Incidental Mutation 'R0540:Greb1'
| ID |
49848 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Greb1
|
| Ensembl Gene |
ENSMUSG00000036523 |
| Gene Name |
gene regulated by estrogen in breast cancer protein |
| Synonyms |
5730583K22Rik |
| MMRRC Submission |
038732-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0540 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
16720616-16850887 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 16732194 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 1589
(Y1589F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124348
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048064]
[ENSMUST00000159120]
[ENSMUST00000162112]
|
| AlphaFold |
Q3UHK3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000048064
AA Change: Y1589F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000044454
Gene: ENSMUSG00000036523
AA Change: Y1589F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GREB1
|
1 |
1954 |
N/A |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159120
AA Change: Y1561F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000125339
Gene: ENSMUSG00000036523
AA Change: Y1561F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
52 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
437 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
1100 |
1118 |
N/A |
INTRINSIC |
|
low complexity region
|
1196 |
1207 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1265 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160755
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162112
AA Change: Y1589F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124348
Gene: ENSMUSG00000036523
AA Change: Y1589F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
52 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
437 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1146 |
N/A |
INTRINSIC |
|
low complexity region
|
1224 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1624 |
1635 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223113
|
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.8%
- 10x: 96.8%
- 20x: 93.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2 |
A |
G |
3: 59,926,627 (GRCm39) |
T199A |
possibly damaging |
Het |
| Als2cl |
C |
A |
9: 110,724,852 (GRCm39) |
Y775* |
probably null |
Het |
| Ankhd1 |
G |
T |
18: 36,773,333 (GRCm39) |
V59F |
probably damaging |
Het |
| Ano4 |
T |
A |
10: 88,859,806 (GRCm39) |
I395F |
probably benign |
Het |
| Apcdd1 |
A |
G |
18: 63,084,967 (GRCm39) |
N388S |
possibly damaging |
Het |
| Arl9 |
A |
G |
5: 77,155,118 (GRCm39) |
Y83C |
possibly damaging |
Het |
| Armc2 |
T |
A |
10: 41,798,691 (GRCm39) |
H706L |
probably benign |
Het |
| Arrb1 |
T |
C |
7: 99,237,403 (GRCm39) |
|
probably null |
Het |
| Atxn1 |
G |
A |
13: 45,711,006 (GRCm39) |
S642L |
probably damaging |
Het |
| Bmp8a |
A |
G |
4: 123,209,723 (GRCm39) |
Y322H |
probably damaging |
Het |
| Btbd3 |
C |
T |
2: 138,125,736 (GRCm39) |
R307W |
possibly damaging |
Het |
| C1galt1 |
T |
C |
6: 7,871,193 (GRCm39) |
I343T |
probably benign |
Het |
| Capn2 |
A |
T |
1: 182,319,749 (GRCm39) |
Y146* |
probably null |
Het |
| Ccdc42 |
C |
T |
11: 68,488,536 (GRCm39) |
Q312* |
probably null |
Het |
| Cd209e |
T |
C |
8: 3,901,265 (GRCm39) |
K130E |
probably benign |
Het |
| Chd3 |
T |
C |
11: 69,235,184 (GRCm39) |
D2054G |
probably damaging |
Het |
| Chrna1 |
T |
C |
2: 73,401,815 (GRCm39) |
N161S |
probably damaging |
Het |
| Clp1 |
C |
T |
2: 84,555,935 (GRCm39) |
A182T |
possibly damaging |
Het |
| Cpsf7 |
G |
T |
19: 10,510,682 (GRCm39) |
E135* |
probably null |
Het |
| Csf2rb2 |
T |
C |
15: 78,172,108 (GRCm39) |
Y325C |
probably benign |
Het |
| Cspg5 |
T |
C |
9: 110,076,460 (GRCm39) |
|
probably null |
Het |
| Ctnna2 |
T |
C |
6: 76,879,413 (GRCm39) |
T824A |
probably benign |
Het |
| Cyp2b13 |
G |
A |
7: 25,781,136 (GRCm39) |
V183I |
probably benign |
Het |
| D430041D05Rik |
C |
T |
2: 104,063,790 (GRCm39) |
R1354H |
probably damaging |
Het |
| Ddx24 |
A |
G |
12: 103,385,326 (GRCm39) |
Y426H |
possibly damaging |
Het |
| Dexi |
G |
T |
16: 10,360,426 (GRCm39) |
Y43* |
probably null |
Het |
| Dlg1 |
G |
A |
16: 31,656,992 (GRCm39) |
V596I |
possibly damaging |
Het |
| Dnah11 |
A |
C |
12: 118,046,246 (GRCm39) |
W1731G |
probably damaging |
Het |
| Dnhd1 |
T |
A |
7: 105,369,995 (GRCm39) |
N4473K |
probably benign |
Het |
| Dync2h1 |
A |
C |
9: 7,051,480 (GRCm39) |
S3152A |
probably benign |
Het |
| Edn3 |
C |
A |
2: 174,602,767 (GRCm39) |
P3Q |
probably damaging |
Het |
| Eif2a |
G |
A |
3: 58,463,073 (GRCm39) |
|
probably null |
Het |
| Emb |
G |
A |
13: 117,369,286 (GRCm39) |
V56I |
possibly damaging |
Het |
| Enpp4 |
A |
T |
17: 44,410,386 (GRCm39) |
C397S |
probably damaging |
Het |
| Exo5 |
A |
G |
4: 120,779,178 (GRCm39) |
V229A |
probably damaging |
Het |
| Fga |
G |
A |
3: 82,935,869 (GRCm39) |
G32E |
probably damaging |
Het |
| Fkbpl |
T |
C |
17: 34,864,333 (GRCm39) |
F34L |
probably benign |
Het |
| Fsd2 |
T |
A |
7: 81,194,765 (GRCm39) |
D466V |
probably damaging |
Het |
| Gcn1 |
T |
C |
5: 115,727,015 (GRCm39) |
V624A |
probably benign |
Het |
| Git2 |
A |
G |
5: 114,886,335 (GRCm39) |
F336L |
probably damaging |
Het |
| H2-K2 |
G |
T |
17: 34,218,474 (GRCm39) |
D127E |
probably damaging |
Het |
| Ints8 |
A |
G |
4: 11,252,926 (GRCm39) |
V52A |
possibly damaging |
Het |
| Kifc1 |
G |
A |
17: 34,105,621 (GRCm39) |
T62I |
probably damaging |
Het |
| Klhl6 |
C |
A |
16: 19,775,764 (GRCm39) |
D265Y |
possibly damaging |
Het |
| Kmt5a |
T |
A |
5: 124,589,373 (GRCm39) |
N190K |
probably damaging |
Het |
| Lce6a |
A |
T |
3: 92,527,635 (GRCm39) |
H57Q |
probably benign |
Het |
| Lipo3 |
A |
T |
19: 33,536,967 (GRCm39) |
I251K |
possibly damaging |
Het |
| Lnpep |
A |
T |
17: 17,758,816 (GRCm39) |
F843I |
probably damaging |
Het |
| Lrrc45 |
C |
T |
11: 120,605,988 (GRCm39) |
R99* |
probably null |
Het |
| Lrrtm1 |
C |
A |
6: 77,221,611 (GRCm39) |
A356E |
probably damaging |
Het |
| Map3k1 |
A |
C |
13: 111,900,044 (GRCm39) |
H493Q |
probably benign |
Het |
| Mcm4 |
A |
T |
16: 15,449,979 (GRCm39) |
|
probably null |
Het |
| Mllt3 |
G |
A |
4: 87,759,281 (GRCm39) |
P256S |
possibly damaging |
Het |
| Mrtfb |
A |
G |
16: 13,199,465 (GRCm39) |
E106G |
probably damaging |
Het |
| Myo7a |
T |
A |
7: 97,721,153 (GRCm39) |
T1271S |
probably damaging |
Het |
| Ncan |
C |
A |
8: 70,567,809 (GRCm39) |
R101L |
possibly damaging |
Het |
| Ndufaf7 |
A |
G |
17: 79,253,885 (GRCm39) |
D361G |
probably benign |
Het |
| Neurod6 |
C |
T |
6: 55,656,572 (GRCm39) |
A22T |
probably benign |
Het |
| Nexn |
T |
A |
3: 151,953,879 (GRCm39) |
K192* |
probably null |
Het |
| Nipsnap2 |
A |
T |
5: 129,831,909 (GRCm39) |
Y234F |
probably damaging |
Het |
| Nlrp10 |
T |
C |
7: 108,523,492 (GRCm39) |
K663E |
probably benign |
Het |
| Nprl2 |
A |
T |
9: 107,422,497 (GRCm39) |
Y329F |
possibly damaging |
Het |
| Nr2f2 |
C |
A |
7: 70,004,460 (GRCm39) |
R264L |
probably damaging |
Het |
| Nsun7 |
A |
T |
5: 66,440,977 (GRCm39) |
K366I |
probably damaging |
Het |
| Nup35 |
T |
A |
2: 80,472,984 (GRCm39) |
M19K |
probably benign |
Het |
| Or10a4 |
T |
A |
7: 106,696,933 (GRCm39) |
I87K |
probably benign |
Het |
| Or11i1 |
A |
T |
3: 106,729,829 (GRCm39) |
F15L |
probably damaging |
Het |
| Or1ad6 |
C |
A |
11: 50,860,670 (GRCm39) |
A275D |
possibly damaging |
Het |
| Or2v1 |
C |
G |
11: 49,025,549 (GRCm39) |
H177D |
probably damaging |
Het |
| Or2w2 |
T |
A |
13: 21,757,948 (GRCm39) |
Y226F |
probably benign |
Het |
| Or5af1 |
T |
A |
11: 58,722,798 (GRCm39) |
S273T |
probably damaging |
Het |
| Or5p51 |
A |
G |
7: 107,444,776 (GRCm39) |
S55P |
probably damaging |
Het |
| Patl2 |
T |
C |
2: 121,957,150 (GRCm39) |
Y128C |
probably benign |
Het |
| Pcdhac2 |
A |
G |
18: 37,278,942 (GRCm39) |
I641V |
probably benign |
Het |
| Peli3 |
T |
C |
19: 4,991,939 (GRCm39) |
M1V |
probably null |
Het |
| Pex16 |
T |
A |
2: 92,205,982 (GRCm39) |
L25* |
probably null |
Het |
| Plekhn1 |
C |
A |
4: 156,307,204 (GRCm39) |
A449S |
possibly damaging |
Het |
| Pot1b |
A |
T |
17: 55,972,765 (GRCm39) |
I469N |
probably damaging |
Het |
| Prdx6 |
A |
C |
1: 161,078,673 (GRCm39) |
L5W |
probably damaging |
Het |
| Prrc1 |
G |
A |
18: 57,507,622 (GRCm39) |
V259I |
possibly damaging |
Het |
| Prss38 |
T |
C |
11: 59,266,369 (GRCm39) |
S30G |
possibly damaging |
Het |
| Rgs6 |
C |
A |
12: 83,106,578 (GRCm39) |
Y151* |
probably null |
Het |
| Ripk4 |
A |
C |
16: 97,545,375 (GRCm39) |
L361R |
probably damaging |
Het |
| Serpinb3d |
C |
T |
1: 107,006,962 (GRCm39) |
D249N |
probably benign |
Het |
| Skint10 |
A |
T |
4: 112,630,224 (GRCm39) |
|
probably null |
Het |
| Smg7 |
A |
T |
1: 152,731,713 (GRCm39) |
N349K |
probably benign |
Het |
| Sohlh2 |
C |
A |
3: 55,115,104 (GRCm39) |
S363Y |
probably damaging |
Het |
| Srsf10 |
A |
G |
4: 135,591,179 (GRCm39) |
T210A |
possibly damaging |
Het |
| Synpo2l |
A |
T |
14: 20,710,748 (GRCm39) |
M624K |
probably damaging |
Het |
| Thsd7a |
T |
A |
6: 12,331,541 (GRCm39) |
|
probably null |
Het |
| Tnc |
A |
T |
4: 63,938,692 (GRCm39) |
V49E |
probably damaging |
Het |
| Tnik |
A |
C |
3: 28,704,308 (GRCm39) |
K989T |
probably damaging |
Het |
| Tnxb |
T |
A |
17: 34,890,892 (GRCm39) |
Y412N |
probably damaging |
Het |
| Trmt44 |
A |
G |
5: 35,726,103 (GRCm39) |
|
probably null |
Het |
| Tsc2 |
A |
T |
17: 24,840,686 (GRCm39) |
V391E |
probably damaging |
Het |
| Ttll5 |
T |
C |
12: 85,980,450 (GRCm39) |
|
probably null |
Het |
| Usp28 |
A |
G |
9: 48,935,360 (GRCm39) |
I104V |
probably benign |
Het |
| Vmn1r64 |
A |
G |
7: 5,887,096 (GRCm39) |
L149S |
probably damaging |
Het |
| Yme1l1 |
T |
A |
2: 23,082,527 (GRCm39) |
M506K |
possibly damaging |
Het |
| Zfp280d |
T |
A |
9: 72,215,247 (GRCm39) |
F98I |
probably damaging |
Het |
| Zfp62 |
C |
A |
11: 49,106,227 (GRCm39) |
T106K |
probably benign |
Het |
|
| Other mutations in Greb1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00155:Greb1
|
APN |
12 |
16,761,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01316:Greb1
|
APN |
12 |
16,748,587 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01464:Greb1
|
APN |
12 |
16,764,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01474:Greb1
|
APN |
12 |
16,734,502 (GRCm39) |
missense |
probably benign |
|
|
IGL01522:Greb1
|
APN |
12 |
16,751,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01824:Greb1
|
APN |
12 |
16,761,717 (GRCm39) |
nonsense |
probably null |
|
|
IGL01837:Greb1
|
APN |
12 |
16,734,452 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01991:Greb1
|
APN |
12 |
16,749,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01996:Greb1
|
APN |
12 |
16,740,846 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02213:Greb1
|
APN |
12 |
16,756,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02267:Greb1
|
APN |
12 |
16,767,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02512:Greb1
|
APN |
12 |
16,742,713 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02583:Greb1
|
APN |
12 |
16,756,296 (GRCm39) |
splice site |
probably benign |
|
|
IGL02613:Greb1
|
APN |
12 |
16,789,889 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02648:Greb1
|
APN |
12 |
16,758,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02679:Greb1
|
APN |
12 |
16,758,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
begraben
|
UTSW |
12 |
16,734,374 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
Eared
|
UTSW |
12 |
16,723,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Humpback
|
UTSW |
12 |
16,751,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
pied_billed
|
UTSW |
12 |
16,774,858 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
rednecked
|
UTSW |
12 |
16,732,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
G1patch:Greb1
|
UTSW |
12 |
16,738,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03048:Greb1
|
UTSW |
12 |
16,783,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0083:Greb1
|
UTSW |
12 |
16,746,452 (GRCm39) |
missense |
probably benign |
|
|
R0100:Greb1
|
UTSW |
12 |
16,730,225 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0100:Greb1
|
UTSW |
12 |
16,730,225 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0220:Greb1
|
UTSW |
12 |
16,732,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0245:Greb1
|
UTSW |
12 |
16,746,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0547:Greb1
|
UTSW |
12 |
16,773,412 (GRCm39) |
missense |
probably benign |
|
|
R0563:Greb1
|
UTSW |
12 |
16,730,268 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0607:Greb1
|
UTSW |
12 |
16,732,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0610:Greb1
|
UTSW |
12 |
16,746,443 (GRCm39) |
missense |
probably benign |
|
|
R0652:Greb1
|
UTSW |
12 |
16,746,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0659:Greb1
|
UTSW |
12 |
16,730,213 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0945:Greb1
|
UTSW |
12 |
16,723,803 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1055:Greb1
|
UTSW |
12 |
16,732,252 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1445:Greb1
|
UTSW |
12 |
16,757,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Greb1
|
UTSW |
12 |
16,761,775 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1503:Greb1
|
UTSW |
12 |
16,774,820 (GRCm39) |
nonsense |
probably null |
|
|
R1566:Greb1
|
UTSW |
12 |
16,761,829 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1614:Greb1
|
UTSW |
12 |
16,751,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1623:Greb1
|
UTSW |
12 |
16,724,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Greb1
|
UTSW |
12 |
16,773,439 (GRCm39) |
splice site |
probably benign |
|
|
R1778:Greb1
|
UTSW |
12 |
16,740,895 (GRCm39) |
missense |
probably benign |
|
|
R1842:Greb1
|
UTSW |
12 |
16,746,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2040:Greb1
|
UTSW |
12 |
16,752,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2153:Greb1
|
UTSW |
12 |
16,749,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2178:Greb1
|
UTSW |
12 |
16,746,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2194:Greb1
|
UTSW |
12 |
16,740,909 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2248:Greb1
|
UTSW |
12 |
16,730,379 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2474:Greb1
|
UTSW |
12 |
16,764,954 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2509:Greb1
|
UTSW |
12 |
16,774,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2861:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2862:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2866:Greb1
|
UTSW |
12 |
16,749,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2890:Greb1
|
UTSW |
12 |
16,754,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3056:Greb1
|
UTSW |
12 |
16,738,592 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3863:Greb1
|
UTSW |
12 |
16,752,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3864:Greb1
|
UTSW |
12 |
16,752,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Greb1
|
UTSW |
12 |
16,732,300 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4493:Greb1
|
UTSW |
12 |
16,748,611 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4548:Greb1
|
UTSW |
12 |
16,749,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4683:Greb1
|
UTSW |
12 |
16,761,774 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4739:Greb1
|
UTSW |
12 |
16,746,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4770:Greb1
|
UTSW |
12 |
16,731,357 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4838:Greb1
|
UTSW |
12 |
16,734,361 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4925:Greb1
|
UTSW |
12 |
16,731,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4982:Greb1
|
UTSW |
12 |
16,774,762 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5009:Greb1
|
UTSW |
12 |
16,774,858 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5086:Greb1
|
UTSW |
12 |
16,758,023 (GRCm39) |
intron |
probably benign |
|
|
R5213:Greb1
|
UTSW |
12 |
16,764,791 (GRCm39) |
nonsense |
probably null |
|
|
R5310:Greb1
|
UTSW |
12 |
16,766,760 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5353:Greb1
|
UTSW |
12 |
16,738,567 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Greb1
|
UTSW |
12 |
16,723,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Greb1
|
UTSW |
12 |
16,758,727 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5708:Greb1
|
UTSW |
12 |
16,723,843 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5837:Greb1
|
UTSW |
12 |
16,738,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5890:Greb1
|
UTSW |
12 |
16,783,422 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5938:Greb1
|
UTSW |
12 |
16,767,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6049:Greb1
|
UTSW |
12 |
16,731,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6093:Greb1
|
UTSW |
12 |
16,734,487 (GRCm39) |
missense |
probably benign |
|
|
R6120:Greb1
|
UTSW |
12 |
16,758,622 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6175:Greb1
|
UTSW |
12 |
16,724,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Greb1
|
UTSW |
12 |
16,766,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6274:Greb1
|
UTSW |
12 |
16,785,152 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6376:Greb1
|
UTSW |
12 |
16,749,580 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6523:Greb1
|
UTSW |
12 |
16,734,374 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6557:Greb1
|
UTSW |
12 |
16,760,384 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6602:Greb1
|
UTSW |
12 |
16,759,441 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6621:Greb1
|
UTSW |
12 |
16,742,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6645:Greb1
|
UTSW |
12 |
16,748,580 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6725:Greb1
|
UTSW |
12 |
16,738,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6750:Greb1
|
UTSW |
12 |
16,738,584 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6863:Greb1
|
UTSW |
12 |
16,734,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6914:Greb1
|
UTSW |
12 |
16,757,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6996:Greb1
|
UTSW |
12 |
16,773,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7083:Greb1
|
UTSW |
12 |
16,773,315 (GRCm39) |
missense |
probably benign |
|
|
R7147:Greb1
|
UTSW |
12 |
16,783,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Greb1
|
UTSW |
12 |
16,724,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7290:Greb1
|
UTSW |
12 |
16,761,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7358:Greb1
|
UTSW |
12 |
16,774,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7395:Greb1
|
UTSW |
12 |
16,759,431 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7526:Greb1
|
UTSW |
12 |
16,766,766 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7530:Greb1
|
UTSW |
12 |
16,767,207 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7536:Greb1
|
UTSW |
12 |
16,732,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7643:Greb1
|
UTSW |
12 |
16,761,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7732:Greb1
|
UTSW |
12 |
16,723,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7740:Greb1
|
UTSW |
12 |
16,790,122 (GRCm39) |
start gained |
probably benign |
|
|
R7747:Greb1
|
UTSW |
12 |
16,724,796 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7760:Greb1
|
UTSW |
12 |
16,773,417 (GRCm39) |
missense |
probably benign |
|
|
R7937:Greb1
|
UTSW |
12 |
16,766,670 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8043:Greb1
|
UTSW |
12 |
16,761,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8259:Greb1
|
UTSW |
12 |
16,774,925 (GRCm39) |
nonsense |
probably null |
|
|
R8553:Greb1
|
UTSW |
12 |
16,773,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8559:Greb1
|
UTSW |
12 |
16,746,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8690:Greb1
|
UTSW |
12 |
16,746,548 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8830:Greb1
|
UTSW |
12 |
16,738,520 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8911:Greb1
|
UTSW |
12 |
16,740,903 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8963:Greb1
|
UTSW |
12 |
16,774,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Greb1
|
UTSW |
12 |
16,734,457 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9013:Greb1
|
UTSW |
12 |
16,789,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9279:Greb1
|
UTSW |
12 |
16,732,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9360:Greb1
|
UTSW |
12 |
16,790,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9563:Greb1
|
UTSW |
12 |
16,774,824 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9616:Greb1
|
UTSW |
12 |
16,790,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9627:Greb1
|
UTSW |
12 |
16,756,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9731:Greb1
|
UTSW |
12 |
16,738,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9761:Greb1
|
UTSW |
12 |
16,751,275 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Greb1
|
UTSW |
12 |
16,746,757 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Greb1
|
UTSW |
12 |
16,752,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTCATTCCACAAGCAGAGAGCTG -3'
(R):5'- TGGGCACATTCTGAGAAGTCACAC -3'
Sequencing Primer
(F):5'- GATGTCAACCTCTAAAACAGCCTTC -3'
(R):5'- tccaatcacaatgctctctctc -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation