably benign |
0.10 |
|
R6008:Vmn2r109
|
UTSW |
17 |
20,540,719 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6334:Vmn2r109
|
UTSW |
17 |
20,541,178 (GRCm38) |
missense |
probably benign |
0.18 |
|
R6377:Vmn2r109
|
UTSW |
17 |
20,564,534 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6738:Vmn2r109
|
UTSW |
17 |
20,554,523 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R6857:Vmn2r109
|
UTSW |
17 |
20,540,670 (GRCm38) |
missense |
probably benign |
0.45 |
|
R6953:Vmn2r109
|
UTSW |
17 |
20,540,711 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7108:Vmn2r109
|
UTSW |
17 |
20,564,744 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7229:Vmn2r109
|
UTSW |
17 |
20,540,963 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R7238:Vmn2r109
|
UTSW |
17 |
20,541,074 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7244:Vmn2r109
|
UTSW |
17 |
20,540,683 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R7292:Vmn2r109
|
UTSW |
17 |
20,541,438 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7354:Vmn2r109
|
UTSW |
17 |
20,540,781 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7357:Vmn2r109
|
UTSW |
17 |
20,541,274 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7522:Vmn2r109
|
UTSW |
17 |
20,554,403 (GRCm38) |
missense |
probably benign |
0.11 |
|
R7596:Vmn2r109
|
UTSW |
17 |
20,540,680 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7728:Vmn2r109
|
UTSW |
17 |
20,552,855 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7859:Vmn2r109
|
UTSW |
17 |
20,541,174 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8113:Vmn2r109
|
UTSW |
17 |
20,554,467 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8153:Vmn2r109
|
UTSW |
17 |
20,564,707 (GRCm38) |
missense |
probably benign |
0.11 |
|
R8977:Vmn2r109
|
UTSW |
17 |
20,554,269 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R9687:Vmn2r109
|
UTSW |
17 |
20,555,070 (GRCm38) |
missense |
|
|
|
Z1176:Vmn2r109
|
UTSW |
17 |
20,552,994 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTTTGATGCCACCAATTCATAG -3'
(R):5'- AAAGGTCATGGTGGCTATGG -3'
Sequencing Primer
(F):5'- GATCAAGAGAGCATATGTGGTTTTC -3'
(R):5'- GCTATGGAAGTCTTCTCTATCTTAGC -3'
|
| Posted On |
2019-12-20 |
Incidental Mutation