Incidental Mutation 'R9563:Greb1'
| ID |
721264 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Greb1
|
| Ensembl Gene |
ENSMUSG00000036523 |
| Gene Name |
gene regulated by estrogen in breast cancer protein |
| Synonyms |
5730583K22Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9563 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
16720616-16850887 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 16774824 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 191
(Y191C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000044454
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048064]
[ENSMUST00000159120]
[ENSMUST00000162112]
|
| AlphaFold |
Q3UHK3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000048064
AA Change: Y191C
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000044454
Gene: ENSMUSG00000036523
AA Change: Y191C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GREB1
|
1 |
1954 |
N/A |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159120
AA Change: Y191C
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000125339
Gene: ENSMUSG00000036523
AA Change: Y191C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
52 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
437 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
1100 |
1118 |
N/A |
INTRINSIC |
|
low complexity region
|
1196 |
1207 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1265 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162112
AA Change: Y191C
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000124348
Gene: ENSMUSG00000036523
AA Change: Y191C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
52 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
437 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1146 |
N/A |
INTRINSIC |
|
low complexity region
|
1224 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1624 |
1635 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 127 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
T |
A |
6: 121,645,009 (GRCm39) |
D953E |
probably damaging |
Het |
| Acod1 |
A |
C |
14: 103,287,109 (GRCm39) |
Y80S |
probably damaging |
Het |
| Actr5 |
A |
G |
2: 158,470,135 (GRCm39) |
D255G |
probably damaging |
Het |
| Akna |
A |
G |
4: 63,312,944 (GRCm39) |
V393A |
probably damaging |
Het |
| Amotl1 |
T |
C |
9: 14,473,513 (GRCm39) |
K562R |
possibly damaging |
Het |
| Amz1 |
T |
A |
5: 140,738,133 (GRCm39) |
D464E |
probably damaging |
Het |
| Anapc1 |
G |
A |
2: 128,505,980 (GRCm39) |
Q619* |
probably null |
Het |
| Arfgef3 |
C |
T |
10: 18,522,275 (GRCm39) |
G584R |
probably damaging |
Het |
| Armt1 |
AC |
A |
10: 4,400,848 (GRCm39) |
|
probably null |
Het |
| Atr |
G |
C |
9: 95,802,833 (GRCm39) |
V1832L |
probably damaging |
Het |
| Bsn |
T |
C |
9: 107,984,616 (GRCm39) |
D374G |
|
Het |
| Cap1 |
A |
G |
4: 122,758,505 (GRCm39) |
V225A |
probably benign |
Het |
| Cc2d1a |
A |
G |
8: 84,863,758 (GRCm39) |
S562P |
probably benign |
Het |
| Ccdc30 |
T |
C |
4: 119,250,821 (GRCm39) |
N141S |
possibly damaging |
Het |
| Cdc42bpb |
A |
G |
12: 111,265,762 (GRCm39) |
V1390A |
possibly damaging |
Het |
| Cdc42ep1 |
A |
T |
15: 78,733,782 (GRCm39) |
H294L |
probably benign |
Het |
| Col6a6 |
C |
A |
9: 105,572,952 (GRCm39) |
G2185C |
probably benign |
Het |
| Col7a1 |
T |
C |
9: 108,791,809 (GRCm39) |
V1232A |
unknown |
Het |
| Copb1 |
A |
G |
7: 113,836,034 (GRCm39) |
I449T |
possibly damaging |
Het |
| Cplane1 |
T |
G |
15: 8,216,563 (GRCm39) |
L594V |
probably benign |
Het |
| Ctdsp2 |
A |
G |
10: 126,832,040 (GRCm39) |
D216G |
probably damaging |
Het |
| Cttnbp2 |
T |
A |
6: 18,367,382 (GRCm39) |
K1645N |
probably benign |
Het |
| Cttnbp2 |
A |
T |
6: 18,427,467 (GRCm39) |
L738* |
probably null |
Het |
| Cul9 |
T |
A |
17: 46,820,897 (GRCm39) |
T1927S |
probably benign |
Het |
| Cyfip2 |
A |
G |
11: 46,151,707 (GRCm39) |
C531R |
probably benign |
Het |
| Cyp2j6 |
A |
G |
4: 96,414,245 (GRCm39) |
I340T |
probably damaging |
Het |
| Daam1 |
A |
G |
12: 71,992,251 (GRCm39) |
E322G |
unknown |
Het |
| Dab2ip |
T |
A |
2: 35,609,915 (GRCm39) |
L710* |
probably null |
Het |
| Degs1l |
G |
T |
1: 180,882,810 (GRCm39) |
V191F |
possibly damaging |
Het |
| Dph1 |
T |
C |
11: 75,076,825 (GRCm39) |
T60A |
possibly damaging |
Het |
| Eme1 |
T |
C |
11: 94,541,339 (GRCm39) |
D161G |
probably benign |
Het |
| Epha3 |
C |
T |
16: 63,366,510 (GRCm39) |
G980D |
possibly damaging |
Het |
| Eri3 |
T |
A |
4: 117,422,013 (GRCm39) |
V136E |
probably benign |
Het |
| Espl1 |
T |
A |
15: 102,228,233 (GRCm39) |
I1669N |
possibly damaging |
Het |
| Exoc6 |
T |
C |
19: 37,588,071 (GRCm39) |
I568T |
probably damaging |
Het |
| F3 |
T |
A |
3: 121,527,822 (GRCm39) |
L85H |
|
Het |
| Fam186b |
G |
A |
15: 99,177,616 (GRCm39) |
A570V |
probably damaging |
Het |
| Fbxw14 |
T |
C |
9: 109,106,335 (GRCm39) |
Y234C |
probably benign |
Het |
| Fbxw25 |
T |
A |
9: 109,483,676 (GRCm39) |
N179Y |
|
Het |
| Foxr1 |
T |
A |
9: 44,352,199 (GRCm39) |
|
probably benign |
Het |
| Gas8 |
T |
A |
8: 124,263,179 (GRCm39) |
V452E |
possibly damaging |
Het |
| Gdpd4 |
T |
C |
7: 97,649,369 (GRCm39) |
V450A |
probably damaging |
Het |
| H3c11 |
T |
C |
13: 21,967,221 (GRCm39) |
D107G |
probably damaging |
Het |
| Haus3 |
G |
A |
5: 34,325,300 (GRCm39) |
R120W |
probably benign |
Het |
| Herc1 |
G |
T |
9: 66,294,193 (GRCm39) |
|
probably null |
Het |
| Hyal2 |
T |
C |
9: 107,447,844 (GRCm39) |
W166R |
probably damaging |
Het |
| Inka1 |
T |
A |
9: 107,861,488 (GRCm39) |
Y276F |
probably benign |
Het |
| Itga7 |
C |
T |
10: 128,789,669 (GRCm39) |
A1003V |
probably damaging |
Het |
| Itga8 |
T |
A |
2: 12,165,219 (GRCm39) |
I797F |
possibly damaging |
Het |
| Kank2 |
T |
C |
9: 21,705,852 (GRCm39) |
T389A |
possibly damaging |
Het |
| Kcnb2 |
T |
A |
1: 15,779,737 (GRCm39) |
I203N |
probably damaging |
Het |
| Kif21b |
T |
A |
1: 136,077,166 (GRCm39) |
L396Q |
probably damaging |
Het |
| Kng1 |
T |
G |
16: 22,879,170 (GRCm39) |
I78S |
probably damaging |
Het |
| Ldlrad4 |
T |
C |
18: 68,387,551 (GRCm39) |
S288P |
probably benign |
Het |
| Lmntd2 |
A |
G |
7: 140,790,701 (GRCm39) |
S516P |
|
Het |
| Lrp1b |
T |
A |
2: 41,185,711 (GRCm39) |
I1449F |
|
Het |
| Lrrk2 |
T |
A |
15: 91,634,043 (GRCm39) |
I1380K |
possibly damaging |
Het |
| Lvrn |
T |
G |
18: 47,017,506 (GRCm39) |
I612S |
probably damaging |
Het |
| Lyst |
T |
C |
13: 13,812,408 (GRCm39) |
L940P |
probably benign |
Het |
| Man2a2 |
T |
A |
7: 80,006,101 (GRCm39) |
M996L |
probably benign |
Het |
| Map3k3 |
T |
A |
11: 106,041,860 (GRCm39) |
I413N |
probably damaging |
Het |
| Map4k5 |
A |
G |
12: 69,863,167 (GRCm39) |
V629A |
probably benign |
Het |
| Mapre2 |
A |
G |
18: 24,023,981 (GRCm39) |
E325G |
unknown |
Het |
| Mbnl1 |
A |
G |
3: 60,520,715 (GRCm39) |
N101S |
probably benign |
Het |
| Meltf |
T |
A |
16: 31,703,869 (GRCm39) |
C199S |
probably damaging |
Het |
| Mmab |
T |
C |
5: 114,574,850 (GRCm39) |
E141G |
probably benign |
Het |
| Mtcl2 |
G |
A |
2: 156,902,182 (GRCm39) |
R278C |
probably damaging |
Het |
| Mtus2 |
T |
C |
5: 148,250,217 (GRCm39) |
L1317P |
|
Het |
| Muc6 |
T |
A |
7: 141,217,783 (GRCm39) |
T2297S |
possibly damaging |
Het |
| Myom2 |
A |
T |
8: 15,158,399 (GRCm39) |
K784* |
probably null |
Het |
| Nek1 |
A |
G |
8: 61,577,157 (GRCm39) |
E1118G |
probably benign |
Het |
| Nrtn |
A |
G |
17: 57,058,416 (GRCm39) |
V195A |
probably damaging |
Het |
| Nsd3 |
G |
A |
8: 26,204,230 (GRCm39) |
V420I |
|
Het |
| Or52e4 |
T |
C |
7: 104,706,281 (GRCm39) |
L276P |
possibly damaging |
Het |
| Or52z13 |
A |
T |
7: 103,247,225 (GRCm39) |
Q234L |
probably benign |
Het |
| Or5ac23 |
T |
C |
16: 59,149,765 (GRCm39) |
I36V |
probably benign |
Het |
| Or5b99 |
T |
A |
19: 12,976,983 (GRCm39) |
I211N |
probably damaging |
Het |
| Or5t9 |
A |
G |
2: 86,659,098 (GRCm39) |
M1V |
probably null |
Het |
| Or6ae1 |
G |
A |
7: 139,742,233 (GRCm39) |
T210I |
probably damaging |
Het |
| Or6c33 |
T |
C |
10: 129,853,287 (GRCm39) |
I19T |
probably benign |
Het |
| Or8b56 |
A |
T |
9: 38,739,014 (GRCm39) |
H3L |
probably benign |
Het |
| Pde10a |
G |
T |
17: 9,020,710 (GRCm39) |
A216S |
unknown |
Het |
| Phldb2 |
T |
C |
16: 45,645,247 (GRCm39) |
T400A |
possibly damaging |
Het |
| Pkd1l1 |
T |
A |
11: 8,815,502 (GRCm39) |
T1920S |
|
Het |
| Ptgs2 |
T |
A |
1: 149,981,419 (GRCm39) |
N567K |
probably benign |
Het |
| Pwp1 |
T |
A |
10: 85,712,370 (GRCm39) |
D141E |
probably damaging |
Het |
| Rab3ip |
T |
C |
10: 116,754,668 (GRCm39) |
E296G |
probably null |
Het |
| Rb1cc1 |
A |
G |
1: 6,314,339 (GRCm39) |
K337R |
probably benign |
Het |
| Rbp3 |
A |
G |
14: 33,677,477 (GRCm39) |
D475G |
probably damaging |
Het |
| Ric3 |
T |
C |
7: 108,637,997 (GRCm39) |
E253G |
possibly damaging |
Het |
| Rictor |
A |
T |
15: 6,797,562 (GRCm39) |
N306I |
possibly damaging |
Het |
| Rnf214 |
A |
T |
9: 45,811,141 (GRCm39) |
V174E |
possibly damaging |
Het |
| Robo3 |
A |
G |
9: 37,340,900 (GRCm39) |
F124S |
probably damaging |
Het |
| Rrad |
A |
G |
8: 105,355,324 (GRCm39) |
F228S |
probably damaging |
Het |
| Scn3a |
A |
T |
2: 65,291,595 (GRCm39) |
M1717K |
probably damaging |
Het |
| Scn3b |
A |
G |
9: 40,193,729 (GRCm39) |
D152G |
probably benign |
Het |
| Scn5a |
C |
A |
9: 119,315,803 (GRCm39) |
R1635L |
probably damaging |
Het |
| Sec61b |
A |
G |
4: 47,483,049 (GRCm39) |
Y93C |
probably damaging |
Het |
| Shprh |
T |
A |
10: 11,042,235 (GRCm39) |
Y739* |
probably null |
Het |
| Skor2 |
C |
T |
18: 76,946,376 (GRCm39) |
H33Y |
unknown |
Het |
| Slc26a7 |
T |
C |
4: 14,519,496 (GRCm39) |
N508S |
probably benign |
Het |
| Slc7a12 |
A |
G |
3: 14,564,360 (GRCm39) |
I349V |
possibly damaging |
Het |
| Slit1 |
T |
C |
19: 41,596,874 (GRCm39) |
Y1075C |
probably damaging |
Het |
| Sltm |
C |
T |
9: 70,480,841 (GRCm39) |
A231V |
unknown |
Het |
| Smg1 |
A |
G |
7: 117,812,208 (GRCm39) |
S52P |
unknown |
Het |
| Sorl1 |
A |
G |
9: 41,957,893 (GRCm39) |
Y584H |
probably damaging |
Het |
| Spmip2 |
A |
T |
3: 79,356,616 (GRCm39) |
M140L |
probably benign |
Het |
| Ssbp1 |
T |
A |
6: 40,454,968 (GRCm39) |
S142R |
probably benign |
Het |
| Stard3 |
A |
G |
11: 98,270,797 (GRCm39) |
|
probably null |
Het |
| Strn3 |
G |
T |
12: 51,674,300 (GRCm39) |
H531N |
possibly damaging |
Het |
| Stx17 |
A |
G |
4: 48,180,739 (GRCm39) |
T195A |
probably damaging |
Het |
| Tekt2 |
C |
T |
4: 126,217,444 (GRCm39) |
R207H |
probably damaging |
Het |
| Tmed5 |
A |
C |
5: 108,280,100 (GRCm39) |
|
probably null |
Het |
| Tmem132a |
C |
T |
19: 10,838,960 (GRCm39) |
R494H |
probably benign |
Het |
| Tom1 |
A |
G |
8: 75,787,177 (GRCm39) |
K406E |
probably benign |
Het |
| Trav5d-4 |
A |
T |
14: 53,239,473 (GRCm39) |
N43Y |
probably damaging |
Het |
| Trbv19 |
G |
T |
6: 41,155,945 (GRCm39) |
K105N |
possibly damaging |
Het |
| Trim34a |
C |
T |
7: 103,910,328 (GRCm39) |
Q377* |
probably null |
Het |
| Trp53bp2 |
T |
A |
1: 182,276,378 (GRCm39) |
N786K |
probably benign |
Het |
| Trpc3 |
A |
G |
3: 36,705,683 (GRCm39) |
M504T |
probably benign |
Het |
| Ttc28 |
A |
T |
5: 111,371,092 (GRCm39) |
M545L |
probably benign |
Het |
| Uggt1 |
A |
C |
1: 36,204,627 (GRCm39) |
V996G |
possibly damaging |
Het |
| Vmn2r65 |
G |
A |
7: 84,589,880 (GRCm39) |
Q679* |
probably null |
Het |
| Wdfy4 |
T |
C |
14: 32,692,833 (GRCm39) |
I2958V |
|
Het |
| Zbtb37 |
C |
T |
1: 160,847,840 (GRCm39) |
S389N |
possibly damaging |
Het |
| Zfp235 |
T |
C |
7: 23,841,669 (GRCm39) |
V696A |
possibly damaging |
Het |
| Zzef1 |
T |
A |
11: 72,765,732 (GRCm39) |
C1420S |
probably damaging |
Het |
|
| Other mutations in Greb1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00155:Greb1
|
APN |
12 |
16,761,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01316:Greb1
|
APN |
12 |
16,748,587 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01464:Greb1
|
APN |
12 |
16,764,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01474:Greb1
|
APN |
12 |
16,734,502 (GRCm39) |
missense |
probably benign |
|
|
IGL01522:Greb1
|
APN |
12 |
16,751,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01824:Greb1
|
APN |
12 |
16,761,717 (GRCm39) |
nonsense |
probably null |
|
|
IGL01837:Greb1
|
APN |
12 |
16,734,452 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01991:Greb1
|
APN |
12 |
16,749,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01996:Greb1
|
APN |
12 |
16,740,846 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02213:Greb1
|
APN |
12 |
16,756,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02267:Greb1
|
APN |
12 |
16,767,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02512:Greb1
|
APN |
12 |
16,742,713 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02583:Greb1
|
APN |
12 |
16,756,296 (GRCm39) |
splice site |
probably benign |
|
|
IGL02613:Greb1
|
APN |
12 |
16,789,889 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02648:Greb1
|
APN |
12 |
16,758,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02679:Greb1
|
APN |
12 |
16,758,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
begraben
|
UTSW |
12 |
16,734,374 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
Eared
|
UTSW |
12 |
16,723,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Humpback
|
UTSW |
12 |
16,751,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
pied_billed
|
UTSW |
12 |
16,774,858 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
rednecked
|
UTSW |
12 |
16,732,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
G1patch:Greb1
|
UTSW |
12 |
16,738,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03048:Greb1
|
UTSW |
12 |
16,783,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0083:Greb1
|
UTSW |
12 |
16,746,452 (GRCm39) |
missense |
probably benign |
|
|
R0100:Greb1
|
UTSW |
12 |
16,730,225 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0100:Greb1
|
UTSW |
12 |
16,730,225 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0220:Greb1
|
UTSW |
12 |
16,732,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0245:Greb1
|
UTSW |
12 |
16,746,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0540:Greb1
|
UTSW |
12 |
16,732,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0547:Greb1
|
UTSW |
12 |
16,773,412 (GRCm39) |
missense |
probably benign |
|
|
R0563:Greb1
|
UTSW |
12 |
16,730,268 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0607:Greb1
|
UTSW |
12 |
16,732,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0610:Greb1
|
UTSW |
12 |
16,746,443 (GRCm39) |
missense |
probably benign |
|
|
R0652:Greb1
|
UTSW |
12 |
16,746,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0659:Greb1
|
UTSW |
12 |
16,730,213 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0945:Greb1
|
UTSW |
12 |
16,723,803 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1055:Greb1
|
UTSW |
12 |
16,732,252 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1445:Greb1
|
UTSW |
12 |
16,757,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Greb1
|
UTSW |
12 |
16,761,775 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1503:Greb1
|
UTSW |
12 |
16,774,820 (GRCm39) |
nonsense |
probably null |
|
|
R1566:Greb1
|
UTSW |
12 |
16,761,829 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1614:Greb1
|
UTSW |
12 |
16,751,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1623:Greb1
|
UTSW |
12 |
16,724,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Greb1
|
UTSW |
12 |
16,773,439 (GRCm39) |
splice site |
probably benign |
|
|
R1778:Greb1
|
UTSW |
12 |
16,740,895 (GRCm39) |
missense |
probably benign |
|
|
R1842:Greb1
|
UTSW |
12 |
16,746,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2040:Greb1
|
UTSW |
12 |
16,752,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2153:Greb1
|
UTSW |
12 |
16,749,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2178:Greb1
|
UTSW |
12 |
16,746,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2194:Greb1
|
UTSW |
12 |
16,740,909 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2248:Greb1
|
UTSW |
12 |
16,730,379 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2474:Greb1
|
UTSW |
12 |
16,764,954 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2509:Greb1
|
UTSW |
12 |
16,774,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2860:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2861:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2862:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2866:Greb1
|
UTSW |
12 |
16,749,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2890:Greb1
|
UTSW |
12 |
16,754,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3056:Greb1
|
UTSW |
12 |
16,738,592 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3863:Greb1
|
UTSW |
12 |
16,752,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3864:Greb1
|
UTSW |
12 |
16,752,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Greb1
|
UTSW |
12 |
16,732,300 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4493:Greb1
|
UTSW |
12 |
16,748,611 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4548:Greb1
|
UTSW |
12 |
16,749,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4683:Greb1
|
UTSW |
12 |
16,761,774 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4739:Greb1
|
UTSW |
12 |
16,746,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4770:Greb1
|
UTSW |
12 |
16,731,357 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4838:Greb1
|
UTSW |
12 |
16,734,361 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4925:Greb1
|
UTSW |
12 |
16,731,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4982:Greb1
|
UTSW |
12 |
16,774,762 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5009:Greb1
|
UTSW |
12 |
16,774,858 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5086:Greb1
|
UTSW |
12 |
16,758,023 (GRCm39) |
intron |
probably benign |
|
|
R5213:Greb1
|
UTSW |
12 |
16,764,791 (GRCm39) |
nonsense |
probably null |
|
|
R5310:Greb1
|
UTSW |
12 |
16,766,760 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5353:Greb1
|
UTSW |
12 |
16,738,567 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Greb1
|
UTSW |
12 |
16,723,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Greb1
|
UTSW |
12 |
16,758,727 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5708:Greb1
|
UTSW |
12 |
16,723,843 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5837:Greb1
|
UTSW |
12 |
16,738,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5890:Greb1
|
UTSW |
12 |
16,783,422 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5938:Greb1
|
UTSW |
12 |
16,767,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6049:Greb1
|
UTSW |
12 |
16,731,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6093:Greb1
|
UTSW |
12 |
16,734,487 (GRCm39) |
missense |
probably benign |
|
|
R6120:Greb1
|
UTSW |
12 |
16,758,622 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6175:Greb1
|
UTSW |
12 |
16,724,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Greb1
|
UTSW |
12 |
16,766,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6274:Greb1
|
UTSW |
12 |
16,785,152 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6376:Greb1
|
UTSW |
12 |
16,749,580 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6523:Greb1
|
UTSW |
12 |
16,734,374 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6557:Greb1
|
UTSW |
12 |
16,760,384 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6602:Greb1
|
UTSW |
12 |
16,759,441 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6621:Greb1
|
UTSW |
12 |
16,742,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6645:Greb1
|
UTSW |
12 |
16,748,580 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6725:Greb1
|
UTSW |
12 |
16,738,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6750:Greb1
|
UTSW |
12 |
16,738,584 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6863:Greb1
|
UTSW |
12 |
16,734,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6914:Greb1
|
UTSW |
12 |
16,757,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6996:Greb1
|
UTSW |
12 |
16,773,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7083:Greb1
|
UTSW |
12 |
16,773,315 (GRCm39) |
missense |
probably benign |
|
|
R7147:Greb1
|
UTSW |
12 |
16,783,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Greb1
|
UTSW |
12 |
16,724,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7290:Greb1
|
UTSW |
12 |
16,761,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7358:Greb1
|
UTSW |
12 |
16,774,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7395:Greb1
|
UTSW |
12 |
16,759,431 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7526:Greb1
|
UTSW |
12 |
16,766,766 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7530:Greb1
|
UTSW |
12 |
16,767,207 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7536:Greb1
|
UTSW |
12 |
16,732,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7643:Greb1
|
UTSW |
12 |
16,761,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7732:Greb1
|
UTSW |
12 |
16,723,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7740:Greb1
|
UTSW |
12 |
16,790,122 (GRCm39) |
start gained |
probably benign |
|
|
R7747:Greb1
|
UTSW |
12 |
16,724,796 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7760:Greb1
|
UTSW |
12 |
16,773,417 (GRCm39) |
missense |
probably benign |
|
|
R7937:Greb1
|
UTSW |
12 |
16,766,670 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8043:Greb1
|
UTSW |
12 |
16,761,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8259:Greb1
|
UTSW |
12 |
16,774,925 (GRCm39) |
nonsense |
probably null |
|
|
R8553:Greb1
|
UTSW |
12 |
16,773,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8559:Greb1
|
UTSW |
12 |
16,746,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8690:Greb1
|
UTSW |
12 |
16,746,548 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8830:Greb1
|
UTSW |
12 |
16,738,520 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8911:Greb1
|
UTSW |
12 |
16,740,903 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8963:Greb1
|
UTSW |
12 |
16,774,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Greb1
|
UTSW |
12 |
16,734,457 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9013:Greb1
|
UTSW |
12 |
16,789,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9279:Greb1
|
UTSW |
12 |
16,732,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9360:Greb1
|
UTSW |
12 |
16,790,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9616:Greb1
|
UTSW |
12 |
16,790,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9627:Greb1
|
UTSW |
12 |
16,756,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9731:Greb1
|
UTSW |
12 |
16,738,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9761:Greb1
|
UTSW |
12 |
16,751,275 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Greb1
|
UTSW |
12 |
16,746,757 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Greb1
|
UTSW |
12 |
16,752,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGTACAGAGATCCCACCC -3'
(R):5'- GGTCTGATTACCAGGACAGGTTC -3'
Sequencing Primer
(F):5'- GAGATCCCACCCCCTCCTAG -3'
(R):5'- CTGATTACCAGGACAGGTTCTCTGC -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation