Mutagenetix > Incidental Mutation

Incidental Mutation 'R1078:Utrn'

85737

Institutional Source

Beutler Lab

Gene Symbol

Utrn

Ensembl Gene

ENSMUSG00000019820

Gene Name

utrophin

Synonyms

G-utrophin, DRP, Dmdl

MMRRC Submission

039164-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1078 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

12382188-12869365 bp(-) (GRCm38)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

T to G at 12455566 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000151628 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076817] [ENSMUST00000217994] [ENSMUST00000218635] [ENSMUST00000219003]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000076817

SMART Domains

Protein: ENSMUSP00000076093
Gene: ENSMUSG00000019820

Domain	Start	End	E-Value	Type
CH	33	133	1.87e-24	SMART
CH	152	250	4.05e-20	SMART
SPEC	312	416	2.31e-18	SMART
SPEC	421	525	4.18e-16	SMART
SPEC	532	636	3.35e-6	SMART
low complexity region	665	679	N/A	INTRINSIC
SPEC	690	795	1.7e-7	SMART
SPEC	801	901	1e-4	SMART
SPEC	910	1012	8.24e-2	SMART
SPEC	1019	1121	1.32e-4	SMART
SPEC	1128	1229	2.64e-4	SMART
SPEC	1236	1333	4.42e-6	SMART
coiled coil region	1375	1401	N/A	INTRINSIC
SPEC	1438	1540	3.62e-2	SMART
SPEC	1547	1648	7.95e-1	SMART
SPEC	1655	1752	3.56e0	SMART
coiled coil region	1766	1795	N/A	INTRINSIC
SPEC	1870	1972	3.63e0	SMART
SPEC	1979	2080	5.15e-16	SMART
SPEC	2087	2183	3.71e0	SMART
SPEC	2227	2330	4.7e-10	SMART
SPEC	2337	2437	1.02e0	SMART
SPEC	2444	2553	2.35e-10	SMART
SPEC	2560	2685	8.77e-10	SMART
SPEC	2692	2794	4.13e-6	SMART
WW	2811	2843	5.59e-7	SMART
Pfam:EF-hand_2	2844	2962	3.8e-41	PFAM
Pfam:EF-hand_3	2966	3057	1.6e-39	PFAM
ZnF_ZZ	3062	3107	6.33e-17	SMART
coiled coil region	3250	3289	N/A	INTRINSIC
coiled coil region	3310	3354	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000217994

Predicted Effect

probably null
Transcript: ENSMUST00000218635

Predicted Effect

probably null
Transcript: ENSMUST00000219003

Meta Mutation Damage Score

0.9590

Coding Region Coverage

1x: 99.7%
3x: 99.1%
10x: 97.4%
20x: 94.4%

Validation Efficiency

96% (53/55)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants have reduced density of acetylcholine receptors and reduced number of junctional folds at neuromuscular junctions. Mice homozygous for utrophin and dystrophin knockouts die prematurely with severe, progressive muscular dystrophy. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610010F05Rik	A	C	11: 23,611,762 (GRCm38)	I358S	probably benign	Het
9130230L23Rik	T	C	5: 65,988,355 (GRCm38)	T138A	unknown	Het
Abi3bp	T	C	16: 56,654,081 (GRCm38)		probably null	Het
Alpk3	A	T	7: 81,078,600 (GRCm38)	M493L	probably benign	Het
Bace2	C	T	16: 97,356,860 (GRCm38)	A20V	unknown	Het
Bms1	T	C	6: 118,405,221 (GRCm38)	D452G	probably benign	Het
Ccdc187	T	C	2: 26,294,377 (GRCm38)	T3A	probably damaging	Het
Ctu2	T	C	8: 122,481,499 (GRCm38)	V95A	possibly damaging	Het
Cyp2a5	A	G	7: 26,835,541 (GRCm38)	K60E	probably benign	Het
Cyp4f13	T	C	17: 32,925,568 (GRCm38)	H318R	probably damaging	Het
Dlgap5	G	A	14: 47,399,566 (GRCm38)	T485M	probably damaging	Het
Dsp	C	T	13: 38,183,106 (GRCm38)		probably benign	Het
Ell2	T	C	13: 75,746,419 (GRCm38)		probably benign	Het
Eml2	A	T	7: 19,179,762 (GRCm38)	Y168F	probably benign	Het
Ep400	C	T	5: 110,735,522 (GRCm38)		probably benign	Het
Ercc4	C	A	16: 13,130,197 (GRCm38)	A336D	probably benign	Het
Fam189a2	T	A	19: 23,973,575 (GRCm38)	R547S	probably benign	Het
Fat4	T	C	3: 38,983,086 (GRCm38)	L3629S	probably benign	Het
Gabbr2	C	T	4: 46,664,833 (GRCm38)	R925H	probably damaging	Het
Gfi1b	A	T	2: 28,613,865 (GRCm38)	W108R	probably damaging	Het
Gtse1	C	T	15: 85,862,307 (GRCm38)	P108L	probably damaging	Het
Hfm1	A	T	5: 106,878,830 (GRCm38)	F140I	probably damaging	Het
Hyal2	T	A	9: 107,572,246 (GRCm38)	H400Q	probably benign	Het
Igfn1	A	G	1: 135,974,847 (GRCm38)	Y371H	probably damaging	Het
Iltifb	T	G	10: 118,290,151 (GRCm38)	*180C	probably null	Het
Kdm2b	T	C	5: 122,961,541 (GRCm38)	T118A	possibly damaging	Het
Lama5	A	T	2: 180,179,764 (GRCm38)		probably benign	Het
Lgr6	C	T	1: 134,994,010 (GRCm38)	A199T	probably damaging	Het
Lmo7	C	T	14: 101,920,474 (GRCm38)		probably benign	Het
Lrrc37a	G	T	11: 103,497,631 (GRCm38)	P2323T	unknown	Het
Lrrc38	A	G	4: 143,350,518 (GRCm38)	Y117C	probably benign	Het
Myo1e	T	C	9: 70,383,999 (GRCm38)	V1024A	probably benign	Het
Myrfl	T	C	10: 116,776,732 (GRCm38)	N904S	possibly damaging	Het
Olfr1015	T	C	2: 85,786,093 (GRCm38)	V194A	possibly damaging	Het
Olfr103	T	A	17: 37,337,026 (GRCm38)	I69F	probably damaging	Het
Olfr1297	T	C	2: 111,621,345 (GRCm38)	H243R	probably damaging	Het
Pld4	A	T	12: 112,763,442 (GRCm38)	I53F	probably benign	Het
Plekhg4	T	A	8: 105,381,677 (GRCm38)	C1117*	probably null	Het
Prss39	G	A	1: 34,502,086 (GRCm38)	E224K	probably benign	Het
Psme1	G	T	14: 55,580,650 (GRCm38)	G149V	probably damaging	Het
Soat2	T	A	15: 102,153,138 (GRCm38)		probably null	Het
Stab2	C	T	10: 86,907,133 (GRCm38)		probably null	Het
Tcf7l2	A	G	19: 55,743,195 (GRCm38)	T127A	probably benign	Het
Tcp1	T	C	17: 12,923,204 (GRCm38)		probably benign	Het
Thbs4	G	A	13: 92,762,926 (GRCm38)		probably benign	Het
Tmf1	T	C	6: 97,173,300 (GRCm38)	D482G	probably damaging	Het
Trim66	G	T	7: 109,472,319 (GRCm38)	P591H	probably damaging	Het
Umodl1	T	C	17: 30,959,373 (GRCm38)	S108P	probably benign	Het
Unc79	T	G	12: 103,074,853 (GRCm38)	M715R	probably benign	Het
Usp34	C	A	11: 23,433,175 (GRCm38)		probably benign	Het
Zfp830	T	C	11: 82,765,339 (GRCm38)		probably null	Het

Other mutations in Utrn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Utrn	APN	10	12,671,830 (GRCm38)	missense	probably damaging	1.00
IGL00469:Utrn	APN	10	12,406,529 (GRCm38)	missense	probably damaging	1.00
IGL00518:Utrn	APN	10	12,666,843 (GRCm38)	splice site	probably benign
IGL00560:Utrn	APN	10	12,455,467 (GRCm38)	nonsense	probably null
IGL00589:Utrn	APN	10	12,678,618 (GRCm38)	missense	possibly damaging	0.53
IGL00662:Utrn	APN	10	12,664,961 (GRCm38)	missense	probably damaging	0.99
IGL00754:Utrn	APN	10	12,663,492 (GRCm38)	missense	probably benign	0.05
IGL00772:Utrn	APN	10	12,649,185 (GRCm38)	missense	probably benign
IGL00775:Utrn	APN	10	12,745,230 (GRCm38)	critical splice donor site	probably null
IGL00782:Utrn	APN	10	12,652,811 (GRCm38)	missense	probably benign	0.13
IGL00962:Utrn	APN	10	12,481,334 (GRCm38)	missense	possibly damaging	0.80
IGL01584:Utrn	APN	10	12,726,367 (GRCm38)	missense	probably benign	0.01
IGL01677:Utrn	APN	10	12,744,157 (GRCm38)	missense	probably damaging	1.00
IGL01695:Utrn	APN	10	12,745,342 (GRCm38)	missense	probably benign	0.00
IGL01743:Utrn	APN	10	12,711,557 (GRCm38)	missense	possibly damaging	0.94
IGL01815:Utrn	APN	10	12,652,716 (GRCm38)	missense	probably benign	0.00
IGL01901:Utrn	APN	10	12,640,928 (GRCm38)	missense	probably damaging	1.00
IGL01982:Utrn	APN	10	12,748,029 (GRCm38)	missense	probably damaging	1.00
IGL01983:Utrn	APN	10	12,669,781 (GRCm38)	missense	probably benign	0.18
IGL02031:Utrn	APN	10	12,735,204 (GRCm38)	missense	probably damaging	1.00
IGL02106:Utrn	APN	10	12,413,973 (GRCm38)	missense	possibly damaging	0.92
IGL02134:Utrn	APN	10	12,643,419 (GRCm38)	missense	probably damaging	0.99
IGL02209:Utrn	APN	10	12,683,295 (GRCm38)	missense	probably damaging	0.97
IGL02217:Utrn	APN	10	12,751,559 (GRCm38)	missense	probably damaging	1.00
IGL02250:Utrn	APN	10	12,436,391 (GRCm38)	missense	probably damaging	1.00
IGL02307:Utrn	APN	10	12,750,065 (GRCm38)	nonsense	probably null
IGL02386:Utrn	APN	10	12,421,608 (GRCm38)	missense	possibly damaging	0.91
IGL02494:Utrn	APN	10	12,710,054 (GRCm38)	missense	probably benign
IGL02631:Utrn	APN	10	12,710,063 (GRCm38)	missense	probably benign	0.00
IGL02729:Utrn	APN	10	12,720,810 (GRCm38)	unclassified	probably benign
IGL02736:Utrn	APN	10	12,421,640 (GRCm38)	missense	probably damaging	1.00
IGL02832:Utrn	APN	10	12,738,193 (GRCm38)	missense	possibly damaging	0.82
IGL02926:Utrn	APN	10	12,690,760 (GRCm38)	missense	probably damaging	0.96
IGL03184:Utrn	APN	10	12,710,166 (GRCm38)	missense	probably benign	0.04
IGL03194:Utrn	APN	10	12,406,429 (GRCm38)	splice site	probably benign
IGL03346:Utrn	APN	10	12,525,352 (GRCm38)	missense	probably benign	0.22
retiring	UTSW	10	12,641,020 (GRCm38)	missense	probably damaging	1.00
shrinking_violet	UTSW	10	12,711,585 (GRCm38)	critical splice acceptor site	probably null
Wallflower	UTSW	10	12,747,975 (GRCm38)	missense	probably damaging	1.00
FR4548:Utrn	UTSW	10	12,633,941 (GRCm38)	critical splice donor site	probably benign
I2288:Utrn	UTSW	10	12,421,640 (GRCm38)	missense	probably damaging	1.00
PIT4677001:Utrn	UTSW	10	12,666,704 (GRCm38)	missense	probably benign	0.06
R0022:Utrn	UTSW	10	12,709,956 (GRCm38)	splice site	probably benign
R0024:Utrn	UTSW	10	12,406,011 (GRCm38)	missense	probably benign	0.00
R0024:Utrn	UTSW	10	12,406,011 (GRCm38)	missense	probably benign	0.00
R0026:Utrn	UTSW	10	12,726,196 (GRCm38)	splice site	probably benign
R0026:Utrn	UTSW	10	12,726,196 (GRCm38)	splice site	probably benign
R0091:Utrn	UTSW	10	12,735,204 (GRCm38)	missense	probably damaging	1.00
R0112:Utrn	UTSW	10	12,686,465 (GRCm38)	nonsense	probably null
R0126:Utrn	UTSW	10	12,711,475 (GRCm38)	missense	probably benign	0.02
R0184:Utrn	UTSW	10	12,667,618 (GRCm38)	missense	probably benign
R0219:Utrn	UTSW	10	12,684,451 (GRCm38)	missense	probably damaging	1.00
R0369:Utrn	UTSW	10	12,634,022 (GRCm38)	missense	probably benign	0.37
R0390:Utrn	UTSW	10	12,710,060 (GRCm38)	missense	probably benign	0.05
R0391:Utrn	UTSW	10	12,525,333 (GRCm38)	splice site	probably benign
R0408:Utrn	UTSW	10	12,384,190 (GRCm38)	makesense	probably null
R0409:Utrn	UTSW	10	12,643,601 (GRCm38)	missense	probably benign	0.01
R0441:Utrn	UTSW	10	12,688,294 (GRCm38)	missense	probably null	0.88
R0504:Utrn	UTSW	10	12,402,895 (GRCm38)	missense	probably benign	0.02
R0730:Utrn	UTSW	10	12,698,158 (GRCm38)	splice site	probably benign
R1171:Utrn	UTSW	10	12,481,308 (GRCm38)	missense	probably damaging	0.99
R1191:Utrn	UTSW	10	12,634,033 (GRCm38)	missense	probably benign	0.02
R1203:Utrn	UTSW	10	12,486,537 (GRCm38)	missense	probably damaging	1.00
R1401:Utrn	UTSW	10	12,649,153 (GRCm38)	missense	probably benign
R1418:Utrn	UTSW	10	12,713,350 (GRCm38)	missense	probably benign
R1439:Utrn	UTSW	10	12,744,049 (GRCm38)	missense	possibly damaging	0.79
R1441:Utrn	UTSW	10	12,683,295 (GRCm38)	missense	probably damaging	0.97
R1445:Utrn	UTSW	10	12,678,574 (GRCm38)	splice site	probably benign
R1509:Utrn	UTSW	10	12,455,441 (GRCm38)	missense	possibly damaging	0.91
R1546:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R1585:Utrn	UTSW	10	12,436,285 (GRCm38)	missense	possibly damaging	0.62
R1621:Utrn	UTSW	10	12,713,283 (GRCm38)	missense	probably benign	0.24
R1637:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R1703:Utrn	UTSW	10	12,727,729 (GRCm38)	splice site	probably benign
R1725:Utrn	UTSW	10	12,663,519 (GRCm38)	missense	probably damaging	0.99
R1735:Utrn	UTSW	10	12,710,138 (GRCm38)	missense	probably benign
R1770:Utrn	UTSW	10	12,475,296 (GRCm38)	missense	probably damaging	0.98
R1778:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R1783:Utrn	UTSW	10	12,463,339 (GRCm38)	missense	probably damaging	1.00
R1818:Utrn	UTSW	10	12,709,964 (GRCm38)	critical splice donor site	probably null
R1829:Utrn	UTSW	10	12,475,274 (GRCm38)	missense	probably damaging	1.00
R1919:Utrn	UTSW	10	12,455,480 (GRCm38)	missense	probably benign	0.15
R1964:Utrn	UTSW	10	12,684,437 (GRCm38)	missense	probably damaging	1.00
R2080:Utrn	UTSW	10	12,737,082 (GRCm38)	missense	probably benign	0.36
R2092:Utrn	UTSW	10	12,678,698 (GRCm38)	missense	probably benign	0.12
R2107:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R2108:Utrn	UTSW	10	12,436,364 (GRCm38)	missense	probably damaging	1.00
R2760:Utrn	UTSW	10	12,690,878 (GRCm38)	missense	probably damaging	1.00
R2884:Utrn	UTSW	10	12,739,361 (GRCm38)	splice site	probably null
R2885:Utrn	UTSW	10	12,739,361 (GRCm38)	splice site	probably null
R2886:Utrn	UTSW	10	12,739,361 (GRCm38)	splice site	probably null
R2903:Utrn	UTSW	10	12,643,428 (GRCm38)	missense	probably damaging	1.00
R2944:Utrn	UTSW	10	12,643,419 (GRCm38)	missense	probably damaging	1.00
R2945:Utrn	UTSW	10	12,486,391 (GRCm38)	missense	possibly damaging	0.50
R3438:Utrn	UTSW	10	12,481,318 (GRCm38)	missense	probably damaging	0.98
R3683:Utrn	UTSW	10	12,666,835 (GRCm38)	missense	probably benign	0.10
R3735:Utrn	UTSW	10	12,478,484 (GRCm38)	missense	probably damaging	1.00
R3907:Utrn	UTSW	10	12,710,182 (GRCm38)	splice site	probably benign
R3923:Utrn	UTSW	10	12,739,479 (GRCm38)	missense	probably benign	0.23
R3925:Utrn	UTSW	10	12,698,042 (GRCm38)	missense	probably benign
R3926:Utrn	UTSW	10	12,698,042 (GRCm38)	missense	probably benign
R3938:Utrn	UTSW	10	12,750,030 (GRCm38)	critical splice donor site	probably null
R3941:Utrn	UTSW	10	12,711,585 (GRCm38)	critical splice acceptor site	probably null
R3958:Utrn	UTSW	10	12,750,108 (GRCm38)	missense	probably damaging	1.00
R4091:Utrn	UTSW	10	12,710,171 (GRCm38)	missense	probably benign	0.10
R4454:Utrn	UTSW	10	12,727,840 (GRCm38)	missense	possibly damaging	0.81
R4585:Utrn	UTSW	10	12,688,306 (GRCm38)	missense	probably benign	0.01
R4667:Utrn	UTSW	10	12,698,053 (GRCm38)	missense	probably benign	0.22
R4684:Utrn	UTSW	10	12,745,240 (GRCm38)	missense	probably damaging	1.00
R4782:Utrn	UTSW	10	12,750,069 (GRCm38)	missense	probably damaging	1.00
R4785:Utrn	UTSW	10	12,654,745 (GRCm38)	missense	probably benign	0.39
R4799:Utrn	UTSW	10	12,750,069 (GRCm38)	missense	probably damaging	1.00
R4829:Utrn	UTSW	10	12,663,461 (GRCm38)	missense	probably benign	0.00
R4878:Utrn	UTSW	10	12,727,758 (GRCm38)	missense	probably damaging	1.00
R4955:Utrn	UTSW	10	12,861,567 (GRCm38)	critical splice donor site	probably null
R4967:Utrn	UTSW	10	12,455,420 (GRCm38)	missense	probably damaging	0.99
R5071:Utrn	UTSW	10	12,384,204 (GRCm38)	splice site	probably null
R5072:Utrn	UTSW	10	12,384,204 (GRCm38)	splice site	probably null
R5186:Utrn	UTSW	10	12,728,777 (GRCm38)	missense	probably damaging	1.00
R5213:Utrn	UTSW	10	12,636,760 (GRCm38)	missense	probably damaging	1.00
R5296:Utrn	UTSW	10	12,401,355 (GRCm38)	missense	probably damaging	1.00
R5309:Utrn	UTSW	10	12,727,769 (GRCm38)	missense	probably damaging	1.00
R5312:Utrn	UTSW	10	12,727,769 (GRCm38)	missense	probably damaging	1.00
R5399:Utrn	UTSW	10	12,640,983 (GRCm38)	missense	probably damaging	1.00
R5407:Utrn	UTSW	10	12,680,625 (GRCm38)	missense	probably damaging	1.00
R5411:Utrn	UTSW	10	12,649,185 (GRCm38)	missense	probably benign
R5428:Utrn	UTSW	10	12,693,431 (GRCm38)	missense	probably benign	0.09
R5595:Utrn	UTSW	10	12,682,318 (GRCm38)	missense	possibly damaging	0.89
R5602:Utrn	UTSW	10	12,750,095 (GRCm38)	missense	probably damaging	1.00
R5608:Utrn	UTSW	10	12,671,837 (GRCm38)	missense	probably benign	0.00
R5678:Utrn	UTSW	10	12,442,018 (GRCm38)	missense	probably damaging	1.00
R5726:Utrn	UTSW	10	12,669,806 (GRCm38)	missense	probably benign
R5804:Utrn	UTSW	10	12,421,625 (GRCm38)	missense	probably damaging	1.00
R5916:Utrn	UTSW	10	12,665,051 (GRCm38)	missense	probably damaging	0.97
R5941:Utrn	UTSW	10	12,486,483 (GRCm38)	missense	probably damaging	1.00
R6014:Utrn	UTSW	10	12,690,876 (GRCm38)	missense	probably benign	0.01
R6015:Utrn	UTSW	10	12,478,424 (GRCm38)	missense	possibly damaging	0.85
R6028:Utrn	UTSW	10	12,654,716 (GRCm38)	missense	probably benign	0.00
R6158:Utrn	UTSW	10	12,690,822 (GRCm38)	missense	probably benign	0.04
R6181:Utrn	UTSW	10	12,739,456 (GRCm38)	missense	probably damaging	1.00
R6300:Utrn	UTSW	10	12,501,476 (GRCm38)	missense	probably benign	0.35
R6367:Utrn	UTSW	10	12,747,975 (GRCm38)	missense	probably damaging	1.00
R6377:Utrn	UTSW	10	12,744,083 (GRCm38)	missense	probably damaging	1.00
R6434:Utrn	UTSW	10	12,525,427 (GRCm38)	missense	probably damaging	1.00
R6498:Utrn	UTSW	10	12,442,093 (GRCm38)	missense	probably benign
R6579:Utrn	UTSW	10	12,748,006 (GRCm38)	missense	probably benign	0.05
R6704:Utrn	UTSW	10	12,745,291 (GRCm38)	missense	probably damaging	0.99
R6736:Utrn	UTSW	10	12,621,303 (GRCm38)	missense	probably benign	0.09
R6755:Utrn	UTSW	10	12,699,087 (GRCm38)	missense	probably benign	0.00
R6793:Utrn	UTSW	10	12,699,100 (GRCm38)	missense	possibly damaging	0.69
R6793:Utrn	UTSW	10	12,640,925 (GRCm38)	critical splice donor site	probably null
R6835:Utrn	UTSW	10	12,727,764 (GRCm38)	missense	probably damaging	1.00
R6919:Utrn	UTSW	10	12,693,470 (GRCm38)	nonsense	probably null
R6920:Utrn	UTSW	10	12,750,470 (GRCm38)	missense	probably damaging	0.98
R7037:Utrn	UTSW	10	12,826,770 (GRCm38)	splice site	probably null
R7038:Utrn	UTSW	10	12,682,338 (GRCm38)	missense	probably damaging	1.00
R7055:Utrn	UTSW	10	12,747,921 (GRCm38)	missense	probably benign	0.23
R7072:Utrn	UTSW	10	12,465,213 (GRCm38)	missense	probably damaging	1.00
R7090:Utrn	UTSW	10	12,684,516 (GRCm38)	missense	possibly damaging	0.58
R7211:Utrn	UTSW	10	12,401,335 (GRCm38)	missense	possibly damaging	0.72
R7248:Utrn	UTSW	10	12,728,818 (GRCm38)	missense	possibly damaging	0.51
R7305:Utrn	UTSW	10	12,385,536 (GRCm38)	missense	probably benign
R7334:Utrn	UTSW	10	12,728,009 (GRCm38)	splice site	probably null
R7348:Utrn	UTSW	10	12,748,018 (GRCm38)	missense	probably damaging	1.00
R7375:Utrn	UTSW	10	12,641,020 (GRCm38)	missense	probably damaging	1.00
R7436:Utrn	UTSW	10	12,439,791 (GRCm38)	missense	possibly damaging	0.72
R7476:Utrn	UTSW	10	12,640,951 (GRCm38)	missense	probably benign
R7514:Utrn	UTSW	10	12,698,089 (GRCm38)	missense	probably benign	0.00
R7527:Utrn	UTSW	10	12,401,382 (GRCm38)	missense	possibly damaging	0.81
R7735:Utrn	UTSW	10	12,744,043 (GRCm38)	critical splice donor site	probably null
R7748:Utrn	UTSW	10	12,614,508 (GRCm38)	missense	probably benign	0.01
R7778:Utrn	UTSW	10	12,486,610 (GRCm38)	missense	probably damaging	1.00
R7824:Utrn	UTSW	10	12,486,610 (GRCm38)	missense	probably damaging	1.00
R7826:Utrn	UTSW	10	12,401,306 (GRCm38)	splice site	probably null
R7872:Utrn	UTSW	10	12,698,129 (GRCm38)	missense	probably benign
R7915:Utrn	UTSW	10	12,465,212 (GRCm38)	missense	probably damaging	1.00
R7922:Utrn	UTSW	10	12,667,527 (GRCm38)	missense	possibly damaging	0.68
R8081:Utrn	UTSW	10	12,548,059 (GRCm38)	start gained	probably benign
R8132:Utrn	UTSW	10	12,682,410 (GRCm38)	missense	probably damaging	0.99
R8167:Utrn	UTSW	10	12,671,814 (GRCm38)	nonsense	probably null
R8186:Utrn	UTSW	10	12,698,123 (GRCm38)	missense	probably benign
R8331:Utrn	UTSW	10	12,614,619 (GRCm38)	missense	probably benign	0.00
R8352:Utrn	UTSW	10	12,813,509 (GRCm38)	missense	probably benign	0.34
R8408:Utrn	UTSW	10	12,670,143 (GRCm38)	missense	possibly damaging	0.69
R8452:Utrn	UTSW	10	12,813,509 (GRCm38)	missense	probably benign	0.34
R8478:Utrn	UTSW	10	12,649,148 (GRCm38)	missense	probably benign
R8489:Utrn	UTSW	10	12,711,446 (GRCm38)	missense	probably benign	0.05
R8516:Utrn	UTSW	10	12,486,510 (GRCm38)	missense	probably damaging	0.99
R8520:Utrn	UTSW	10	12,670,186 (GRCm38)	nonsense	probably null
R8550:Utrn	UTSW	10	12,813,585 (GRCm38)	intron	probably benign
R8856:Utrn	UTSW	10	12,667,607 (GRCm38)	missense	probably benign
R8881:Utrn	UTSW	10	12,547,993 (GRCm38)	missense	possibly damaging	0.46
R9180:Utrn	UTSW	10	12,669,719 (GRCm38)	missense	probably damaging	1.00
R9186:Utrn	UTSW	10	12,614,574 (GRCm38)	missense	probably benign
R9216:Utrn	UTSW	10	12,813,485 (GRCm38)	missense	probably benign	0.19
R9251:Utrn	UTSW	10	12,636,787 (GRCm38)	missense	probably benign	0.01
R9273:Utrn	UTSW	10	12,633,963 (GRCm38)	missense	probably damaging	0.97
R9307:Utrn	UTSW	10	12,678,731 (GRCm38)	missense	probably benign	0.02
R9344:Utrn	UTSW	10	12,684,531 (GRCm38)	missense	probably benign	0.17
R9419:Utrn	UTSW	10	12,688,381 (GRCm38)	missense	probably damaging	1.00
R9435:Utrn	UTSW	10	12,643,429 (GRCm38)	missense	probably damaging	1.00
R9623:Utrn	UTSW	10	12,406,481 (GRCm38)	missense	probably damaging	1.00
R9650:Utrn	UTSW	10	12,738,185 (GRCm38)	missense	probably benign	0.00
R9653:Utrn	UTSW	10	12,663,445 (GRCm38)	missense	probably benign	0.41
R9653:Utrn	UTSW	10	12,621,379 (GRCm38)	missense	probably benign	0.17
R9672:Utrn	UTSW	10	12,727,869 (GRCm38)	missense	possibly damaging	0.68
R9678:Utrn	UTSW	10	12,739,415 (GRCm38)	missense	probably benign	0.00
R9741:Utrn	UTSW	10	12,826,820 (GRCm38)	missense	probably benign
R9765:Utrn	UTSW	10	12,735,177 (GRCm38)	missense	probably damaging	0.99
R9799:Utrn	UTSW	10	12,709,992 (GRCm38)	missense	probably benign	0.01
RF009:Utrn	UTSW	10	12,633,945 (GRCm38)	nonsense	probably null
V1662:Utrn	UTSW	10	12,421,640 (GRCm38)	missense	probably damaging	1.00
X0018:Utrn	UTSW	10	12,735,198 (GRCm38)	missense	probably damaging	1.00
Z1176:Utrn	UTSW	10	12,688,429 (GRCm38)	critical splice acceptor site	probably null
Z1176:Utrn	UTSW	10	12,682,360 (GRCm38)	nonsense	probably null
Z1177:Utrn	UTSW	10	12,621,379 (GRCm38)	missense	probably benign	0.17
Z1177:Utrn	UTSW	10	12,525,406 (GRCm38)	nonsense	probably null
Z1186:Utrn	UTSW	10	12,669,747 (GRCm38)	missense	probably damaging	1.00
Z1189:Utrn	UTSW	10	12,669,747 (GRCm38)	missense	probably damaging	1.00
Z1191:Utrn	UTSW	10	12,669,747 (GRCm38)	missense	probably damaging	1.00
Z1192:Utrn	UTSW	10	12,669,747 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACACATATCGACGCAGAGTGGAAC -3'
(R):5'- GTGAGCTAACATGAGGTGACCAGTG -3'

Sequencing Primer
(F):5'- GGAACATTGACCAAGTCCTTGTG -3'
(R):5'- TTCTGTACTGAAAAACACAGAGCG -3'

Posted On

2013-11-18