Incidental Mutation 'R0415:Plxna1'
| ID |
40232 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxna1
|
| Ensembl Gene |
ENSMUSG00000030084 |
| Gene Name |
plexin A1 |
| Synonyms |
NOV, PlexA1, Plxn1, 2600013D04Rik |
| MMRRC Submission |
038617-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.888)
|
| Stock # |
R0415 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
89293295-89339595 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 89334318 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Tyrosine
at position 104
(H104Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000063066
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049845]
[ENSMUST00000163139]
|
| AlphaFold |
P70206 |
| PDB Structure |
The Plexin A1 intracellular region in complex with Rac1 [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049845
AA Change: H104Y
PolyPhen 2
Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000063066
Gene: ENSMUSG00000030084
AA Change: H104Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
Sema
|
49 |
494 |
7.43e-126 |
SMART |
|
PSI
|
512 |
562 |
6.4e-11 |
SMART |
|
PSI
|
658 |
705 |
9.78e-7 |
SMART |
|
low complexity region
|
759 |
772 |
N/A |
INTRINSIC |
|
PSI
|
806 |
860 |
7.24e-10 |
SMART |
|
IPT
|
861 |
957 |
3.2e-26 |
SMART |
|
IPT
|
958 |
1043 |
1.59e-21 |
SMART |
|
IPT
|
1045 |
1145 |
6.86e-26 |
SMART |
|
IPT
|
1147 |
1242 |
1.64e-5 |
SMART |
|
transmembrane domain
|
1243 |
1265 |
N/A |
INTRINSIC |
|
Pfam:Plexin_cytopl
|
1316 |
1864 |
8.8e-263 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163139
AA Change: H104Y
PolyPhen 2
Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000131840
Gene: ENSMUSG00000030084
AA Change: H104Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
Sema
|
49 |
494 |
7.43e-126 |
SMART |
|
PSI
|
512 |
562 |
6.4e-11 |
SMART |
|
PSI
|
658 |
705 |
9.78e-7 |
SMART |
|
low complexity region
|
759 |
772 |
N/A |
INTRINSIC |
|
PSI
|
806 |
860 |
7.24e-10 |
SMART |
|
IPT
|
861 |
957 |
3.2e-26 |
SMART |
|
IPT
|
958 |
1043 |
1.59e-21 |
SMART |
|
IPT
|
1045 |
1145 |
6.86e-26 |
SMART |
|
IPT
|
1147 |
1242 |
1.64e-5 |
SMART |
|
transmembrane domain
|
1243 |
1265 |
N/A |
INTRINSIC |
|
Pfam:Plexin_cytopl
|
1315 |
1864 |
2.5e-264 |
PFAM |
|
| Meta Mutation Damage Score |
0.1593 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.6%
|
| Validation Efficiency |
97% (99/102) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit bone cellularity abnormalities, altered dendritic cell physiology, abnormal proprioceptive and oligodendrocyte morphology, and increased lymphatic branching complexity and LEC numbers. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933427G23Rik |
A |
T |
5: 24,036,048 (GRCm39) |
|
noncoding transcript |
Het |
| Acox2 |
A |
G |
14: 8,243,835 (GRCm38) |
|
probably benign |
Het |
| Adgb |
T |
C |
10: 10,306,811 (GRCm39) |
|
probably null |
Het |
| Adgra3 |
C |
A |
5: 50,119,099 (GRCm39) |
|
probably benign |
Het |
| Adgre4 |
G |
A |
17: 56,159,288 (GRCm39) |
V658I |
probably benign |
Het |
| Ahnak |
A |
G |
19: 8,990,235 (GRCm39) |
|
probably benign |
Het |
| Anapc2 |
A |
G |
2: 25,168,337 (GRCm39) |
T159A |
probably damaging |
Het |
| Arfgef3 |
A |
G |
10: 18,488,875 (GRCm39) |
|
probably benign |
Het |
| Atf7ip |
C |
T |
6: 136,537,010 (GRCm39) |
S81L |
possibly damaging |
Het |
| Cacna1i |
A |
G |
15: 80,253,031 (GRCm39) |
|
probably benign |
Het |
| Camk1 |
A |
T |
6: 113,318,852 (GRCm39) |
Y20* |
probably null |
Het |
| Ccdc40 |
T |
C |
11: 119,122,944 (GRCm39) |
Y249H |
possibly damaging |
Het |
| Cd109 |
T |
A |
9: 78,619,897 (GRCm39) |
S1380T |
probably benign |
Het |
| Cfap57 |
A |
T |
4: 118,426,628 (GRCm39) |
L1107Q |
possibly damaging |
Het |
| Col6a4 |
C |
T |
9: 105,952,279 (GRCm39) |
V540I |
probably damaging |
Het |
| Cst9 |
T |
A |
2: 148,680,362 (GRCm39) |
|
probably benign |
Het |
| Cul5 |
C |
T |
9: 53,578,370 (GRCm39) |
V73I |
probably benign |
Het |
| Cxcl16 |
T |
A |
11: 70,349,574 (GRCm39) |
K84* |
probably null |
Het |
| Cyp2c29 |
T |
C |
19: 39,317,539 (GRCm39) |
|
probably benign |
Het |
| D6Ertd527e |
C |
G |
6: 87,088,506 (GRCm39) |
T223S |
unknown |
Het |
| Dip2c |
C |
T |
13: 9,618,325 (GRCm39) |
|
probably benign |
Het |
| Dis3 |
A |
T |
14: 99,324,892 (GRCm39) |
I513N |
probably damaging |
Het |
| Dnajc16 |
A |
T |
4: 141,516,359 (GRCm39) |
L3* |
probably null |
Het |
| Dop1a |
T |
A |
9: 86,388,555 (GRCm39) |
L480M |
probably damaging |
Het |
| Eml6 |
A |
G |
11: 29,699,392 (GRCm39) |
V1787A |
possibly damaging |
Het |
| Etnk1 |
A |
G |
6: 143,126,500 (GRCm39) |
N115S |
probably damaging |
Het |
| Fryl |
T |
C |
5: 73,255,757 (GRCm39) |
Y758C |
probably damaging |
Het |
| Gbp4 |
G |
A |
5: 105,268,972 (GRCm39) |
R394C |
possibly damaging |
Het |
| Ggnbp2 |
A |
C |
11: 84,724,051 (GRCm39) |
|
probably benign |
Het |
| Gm7137 |
A |
G |
10: 77,624,007 (GRCm39) |
|
probably benign |
Het |
| Gstm2 |
T |
A |
3: 107,891,322 (GRCm39) |
Q132L |
probably benign |
Het |
| Habp2 |
T |
C |
19: 56,306,149 (GRCm39) |
|
probably benign |
Het |
| Hectd2 |
T |
C |
19: 36,562,284 (GRCm39) |
|
probably benign |
Het |
| Htr6 |
A |
G |
4: 138,789,392 (GRCm39) |
I291T |
possibly damaging |
Het |
| Ighg2c |
T |
C |
12: 113,251,530 (GRCm39) |
D199G |
unknown |
Het |
| Itih2 |
A |
G |
2: 10,110,426 (GRCm39) |
|
probably benign |
Het |
| Kcnab2 |
A |
G |
4: 152,479,593 (GRCm39) |
F248S |
probably benign |
Het |
| Kcnc4 |
T |
C |
3: 107,352,749 (GRCm39) |
K610E |
probably damaging |
Het |
| Kcnk16 |
T |
A |
14: 20,313,043 (GRCm39) |
|
probably null |
Het |
| Kndc1 |
C |
T |
7: 139,510,037 (GRCm39) |
T1293I |
probably damaging |
Het |
| Lcp1 |
A |
T |
14: 75,464,446 (GRCm39) |
I556F |
possibly damaging |
Het |
| Lrrc8d |
T |
C |
5: 105,959,731 (GRCm39) |
L47P |
probably damaging |
Het |
| Lyset |
T |
A |
12: 102,711,135 (GRCm39) |
Y119* |
probably null |
Het |
| Lyst |
T |
C |
13: 13,886,195 (GRCm39) |
|
probably benign |
Het |
| Macrod2 |
G |
A |
2: 142,052,065 (GRCm39) |
|
probably null |
Het |
| Mical2 |
C |
T |
7: 111,980,235 (GRCm39) |
R70C |
probably damaging |
Het |
| Mllt3 |
ACTGCTGCTGCTGCTGCTGCT |
ACTGCTGCTGCTGCTGCT |
4: 87,759,576 (GRCm39) |
|
probably benign |
Het |
| Msh3 |
A |
G |
13: 92,483,294 (GRCm39) |
V283A |
possibly damaging |
Het |
| Nup205 |
T |
C |
6: 35,191,569 (GRCm39) |
|
probably benign |
Het |
| Nxpe2 |
T |
C |
9: 48,237,914 (GRCm39) |
T114A |
probably damaging |
Het |
| Or51e2 |
C |
T |
7: 102,391,294 (GRCm39) |
M305I |
probably benign |
Het |
| Or5m10 |
A |
T |
2: 85,717,782 (GRCm39) |
I213F |
possibly damaging |
Het |
| Or5m9 |
A |
T |
2: 85,877,399 (GRCm39) |
H191L |
probably benign |
Het |
| Or8c15 |
A |
T |
9: 38,121,269 (GRCm39) |
M305L |
probably benign |
Het |
| Or8g2 |
A |
G |
9: 39,821,279 (GRCm39) |
Y60C |
probably damaging |
Het |
| Pard3 |
G |
A |
8: 128,337,047 (GRCm39) |
G1221D |
probably damaging |
Het |
| Pax5 |
G |
A |
4: 44,691,886 (GRCm39) |
A120V |
probably damaging |
Het |
| Pcsk6 |
C |
T |
7: 65,683,622 (GRCm39) |
R746C |
probably damaging |
Het |
| Pif1 |
G |
A |
9: 65,495,333 (GRCm39) |
C81Y |
probably benign |
Het |
| Plcb1 |
A |
G |
2: 135,179,419 (GRCm39) |
Y609C |
probably damaging |
Het |
| Plcd4 |
C |
A |
1: 74,591,256 (GRCm39) |
S217Y |
probably damaging |
Het |
| Polr2k |
A |
G |
15: 36,175,602 (GRCm39) |
Y45C |
probably damaging |
Het |
| Prex1 |
A |
G |
2: 166,428,619 (GRCm39) |
|
probably benign |
Het |
| Pth2r |
A |
G |
1: 65,427,598 (GRCm39) |
M424V |
probably benign |
Het |
| Pygm |
A |
G |
19: 6,441,396 (GRCm39) |
R464G |
probably benign |
Het |
| Rad51c |
A |
G |
11: 87,288,481 (GRCm39) |
L234P |
probably damaging |
Het |
| Rnf145 |
A |
G |
11: 44,415,965 (GRCm39) |
Y60C |
probably damaging |
Het |
| Rnf167 |
T |
C |
11: 70,540,525 (GRCm39) |
I135T |
probably damaging |
Het |
| Rnf213 |
A |
T |
11: 119,305,295 (GRCm39) |
I509F |
probably damaging |
Het |
| Ro60 |
G |
T |
1: 143,635,813 (GRCm39) |
N444K |
probably benign |
Het |
| Ryr2 |
T |
C |
13: 11,884,042 (GRCm39) |
S213G |
probably damaging |
Het |
| Selenbp1 |
T |
C |
3: 94,844,224 (GRCm39) |
V27A |
possibly damaging |
Het |
| Selenof |
T |
G |
3: 144,283,453 (GRCm39) |
L14R |
probably damaging |
Het |
| Sfswap |
A |
T |
5: 129,581,190 (GRCm39) |
D121V |
probably damaging |
Het |
| Slc25a34 |
C |
A |
4: 141,347,780 (GRCm39) |
M300I |
possibly damaging |
Het |
| Slc34a3 |
T |
G |
2: 25,119,122 (GRCm39) |
T583P |
probably benign |
Het |
| Slc66a3 |
C |
A |
12: 17,047,711 (GRCm39) |
|
probably benign |
Het |
| Smg1 |
C |
A |
7: 117,781,691 (GRCm39) |
A1199S |
probably benign |
Het |
| Spint1 |
A |
G |
2: 119,076,096 (GRCm39) |
T231A |
probably damaging |
Het |
| Sptbn1 |
A |
C |
11: 30,099,576 (GRCm39) |
N229K |
probably damaging |
Het |
| Sult2b1 |
A |
G |
7: 45,379,516 (GRCm39) |
|
probably benign |
Het |
| Tas2r123 |
A |
T |
6: 132,824,801 (GRCm39) |
M233L |
probably damaging |
Het |
| Tbcel |
C |
A |
9: 42,355,796 (GRCm39) |
C139F |
probably benign |
Het |
| Thbs2 |
A |
C |
17: 14,900,235 (GRCm39) |
S573A |
probably benign |
Het |
| Tmem132c |
A |
G |
5: 127,640,769 (GRCm39) |
E980G |
probably damaging |
Het |
| Tmem247 |
G |
T |
17: 87,229,750 (GRCm39) |
C197F |
probably damaging |
Het |
| Tmem43 |
C |
A |
6: 91,459,300 (GRCm39) |
P257Q |
probably benign |
Het |
| Tmprss13 |
A |
G |
9: 45,248,430 (GRCm39) |
|
probably null |
Het |
| Ubr5 |
T |
C |
15: 37,973,224 (GRCm39) |
T2626A |
probably damaging |
Het |
| Vmn1r196 |
T |
A |
13: 22,478,006 (GRCm39) |
V215D |
probably damaging |
Het |
| Vmn1r22 |
G |
T |
6: 57,877,317 (GRCm39) |
T220K |
probably benign |
Het |
| Vmn2r116 |
G |
A |
17: 23,606,253 (GRCm39) |
M388I |
possibly damaging |
Het |
| Vmn2r74 |
A |
C |
7: 85,610,618 (GRCm39) |
C25G |
probably damaging |
Het |
| Xndc1 |
T |
C |
7: 101,729,823 (GRCm39) |
|
probably benign |
Het |
| Zfp282 |
A |
G |
6: 47,874,815 (GRCm39) |
D340G |
probably damaging |
Het |
| Zfp282 |
T |
A |
6: 47,881,987 (GRCm39) |
I558N |
possibly damaging |
Het |
| Zfp316 |
T |
A |
5: 143,250,246 (GRCm39) |
T56S |
unknown |
Het |
| Zfp345 |
A |
G |
2: 150,316,479 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Plxna1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00427:Plxna1
|
APN |
6 |
89,297,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01358:Plxna1
|
APN |
6 |
89,299,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01475:Plxna1
|
APN |
6 |
89,331,870 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL01480:Plxna1
|
APN |
6 |
89,321,078 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL01585:Plxna1
|
APN |
6 |
89,306,538 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01804:Plxna1
|
APN |
6 |
89,306,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01909:Plxna1
|
APN |
6 |
89,309,066 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01989:Plxna1
|
APN |
6 |
89,306,396 (GRCm39) |
nonsense |
probably null |
|
|
IGL02015:Plxna1
|
APN |
6 |
89,319,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02023:Plxna1
|
APN |
6 |
89,334,314 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02668:Plxna1
|
APN |
6 |
89,334,251 (GRCm39) |
nonsense |
probably null |
|
|
IGL02703:Plxna1
|
APN |
6 |
89,333,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02954:Plxna1
|
APN |
6 |
89,301,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03212:Plxna1
|
APN |
6 |
89,308,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4544001:Plxna1
|
UTSW |
6 |
89,334,411 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0055:Plxna1
|
UTSW |
6 |
89,306,721 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0055:Plxna1
|
UTSW |
6 |
89,306,721 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0147:Plxna1
|
UTSW |
6 |
89,297,692 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0149:Plxna1
|
UTSW |
6 |
89,297,595 (GRCm39) |
missense |
probably null |
0.95 |
|
R0166:Plxna1
|
UTSW |
6 |
89,310,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0200:Plxna1
|
UTSW |
6 |
89,300,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0841:Plxna1
|
UTSW |
6 |
89,309,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1018:Plxna1
|
UTSW |
6 |
89,319,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1240:Plxna1
|
UTSW |
6 |
89,298,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1355:Plxna1
|
UTSW |
6 |
89,297,748 (GRCm39) |
unclassified |
probably benign |
|
|
R1700:Plxna1
|
UTSW |
6 |
89,333,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1776:Plxna1
|
UTSW |
6 |
89,312,446 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1957:Plxna1
|
UTSW |
6 |
89,308,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2314:Plxna1
|
UTSW |
6 |
89,301,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2968:Plxna1
|
UTSW |
6 |
89,319,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3118:Plxna1
|
UTSW |
6 |
89,333,958 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3522:Plxna1
|
UTSW |
6 |
89,314,335 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3619:Plxna1
|
UTSW |
6 |
89,334,435 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3766:Plxna1
|
UTSW |
6 |
89,311,757 (GRCm39) |
unclassified |
probably benign |
|
|
R3847:Plxna1
|
UTSW |
6 |
89,333,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3849:Plxna1
|
UTSW |
6 |
89,333,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3872:Plxna1
|
UTSW |
6 |
89,309,674 (GRCm39) |
nonsense |
probably null |
|
|
R4555:Plxna1
|
UTSW |
6 |
89,300,310 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4709:Plxna1
|
UTSW |
6 |
89,311,733 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4726:Plxna1
|
UTSW |
6 |
89,299,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4739:Plxna1
|
UTSW |
6 |
89,309,657 (GRCm39) |
splice site |
probably null |
|
|
R5053:Plxna1
|
UTSW |
6 |
89,299,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5221:Plxna1
|
UTSW |
6 |
89,297,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5449:Plxna1
|
UTSW |
6 |
89,300,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5480:Plxna1
|
UTSW |
6 |
89,301,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5575:Plxna1
|
UTSW |
6 |
89,301,523 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5743:Plxna1
|
UTSW |
6 |
89,333,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5744:Plxna1
|
UTSW |
6 |
89,311,664 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5754:Plxna1
|
UTSW |
6 |
89,310,087 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5868:Plxna1
|
UTSW |
6 |
89,299,704 (GRCm39) |
splice site |
probably benign |
|
|
R5988:Plxna1
|
UTSW |
6 |
89,334,522 (GRCm39) |
nonsense |
probably null |
|
|
R6190:Plxna1
|
UTSW |
6 |
89,333,586 (GRCm39) |
nonsense |
probably null |
|
|
R6425:Plxna1
|
UTSW |
6 |
89,311,647 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6561:Plxna1
|
UTSW |
6 |
89,333,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6623:Plxna1
|
UTSW |
6 |
89,299,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6638:Plxna1
|
UTSW |
6 |
89,301,382 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6701:Plxna1
|
UTSW |
6 |
89,296,430 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6825:Plxna1
|
UTSW |
6 |
89,297,597 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6911:Plxna1
|
UTSW |
6 |
89,297,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7073:Plxna1
|
UTSW |
6 |
89,334,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7177:Plxna1
|
UTSW |
6 |
89,300,311 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7235:Plxna1
|
UTSW |
6 |
89,317,573 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7419:Plxna1
|
UTSW |
6 |
89,334,584 (GRCm39) |
missense |
unknown |
|
|
R7511:Plxna1
|
UTSW |
6 |
89,318,889 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7543:Plxna1
|
UTSW |
6 |
89,299,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7665:Plxna1
|
UTSW |
6 |
89,301,520 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7678:Plxna1
|
UTSW |
6 |
89,308,882 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7748:Plxna1
|
UTSW |
6 |
89,314,335 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7748:Plxna1
|
UTSW |
6 |
89,314,334 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7877:Plxna1
|
UTSW |
6 |
89,300,241 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8025:Plxna1
|
UTSW |
6 |
89,308,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8171:Plxna1
|
UTSW |
6 |
89,334,102 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8277:Plxna1
|
UTSW |
6 |
89,334,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8782:Plxna1
|
UTSW |
6 |
89,300,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8867:Plxna1
|
UTSW |
6 |
89,310,079 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9245:Plxna1
|
UTSW |
6 |
89,314,320 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9253:Plxna1
|
UTSW |
6 |
89,334,522 (GRCm39) |
nonsense |
probably null |
|
|
R9269:Plxna1
|
UTSW |
6 |
89,306,541 (GRCm39) |
missense |
probably null |
1.00 |
|
R9273:Plxna1
|
UTSW |
6 |
89,296,364 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9281:Plxna1
|
UTSW |
6 |
89,300,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9368:Plxna1
|
UTSW |
6 |
89,314,138 (GRCm39) |
missense |
probably benign |
|
|
R9440:Plxna1
|
UTSW |
6 |
89,318,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9526:Plxna1
|
UTSW |
6 |
89,319,633 (GRCm39) |
missense |
probably benign |
|
|
R9601:Plxna1
|
UTSW |
6 |
89,308,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9714:Plxna1
|
UTSW |
6 |
89,296,440 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9782:Plxna1
|
UTSW |
6 |
89,333,817 (GRCm39) |
missense |
probably benign |
0.01 |
|
S24628:Plxna1
|
UTSW |
6 |
89,334,318 (GRCm39) |
missense |
probably benign |
0.12 |
|
V8831:Plxna1
|
UTSW |
6 |
89,334,119 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Plxna1
|
UTSW |
6 |
89,298,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCAAACATGTCAGCATCTTCCTC -3'
(R):5'- ACCTGGTGGTTCACGAACAGACAG -3'
Sequencing Primer
(F):5'- TGTGCCCACGAAGAGCTTG -3'
(R):5'- CAGACAGGAGAGGTATATGTTGG -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation