Incidental Mutation 'R6334:Vmn2r109'
| ID |
510730 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r109
|
| Ensembl Gene |
ENSMUSG00000090572 |
| Gene Name |
vomeronasal 2, receptor 109 |
| Synonyms |
EG627814 |
| MMRRC Submission |
044488-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R6334 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20760779-20785018 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 20761440 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 639
(N639S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132641
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167093]
|
| AlphaFold |
K7N747 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167093
AA Change: N639S
PolyPhen 2
Score 0.180 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: N639S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
1.4e-35 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
7.4e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
100% (64/64) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
T |
A |
11: 58,770,940 (GRCm39) |
S141T |
probably benign |
Het |
| Afap1l2 |
A |
G |
19: 56,906,408 (GRCm39) |
|
probably null |
Het |
| Aox1 |
C |
T |
1: 58,346,566 (GRCm39) |
Q567* |
probably null |
Het |
| Aqp4 |
T |
A |
18: 15,526,648 (GRCm39) |
M278L |
probably benign |
Het |
| Atp23 |
A |
C |
10: 126,723,538 (GRCm39) |
L188R |
probably benign |
Het |
| Catsperg1 |
C |
T |
7: 28,905,782 (GRCm39) |
G215D |
probably benign |
Het |
| Cavin4 |
T |
C |
4: 48,663,824 (GRCm39) |
V68A |
possibly damaging |
Het |
| Ccl4 |
T |
C |
11: 83,553,504 (GRCm39) |
S6P |
unknown |
Het |
| Cfap46 |
T |
C |
7: 139,260,747 (GRCm39) |
E117G |
probably damaging |
Het |
| Cfhr4 |
A |
G |
1: 139,701,662 (GRCm39) |
|
probably null |
Het |
| Chek1 |
A |
G |
9: 36,625,788 (GRCm39) |
S286P |
possibly damaging |
Het |
| Cntn4 |
G |
A |
6: 106,321,747 (GRCm39) |
V35I |
probably benign |
Het |
| Cntn4 |
C |
A |
6: 106,483,153 (GRCm39) |
P236Q |
probably benign |
Het |
| Cyp2d40 |
C |
A |
15: 82,645,753 (GRCm39) |
G84V |
probably benign |
Het |
| Dnah12 |
A |
T |
14: 26,427,989 (GRCm39) |
H205L |
possibly damaging |
Het |
| Dock1 |
G |
A |
7: 134,453,305 (GRCm39) |
V845I |
probably benign |
Het |
| Drg1 |
T |
C |
11: 3,216,292 (GRCm39) |
K7E |
possibly damaging |
Het |
| Eloa |
G |
A |
4: 135,737,133 (GRCm39) |
P488S |
probably damaging |
Het |
| Evi5 |
G |
A |
5: 107,968,387 (GRCm39) |
R187* |
probably null |
Het |
| Fam53a |
T |
A |
5: 33,758,219 (GRCm39) |
L301F |
probably damaging |
Het |
| Fmnl3 |
T |
C |
15: 99,235,534 (GRCm39) |
K63E |
probably damaging |
Het |
| Gast |
C |
A |
11: 100,227,438 (GRCm39) |
Q44K |
probably benign |
Het |
| Gng10 |
T |
A |
4: 59,035,257 (GRCm39) |
V7E |
probably benign |
Het |
| Gtf3c5 |
G |
A |
2: 28,460,474 (GRCm39) |
T375I |
probably benign |
Het |
| Haus5 |
C |
T |
7: 30,358,401 (GRCm39) |
W298* |
probably null |
Het |
| Hspa14 |
A |
T |
2: 3,490,109 (GRCm39) |
|
probably null |
Het |
| Kcna3 |
T |
C |
3: 106,943,740 (GRCm39) |
M1T |
probably null |
Het |
| Kcnj15 |
T |
G |
16: 95,097,095 (GRCm39) |
L239R |
probably damaging |
Het |
| Klhl2 |
G |
T |
8: 65,212,842 (GRCm39) |
D232E |
probably benign |
Het |
| Lamb3 |
A |
T |
1: 193,017,782 (GRCm39) |
I888F |
probably damaging |
Het |
| Lars1 |
C |
A |
18: 42,350,551 (GRCm39) |
M919I |
probably benign |
Het |
| Lfng |
T |
C |
5: 140,598,522 (GRCm39) |
V247A |
possibly damaging |
Het |
| Lrp1b |
C |
T |
2: 41,679,045 (GRCm39) |
A16T |
probably benign |
Het |
| Mamdc2 |
A |
T |
19: 23,341,270 (GRCm39) |
I235N |
probably damaging |
Het |
| Map9 |
T |
A |
3: 82,290,612 (GRCm39) |
L492Q |
probably damaging |
Het |
| Mcpt8 |
A |
G |
14: 56,322,604 (GRCm39) |
V14A |
possibly damaging |
Het |
| Myo1b |
T |
C |
1: 51,807,810 (GRCm39) |
K823R |
probably null |
Het |
| Nbea |
G |
T |
3: 55,944,570 (GRCm39) |
T598K |
probably damaging |
Het |
| Nrcam |
C |
A |
12: 44,619,083 (GRCm39) |
H877N |
probably benign |
Het |
| Nrxn2 |
T |
C |
19: 6,581,322 (GRCm39) |
|
probably null |
Het |
| Nwd2 |
A |
T |
5: 63,957,596 (GRCm39) |
I309F |
possibly damaging |
Het |
| Phyhd1 |
G |
A |
2: 30,164,736 (GRCm39) |
|
probably null |
Het |
| Pkp2 |
C |
T |
16: 16,043,933 (GRCm39) |
T229I |
probably damaging |
Het |
| Plagl2 |
G |
A |
2: 153,074,611 (GRCm39) |
P97S |
probably benign |
Het |
| Plekhh2 |
C |
A |
17: 84,874,294 (GRCm39) |
N526K |
probably benign |
Het |
| Plin4 |
A |
G |
17: 56,410,261 (GRCm39) |
L1217P |
probably benign |
Het |
| Polr3e |
T |
C |
7: 120,527,222 (GRCm39) |
S67P |
possibly damaging |
Het |
| Postn |
A |
G |
3: 54,292,703 (GRCm39) |
K757E |
probably benign |
Het |
| Prpf39 |
T |
A |
12: 65,089,587 (GRCm39) |
|
probably null |
Het |
| Ptprg |
C |
T |
14: 12,166,832 (GRCm38) |
T745I |
probably damaging |
Het |
| Pxylp1 |
C |
G |
9: 96,707,307 (GRCm39) |
A292P |
probably damaging |
Het |
| Rpl35 |
G |
T |
2: 38,891,754 (GRCm39) |
D82E |
possibly damaging |
Het |
| Slc9a1 |
G |
A |
4: 133,149,519 (GRCm39) |
V782I |
possibly damaging |
Het |
| Syn2 |
T |
A |
6: 115,240,875 (GRCm39) |
M415K |
possibly damaging |
Het |
| Tmem117 |
A |
C |
15: 94,909,324 (GRCm39) |
I246L |
probably benign |
Het |
| Tmem221 |
A |
T |
8: 72,011,428 (GRCm39) |
V9E |
probably damaging |
Het |
| Trav13-5 |
A |
G |
14: 54,033,399 (GRCm39) |
T103A |
probably damaging |
Het |
| Ubxn7 |
T |
A |
16: 32,191,007 (GRCm39) |
|
probably null |
Het |
| Vmn2r101 |
G |
T |
17: 19,810,112 (GRCm39) |
M299I |
possibly damaging |
Het |
| Vmn2r103 |
T |
A |
17: 20,014,344 (GRCm39) |
S379T |
probably damaging |
Het |
| Wdr26 |
T |
C |
1: 181,030,771 (GRCm39) |
|
|
Het |
| Zfp109 |
T |
A |
7: 23,928,308 (GRCm39) |
Y367F |
probably damaging |
Het |
| Zfp143 |
G |
A |
7: 109,685,338 (GRCm39) |
C389Y |
probably damaging |
Het |
| Zfp553 |
G |
T |
7: 126,836,064 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r109 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01313:Vmn2r109
|
APN |
17 |
20,770,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01383:Vmn2r109
|
APN |
17 |
20,761,383 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01469:Vmn2r109
|
APN |
17 |
20,761,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01762:Vmn2r109
|
APN |
17 |
20,774,654 (GRCm39) |
missense |
probably benign |
|
|
IGL01864:Vmn2r109
|
APN |
17 |
20,761,396 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02028:Vmn2r109
|
APN |
17 |
20,761,342 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02074:Vmn2r109
|
APN |
17 |
20,774,603 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02162:Vmn2r109
|
APN |
17 |
20,774,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02474:Vmn2r109
|
APN |
17 |
20,761,150 (GRCm39) |
missense |
probably benign |
|
|
IGL02490:Vmn2r109
|
APN |
17 |
20,761,246 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02604:Vmn2r109
|
APN |
17 |
20,760,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02669:Vmn2r109
|
APN |
17 |
20,774,518 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02705:Vmn2r109
|
APN |
17 |
20,774,062 (GRCm39) |
missense |
probably benign |
|
|
IGL02745:Vmn2r109
|
APN |
17 |
20,761,512 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Vmn2r109
|
UTSW |
17 |
20,774,839 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0389:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0470:Vmn2r109
|
UTSW |
17 |
20,773,148 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0570:Vmn2r109
|
UTSW |
17 |
20,760,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0855:Vmn2r109
|
UTSW |
17 |
20,761,670 (GRCm39) |
nonsense |
probably null |
|
|
R0882:Vmn2r109
|
UTSW |
17 |
20,774,842 (GRCm39) |
splice site |
probably benign |
|
|
R1241:Vmn2r109
|
UTSW |
17 |
20,775,503 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1587:Vmn2r109
|
UTSW |
17 |
20,761,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Vmn2r109
|
UTSW |
17 |
20,774,072 (GRCm39) |
nonsense |
probably null |
|
|
R1957:Vmn2r109
|
UTSW |
17 |
20,784,969 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1962:Vmn2r109
|
UTSW |
17 |
20,774,185 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2020:Vmn2r109
|
UTSW |
17 |
20,761,448 (GRCm39) |
nonsense |
probably null |
|
|
R2073:Vmn2r109
|
UTSW |
17 |
20,784,974 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2436:Vmn2r109
|
UTSW |
17 |
20,774,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3123:Vmn2r109
|
UTSW |
17 |
20,761,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3839:Vmn2r109
|
UTSW |
17 |
20,774,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4019:Vmn2r109
|
UTSW |
17 |
20,774,074 (GRCm39) |
missense |
probably benign |
|
|
R4428:Vmn2r109
|
UTSW |
17 |
20,773,286 (GRCm39) |
missense |
probably benign |
|
|
R4584:Vmn2r109
|
UTSW |
17 |
20,774,820 (GRCm39) |
nonsense |
probably null |
|
|
R4652:Vmn2r109
|
UTSW |
17 |
20,761,656 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r109
|
UTSW |
17 |
20,761,605 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4823:Vmn2r109
|
UTSW |
17 |
20,774,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4831:Vmn2r109
|
UTSW |
17 |
20,761,494 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4907:Vmn2r109
|
UTSW |
17 |
20,770,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5011:Vmn2r109
|
UTSW |
17 |
20,775,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r109
|
UTSW |
17 |
20,774,603 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5600:Vmn2r109
|
UTSW |
17 |
20,761,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5602:Vmn2r109
|
UTSW |
17 |
20,760,933 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5652:Vmn2r109
|
UTSW |
17 |
20,760,781 (GRCm39) |
makesense |
probably null |
|
|
R5702:Vmn2r109
|
UTSW |
17 |
20,774,407 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5706:Vmn2r109
|
UTSW |
17 |
20,774,567 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5714:Vmn2r109
|
UTSW |
17 |
20,773,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Vmn2r109
|
UTSW |
17 |
20,761,318 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6008:Vmn2r109
|
UTSW |
17 |
20,760,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6377:Vmn2r109
|
UTSW |
17 |
20,784,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6738:Vmn2r109
|
UTSW |
17 |
20,774,785 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6857:Vmn2r109
|
UTSW |
17 |
20,760,932 (GRCm39) |
missense |
probably benign |
0.45 |
|
R6953:Vmn2r109
|
UTSW |
17 |
20,760,973 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7108:Vmn2r109
|
UTSW |
17 |
20,785,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7229:Vmn2r109
|
UTSW |
17 |
20,761,225 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7238:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7244:Vmn2r109
|
UTSW |
17 |
20,760,945 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7292:Vmn2r109
|
UTSW |
17 |
20,761,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7354:Vmn2r109
|
UTSW |
17 |
20,761,043 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7357:Vmn2r109
|
UTSW |
17 |
20,761,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7522:Vmn2r109
|
UTSW |
17 |
20,774,665 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7596:Vmn2r109
|
UTSW |
17 |
20,760,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7728:Vmn2r109
|
UTSW |
17 |
20,773,117 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7859:Vmn2r109
|
UTSW |
17 |
20,761,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7871:Vmn2r109
|
UTSW |
17 |
20,760,782 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8113:Vmn2r109
|
UTSW |
17 |
20,774,729 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8153:Vmn2r109
|
UTSW |
17 |
20,784,969 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8977:Vmn2r109
|
UTSW |
17 |
20,774,531 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R9687:Vmn2r109
|
UTSW |
17 |
20,775,332 (GRCm39) |
missense |
|
|
|
Z1176:Vmn2r109
|
UTSW |
17 |
20,773,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGTTGCCATCCATATTCCACAAAG -3'
(R):5'- TCTGTCCTACAAAGACCCGTTG -3'
Sequencing Primer
(F):5'- CCATATTCCACAAAGAAGAAGTTGG -3'
(R):5'- TTGGGGGTGACACTAGCCAAC -3'
|
| Posted On |
2018-04-02 |
Incidental Mutation